We are iGEM INSA-UPS_France, a French team composed of students from Toulouse and Lyon. Our project is about crocodiles and cholera... Scroll to know more about it!
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The responsible: Vibrio cholerae
Contaminates water and affects people in developing countries, war zones and natural disaster zones
Last epidemy in an occidental country
Number of cases per year
Number of concerned countries
→ Implemented solutions and their problems:
Too complicated to measure out
Too complicated to set up for big volumes
A synthetic biology innovative approach!
Fight V. cholerae with crocodile antimicrobial peptides!
Our hero: Sobki the crocodile
Can produce antimicrobial peptides that enables him to destroy V. cholerae in his natural habitat
Our system is made of two engineered microorganisms: Vibrio harveyi to detect V. cholerae and Pichia pastoris to produce crocodile AMPs. Thus one of our biggest challenge is to create an eukaryote-prokaryote communication system.