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Revision as of 19:21, 9 October 2017

About Us

iGEM UNC-Asheville

TCEasy

Degradation of Tricholoretheylene through a novel metabolic pathway.

The Problem


Toxic byproducts are seeping into our water table. We need to fix that.


A local problem, but probably local to you too.


Trichloroethylene (TCE) is volatile organic solvent that is useful as a degreasing agent. It has also been used in dry-cleaning fluid and as an additive in paint removers, adhesives and spot removers.1 According to the EPA and the International Agency for Research Cancer (IARC), there is definitive evidence of TCE causing kidney cancer, and more limited evidence for its’ correlation with liver cancer and non-Hodgkin lymphoma. Acute exposure to TCE of between 17-85 ppm can cause central nervous system depression with symptoms including ataxia, short term memory loss and long term oculomotor dysfunction.2 According to the Agency for toxic substance and Disease Registry (ATSDR), TCE has been found in at least 1,045 of the 1,699 National Priorities List sites identified by the EPA.3