Difference between revisions of "Team:TU-Eindhoven"
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Revision as of 12:04, 30 August 2017
GUPPI: Gelation Using Protein Protein Interactions sdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfgsdfjsdhfjkslsdgdfgldfjgsdjfg
Cancer is a major cause of death worldwide. With our project, GUPPI, we hope to set the basics of a system that can encapsulate the cancerous tissue to prevent spreading of cancer in an early stage. GUPPI utilizes Protein Protein Interactions and is inspired by the formation of membraneless organelles by multivalent interactions. A designed protein scaffold and its binding partner, both having sequential repeating units, will respond to an inducer and form a gel-like structure. We envision that later on, GUPPI can respond to extracellular conditions that will act as an inducer of the gelation to specifically target and encapsulate the desired tissue. Advantages of the GUPPI systems is that the multivalency of the designed proteins can be tuned and that interactions can be adapted. Furthermore, a rule-base-model is developed to predict, verify and characterize the wet-lab experiments and act as an additional support.
