Team:CCU Taiwan/HP/Silver

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Silver

Our human practices including several aspects, such as biosafety, social activity and public education. Since Carindex is a genetically engineered product, so our work focuses on promotion of the knowledge of genetically engineered product and survey on people's concern about it.

Self-learning

1. The Third International Symposium on Epigenetic Genomics:

In order to complete our project and products, we need various knowledge from different fields. In May, 2017, the whole team participated in the third International Symposium on Epigenetic Genomics organized by the National Chung Cheng University. In this conference, we learned a lot from the professions and ask them a lot of question regarding many fields, including oral health studies. We had received a lot of precious information from the conference, we also had some discusses about the Biosafety with those lecturers. They helped us to ensure that our product are provided with the safest and most reliable biological safety cabinet to protect us and environment.

   

2. Safety Training:

Knowing that biosafety has always been a discussed issue in the society, in order to let the community trust our research and at the same time, promote our products, all of us participated in the safety training held at the school in the middle of September.


3. MIT beyond food mini bootcamp:

Since one of our goals is to win the entrepreneurship special prize, e participated in the "MIT beyond food mini bootcamp" held in Taiwan during May, 2017. Through this two-day camp, we learned a lot from many entrepreneurs in this field and experienced operation as a businessman. This helped us have a clear and better idea for our entrepreneurship plan.



Engagement with local

1.Product Pamphlet:

In order to let the public understand our product in an easy way, we released pamphlets regarding it. In the pamphlet, we briefly introduced how our product can be used, the technology that is applied, let them know that Carindex is a genetic engineered product. Then we tell them about the kill switch in our gene circuit design in order to introduce the concept of biosafety, at the same time, promoting the safety of our product.

2. Taiwan Health Insurance System:

Taiwan's health insurance has always been a discussed issue of social policy.
When we conducted the PMR market survey, we found that the general public did not have a complete understanding of Taiwan health insurance.
What’s worse is that this leads to the abuse of social welfare system, resulting in the waste of social resources and the burden of state finances.
Carindex is expected to be able to collaborate with the country's health insurance system, and hoping that users will be able to know and improve their oral condition.
Due to the nature of dental caries, they are easily ignored by patients since it won't make them feel hurt at the beginning.
Nonetheless, it would be too late to go to the dentist after it hurts. The worst result might be doing tooth implantation, a painful and costly procedure to the patient, and to the government pocket as well.
In order to save the follow-up medical resources, Carindex can help users on early caries detection so that potential patient would go to the dentist early and cure dental caries before it became serious.
We want to let the public know about the fact of the health insurance system and also having a correct concept about it, so we made a series of detailed introduction in order to do so.
We explained the meaning of health insurance and it's condition in Taiwan over the past few years.
Expectedly, this could bring the public a correct concept to maintain a sustainable development of national resources.

Education engagement

1. Synthetic Biology Camp:

We set up plans to promote synthetic biology. We went to universities and senior high schools, introduced iGEM, synthetic biology and our project to the students so that they can understand biotechnology as well as the various aspects of the impacts from it. Many students had concerns about genetic engineered product at first, however, after introducing what we are doing and also the kill switch that we designed, we ease their concern. According to the feedbacks we collected after class, most of them grasped a better concept of synthetic biology, genetic engineering, and also the biosafety.




Professional Visiting

1. Visiting the Profession:

We visited Professor Mrs. Xiu-mei Chen of Taiwan University of Science and Technology in June this year, and asked her about the technology of detecting the concentration of bacteria on the chip. Then we learned that the chip developed by Professor Chen Xiumei could detect the concentration of many bacteria as well as the one we wanted to detect Streptococcus mutans, S. mutans. Therefore, we asked Professor Chen Xiu Mei about the technology and gained lots of meaningful advices to improve Caridex.


2. Inviting Professions:

In order to make our product more fitting to the market, we invited the CEO of the Renew Biocare Corporation Mr. Ully to discuss the current development of the device. During the discussion, we got a chance to know the similar products on the market. We absorbed the relevant advantages of those products and managed to apply them onto our product to improve the whole project.
Furthermore, this company is one of the leading dental materials companies in the world, so we also asked them to help us check whether our product is safe and forward-looking.
Additionally, we invited to the National Yunlin University of Science and Technology teacher Mr. Zhong-guang Chen to teach us how to establish a product business model design, to help us in the subsequent commercialization of the product.


3. Visiting Dentists

We visited multiple dentists in order to understand the actual needs of the patient and their actual oral condition. Furthermore, dentist had a better understanding about what users really concerned about, especially the safety of our product. Those information helped us to get closer to meet the demands of the public.

Survey

1. Oral Condition Survey:

In order to understand the oral status of the community in Taiwan, whether they have right concept of oral health care, and their thoughts on our product, we conducted an online survey. The survey results are as below:
Total sample number is 678 people.





Summary

From the graphs above, we can see that although the average level of concern for oral health is high, and more than half of the people go to dentist regularly, still, more than 80% of people have oral diseases. Much more worse than those that don’t go to the dentist regularly. So we think that preventive oral treatment is necessary in Taiwan and Carindex is here to solve the problem.

2. GMP Concern:

Genetic engineered product has always been an issue of concern to the public. In order to understand how many people are skeptical about it, we conducted a series of surveys, including online questionnaires, written form questionnaires and booth activities. We managed to build an equal platform for communication of the public, not only to tell them about what we know about genetic engineered product but also listen to their thoughts. After the survey, we held public booth, university camps, and experiment activities for senior high school students.
Finally, we made a analysis how public think about genetic engineered product before and after these activities. The results are as follows:
Total sample is 156 people.




Summary

From the graphs above, they showed that we not only gave people a better understanding about genetic engineered product but also dispelled their misunderstandings of it after interacting with them.

3. Rick assessment:

Based on this result, most people are concerned about the eco-environment and human health. So, we confirm the biosafety of our product both on user and environment aspect.
Q:What if the bacteria ( like E.coli) get out of the device ?
A:We have a system called kill switch which and it will be turned on if bacteria break out the device, the switch will be turned on, and the toxin protein, mazF, will express toxicity, then kill E.coli by cutting its mRNA.
Q:How will you deal with the consumptive materials includes three glide glass after using?
A:Although our consumables seem like it can just be used one time, we have a kill switch to let we recycle them after customers have used. We try to avoid of doing great harm to environment in this way.

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