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+ | <div class="scu_title"> | ||
+ | <p class="scu_title">Rhythmic Production of Melatonin in <i>E.coli</p> | ||
+ | |||
+ | <p class="scu_vice_title">Nowadays, insomnia and circadian rhythm disorders are increasingly plaguing individuals' daily life. | ||
+ | According to NIH reports, around 50-70 million U.S. adults are suffering from sleep insufficiency and poor-quality sleep. | ||
+ | The circadian rhythm in human is predominantly under the regulation of melatonin, a hormone produced by pineal gland | ||
+ | periodically. This year we want to use engineered E.coli to mimic this process in human. We propose to <strong>construct a melatonin | ||
+ | biosynthesis pathway in <i>E.coli</i> to produce melatonin</strong>, while simultaneously<strong> couple this process with periodically-optimized | ||
+ | repressilator</strong>, a synthetic genetic oscillator with higher precision, with the intention to <strong>render melatonin production | ||
+ | resemble mammalian periodicity in<i> E.coli</i>.</strong> </p> | ||
+ | </div> | ||
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Revision as of 18:42, 26 October 2017