Difference between revisions of "Team:Lambert GA"

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{{Lambert_GA}}
 
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<h1> Welcome to iGEM 2017- tester! </h1>
 
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<p>Your team has been approved and you are ready to start the iGEM season! </p>
 
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<h5>Before you start: </h5>
 
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<p> Please read the following pages:</p>
 
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<ul>
 
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<li>  <a href="https://2017.igem.org/Competition">Competition Hub</a> </li>
 
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<li> <a href="https://2017.igem.org/Competition/Deliverables/Wiki">Wiki Requirements page</a></li>
 
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<li> <a href="https://2017.igem.org/Resources/Template_Documentation">Template documentation</a></li>
 
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<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>
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<h5> Wiki template information </h5>
 
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<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2017.igem.org/Judging/Pages_for_Awards">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
 
  
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<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
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<p> <a href="https://2017.igem.org/wiki/index.php?title=Team:Example&action=edit"> </a>Use WikiTools - Edit in the black menu bar to edit this page</p>
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<div id="headerLinks">
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<a href="https://2016.igem.org/Team:LambertGA" class="dropbtn">Home</a><!--
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--><li class="dropdown" >
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      <a href="https://2016.igem.org/Team:LambertGA/Team" class="dropbtn">Team</a>
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      <div class="dropdown-content">
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      <a class="drplink" style="transition: color 0.5s ease-in-out;" href="https://2016.igem.org/Team:LambertGA/Team">Team</a>
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      <a class="drplink" style="transition: color 0.5s ease-in-out;" href="https://2016.igem.org/Team:LambertGA/Collaborations">Collaborations</a>
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    </div>
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  </li><!--
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--><li class="dropdown">
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  <a href="https://2016.igem.org/Team:LambertGA/Description" class="dropbtn">Project</a>
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    <div class="dropdown-content" style="transition: display 0.5s ease-in-out;">
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      <a class="drplink" style="transition: color 0.5s ease-in-out;" href="https://2016.igem.org/Team:LambertGA/Description">Description</a>
 +
      <a class="drplink" style="transition: color 0.5s ease-in-out;" href="https://2016.igem.org/Team:LambertGA/Design">Design</a>
 +
      <a class="drplink" style="transition: color 0.5s ease-in-out;" href="https://2016.igem.org/Team:LambertGA/Experiments">Experiments</a>
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      <a class="drplink" style="transition: color 0.5s ease-in-out;" href="https://2016.igem.org/Team:LambertGA/Proof">Proof of Concept</a>
 +
      <a class="drplink" style="transition: color 0.5s ease-in-out;" href="https://2016.igem.org/Team:LambertGA/Results">Results</a>
 +
      <a class="drplink" style="transition: color 0.5s ease-in-out;" href="https://2016.igem.org/Team:LambertGA/Notebook">Notebook</a>
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    </div>
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  </li><!--
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--><li class="dropdown" >
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      <a href="https://2016.igem.org/Team:LambertGA/Parts" class="dropbtn">Parts</a>
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      <div class="dropdown-content">
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      <a class="drplink" style="transition: color 0.5s ease-in-out;"
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href="https://2016.igem.org/Team:LambertGA/Parts">Parts</a>
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      <a class="drplink" style="transition: color 0.5s ease-in-out;"
 +
href="https://2016.igem.org/Team:LambertGA/Basic_Part">Basic Parts</a>
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      <a class="drplink" style="transition: color 0.5s ease-in-out;" href="https://2016.igem.org/Team:LambertGA/Composite_Part">Composite Parts</a>
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    </div>
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  </li><!--
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--><a  href="https://2016.igem.org/Team:LambertGA/Attributions"class="dropbtn">Attributions</a><!--
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--><a  href="https://2016.igem.org/Team:LambertGA/Safety"class="dropbtn">Safety</a><!--
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--><li class="dropdown" >
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      <a href="https://2016.igem.org/Team:LambertGA/Human_Practices" class="dropbtn">Human Practices</a>
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      <div class="dropdown-content">
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      <a class="drplink" style="transition: color 0.5s ease-in-out;" href="https://2016.igem.org/Team:LambertGA/Human_Practices">Human Practices</a>
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      <a class="drplink" style="transition: color 0.5s ease-in-out;" href="https://2016.igem.org/Team:LambertGA/HP/Silver">Silver</a>
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      <a class="drplink" style="transition: color 0.5s ease-in-out;" href="https://2016.igem.org/Team:LambertGA/HP/Gold">Gold</a>
 +
      <a class="drplink" style="transition: color 0.5s ease-in-out;" href="https://2016.igem.org/Team:LambertGA/Integrated_Practices">Integrated Practices</a>
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      <a class="drplink" style="transition: color 0.5s ease-in-out;" href="https://2016.igem.org/Team:LambertGA/Engagement">Engagement</a>
 +
    </div>
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  </li><!--
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--><li class="dropdown" >
 +
      <a href="https://2016.igem.org/Team:LambertGA/Hardware" class="dropbtn">Awards</a>
 +
      <div class="dropdown-content">
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      <a class="drplink" style="transition: color 0.5s ease-in-out;" href="https://2016.igem.org/Team:LambertGA/Hardware">Hardware</a>
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      <a class="drplink" style="transition: color 0.5s ease-in-out;" href="https://2016.igem.org/Team:LambertGA/Measurement">Measurement</a>
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      <a class="drplink" style="transition: color 0.5s ease-in-out;" href="https://2016.igem.org/Team:LambertGA/Model">Model</a>
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    </div>
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  </li>
  
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<h5>Tips</h5>
 
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
 
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<ul>
 
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
 
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<li>Be clear about what you are doing and how you plan to do this.</li>
 
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
 
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
 
−
<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
 
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2017.igem.org/Calendar">iGEM 2017 calendar</a> </li>
 
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<li>Have lots of fun! </li>
 
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</ul>
 
 
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<div class="column half_size" >
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<h5>Inspiration</h5>
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<div id="mainbanner">
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<p> You can also view other team wikis for inspiration! Here are some examples:</p>
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            <img src="https://static.igem.org/mediawiki/2016/e/ef/T--LambertGA--clear_banner.jpg" style="width:100%" align="middle">
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<ul>
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            </div>
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<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
+
 
−
<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
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<div class="column full_size" style="background-color:white" >
−
<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
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−
<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
+
 
−
<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
+
<script type="text/javascript"></script>
−
<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
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</ul>
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<center> <img src="https://static.igem.org/mediawiki/2016/a/a4/T--LambertGA--gray_switch.png" style="width:45%; padding-top:80px;" align="middle">
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<h2> Characterization of Nonlysosomal Proteolysis </h2>
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<br>
  
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<h5> Uploading pictures and files </h5>
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Micronutrient deficiency is one of the leading causes of death in the world. According to the World Health Organization (WHO), more than 2 billion people - over 30% of the world’s population - suffer from micronutrient deficiencies today. In response, healthcare providers around the world have organized research facilities to diagnose and treat micronutrient deficiency. However, diagnosing these deficiencies has proved to be extremely expensive and, in many cases, very time consuming. To address this growing concern, medical researchers and synthetic biologists are creating simple and inexpensive “biosensors” that serve as handy diagnostic tests to use in the field to visualize micronutrient levels and determine whether the patient and population in general are lacking critical micronutrients in their diet. Despite these benefits, this versatile tool often yields inaccurate results, potentially leading to faulty diagnosis and the endangerment of an entire community.  
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<p> You can upload your pictures and files to the iGEM 2017 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
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−
When you upload, set the "Destination Filename" to <br><code>T--YourOfficialTeamName--NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)<br><br>
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<br>
 +
<br>
 +
With this in mind, the 2016 Lambert iGEM Team has focused primarily on enhancing existing biosensors and aiding in the diagnosis of micronutrient deficiencies throughout the world. We studied protein degradation and devised a “switch” to prevent the overexpression of specific reporters in biosensors in order to fine-tune biosensor accuracy. By using SsrA degradation tags, we characterized ClpXP, a protease involved in non-lysosomal proteolysis in many prokaryotes, to quantify the relative strength of degradation in GFP and purple chromoproteins.
  
−
<a href="https://2017.igem.org/Special:Upload">
 
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UPLOAD FILES
 
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</a>
 
 
</p>
 
</p>
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</div>
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<center>
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<br>
 +
<img src="https://static.igem.org/mediawiki/2016/e/ef/T--LambertGA--newsilvermedal.jpg">
 +
<br><br>
  
 +
<h2> Silver Medal </h2><br>
 +
<h2> Nominated for Best Wiki </h2><br>
 +
<h2> Nominated for Best Poster </h2><br>
 +
</center>
  
 +
<div class="button_click"  onClick=" parent.location= 'https://2016.igem.org/Special:Upload '">
  
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<!--<h2>2015 Lambert iGEM</h2>-->
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                <div id="officialLogo">
  
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                </div>
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            </footer>
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<div id="space2">
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<div id="sponsors-bottom">
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<a href="http://www.forsyth.k12.ga.us/lhs"><img src="https://static.igem.org/mediawiki/2016/9/9e/T--LambertGA--longhorn_iGEM_logo.png" class="transparent" style="height:100px;padding:20px;"></a>
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Revision as of 15:40, 23 June 2017

Characterization of Nonlysosomal Proteolysis


Micronutrient deficiency is one of the leading causes of death in the world. According to the World Health Organization (WHO), more than 2 billion people - over 30% of the world’s population - suffer from micronutrient deficiencies today. In response, healthcare providers around the world have organized research facilities to diagnose and treat micronutrient deficiency. However, diagnosing these deficiencies has proved to be extremely expensive and, in many cases, very time consuming. To address this growing concern, medical researchers and synthetic biologists are creating simple and inexpensive “biosensors” that serve as handy diagnostic tests to use in the field to visualize micronutrient levels and determine whether the patient and population in general are lacking critical micronutrients in their diet. Despite these benefits, this versatile tool often yields inaccurate results, potentially leading to faulty diagnosis and the endangerment of an entire community.

With this in mind, the 2016 Lambert iGEM Team has focused primarily on enhancing existing biosensors and aiding in the diagnosis of micronutrient deficiencies throughout the world. We studied protein degradation and devised a “switch” to prevent the overexpression of specific reporters in biosensors in order to fine-tune biosensor accuracy. By using SsrA degradation tags, we characterized ClpXP, a protease involved in non-lysosomal proteolysis in many prokaryotes, to quantify the relative strength of degradation in GFP and purple chromoproteins.




Silver Medal


Nominated for Best Wiki


Nominated for Best Poster