Difference between revisions of "Team:ManhattanCol Bronx"

 
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       <center><img style="margin: 0 auto"src="https://preview.ibb.co/gTFPf5/manhattan_college_1.jpg" alt="Campus" width="847" height="600"></center>
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       <center><img style="margin: 0 auto"src="https://static.igem.org/mediawiki/2017/d/d3/Manhattan_College_Campus.jpeg" alt="Campus" width="1250" height="850"></center>
 
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      <h2>Hello! We’re the Manhattan College iGEM!</h2>
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      <p>We are group of undergrads that came together because we are really passionate about synthetic biology. We spent our summer working on synthesizing e-Coli. We learned a lot about bioengineering and had fun doing it.</p>
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Hello! We're the Manhattan College iGEM Team!
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We are undergrads with different backgrounds, but one common interest in the field of synthetic biology. We spent our summer working on making biological fuel cells more efficient at producing energy with the use of E. coli. Basically, we're making a BACTERY!</font></p>
 
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      <center><img src="https://preview.ibb.co/eV8rtQ/Five_Facts_about_E_coli_img_n9tu6xevuv4y66l3rwyn3rzwak6j8up8h7n8um9fws.png"  alt="Yew Berries" width="741" height="600"></center>
 
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      <h2>CANCER MEDICINE PLANT IN SHORT SUPPLY</h2>
 
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      <p>The main Taxol plant (Taxus Bervifolia) is few in number <br /> Duke iGEM engineers and grows bacteria through humane methods to provide infinite supplies of taxol to treat cancer</p>
 
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<section class="bg-primary" id="about" style="background-image: url(https://encrypted-tbn0.gstatic.com/images?q=tbn:ANd9GcSQ8ll8v-ZIuPIPMJdnN3-0Avf9p92ndEJoCgGFZN3Tpo_-41PmDkKYJumq); background-size: cover; background-position: center">
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<section class="bg-primary" id="about" style="background-image: url(https://static.igem.org/mediawiki/2017/5/56/Manhattan_College_homepage_background.jpeg); background-size: cover; background-position: center">
 
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                    <h1 class="section-heading" style="font-family: Indie Flower; font-weight:bolder; font-size: 55px">How to Produce Lots of <br/>Cancer Drugs Sustainably?</h1>
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<p><font face="Comic Sans MS" size="55" color="#BCF5A9">How to Produce Lots of <br/>Electricity Using a Biological Fuel Cell?</font></p>
 
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                <p class="text-right" style="color: black;font-family: Indie Flower; Comic Sans MS; font-size: 30px;">Presented by Duke iGEM <img src="https://static.igem.org/mediawiki/2016/c/c4/T--Duke--logo_and_.jpeg" width="10%"></p>
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            <p class="text-right" style="color: black;font-family: Indie Flower; Comic Sans MS; font-size: 20px;">Presented by Manhattan iGEM <img src="https://image.ibb.co/for2YQ/unnamed.png" width="8%"></p>
 
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<h2 style="color:#337ab7; font-family: Muli; font-size: 3em"><span class="glyphicon glyphicon-question-sign" aria-hidden="true"></span> Identifying Cancer Drug in Short Supply</h2>
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<h2><font face="Tahoma" size="+4" color="#088A08">Combining Biological Cells with Electricity</h2>
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<p>Our case is taxol, a famous chemotherapy drug that derives its chemistry from Pacific Yew Tree barks.</p>
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<p><font face="Tahoma" size="+2" color="#0B1907">Our case is using Glucose Oxidase</p>
 
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<img src="https://static.igem.org/mediawiki/2017/f/f4/Manhattan_College_Glucose_Oxidase_Rxn.png"style="display:block; margin-left:auto;margin-right:auto" width="99%">
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<h4><font face="Tahoma" size="+2" color="#0B1907">Glucose oxidase catalyzes the oxidation of glucose to gluconic acid, by utilizing molecular oxygen as an electron acceptor with simultaneous production of hydrogen peroxide.</h4>
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<h4 style="font-family:Raleway; display:block; margin-right:1em;text-align:center">Annotated Taxol 2D Structure <span class="text-muted">(3D Structure in Project Page)</span></h4>
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<h6>PDB Citation: Bank, RCSB Protein Data. "TAXOL." RCSB PDB. N.p., n.d. Web. 27 Sept. 2016.</h6>
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      <p style="font-family: Raleway; font-size:20px">The lack of chemotherapy drugs risks patients' lives. Taxol is a famous and effective cancer drug whose production rests on the steady supply of Pacific Yew Trees. However, as more people develop cancer, Pacific Yew Trees are being overharvested and endangered.</p>
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      <p><font face="Tahoma" size="+2" color="#088A08">Introduction</p>
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  <p style="font-family: Raleway; font-size:20px">In the forseeable future, there will be fewer Yew Trees. Taxol will become less affordable for patients. Worse, when Yew Trees become extinct, Taxol will lose its most essential ingredient. What can we do?</p>
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<p><font face="Tahoma" color="#0B1907">Synthetic biology utilizes concepts in engineering and mathematical modeling to design ways in which to genetically manipulate biological system in order to alter or create unique physiological pathways.  DNA serves as the functional units in the architecture of improved blueprints of existing organisms. </p>
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<p><font face="Tahoma" color="#0B1907">An enzymatic biofuel cell is a type of biochemical cell that uses catalysts, specifically enzymes, to oxidize its fuel, in this case, glucose. In this project glucose oxidase from aspergillus niger is required at the anode, which is the cell in which oxidation occurs. The enzyme makes 24 electrons </p>
  
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      <p style="font-family: Raleway; font-size:20px">After an analysis of Yew Trees' genetic structure relevant to taxol production, we identified eight transferrable essential genetic sequences for producing taxol ingredients.</p>
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  <p style="font-family: Raleway; font-size:20px">Therefore, it's possible to reinvent taxol production. The next important step is to find the perfect replacement producer to relieve the Yew Trees of their noble duty.</p>
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<h2 style="color:#337ab7;font-family: Muli; font-size:3em" ><span class="glyphicon glyphicon-search" aria-hidden="true"></span> Rethink the Production Process</h2>
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<p>New producer will dramatically increase taxol production, allow Pacific Yew Trees a permanent break from overharvest and danger of extinction. </p>
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<h2 style="color:#337ab7;font-family: Muli;font-size:3em"><i class="fa fa-check-square-o" aria-hidden="true"></i></span> Bacteria!</h2>
 
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<p>Bacterial Production in a controlled lab is safe and sustainable, with a dramatically larger yield!</p>
 
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      <p style="font-family: Raleway; font-size:20px">At Duke iGEM, we have already begun the process of sequentially arranging these genes and growing bacteria with these new powers. </p>
 
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  <p style="font-family: Raleway; font-size:20px">We believe our idea is implementable and has a revolutionary positive impact on future treatments of cancer, saving more lives at a lower cost.</p>
 
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         <p class="text-muted" style="font-size:20px;font-family: Raleway;text-align:center">@ 2016 Duke University iGEM</p>
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         <p class="text-muted" style="font-size:20px;font-family: Raleway;text-align:center">@ 2017 Manhattan College iGEM</p>
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Latest revision as of 19:30, 30 October 2017