Difference between revisions of "Team:TAS Taipei"
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}); | }); | ||
</script> | </script> | ||
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| + | <!--Nav Bar--> | ||
<div class="container" style='z-index:10;position:relative;'> | <div class="container" style='z-index:10;position:relative;'> | ||
| − | + | <div class="row center-block" style = "text-align: left;"> | |
| − | + | <nav style='font-family:Lato;font-size:22px;background-color:#1C77C3;-webkit-transform: translateZ(0);z-index: 100;position: fixed;box-shadow: 0px 0px 10px black;'> | |
| − | + | <ul style='margin-left:0px'> | |
| − | + | <li class="dropdown"> | |
<a href="https://2017.igem.org/Team:TAS_Taipei/Background"><h4 class="dropdown-toggle disabled" data-toggle="dropdown"><b>PROJECT</b></h4></a> | <a href="https://2017.igem.org/Team:TAS_Taipei/Background"><h4 class="dropdown-toggle disabled" data-toggle="dropdown"><b>PROJECT</b></h4></a> | ||
<div class="dropdown-menu"> | <div class="dropdown-menu"> | ||
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<h5><a href="https://2017.igem.org/Team:TAS_Taipei/Parts">Parts</a></h5> | <h5><a href="https://2017.igem.org/Team:TAS_Taipei/Parts">Parts</a></h5> | ||
</div> | </div> | ||
| − | + | </div> | |
<div style='height:140px;'> | <div style='height:140px;'> | ||
<img src="https://static.igem.org/mediawiki/2016/1/11/T--TAS_Taipei--TAS_Icon_Project.png"> | <img src="https://static.igem.org/mediawiki/2016/1/11/T--TAS_Taipei--TAS_Icon_Project.png"> | ||
| − | <h4><b>Cataracts</b> - the leading cause of blindness. Find out how we can non-invasively <b>treat</b> and <b>prevent</b> cataract formation. | + | <h4> |
| − | + | <b>Cataracts</b> - the leading cause of blindness. Find out how we can non-invasively <b>treat</b> and <b>prevent</b> cataract formation. | |
| − | + | </h4> | |
| + | </div> | ||
</div> | </div> | ||
| − | </li> | + | </li> <!--Project--> |
| − | + | <li class="dropdown"> | |
<a href="https://2017.igem.org/Team:TAS_Taipei/Experimental_Summary"><h4 class='dropdown-toggle disabled' data-toggle="dropdown"><b>EXPERIMENTAL</b></h4></a> | <a href="https://2017.igem.org/Team:TAS_Taipei/Experimental_Summary"><h4 class='dropdown-toggle disabled' data-toggle="dropdown"><b>EXPERIMENTAL</b></h4></a> | ||
<div class="dropdown-menu"> | <div class="dropdown-menu"> | ||
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</div> | </div> | ||
</div> | </div> | ||
| − | </li> | + | </li> <!--Experimental--> |
| − | + | <li class="dropdown"> | |
<a href="https://2017.igem.org/Team:TAS_Taipei/Model"><h4 class='dropdown-toggle disabled' data-toggle="dropdown"><b>MODEL</b></h4></a> | <a href="https://2017.igem.org/Team:TAS_Taipei/Model"><h4 class='dropdown-toggle disabled' data-toggle="dropdown"><b>MODEL</b></h4></a> | ||
<div class="dropdown-menu"> | <div class="dropdown-menu"> | ||
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</div> | </div> | ||
</div> | </div> | ||
| − | </li> | + | </li> <!--Model--> |
| − | + | <li class="dropdown"> | |
<a href="https://2017.igem.org/Team:TAS_Taipei/Human_Practices"><h4 class='dropdown-toggle disabled' data-toggle="dropdown"><b>HUMAN PRACTICE</b></h4></a> | <a href="https://2017.igem.org/Team:TAS_Taipei/Human_Practices"><h4 class='dropdown-toggle disabled' data-toggle="dropdown"><b>HUMAN PRACTICE</b></h4></a> | ||
<div class="dropdown-menu"> | <div class="dropdown-menu"> | ||
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</div> | </div> | ||
</div> | </div> | ||
| − | </li> | + | </li> <!--Human Practice--> |
| − | + | <li class="dropdown"> | |
<a href="https://2017.igem.org/Team:TAS_Taipei/Safety"><h4 class='dropdown-toggle disabled' data-toggle="dropdown"><b>SAFETY</b></h4></a> | <a href="https://2017.igem.org/Team:TAS_Taipei/Safety"><h4 class='dropdown-toggle disabled' data-toggle="dropdown"><b>SAFETY</b></h4></a> | ||
<div class="dropdown-menu"> | <div class="dropdown-menu"> | ||
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</div> | </div> | ||
</div> | </div> | ||
| − | </li> | + | </li> <!--Safety--> |
| − | + | <li class="dropdown"> | |
| − | <a href="https://2017.igem.org/Team:TAS_Taipei/Team"><h4 class='dropdown-toggle disabled' data-toggle="dropdown"><b>TEAM</b></h4></a> | + | <a href="https://2017.igem.org/Team:TAS_Taipei/Team"><h4 class='dropdown-toggle disabled' data-toggle="dropdown"> |
| + | <b>TEAM</b></h4></a> | ||
<div class="dropdown-menu"> | <div class="dropdown-menu"> | ||
<div class='subcategories_container'> | <div class='subcategories_container'> | ||
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</div> | </div> | ||
</div> | </div> | ||
| − | </li> | + | </li> <!--Team--> |
| − | + | </ul> | |
| − | + | </nav> | |
| − | </div> | + | </div> |
| + | </div> | ||
<br> | <br> | ||
<br> | <br> | ||
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</div> | </div> | ||
</div> | </div> | ||
| − | <div><div u="image" style = "text-align:center;width:10%"><image src="https://static.igem.org/mediawiki/2017/5/58/T--TAS_Taipei--TeamPhoto.jpg"/></div> | + | <div> |
| − | + | <div u="image" style = "text-align:center;width:10%"><image src="https://static.igem.org/mediawiki/2017/5/58/T--TAS_Taipei--TeamPhoto.jpg"/> | |
| − | + | </div> | |
| + | <div> | ||
| + | <div u="image" style = "lightgrey;text-align:center"><image style = "width:1080px" src="https://static.igem.org/mediawiki/2016/5/58/T--TAS_Taipei--TeamPhoto.jpg"/></div> | ||
| + | <div u="caption" t="T" style="box-shadow: 0 0 10px 0;background-color:purple;padding:10px;position: absolute; top: 30px; left: 120px;border-style:solid;border-color:gold;border-width:10px"> | ||
<p style = "color:white;font-size:30px;"> | <p style = "color:white;font-size:30px;"> | ||
<b>TAS Taipei: 2017 iGEM Team</b> | <b>TAS Taipei: 2017 iGEM Team</b> | ||
</p> | </p> | ||
| − | + | </div> | |
</div> | </div> | ||
</div> | </div> | ||
Revision as of 07:07, 15 May 2017
ABSTRACT
Cataracts, the clouding of the lens, cause half of the world's blindness. Most cataracts are age-related and arise when crystallin proteins in the lens become oxidized and aggregate over time. Surgery is currently the only recognized treatment to effectively cure cataracts, but this method is expensive and invasive. Therefore, we formulated a natural and non-invasive alternative. In the eye, a natural antioxidant glutathione (GSH)—produced by the enzyme glutathione reductase (GSR)—exists to combat oxidation, but GSH levels decrease with age. Studies have also suggested that another enzyme—25-hydroxylase (CH25H)—can convert cholesterol in the eye into 25-hydroxycholesterol (25HC), which reverses crystallin aggregation. We expressed and purified GSR and CH25H for the prevention and treatment of cataracts, respectively. To deliver these proteins through the cornea and into the lens, we engineered biodegradable chitosan nanoparticles, thus creating a natural and non-invasive alternative to surgery.
