Difference between revisions of "Team:ASIJ TOKYO/Description"

 
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{{ASIJ_TOKYO}}
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<h1>Description</h1>
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<p>Tell us about your project, describe what moves you and why this is something important for your team.</p>
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<h5>What should this page contain?</h5>
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<li>Colorectal cancer remains the second most lethal cancer in the United States, often beginning as benign polyps in the colon and rectum. Despite relative ease of treatment, cases of CRC are usually detected in its late stages, rendering care difficult. CRC results from the mutation of multiple genes involved with the regulation of cell proliferation and DNA repair, with the ASIJ iGEM team focusing primarily on the Wnt pathway. The activation of the Wnt pathway specifically inhibits the degradation of beta-catenin, a protein that triggers the mutation of oncogenes and TSG’s. Through detection of these mutated genes and their subsequent downstream proteins, our team aims to develop an early screening method that can be adapted to a CRC detecting home-kit. </li>
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<li> A clear and concise description of your project.</li>
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<li>References and sources to document your research.</li>
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<h5>Advice on writing your Project Description</h5>
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<p>
 
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We encourage you to put up a lot of information and content on your wiki, but we also encourage you to include summaries as much as possible. If you think of the sections in your project description as the sections in a publication, you should try to be consist, accurate and unambiguous in your achievements.
 
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</p>
 
  
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Judges like to read your wiki and know exactly what you have achieved. This is how you should think about these sections; from the point of view of the judge evaluating you at the end of the year.
 
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<h5>References</h5>
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<p>iGEM teams are encouraged to record references you use during the course of your research. They should be posted somewhere on your wiki so that judges and other visitors can see how you thought about your project and what works inspired you.</p>
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<h5>Inspiration</h5>
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<p>See how other teams have described and presented their projects: </p>
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<li><a href="https://2016.igem.org/Team:Imperial_College/Description">2016 Imperial College</a></li>
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  <a href="https://2017.igem.org/Team:ASIJ_TOKYO">Home</a>
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<li><a href="https://2016.igem.org/Team:Wageningen_UR/Description">2016 Wageningen UR</a></li>
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<li><a href="https://2014.igem.org/Team:UC_Davis/Project_Overview"> 2014 UC Davis</a></li>
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  <div class="dropdown">
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<li><a href="https://2014.igem.org/Team:SYSU-Software/Overview">2014 SYSU Software</a></li>
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  <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Team">Team</a>
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</ul>
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    <div class="dropdown-content">
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Team">Team</a>
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Collaborations">Collaborations</a>
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Attributions">Attributions</a>
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    </div>
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  </div>
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      <a href="#">Project</a>
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    <div class="dropdown-content">
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Description">Description</a>
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Design">Design</a>
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Experiments">Experiments</a>
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Notebook">Notebook</a>
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Results">Results</a>
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    </div>
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  </div>
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  <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Parts">Parts</a>
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  <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Safety">Safety</a>
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  <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Engagement">Human Practices</a>
 
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<div class="content">
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<h2 class="major"style="color:#ffffff;">Description</h2>
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<h2 class="major">Construct Model</h2>
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<p>Building off of a rapamycin induced split-luciferase system characterized by the 2015 Peking iGEM team, our construct consists of a promoter reporter system that looks at two downstream products, c-Myc and COX-2 (Peking iGEM Team 2015, 2015). These products are assembled into a construct composed of fusion proteins as well as split luciferase fragments (COX-2 - FRB - nLuc and c-Myc - FKBP - cLuc). In the presence of rapamycin, the interacting protein partners dimerize and subsequently cause luciferase to activate. In order to test this model, we created vectors of our constructs and inserted them into E. coli cells. </p>
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<a href="#" class="image"><img src="https://static.igem.org/mediawiki/2017/c/cc/Diagram_Models_%283%29-1.jpg" /></a>
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<h3 class="major">Figure 1</h3>
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<p>Our gene production construct is modeled to produce COX-2 and c-Myc, which we used to simulate conditions in human bodies when these proteins are overproduced, in the case of CRC. The construct consists of an Anderson promoter, a ribosomal binding site, a COX-2 gene/c-Myc gene, and a terminator.</p>
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<a href="#" class="image"><img src="https://static.igem.org/mediawiki/2017/9/90/P-Rsystemanchiegg.jpg" title="Click to return back to the top." /></a>
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<h3 class="major">Figure 2</h3>
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<p>Our promoter-reporter construct is built so that only when there is both COX-2 and c-Myc will the binding sites be able to come together and glow with the addition of rapamycin. The construct built to bind with COX-2 consists of a COX-2 promoter, FRB, n-Luc, and terminator. The construct built to bind with c-Myc consists of a c-Myc promoter, FKBP, c-Luc, and terminator.</p>
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<a href="#" class="image"><img src="https://static.igem.org/mediawiki/2017/a/a5/P-Rsystemanchiegg2.jpg" title="Click to return back to the top." /></a>
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<h3 class="major">Figure 3</h3>
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<p>Our promoter-reporter system consists of two separate constructs each with a gene-specific promoter attached to a non-specific binding site fused to a domain of split luciferase. One construct consists of a COX-2 promoter, a FRB domain, and n-Luc, and the other consists of a c-Myc promoter, a FKBP domain, and c-Luc. The split system is built so that only when the presence of both COX-2 and c-Myc is detected will the binding sites be able to come together with the addition of rapamycin and cause glowing.</p>
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<a href="#" class="image"><img src="https://static.igem.org/mediawiki/2017/e/ec/Insolutionanchiegg.jpg" title="Click to return back to the top." /></a>
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<h3 class="major">Figure 4</h3>
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<p>In solution, our two gene constructs are able to simulate the conditions in the human body by producing proteins COX-2 and c-Myc. These proteins then interact with the promoter-reporter constructs by connecting to the non- specific binding sites, allowing the dimerization of the FKBP-Rapamycin-FRB complex. This then orients the split- luciferase so they can come together.</p>
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margin: -0.4375em 0 -1px -0.4375em;
 +
}
 +
 +
.\31 2u\28xlarge\29, .\31 2u\24\28xlarge\29 {
 +
width: 100%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 1u\28xlarge\29, .\31 1u\24\28xlarge\29 {
 +
width: 91.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 0u\28xlarge\29, .\31 0u\24\28xlarge\29 {
 +
width: 83.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\39 u\28xlarge\29, .\39 u\24\28xlarge\29 {
 +
width: 75%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\38 u\28xlarge\29, .\38 u\24\28xlarge\29 {
 +
width: 66.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\37 u\28xlarge\29, .\37 u\24\28xlarge\29 {
 +
width: 58.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\36 u\28xlarge\29, .\36 u\24\28xlarge\29 {
 +
width: 50%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\35 u\28xlarge\29, .\35 u\24\28xlarge\29 {
 +
width: 41.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\34 u\28xlarge\29, .\34 u\24\28xlarge\29 {
 +
width: 33.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\33 u\28xlarge\29, .\33 u\24\28xlarge\29 {
 +
width: 25%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\32 u\28xlarge\29, .\32 u\24\28xlarge\29 {
 +
width: 16.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 u\28xlarge\29, .\31 u\24\28xlarge\29 {
 +
width: 8.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 2u\24\28xlarge\29 + *,
 +
.\31 1u\24\28xlarge\29 + *,
 +
.\31 0u\24\28xlarge\29 + *,
 +
.\39 u\24\28xlarge\29 + *,
 +
.\38 u\24\28xlarge\29 + *,
 +
.\37 u\24\28xlarge\29 + *,
 +
.\36 u\24\28xlarge\29 + *,
 +
.\35 u\24\28xlarge\29 + *,
 +
.\34 u\24\28xlarge\29 + *,
 +
.\33 u\24\28xlarge\29 + *,
 +
.\32 u\24\28xlarge\29 + *,
 +
.\31 u\24\28xlarge\29 + * {
 +
clear: left;
 +
}
 +
 +
.\-11u\28xlarge\29 {
 +
margin-left: 91.66667%;
 +
}
 +
 +
.\-10u\28xlarge\29 {
 +
margin-left: 83.33333%;
 +
}
 +
 +
.\-9u\28xlarge\29 {
 +
margin-left: 75%;
 +
}
 +
 +
.\-8u\28xlarge\29 {
 +
margin-left: 66.66667%;
 +
}
 +
 +
.\-7u\28xlarge\29 {
 +
margin-left: 58.33333%;
 +
}
 +
 +
.\-6u\28xlarge\29 {
 +
margin-left: 50%;
 +
}
 +
 +
.\-5u\28xlarge\29 {
 +
margin-left: 41.66667%;
 +
}
 +
 +
.\-4u\28xlarge\29 {
 +
margin-left: 33.33333%;
 +
}
 +
 +
.\-3u\28xlarge\29 {
 +
margin-left: 25%;
 +
}
 +
 +
.\-2u\28xlarge\29 {
 +
margin-left: 16.66667%;
 +
}
 +
 +
.\-1u\28xlarge\29 {
 +
margin-left: 8.33333%;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 1280px) {
 +
 +
.row > * {
 +
padding: 0 0 0 1.75em;
 +
}
 +
 +
.row {
 +
margin: 0 0 -1px -1.75em;
 +
}
 +
 +
.row.uniform > * {
 +
padding: 1.75em 0 0 1.75em;
 +
}
 +
 +
.row.uniform {
 +
margin: -1.75em 0 -1px -1.75em;
 +
}
 +
 +
.row.\32 00\25 > * {
 +
padding: 0 0 0 3.5em;
 +
}
 +
 +
.row.\32 00\25 {
 +
margin: 0 0 -1px -3.5em;
 +
}
 +
 +
.row.uniform.\32 00\25 > * {
 +
padding: 3.5em 0 0 3.5em;
 +
}
 +
 +
.row.uniform.\32 00\25 {
 +
margin: -3.5em 0 -1px -3.5em;
 +
}
 +
 +
.row.\31 50\25 > * {
 +
padding: 0 0 0 2.625em;
 +
}
 +
 +
.row.\31 50\25 {
 +
margin: 0 0 -1px -2.625em;
 +
}
 +
 +
.row.uniform.\31 50\25 > * {
 +
padding: 2.625em 0 0 2.625em;
 +
}
 +
 +
.row.uniform.\31 50\25 {
 +
margin: -2.625em 0 -1px -2.625em;
 +
}
 +
 +
.row.\35 0\25 > * {
 +
padding: 0 0 0 0.875em;
 +
}
 +
 +
.row.\35 0\25 {
 +
margin: 0 0 -1px -0.875em;
 +
}
 +
 +
.row.uniform.\35 0\25 > * {
 +
padding: 0.875em 0 0 0.875em;
 +
}
 +
 +
.row.uniform.\35 0\25 {
 +
margin: -0.875em 0 -1px -0.875em;
 +
}
 +
 +
.row.\32 5\25 > * {
 +
padding: 0 0 0 0.4375em;
 +
}
 +
 +
.row.\32 5\25 {
 +
margin: 0 0 -1px -0.4375em;
 +
}
 +
 +
.row.uniform.\32 5\25 > * {
 +
padding: 0.4375em 0 0 0.4375em;
 +
}
 +
 +
.row.uniform.\32 5\25 {
 +
margin: -0.4375em 0 -1px -0.4375em;
 +
}
 +
 +
.\31 2u\28large\29, .\31 2u\24\28large\29 {
 +
width: 100%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 1u\28large\29, .\31 1u\24\28large\29 {
 +
width: 91.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 0u\28large\29, .\31 0u\24\28large\29 {
 +
width: 83.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\39 u\28large\29, .\39 u\24\28large\29 {
 +
width: 75%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\38 u\28large\29, .\38 u\24\28large\29 {
 +
width: 66.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\37 u\28large\29, .\37 u\24\28large\29 {
 +
width: 58.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\36 u\28large\29, .\36 u\24\28large\29 {
 +
width: 50%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\35 u\28large\29, .\35 u\24\28large\29 {
 +
width: 41.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\34 u\28large\29, .\34 u\24\28large\29 {
 +
width: 33.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\33 u\28large\29, .\33 u\24\28large\29 {
 +
width: 25%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\32 u\28large\29, .\32 u\24\28large\29 {
 +
width: 16.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 u\28large\29, .\31 u\24\28large\29 {
 +
width: 8.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 2u\24\28large\29 + *,
 +
.\31 1u\24\28large\29 + *,
 +
.\31 0u\24\28large\29 + *,
 +
.\39 u\24\28large\29 + *,
 +
.\38 u\24\28large\29 + *,
 +
.\37 u\24\28large\29 + *,
 +
.\36 u\24\28large\29 + *,
 +
.\35 u\24\28large\29 + *,
 +
.\34 u\24\28large\29 + *,
 +
.\33 u\24\28large\29 + *,
 +
.\32 u\24\28large\29 + *,
 +
.\31 u\24\28large\29 + * {
 +
clear: left;
 +
}
 +
 +
.\-11u\28large\29 {
 +
margin-left: 91.66667%;
 +
}
 +
 +
.\-10u\28large\29 {
 +
margin-left: 83.33333%;
 +
}
 +
 +
.\-9u\28large\29 {
 +
margin-left: 75%;
 +
}
 +
 +
.\-8u\28large\29 {
 +
margin-left: 66.66667%;
 +
}
 +
 +
.\-7u\28large\29 {
 +
margin-left: 58.33333%;
 +
}
 +
 +
.\-6u\28large\29 {
 +
margin-left: 50%;
 +
}
 +
 +
.\-5u\28large\29 {
 +
margin-left: 41.66667%;
 +
}
 +
 +
.\-4u\28large\29 {
 +
margin-left: 33.33333%;
 +
}
 +
 +
.\-3u\28large\29 {
 +
margin-left: 25%;
 +
}
 +
 +
.\-2u\28large\29 {
 +
margin-left: 16.66667%;
 +
}
 +
 +
.\-1u\28large\29 {
 +
margin-left: 8.33333%;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 980px) {
 +
 +
.row > * {
 +
padding: 0 0 0 1.75em;
 +
}
 +
 +
.row {
 +
margin: 0 0 -1px -1.75em;
 +
}
 +
 +
.row.uniform > * {
 +
padding: 1.75em 0 0 1.75em;
 +
}
 +
 +
.row.uniform {
 +
margin: -1.75em 0 -1px -1.75em;
 +
}
 +
 +
.row.\32 00\25 > * {
 +
padding: 0 0 0 3.5em;
 +
}
 +
 +
.row.\32 00\25 {
 +
margin: 0 0 -1px -3.5em;
 +
}
 +
 +
.row.uniform.\32 00\25 > * {
 +
padding: 3.5em 0 0 3.5em;
 +
}
 +
 +
.row.uniform.\32 00\25 {
 +
margin: -3.5em 0 -1px -3.5em;
 +
}
 +
 +
.row.\31 50\25 > * {
 +
padding: 0 0 0 2.625em;
 +
}
 +
 +
.row.\31 50\25 {
 +
margin: 0 0 -1px -2.625em;
 +
}
 +
 +
.row.uniform.\31 50\25 > * {
 +
padding: 2.625em 0 0 2.625em;
 +
}
 +
 +
.row.uniform.\31 50\25 {
 +
margin: -2.625em 0 -1px -2.625em;
 +
}
 +
 +
.row.\35 0\25 > * {
 +
padding: 0 0 0 0.875em;
 +
}
 +
 +
.row.\35 0\25 {
 +
margin: 0 0 -1px -0.875em;
 +
}
 +
 +
.row.uniform.\35 0\25 > * {
 +
padding: 0.875em 0 0 0.875em;
 +
}
 +
 +
.row.uniform.\35 0\25 {
 +
margin: -0.875em 0 -1px -0.875em;
 +
}
 +
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.row.\32 5\25 > * {
 +
padding: 0 0 0 0.4375em;
 +
}
 +
 +
.row.\32 5\25 {
 +
margin: 0 0 -1px -0.4375em;
 +
}
 +
 +
.row.uniform.\32 5\25 > * {
 +
padding: 0.4375em 0 0 0.4375em;
 +
}
 +
 +
.row.uniform.\32 5\25 {
 +
margin: -0.4375em 0 -1px -0.4375em;
 +
}
 +
 +
.\31 2u\28medium\29, .\31 2u\24\28medium\29 {
 +
width: 100%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 1u\28medium\29, .\31 1u\24\28medium\29 {
 +
width: 91.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 0u\28medium\29, .\31 0u\24\28medium\29 {
 +
width: 83.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\39 u\28medium\29, .\39 u\24\28medium\29 {
 +
width: 75%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\38 u\28medium\29, .\38 u\24\28medium\29 {
 +
width: 66.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
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.\37 u\28medium\29, .\37 u\24\28medium\29 {
 +
width: 58.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\36 u\28medium\29, .\36 u\24\28medium\29 {
 +
width: 50%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\35 u\28medium\29, .\35 u\24\28medium\29 {
 +
width: 41.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\34 u\28medium\29, .\34 u\24\28medium\29 {
 +
width: 33.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\33 u\28medium\29, .\33 u\24\28medium\29 {
 +
width: 25%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\32 u\28medium\29, .\32 u\24\28medium\29 {
 +
width: 16.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 u\28medium\29, .\31 u\24\28medium\29 {
 +
width: 8.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 2u\24\28medium\29 + *,
 +
.\31 1u\24\28medium\29 + *,
 +
.\31 0u\24\28medium\29 + *,
 +
.\39 u\24\28medium\29 + *,
 +
.\38 u\24\28medium\29 + *,
 +
.\37 u\24\28medium\29 + *,
 +
.\36 u\24\28medium\29 + *,
 +
.\35 u\24\28medium\29 + *,
 +
.\34 u\24\28medium\29 + *,
 +
.\33 u\24\28medium\29 + *,
 +
.\32 u\24\28medium\29 + *,
 +
.\31 u\24\28medium\29 + * {
 +
clear: left;
 +
}
 +
 +
.\-11u\28medium\29 {
 +
margin-left: 91.66667%;
 +
}
 +
 +
.\-10u\28medium\29 {
 +
margin-left: 83.33333%;
 +
}
 +
 +
.\-9u\28medium\29 {
 +
margin-left: 75%;
 +
}
 +
 +
.\-8u\28medium\29 {
 +
margin-left: 66.66667%;
 +
}
 +
 +
.\-7u\28medium\29 {
 +
margin-left: 58.33333%;
 +
}
 +
 +
.\-6u\28medium\29 {
 +
margin-left: 50%;
 +
}
 +
 +
.\-5u\28medium\29 {
 +
margin-left: 41.66667%;
 +
}
 +
 +
.\-4u\28medium\29 {
 +
margin-left: 33.33333%;
 +
}
 +
 +
.\-3u\28medium\29 {
 +
margin-left: 25%;
 +
}
 +
 +
.\-2u\28medium\29 {
 +
margin-left: 16.66667%;
 +
}
 +
 +
.\-1u\28medium\29 {
 +
margin-left: 8.33333%;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
.row > * {
 +
padding: 0 0 0 1.25em;
 +
}
 +
 +
.row {
 +
margin: 0 0 -1px -1.25em;
 +
}
 +
 +
.row.uniform > * {
 +
padding: 1.25em 0 0 1.25em;
 +
}
 +
 +
.row.uniform {
 +
margin: -1.25em 0 -1px -1.25em;
 +
}
 +
 +
.row.\32 00\25 > * {
 +
padding: 0 0 0 2.5em;
 +
}
 +
 +
.row.\32 00\25 {
 +
margin: 0 0 -1px -2.5em;
 +
}
 +
 +
.row.uniform.\32 00\25 > * {
 +
padding: 2.5em 0 0 2.5em;
 +
}
 +
 +
.row.uniform.\32 00\25 {
 +
margin: -2.5em 0 -1px -2.5em;
 +
}
 +
 +
.row.\31 50\25 > * {
 +
padding: 0 0 0 1.875em;
 +
}
 +
 +
.row.\31 50\25 {
 +
margin: 0 0 -1px -1.875em;
 +
}
 +
 +
.row.uniform.\31 50\25 > * {
 +
padding: 1.875em 0 0 1.875em;
 +
}
 +
 +
.row.uniform.\31 50\25 {
 +
margin: -1.875em 0 -1px -1.875em;
 +
}
 +
 +
.row.\35 0\25 > * {
 +
padding: 0 0 0 0.625em;
 +
}
 +
 +
.row.\35 0\25 {
 +
margin: 0 0 -1px -0.625em;
 +
}
 +
 +
.row.uniform.\35 0\25 > * {
 +
padding: 0.625em 0 0 0.625em;
 +
}
 +
 +
.row.uniform.\35 0\25 {
 +
margin: -0.625em 0 -1px -0.625em;
 +
}
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.row.\32 5\25 > * {
 +
padding: 0 0 0 0.3125em;
 +
}
 +
 +
.row.\32 5\25 {
 +
margin: 0 0 -1px -0.3125em;
 +
}
 +
 +
.row.uniform.\32 5\25 > * {
 +
padding: 0.3125em 0 0 0.3125em;
 +
}
 +
 +
.row.uniform.\32 5\25 {
 +
margin: -0.3125em 0 -1px -0.3125em;
 +
}
 +
 +
.\31 2u\28small\29, .\31 2u\24\28small\29 {
 +
width: 100%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 1u\28small\29, .\31 1u\24\28small\29 {
 +
width: 91.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 0u\28small\29, .\31 0u\24\28small\29 {
 +
width: 83.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\39 u\28small\29, .\39 u\24\28small\29 {
 +
width: 75%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\38 u\28small\29, .\38 u\24\28small\29 {
 +
width: 66.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\37 u\28small\29, .\37 u\24\28small\29 {
 +
width: 58.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\36 u\28small\29, .\36 u\24\28small\29 {
 +
width: 50%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\35 u\28small\29, .\35 u\24\28small\29 {
 +
width: 41.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\34 u\28small\29, .\34 u\24\28small\29 {
 +
width: 33.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\33 u\28small\29, .\33 u\24\28small\29 {
 +
width: 25%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\32 u\28small\29, .\32 u\24\28small\29 {
 +
width: 16.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 u\28small\29, .\31 u\24\28small\29 {
 +
width: 8.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 2u\24\28small\29 + *,
 +
.\31 1u\24\28small\29 + *,
 +
.\31 0u\24\28small\29 + *,
 +
.\39 u\24\28small\29 + *,
 +
.\38 u\24\28small\29 + *,
 +
.\37 u\24\28small\29 + *,
 +
.\36 u\24\28small\29 + *,
 +
.\35 u\24\28small\29 + *,
 +
.\34 u\24\28small\29 + *,
 +
.\33 u\24\28small\29 + *,
 +
.\32 u\24\28small\29 + *,
 +
.\31 u\24\28small\29 + * {
 +
clear: left;
 +
}
 +
 +
.\-11u\28small\29 {
 +
margin-left: 91.66667%;
 +
}
 +
 +
.\-10u\28small\29 {
 +
margin-left: 83.33333%;
 +
}
 +
 +
.\-9u\28small\29 {
 +
margin-left: 75%;
 +
}
 +
 +
.\-8u\28small\29 {
 +
margin-left: 66.66667%;
 +
}
 +
 +
.\-7u\28small\29 {
 +
margin-left: 58.33333%;
 +
}
 +
 +
.\-6u\28small\29 {
 +
margin-left: 50%;
 +
}
 +
 +
.\-5u\28small\29 {
 +
margin-left: 41.66667%;
 +
}
 +
 +
.\-4u\28small\29 {
 +
margin-left: 33.33333%;
 +
}
 +
 +
.\-3u\28small\29 {
 +
margin-left: 25%;
 +
}
 +
 +
.\-2u\28small\29 {
 +
margin-left: 16.66667%;
 +
}
 +
 +
.\-1u\28small\29 {
 +
margin-left: 8.33333%;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
.row > * {
 +
padding: 0 0 0 1.25em;
 +
}
 +
 +
.row {
 +
margin: 0 0 -1px -1.25em;
 +
}
 +
 +
.row.uniform > * {
 +
padding: 1.25em 0 0 1.25em;
 +
}
 +
 +
.row.uniform {
 +
margin: -1.25em 0 -1px -1.25em;
 +
}
 +
 +
.row.\32 00\25 > * {
 +
padding: 0 0 0 2.5em;
 +
}
 +
 +
.row.\32 00\25 {
 +
margin: 0 0 -1px -2.5em;
 +
}
 +
 +
.row.uniform.\32 00\25 > * {
 +
padding: 2.5em 0 0 2.5em;
 +
}
 +
 +
.row.uniform.\32 00\25 {
 +
margin: -2.5em 0 -1px -2.5em;
 +
}
 +
 +
.row.\31 50\25 > * {
 +
padding: 0 0 0 1.875em;
 +
}
 +
 +
.row.\31 50\25 {
 +
margin: 0 0 -1px -1.875em;
 +
}
 +
 +
.row.uniform.\31 50\25 > * {
 +
padding: 1.875em 0 0 1.875em;
 +
}
 +
 +
.row.uniform.\31 50\25 {
 +
margin: -1.875em 0 -1px -1.875em;
 +
}
 +
 +
.row.\35 0\25 > * {
 +
padding: 0 0 0 0.625em;
 +
}
 +
 +
.row.\35 0\25 {
 +
margin: 0 0 -1px -0.625em;
 +
}
 +
 +
.row.uniform.\35 0\25 > * {
 +
padding: 0.625em 0 0 0.625em;
 +
}
 +
 +
.row.uniform.\35 0\25 {
 +
margin: -0.625em 0 -1px -0.625em;
 +
}
 +
 +
.row.\32 5\25 > * {
 +
padding: 0 0 0 0.3125em;
 +
}
 +
 +
.row.\32 5\25 {
 +
margin: 0 0 -1px -0.3125em;
 +
}
 +
 +
.row.uniform.\32 5\25 > * {
 +
padding: 0.3125em 0 0 0.3125em;
 +
}
 +
 +
.row.uniform.\32 5\25 {
 +
margin: -0.3125em 0 -1px -0.3125em;
 +
}
 +
 +
.\31 2u\28xsmall\29, .\31 2u\24\28xsmall\29 {
 +
width: 100%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 1u\28xsmall\29, .\31 1u\24\28xsmall\29 {
 +
width: 91.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 0u\28xsmall\29, .\31 0u\24\28xsmall\29 {
 +
width: 83.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\39 u\28xsmall\29, .\39 u\24\28xsmall\29 {
 +
width: 75%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\38 u\28xsmall\29, .\38 u\24\28xsmall\29 {
 +
width: 66.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\37 u\28xsmall\29, .\37 u\24\28xsmall\29 {
 +
width: 58.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\36 u\28xsmall\29, .\36 u\24\28xsmall\29 {
 +
width: 50%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\35 u\28xsmall\29, .\35 u\24\28xsmall\29 {
 +
width: 41.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\34 u\28xsmall\29, .\34 u\24\28xsmall\29 {
 +
width: 33.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\33 u\28xsmall\29, .\33 u\24\28xsmall\29 {
 +
width: 25%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\32 u\28xsmall\29, .\32 u\24\28xsmall\29 {
 +
width: 16.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 u\28xsmall\29, .\31 u\24\28xsmall\29 {
 +
width: 8.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 2u\24\28xsmall\29 + *,
 +
.\31 1u\24\28xsmall\29 + *,
 +
.\31 0u\24\28xsmall\29 + *,
 +
.\39 u\24\28xsmall\29 + *,
 +
.\38 u\24\28xsmall\29 + *,
 +
.\37 u\24\28xsmall\29 + *,
 +
.\36 u\24\28xsmall\29 + *,
 +
.\35 u\24\28xsmall\29 + *,
 +
.\34 u\24\28xsmall\29 + *,
 +
.\33 u\24\28xsmall\29 + *,
 +
.\32 u\24\28xsmall\29 + *,
 +
.\31 u\24\28xsmall\29 + * {
 +
clear: left;
 +
}
 +
 +
.\-11u\28xsmall\29 {
 +
margin-left: 91.66667%;
 +
}
 +
 +
.\-10u\28xsmall\29 {
 +
margin-left: 83.33333%;
 +
}
 +
 +
.\-9u\28xsmall\29 {
 +
margin-left: 75%;
 +
}
 +
 +
.\-8u\28xsmall\29 {
 +
margin-left: 66.66667%;
 +
}
 +
 +
.\-7u\28xsmall\29 {
 +
margin-left: 58.33333%;
 +
}
 +
 +
.\-6u\28xsmall\29 {
 +
margin-left: 50%;
 +
}
 +
 +
.\-5u\28xsmall\29 {
 +
margin-left: 41.66667%;
 +
}
 +
 +
.\-4u\28xsmall\29 {
 +
margin-left: 33.33333%;
 +
}
 +
 +
.\-3u\28xsmall\29 {
 +
margin-left: 25%;
 +
}
 +
 +
.\-2u\28xsmall\29 {
 +
margin-left: 16.66667%;
 +
}
 +
 +
.\-1u\28xsmall\29 {
 +
margin-left: 8.33333%;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 360px) {
 +
 +
.row > * {
 +
padding: 0 0 0 1.25em;
 +
}
 +
 +
.row {
 +
margin: 0 0 -1px -1.25em;
 +
}
 +
 +
.row.uniform > * {
 +
padding: 1.25em 0 0 1.25em;
 +
}
 +
 +
.row.uniform {
 +
margin: -1.25em 0 -1px -1.25em;
 +
}
 +
 +
.row.\32 00\25 > * {
 +
padding: 0 0 0 2.5em;
 +
}
 +
 +
.row.\32 00\25 {
 +
margin: 0 0 -1px -2.5em;
 +
}
 +
 +
.row.uniform.\32 00\25 > * {
 +
padding: 2.5em 0 0 2.5em;
 +
}
 +
 +
.row.uniform.\32 00\25 {
 +
margin: -2.5em 0 -1px -2.5em;
 +
}
 +
 +
.row.\31 50\25 > * {
 +
padding: 0 0 0 1.875em;
 +
}
 +
 +
.row.\31 50\25 {
 +
margin: 0 0 -1px -1.875em;
 +
}
 +
 +
.row.uniform.\31 50\25 > * {
 +
padding: 1.875em 0 0 1.875em;
 +
}
 +
 +
.row.uniform.\31 50\25 {
 +
margin: -1.875em 0 -1px -1.875em;
 +
}
 +
 +
.row.\35 0\25 > * {
 +
padding: 0 0 0 0.625em;
 +
}
 +
 +
.row.\35 0\25 {
 +
margin: 0 0 -1px -0.625em;
 +
}
 +
 +
.row.uniform.\35 0\25 > * {
 +
padding: 0.625em 0 0 0.625em;
 +
}
 +
 +
.row.uniform.\35 0\25 {
 +
margin: -0.625em 0 -1px -0.625em;
 +
}
 +
 +
.row.\32 5\25 > * {
 +
padding: 0 0 0 0.3125em;
 +
}
 +
 +
.row.\32 5\25 {
 +
margin: 0 0 -1px -0.3125em;
 +
}
 +
 +
.row.uniform.\32 5\25 > * {
 +
padding: 0.3125em 0 0 0.3125em;
 +
}
 +
 +
.row.uniform.\32 5\25 {
 +
margin: -0.3125em 0 -1px -0.3125em;
 +
}
 +
 +
.\31 2u\28xxsmall\29, .\31 2u\24\28xxsmall\29 {
 +
width: 100%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 1u\28xxsmall\29, .\31 1u\24\28xxsmall\29 {
 +
width: 91.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 0u\28xxsmall\29, .\31 0u\24\28xxsmall\29 {
 +
width: 83.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\39 u\28xxsmall\29, .\39 u\24\28xxsmall\29 {
 +
width: 75%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\38 u\28xxsmall\29, .\38 u\24\28xxsmall\29 {
 +
width: 66.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\37 u\28xxsmall\29, .\37 u\24\28xxsmall\29 {
 +
width: 58.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\36 u\28xxsmall\29, .\36 u\24\28xxsmall\29 {
 +
width: 50%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\35 u\28xxsmall\29, .\35 u\24\28xxsmall\29 {
 +
width: 41.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\34 u\28xxsmall\29, .\34 u\24\28xxsmall\29 {
 +
width: 33.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\33 u\28xxsmall\29, .\33 u\24\28xxsmall\29 {
 +
width: 25%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\32 u\28xxsmall\29, .\32 u\24\28xxsmall\29 {
 +
width: 16.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 u\28xxsmall\29, .\31 u\24\28xxsmall\29 {
 +
width: 8.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 2u\24\28xxsmall\29 + *,
 +
.\31 1u\24\28xxsmall\29 + *,
 +
.\31 0u\24\28xxsmall\29 + *,
 +
.\39 u\24\28xxsmall\29 + *,
 +
.\38 u\24\28xxsmall\29 + *,
 +
.\37 u\24\28xxsmall\29 + *,
 +
.\36 u\24\28xxsmall\29 + *,
 +
.\35 u\24\28xxsmall\29 + *,
 +
.\34 u\24\28xxsmall\29 + *,
 +
.\33 u\24\28xxsmall\29 + *,
 +
.\32 u\24\28xxsmall\29 + *,
 +
.\31 u\24\28xxsmall\29 + * {
 +
clear: left;
 +
}
 +
 +
.\-11u\28xxsmall\29 {
 +
margin-left: 91.66667%;
 +
}
 +
 +
.\-10u\28xxsmall\29 {
 +
margin-left: 83.33333%;
 +
}
 +
 +
.\-9u\28xxsmall\29 {
 +
margin-left: 75%;
 +
}
 +
 +
.\-8u\28xxsmall\29 {
 +
margin-left: 66.66667%;
 +
}
 +
 +
.\-7u\28xxsmall\29 {
 +
margin-left: 58.33333%;
 +
}
 +
 +
.\-6u\28xxsmall\29 {
 +
margin-left: 50%;
 +
}
 +
 +
.\-5u\28xxsmall\29 {
 +
margin-left: 41.66667%;
 +
}
 +
 +
.\-4u\28xxsmall\29 {
 +
margin-left: 33.33333%;
 +
}
 +
 +
.\-3u\28xxsmall\29 {
 +
margin-left: 25%;
 +
}
 +
 +
.\-2u\28xxsmall\29 {
 +
margin-left: 16.66667%;
 +
}
 +
 +
.\-1u\28xxsmall\29 {
 +
margin-left: 8.33333%;
 +
}
 +
 +
}
 +
 +
/* Basic */
 +
 +
@-ms-viewport {
 +
width: device-width;
 +
}
 +
 +
body {
 +
-ms-overflow-style: scrollbar;
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
html, body {
 +
min-width: 320px;
 +
}
 +
 +
}
 +
 +
body {
 +
background-color: #dbe9d8;
 +
background-image: linear-gradient(to top, rgba(46, 49, 65, 0.8), rgba(46, 49, 65, 0.8)), url("../../images/bg.jpg");
 +
background-size: auto, cover;
 +
background-attachment: fixed, fixed;
 +
background-position: center, center;
 +
}
 +
 +
body.is-loading *, body.is-loading *:before, body.is-loading *:after {
 +
-moz-animation: none !important;
 +
-webkit-animation: none !important;
 +
-ms-animation: none !important;
 +
animation: none !important;
 +
-moz-transition: none !important;
 +
-webkit-transition: none !important;
 +
-ms-transition: none !important;
 +
transition: none !important;
 +
}
 +
 +
/* Type */
 +
 +
body, input, select, textarea {
 +
color: #ffffff;
 +
font-family: "Source Sans Pro", Helvetica, sans-serif;
 +
font-size: 16.5pt;
 +
font-weight: 300;
 +
line-height: 1.65;
 +
}
 +
 +
@media screen and (max-width: 1680px) {
 +
 +
body, input, select, textarea {
 +
font-size: 13pt;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 1280px) {
 +
 +
body, input, select, textarea {
 +
font-size: 12pt;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 980px) {
 +
 +
body, input, select, textarea {
 +
font-size: 12pt;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
body, input, select, textarea {
 +
font-size: 12pt;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
body, input, select, textarea {
 +
font-size: 12pt;
 +
}
 +
 +
}
 +
 +
a {
 +
-moz-transition: color 0.2s ease-in-out, border-bottom-color 0.2s ease-in-out;
 +
-webkit-transition: color 0.2s ease-in-out, border-bottom-color 0.2s ease-in-out;
 +
-ms-transition: color 0.2s ease-in-out, border-bottom-color 0.2s ease-in-out;
 +
transition: color 0.2s ease-in-out, border-bottom-color 0.2s ease-in-out;
 +
border-bottom: dotted 1px rgba(255, 255, 255, 0.35);
 +
color: #ffffff;
 +
text-decoration: none;
 +
}
 +
 +
a:hover {
 +
border-bottom-color: transparent;
 +
color: #ffffff !important;
 +
}
 +
 +
a.special:not(.button) {
 +
text-decoration: none;
 +
border-bottom: 0;
 +
display: block;
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-size: 0.8em;
 +
font-weight: 700;
 +
letter-spacing: 0.1em;
 +
margin: 0 0 2em 0;
 +
text-transform: uppercase;
 +
}
 +
 +
a.special:not(.button):before {
 +
-moz-osx-font-smoothing: grayscale;
 +
-webkit-font-smoothing: antialiased;
 +
font-family: FontAwesome;
 +
font-style: normal;
 +
font-weight: normal;
 +
text-transform: none !important;
 +
}
 +
 +
a.special:not(.button):before {
 +
-moz-transition: background-color 0.2s ease-in-out;
 +
-webkit-transition: background-color 0.2s ease-in-out;
 +
-ms-transition: background-color 0.2s ease-in-out;
 +
transition: background-color 0.2s ease-in-out;
 +
border-radius: 100%;
 +
border: solid 2px rgba(255, 255, 255, 0.125);
 +
content: '\f105';
 +
display: inline-block;
 +
font-size: 1.25em;
 +
height: 2em;
 +
line-height: 1.65em;
 +
margin-right: 0.85em;
 +
text-align: center;
 +
text-indent: 0.15em;
 +
vertical-align: middle;
 +
width: 2em;
 +
}
 +
 +
a.special:not(.button):hover:before {
 +
background-color: rgba(255, 255, 255, 0.025);
 +
}
 +
 +
a.special:not(.button):active:before {
 +
background-color: rgba(255, 255, 255, 0.075);
 +
}
 +
 +
strong, b {
 +
color: #ffffff;
 +
font-weight: 600;
 +
}
 +
 +
em, i {
 +
font-style: italic;
 +
}
 +
 +
p {
 +
margin: 0 0 2em 0;
 +
}
 +
 +
h1, h2, h3, h4, h5, h6 {
 +
color: #ffffff;
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-weight: 700;
 +
letter-spacing: 0.1em;
 +
margin: 0 0 1em 0;
 +
text-transform: uppercase;
 +
}
 +
 +
h1 a, h2 a, h3 a, h4 a, h5 a, h6 a {
 +
color: inherit;
 +
text-decoration: none;
 +
}
 +
 +
h1 span, h2 span, h3 span, h4 span, h5 span, h6 span {
 +
font-weight: 200;
 +
}
 +
 +
h1.major, h2.major, h3.major, h4.major, h5.major, h6.major {
 +
padding-bottom: 1em;
 +
border-bottom: solid 2px rgba(255, 255, 255, 0.125);
 +
}
 +
 +
h2 {
 +
font-size: 1.2em;
 +
}
 +
 +
h3 {
 +
font-size: 0.9em;
 +
}
 +
 +
h4 {
 +
font-size: 0.7em;
 +
}
 +
 +
h5 {
 +
font-size: 0.7em;
 +
}
 +
 +
h6 {
 +
font-size: 0.7em;
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
h2 {
 +
font-size: 1em;
 +
}
 +
 +
h3 {
 +
font-size: 0.8em;
 +
}
 +
 +
}
 +
 +
sub {
 +
font-size: 0.8em;
 +
position: relative;
 +
top: 0.5em;
 +
}
 +
 +
sup {
 +
font-size: 0.8em;
 +
position: relative;
 +
top: -0.5em;
 +
}
 +
 +
blockquote {
 +
border-left: solid 4px rgba(255, 255, 255, 0.125);
 +
font-style: italic;
 +
margin: 0 0 2em 0;
 +
padding: 0.5em 0 0.5em 2em;
 +
}
 +
 +
code {
 +
background: rgba(255, 255, 255, 0.025);
 +
border-radius: 5px;
 +
border: solid 2px rgba(255, 255, 255, 0.125);
 +
font-family: "Courier New", monospace;
 +
font-size: 0.9em;
 +
margin: 0 0.25em;
 +
padding: 0.25em 0.65em;
 +
}
 +
 +
pre {
 +
-webkit-overflow-scrolling: touch;
 +
font-family: "Courier New", monospace;
 +
font-size: 0.9em;
 +
margin: 0 0 2em 0;
 +
}
 +
 +
pre code {
 +
display: block;
 +
line-height: 1.75em;
 +
padding: 1em 1.5em;
 +
overflow-x: auto;
 +
}
 +
 +
hr {
 +
border: 0;
 +
border-bottom: solid 2px rgba(255, 255, 255, 0.125);
 +
margin: 2.5em 0;
 +
}
 +
 +
hr.major {
 +
margin: 4em 0;
 +
}
 +
 +
.align-left {
 +
text-align: left;
 +
}
 +
 +
.align-center {
 +
text-align: center;
 +
}
 +
 +
.align-right {
 +
text-align: left;
 +
}
 +
 +
/* Section/Article */
 +
 +
section.special, article.special {
 +
text-align: center;
 +
}
 +
 +
/* Form */
 +
 +
form {
 +
margin: 0 0 2em 0;
 +
}
 +
 +
form .field {
 +
margin: 0 0 2em 0;
 +
}
 +
 +
form .field label {
 +
margin-top: -1.5em;
 +
}
 +
 +
form .field:first-child label {
 +
margin-top: 0;
 +
}
 +
 +
form > :last-child {
 +
margin-bottom: 0;
 +
}
 +
 +
label {
 +
color: #ffffff;
 +
display: block;
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-size: 0.8em;
 +
font-weight: 700;
 +
letter-spacing: 0.1em;
 +
margin: 0 0 0.7em 0;
 +
text-transform: uppercase;
 +
}
 +
 +
input[type="text"],
 +
input[type="password"],
 +
input[type="email"],
 +
input[type="tel"],
 +
select,
 +
textarea {
 +
-moz-appearance: none;
 +
-webkit-appearance: none;
 +
-ms-appearance: none;
 +
appearance: none;
 +
background: rgba(255, 255, 255, 0.025);
 +
border-radius: 5px;
 +
border: none;
 +
border: solid 2px rgba(255, 255, 255, 0.125);
 +
color: inherit;
 +
display: block;
 +
outline: 0;
 +
padding: 0 1em;
 +
text-decoration: none;
 +
width: 100%;
 +
}
 +
 +
input[type="text"]:invalid,
 +
input[type="password"]:invalid,
 +
input[type="email"]:invalid,
 +
input[type="tel"]:invalid,
 +
select:invalid,
 +
textarea:invalid {
 +
box-shadow: none;
 +
}
 +
 +
input[type="text"]:focus,
 +
input[type="password"]:focus,
 +
input[type="email"]:focus,
 +
input[type="tel"]:focus,
 +
select:focus,
 +
textarea:focus {
 +
border-color: #6a588e;
 +
}
 +
 +
.select-wrapper {
 +
text-decoration: none;
 +
display: block;
 +
position: relative;
 +
}
 +
 +
.select-wrapper:before {
 +
-moz-osx-font-smoothing: grayscale;
 +
-webkit-font-smoothing: antialiased;
 +
font-family: FontAwesome;
 +
font-style: normal;
 +
font-weight: normal;
 +
text-transform: none !important;
 +
}
 +
 +
.select-wrapper:before {
 +
color: rgba(255, 255, 255, 0.125);
 +
content: '\f078';
 +
display: block;
 +
height: 2.75em;
 +
line-height: 2.75em;
 +
pointer-events: none;
 +
position: absolute;
 +
right: 0;
 +
text-align: center;
 +
top: 0;
 +
width: 2.75em;
 +
}
 +
 +
.select-wrapper select::-ms-expand {
 +
display: none;
 +
}
 +
 +
select option {
 +
color: #ffffff;
 +
background: #dbe9d8;
 +
}
 +
 +
input[type="text"],
 +
input[type="password"],
 +
input[type="email"],
 +
select {
 +
height: 2.75em;
 +
}
 +
 +
textarea {
 +
padding: 0.75em 1em;
 +
}
 +
 +
input[type="checkbox"],
 +
input[type="radio"] {
 +
-moz-appearance: none;
 +
-webkit-appearance: none;
 +
-ms-appearance: none;
 +
appearance: none;
 +
display: block;
 +
float: left;
 +
margin-right: -2em;
 +
opacity: 0;
 +
width: 1em;
 +
z-index: -1;
 +
}
 +
 +
input[type="checkbox"] + label,
 +
input[type="radio"] + label {
 +
text-decoration: none;
 +
color: #ffffff;
 +
cursor: pointer;
 +
display: inline-block;
 +
font-size: 1em;
 +
font-family: "Source Sans Pro", Helvetica, sans-serif;
 +
text-transform: none;
 +
letter-spacing: 0;
 +
font-weight: 300;
 +
padding-left: 2.4em;
 +
padding-right: 0.75em;
 +
position: relative;
 +
}
 +
 +
input[type="checkbox"] + label:before,
 +
input[type="radio"] + label:before {
 +
-moz-osx-font-smoothing: grayscale;
 +
-webkit-font-smoothing: antialiased;
 +
font-family: FontAwesome;
 +
font-style: normal;
 +
font-weight: normal;
 +
text-transform: none !important;
 +
}
 +
 +
input[type="checkbox"] + label:before,
 +
input[type="radio"] + label:before {
 +
background: rgba(255, 255, 255, 0.025);
 +
border-radius: 5px;
 +
border: solid 2px rgba(255, 255, 255, 0.125);
 +
content: '';
 +
display: inline-block;
 +
height: 1.65em;
 +
left: 0;
 +
line-height: 1.58125em;
 +
position: absolute;
 +
text-align: center;
 +
top: 0;
 +
width: 1.65em;
 +
}
 +
 +
input[type="checkbox"]:checked + label:before,
 +
input[type="radio"]:checked + label:before {
 +
background: #ffffff;
 +
border-color: #ffffff;
 +
content: '\f00c';
 +
color: #dbe9d8;
 +
}
 +
 +
input[type="checkbox"]:focus + label:before,
 +
input[type="radio"]:focus + label:before {
 +
border-color: #dbe9d8;
 +
}
 +
 +
input[type="checkbox"] + label:before {
 +
border-radius: 5px;
 +
}
 +
 +
input[type="radio"] + label:before {
 +
border-radius: 100%;
 +
}
 +
 +
::-webkit-input-placeholder {
 +
color: rgba(255, 255, 255, 0.35) !important;
 +
opacity: 1.0;
 +
}
 +
 +
:-moz-placeholder {
 +
color: rgba(255, 255, 255, 0.35) !important;
 +
opacity: 1.0;
 +
}
 +
 +
::-moz-placeholder {
 +
color: rgba(255, 255, 255, 0.35) !important;
 +
opacity: 1.0;
 +
}
 +
 +
:-ms-input-placeholder {
 +
color: rgba(255, 255, 255, 0.35) !important;
 +
opacity: 1.0;
 +
}
 +
 +
.polyfill-placeholder {
 +
color: rgba(255, 255, 255, 0.35) !important;
 +
opacity: 1.0;
 +
}
 +
 +
/* Box */
 +
 +
.box {
 +
border-radius: 5px;
 +
border: solid 2px rgba(255, 255, 255, 0.125);
 +
margin-bottom: 2em;
 +
padding: 1.5em;
 +
}
 +
 +
.box > :last-child,
 +
.box > :last-child > :last-child,
 +
.box > :last-child > :last-child > :last-child {
 +
margin-bottom: 0;
 +
}
 +
 +
.box.alt {
 +
border: 0;
 +
border-radius: 0;
 +
padding: 0;
 +
}
 +
 +
/* Icon */
 +
 +
.icon {
 +
text-decoration: none;
 +
border-bottom: none;
 +
position: relative;
 +
}
 +
 +
.icon:before {
 +
-moz-osx-font-smoothing: grayscale;
 +
-webkit-font-smoothing: antialiased;
 +
font-family: FontAwesome;
 +
font-style: normal;
 +
font-weight: normal;
 +
text-transform: none !important;
 +
}
 +
 +
.icon > .label {
 +
display: none;
 +
}
 +
 +
/* Image */
 +
 +
.image {
 +
border-radius: 5px;
 +
border: 0;
 +
display: inline-block;
 +
position: relative;
 +
}
 +
 +
.image img {
 +
border-radius: 5px;
 +
display: block;
 +
}
 +
 +
.image.left, .image.right {
 +
max-width: 40%;
 +
}
 +
 +
.image.left img, .image.right img {
 +
width: 100%;
 +
}
 +
 +
.image.left {
 +
float: left;
 +
padding: 0 1.5em 1em 0;
 +
top: 0.25em;
 +
}
 +
 +
.image.right {
 +
float: right;
 +
padding: 0 0 1em 1.5em;
 +
top: 0.25em;
 +
}
 +
 +
.image.fit {
 +
display: block;
 +
margin: 0 0 2em 0;
 +
width: 100%;
 +
}
 +
 +
.image.fit img {
 +
width: 100%;
 +
}
 +
 +
.image.main {
 +
display: block;
 +
margin: 0 0 3em 0;
 +
width: 100%;
 +
}
 +
 +
.image.main img {
 +
width: 100%;
 +
}
 +
 +
/* List */
 +
 +
ol {
 +
list-style: decimal;
 +
margin: 0 0 2em 0;
 +
padding-left: 1.25em;
 +
}
 +
 +
ol li {
 +
padding-left: 0.25em;
 +
}
 +
 +
ul {
 +
list-style: disc;
 +
margin: 0 0 2em 0;
 +
padding-left: 1em;
 +
}
 +
 +
ul li {
 +
padding-left: 0.5em;
 +
}
 +
 +
ul.alt {
 +
list-style: none;
 +
padding-left: 0;
 +
}
 +
 +
ul.alt li {
 +
border-top: solid 1px rgba(255, 255, 255, 0.125);
 +
padding: 0.5em 0;
 +
}
 +
 +
ul.alt li:first-child {
 +
border-top: 0;
 +
padding-top: 0;
 +
}
 +
 +
ul.icons {
 +
cursor: default;
 +
list-style: none;
 +
padding-left: 0;
 +
}
 +
 +
ul.icons li {
 +
display: inline-block;
 +
padding: 0 1em 0 0;
 +
}
 +
 +
ul.icons li:last-child {
 +
padding-right: 0;
 +
}
 +
 +
ul.icons li .icon:before {
 +
font-size: 1.25em;
 +
}
 +
 +
ul.actions {
 +
cursor: default;
 +
list-style: none;
 +
padding-left: 0;
 +
}
 +
 +
ul.actions li {
 +
display: inline-block;
 +
padding: 0 1em 0 0;
 +
vertical-align: middle;
 +
}
 +
 +
ul.actions li:last-child {
 +
padding-right: 0;
 +
}
 +
 +
ul.actions.small li {
 +
padding: 0 0.5em 0 0;
 +
}
 +
 +
ul.actions.vertical li {
 +
display: block;
 +
padding: 1em 0 0 0;
 +
}
 +
 +
ul.actions.vertical li:first-child {
 +
padding-top: 0;
 +
}
 +
 +
ul.actions.vertical li > * {
 +
margin-bottom: 0;
 +
}
 +
 +
ul.actions.vertical.small li {
 +
padding: 0.5em 0 0 0;
 +
}
 +
 +
ul.actions.vertical.small li:first-child {
 +
padding-top: 0;
 +
}
 +
 +
ul.actions.fit {
 +
display: table;
 +
margin-left: -1em;
 +
padding: 0;
 +
table-layout: fixed;
 +
width: calc(100% + 1em);
 +
}
 +
 +
ul.actions.fit li {
 +
display: table-cell;
 +
padding: 0 0 0 1em;
 +
}
 +
 +
ul.actions.fit li > * {
 +
margin-bottom: 0;
 +
}
 +
 +
ul.actions.fit.small {
 +
margin-left: -0.5em;
 +
width: calc(100% + 0.5em);
 +
}
 +
 +
ul.actions.fit.small li {
 +
padding: 0 0 0 0.5em;
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
ul.actions {
 +
margin: 0 0 2em 0;
 +
}
 +
 +
ul.actions li {
 +
padding: 1em 0 0 0;
 +
display: block;
 +
text-align: center;
 +
width: 100%;
 +
}
 +
 +
ul.actions li:first-child {
 +
padding-top: 0;
 +
}
 +
 +
ul.actions li > * {
 +
width: 100%;
 +
margin: 0 !important;
 +
}
 +
 +
ul.actions.small li {
 +
padding: 0.5em 0 0 0;
 +
}
 +
 +
ul.actions.small li:first-child {
 +
padding-top: 0;
 +
}
 +
 +
}
 +
 +
ul.contact {
 +
list-style: none;
 +
padding: 0;
 +
}
 +
 +
ul.contact li {
 +
text-decoration: none;
 +
margin: 2.5em 0 0 0;
 +
padding: 0 0 0 3.25em;
 +
position: relative;
 +
}
 +
 +
ul.contact li:before {
 +
-moz-osx-font-smoothing: grayscale;
 +
-webkit-font-smoothing: antialiased;
 +
font-family: FontAwesome;
 +
font-style: normal;
 +
font-weight: normal;
 +
text-transform: none !important;
 +
}
 +
 +
ul.contact li:before {
 +
border-radius: 100%;
 +
border: solid 2px rgba(255, 255, 255, 0.125);
 +
display: inline-block;
 +
font-size: 0.8em;
 +
height: 2.5em;
 +
left: 0;
 +
line-height: 2.35em;
 +
position: absolute;
 +
text-align: center;
 +
top: 0;
 +
width: 2.5em;
 +
}
 +
 +
ul.contact li:first-child {
 +
margin-top: 0;
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
ul.contact li {
 +
margin: 1.5em 0 0 0;
 +
}
 +
 +
}
 +
 +
ul.pagination {
 +
cursor: default;
 +
list-style: none;
 +
padding-left: 0;
 +
}
 +
 +
ul.pagination li {
 +
display: inline-block;
 +
padding-left: 0;
 +
vertical-align: middle;
 +
}
 +
 +
ul.pagination li > .page {
 +
-moz-transition: background-color 0.2s ease-in-out, color 0.2s ease-in-out;
 +
-webkit-transition: background-color 0.2s ease-in-out, color 0.2s ease-in-out;
 +
-ms-transition: background-color 0.2s ease-in-out, color 0.2s ease-in-out;
 +
transition: background-color 0.2s ease-in-out, color 0.2s ease-in-out;
 +
border-bottom: 0;
 +
border-radius: 5px;
 +
display: inline-block;
 +
height: 1.5em;
 +
line-height: 1.5em;
 +
margin: 0 0.125em;
 +
min-width: 1.5em;
 +
padding: 0 0.5em;
 +
text-align: center;
 +
}
 +
 +
ul.pagination li > .page:hover {
 +
background-color: rgba(255, 255, 255, 0.025);
 +
}
 +
 +
ul.pagination li > .page.active {
 +
background-color: #dbe9d8;
 +
}
 +
 +
ul.pagination li:first-child {
 +
padding-right: 0.75em;
 +
}
 +
 +
ul.pagination li:last-child {
 +
padding-left: 0.75em;
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
ul.pagination li:nth-child(n+2):nth-last-child(n+2) {
 +
display: none;
 +
}
 +
 +
ul.pagination li .button {
 +
width: 100%;
 +
}
 +
 +
ul.pagination li:first-child {
 +
width: calc(50% - 2px);
 +
text-align: left;
 +
padding-right: 0.325em;
 +
}
 +
 +
ul.pagination li:last-child {
 +
width: calc(50% - 2px);
 +
text-align: left;
 +
padding-left: 0.325em;
 +
}
 +
 +
}
 +
 +
dl {
 +
margin: 0 0 2em 0;
 +
}
 +
 +
dl dt {
 +
display: block;
 +
font-weight: 600;
 +
margin: 0 0 1em 0;
 +
}
 +
 +
dl dd {
 +
margin-left: 2em;
 +
}
 +
 +
/* Table */
 +
 +
.table-wrapper {
 +
-webkit-overflow-scrolling: touch;
 +
overflow-x: auto;
 +
}
 +
 +
table {
 +
margin: 0 0 2em 0;
 +
width: 100%;
 +
}
 +
 +
table tbody tr {
 +
border: solid 1px rgba(255, 255, 255, 0.125);
 +
border-left: 0;
 +
border-right: 0;
 +
}
 +
 +
table tbody tr:nth-child(2n + 1) {
 +
background-color: rgba(255, 255, 255, 0.025);
 +
}
 +
 +
table td {
 +
padding: 0.75em 0.75em;
 +
}
 +
 +
table th {
 +
color: #ffffff;
 +
font-size: 0.9em;
 +
font-weight: 600;
 +
padding: 0 0.75em 0.75em 0.75em;
 +
text-align: left;
 +
}
 +
 +
table thead {
 +
border-bottom: solid 2px rgba(255, 255, 255, 0.125);
 +
}
 +
 +
table tfoot {
 +
border-top: solid 2px rgba(255, 255, 255, 0.125);
 +
}
 +
 +
table.alt {
 +
border-collapse: separate;
 +
}
 +
 +
table.alt tbody tr td {
 +
border: solid 1px rgba(255, 255, 255, 0.125);
 +
border-left-width: 0;
 +
border-top-width: 0;
 +
}
 +
 +
table.alt tbody tr td:first-child {
 +
border-left-width: 1px;
 +
}
 +
 +
table.alt tbody tr:first-child td {
 +
border-top-width: 1px;
 +
}
 +
 +
table.alt thead {
 +
border-bottom: 0;
 +
}
 +
 +
table.alt tfoot {
 +
border-top: 0;
 +
}
 +
 +
/* Button */
 +
 +
input[type="submit"],
 +
input[type="reset"],
 +
input[type="button"],
 +
button,
 +
.button {
 +
-moz-appearance: none;
 +
-webkit-appearance: none;
 +
-ms-appearance: none;
 +
appearance: none;
 +
-moz-transition: background-color 0.2s ease-in-out;
 +
-webkit-transition: background-color 0.2s ease-in-out;
 +
-ms-transition: background-color 0.2s ease-in-out;
 +
transition: background-color 0.2s ease-in-out;
 +
background-color: transparent;
 +
border-radius: 5px;
 +
border: 0;
 +
box-shadow: inset 0 0 0 2px rgba(255, 255, 255, 0.125);
 +
color: #ffffff !important;
 +
cursor: pointer;
 +
display: inline-block;
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-size: 0.8em;
 +
font-weight: 700;
 +
height: 3.75em;
 +
letter-spacing: 0.1em;
 +
line-height: 3.75em;
 +
padding: 0 2.25em;
 +
text-align: center;
 +
text-decoration: none;
 +
text-transform: uppercase;
 +
white-space: nowrap;
 +
}
 +
 +
input[type="submit"]:hover,
 +
input[type="reset"]:hover,
 +
input[type="button"]:hover,
 +
button:hover,
 +
.button:hover {
 +
background-color: rgba(255, 255, 255, 0.025);
 +
}
 +
 +
input[type="submit"]:active,
 +
input[type="reset"]:active,
 +
input[type="button"]:active,
 +
button:active,
 +
.button:active {
 +
background-color: rgba(255, 255, 255, 0.075);
 +
}
 +
 +
input[type="submit"].icon:before,
 +
input[type="reset"].icon:before,
 +
input[type="button"].icon:before,
 +
button.icon:before,
 +
.button.icon:before {
 +
margin-right: 0.5em;
 +
color: rgba(255, 255, 255, 0.35);
 +
}
 +
 +
input[type="submit"].special,
 +
input[type="reset"].special,
 +
input[type="button"].special,
 +
button.special,
 +
.button.special {
 +
background-color: #dbe9d8;
 +
box-shadow: none;
 +
}
 +
 +
input[type="submit"].special:hover,
 +
input[type="reset"].special:hover,
 +
input[type="button"].special:hover,
 +
button.special:hover,
 +
.button.special:hover {
 +
background-color: #6a588e;
 +
}
 +
 +
input[type="submit"].special:active,
 +
input[type="reset"].special:active,
 +
input[type="button"].special:active,
 +
button.special:active,
 +
.button.special:active {
 +
background-color: #dbe9d8;
 +
}
 +
 +
input[type="submit"].special.icon:before,
 +
input[type="reset"].special.icon:before,
 +
input[type="button"].special.icon:before,
 +
button.special.icon:before,
 +
.button.special.icon:before {
 +
color: #7985b0;
 +
}
 +
 +
input[type="submit"].fit,
 +
input[type="reset"].fit,
 +
input[type="button"].fit,
 +
button.fit,
 +
.button.fit {
 +
display: block;
 +
margin: 0 0 1em 0;
 +
width: 100%;
 +
}
 +
 +
input[type="submit"].small,
 +
input[type="reset"].small,
 +
input[type="button"].small,
 +
button.small,
 +
.button.small {
 +
font-size: 0.6em;
 +
}
 +
 +
input[type="submit"].big,
 +
input[type="reset"].big,
 +
input[type="button"].big,
 +
button.big,
 +
.button.big {
 +
font-size: 1em;
 +
}
 +
 +
input[type="submit"].disabled, input[type="submit"]:disabled,
 +
input[type="reset"].disabled,
 +
input[type="reset"]:disabled,
 +
input[type="button"].disabled,
 +
input[type="button"]:disabled,
 +
button.disabled,
 +
button:disabled,
 +
.button.disabled,
 +
.button:disabled {
 +
opacity: 0.25;
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
input[type="submit"],
 +
input[type="reset"],
 +
input[type="button"],
 +
button,
 +
.button {
 +
padding: 0;
 +
}
 +
 +
}
 +
 +
/* Features */
 +
 +
.features {
 +
display: -moz-flex;
 +
display: -webkit-flex;
 +
display: -ms-flex;
 +
display: flex;
 +
-moz-flex-wrap: wrap;
 +
-webkit-flex-wrap: wrap;
 +
-ms-flex-wrap: wrap;
 +
flex-wrap: wrap;
 +
margin: 0 0 2em 0;
 +
}
 +
 +
.features article {
 +
padding: 1.75em 1.75em 0.1em 1.75em ;
 +
background-color: #f2efe8;
 +
border-radius: 5px;
 +
margin: 1.5em 3em 1.5em 0;
 +
width: calc(50% - 1.5em);
 +
}
 +
 +
.features article:nth-child(2n) {
 +
margin-right: 0;
 +
}
 +
 +
.features article .image {
 +
border-radius: 5px 5px 0 0;
 +
display: block;
 +
margin-bottom: 1.75em;
 +
margin-left: -1.75em;
 +
margin-top: -1.75em;
 +
position: relative;
 +
width: calc(100% + 3.5em);
 +
}
 +
 +
.features article .image img {
 +
border-radius: 5px 5px 0 0;
 +
width: 100%;
 +
}
 +
 +
@media screen and (max-width: 980px) {
 +
 +
.features article {
 +
margin: 1em 2em 1em 0;
 +
width: calc(50% - 1em);
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
.features article {
 +
padding: 1.5em 1.5em 0.1em 1.5em ;
 +
margin: 0.875em 1.75em 0.875em 0;
 +
width: calc(50% - 0.875em - 1px);
 +
}
 +
 +
.features article .image {
 +
margin-bottom: 1.5em;
 +
margin-left: -1.5em;
 +
margin-top: -1.5em;
 +
width: calc(100% + 3em);
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
.features {
 +
display: block;
 +
}
 +
 +
.features article {
 +
width: 100%;
 +
margin: 0 0 2em 0 !important;
 +
}
 +
 +
}
 +
 +
/* Header */
 +
 +
#header {
 +
-moz-transition: background-color 0.2s ease-in-out;
 +
-webkit-transition: background-color 0.2s ease-in-out;
 +
-ms-transition: background-color 0.2s ease-in-out;
 +
transition: background-color 0.2s ease-in-out;
 +
background-color: rgba(53, 56, 73, 0.95);
 +
height: 3.5em;
 +
left: 0;
 +
line-height: 3.5em;
 +
padding: 0 1.25em;
 +
position: fixed;
 +
top: 0;
 +
width: 100%;
 +
z-index: 10000;
 +
}
 +
 +
#header h1 {
 +
-moz-transition: opacity 0.2s ease-in-out, visibility 0.2s;
 +
-webkit-transition: opacity 0.2s ease-in-out, visibility 0.2s;
 +
-ms-transition: opacity 0.2s ease-in-out, visibility 0.2s;
 +
transition: opacity 0.2s ease-in-out, visibility 0.2s;
 +
border-bottom: 0;
 +
font-size: 0.8em;
 +
margin-bottom: 0;
 +
opacity: 1;
 +
visibility: visible;
 +
}
 +
 +
#header h1 a {
 +
border: 0;
 +
}
 +
 +
#header nav {
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-size: 0.8em;
 +
font-weight: 700;
 +
height: 3em;
 +
letter-spacing: 0.1em;
 +
line-height: 3em;
 +
position: absolute;
 +
right: 0.7em;
 +
text-transform: uppercase;
 +
top: 0.7em;
 +
}
 +
 +
#header nav a {
 +
border: 0;
 +
display: inline-block;
 +
padding: 0 1em;
 +
}
 +
 +
#header nav a:before {
 +
float: right;
 +
margin-left: 0.75em;
 +
}
 +
 +
#header nav a[href="#menu"] {
 +
text-decoration: none;
 +
-moz-transition: background-color 0.2s ease-in-out;
 +
-webkit-transition: background-color 0.2s ease-in-out;
 +
-ms-transition: background-color 0.2s ease-in-out;
 +
transition: background-color 0.2s ease-in-out;
 +
border-radius: 5px;
 +
box-shadow: inset 0 0 0 2px rgba(255, 255, 255, 0.125);
 +
padding: 0 1.35em;
 +
}
 +
 +
#header nav a[href="#menu"]:before {
 +
-moz-osx-font-smoothing: grayscale;
 +
-webkit-font-smoothing: antialiased;
 +
font-family: FontAwesome;
 +
font-style: normal;
 +
font-weight: normal;
 +
text-transform: none !important;
 +
}
 +
 +
#header nav a[href="#menu"]:before {
 +
content: '\f0c9';
 +
}
 +
 +
#header nav a[href="#menu"]:hover {
 +
background-color: rgba(255, 255, 255, 0.025);
 +
}
 +
 +
#header nav a[href="#menu"]:active {
 +
background-color: rgba(255, 255, 255, 0.075);
 +
}
 +
 +
#header.alt {
 +
background-color: transparent;
 +
}
 +
 +
#header.alt h1 {
 +
opacity: 0;
 +
visibility: hidden;
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
#header {
 +
height: 2.75em;
 +
line-height: 2.75em;
 +
}
 +
 +
#header nav {
 +
top: 0;
 +
right: 0;
 +
height: inherit;
 +
line-height: inherit;
 +
}
 +
 +
#header nav a {
 +
height: inherit;
 +
line-height: inherit;
 +
}
 +
 +
#header nav a[href="#menu"] {
 +
box-shadow: none;
 +
padding: 0 1em;
 +
border-radius: 0;
 +
}
 +
 +
#header nav a[href="#menu"]:hover, #header nav a[href="#menu"]:active {
 +
background-color: inherit;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
#header nav a[href="#menu"] {
 +
width: 4em;
 +
white-space: nowrap;
 +
text-indent: 4em;
 +
position: relative;
 +
}
 +
 +
#header nav a[href="#menu"]:before {
 +
width: inherit;
 +
position: absolute;
 +
top: 0;
 +
left: 0;
 +
text-indent: 0;
 +
text-align: left;
 +
margin-left: 0;
 +
padding-right: 1.25em;
 +
}
 +
 +
}
 +
 +
/* Menu */
 +
 +
#page-wrapper {
 +
-moz-transition: -moz-filter 0.25s ease;
 +
-webkit-transition: -webkit-filter 0.25s ease;
 +
-ms-transition: -ms-filter 0.25s ease;
 +
transition: filter 0.25s ease;
 +
}
 +
 +
#menu {
 +
-moz-align-items: center;
 +
-webkit-align-items: center;
 +
-ms-align-items: center;
 +
align-items: center;
 +
display: -moz-flex;
 +
display: -webkit-flex;
 +
display: -ms-flex;
 +
display: flex;
 +
-moz-justify-content: center;
 +
-webkit-justify-content: center;
 +
-ms-justify-content: center;
 +
justify-content: center;
 +
-moz-pointer-events: none;
 +
-webkit-pointer-events: none;
 +
-ms-pointer-events: none;
 +
pointer-events: none;
 +
-moz-transition: opacity 0.35s ease, visibility 0.35s;
 +
-webkit-transition: opacity 0.35s ease, visibility 0.35s;
 +
-ms-transition: opacity 0.35s ease, visibility 0.35s;
 +
transition: opacity 0.35s ease, visibility 0.35s;
 +
-moz-user-select: none;
 +
-webkit-user-select: none;
 +
-ms-user-select: none;
 +
user-select: none;
 +
-webkit-tap-highlight-color: transparent;
 +
background: rgba(46, 49, 65, 0.8);
 +
cursor: default;
 +
height: 100%;
 +
left: 0;
 +
opacity: 0;
 +
position: fixed;
 +
text-align: center;
 +
top: 0;
 +
visibility: hidden;
 +
width: 100%;
 +
}
 +
 +
#menu .inner {
 +
padding: 2.5em 1.5em 0.5em 1.5em ;
 +
-moz-transform: translateY(0.5em);
 +
-webkit-transform: translateY(0.5em);
 +
-ms-transform: translateY(0.5em);
 +
transform: translateY(0.5em);
 +
-moz-transition: opacity 0.35s ease, -moz-transform 0.35s ease;
 +
-webkit-transition: opacity 0.35s ease, -webkit-transform 0.35s ease;
 +
-ms-transition: opacity 0.35s ease, -ms-transform 0.35s ease;
 +
transition: opacity 0.35s ease, transform 0.35s ease;
 +
-webkit-overflow-scrolling: touch;
 +
background: #dbe9d8;
 +
border-radius: 5px;
 +
display: block;
 +
max-width: 100%;
 +
opacity: 0;
 +
position: relative;
 +
width: 18em;
 +
}
 +
 +
#menu h2 {
 +
border-bottom: solid 2px rgba(255, 255, 255, 0.125);
 +
padding-bottom: 1em;
 +
}
 +
 +
#menu .close {
 +
background-image: url("images/close.svg");
 +
background-position: 75% 25%;
 +
background-repeat: no-repeat;
 +
background-size: 2em 2em;
 +
border: 0;
 +
content: '';
 +
display: block;
 +
height: 4em;
 +
overflow: hidden;
 +
position: absolute;
 +
right: 0;
 +
text-align: center;
 +
text-indent: 4em;
 +
top: 0;
 +
width: 4em;
 +
}
 +
 +
#menu .links {
 +
list-style: none;
 +
margin-bottom: 1.5em;
 +
padding: 0;
 +
}
 +
 +
#menu .links li {
 +
padding: 0;
 +
}
 +
 +
#menu .links li a {
 +
border-radius: 5px;
 +
border: 0;
 +
display: block;
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-size: 0.8em;
 +
font-weight: 200;
 +
letter-spacing: 0.1em;
 +
line-height: 1.85em;
 +
padding: 0.75em 0;
 +
text-transform: uppercase;
 +
}
 +
 +
#menu .links li a:hover {
 +
background: #dbe9d8;
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
#menu .inner {
 +
max-height: 100%;
 +
overflow-y: auto;
 +
overflow-x: hidden;
 +
}
 +
 +
#menu .inner .close {
 +
background-size: 1.5em 1.5em;
 +
}
 +
 +
}
 +
 +
body.is-menu-visible #page-wrapper {
 +
-moz-filter: blur(1.5px);
 +
-webkit-filter: blur(1.5px);
 +
-ms-filter: blur(1.5px);
 +
filter: blur(1.5px);
 +
}
 +
 +
body.is-menu-visible #menu {
 +
-moz-pointer-events: auto;
 +
-webkit-pointer-events: auto;
 +
-ms-pointer-events: auto;
 +
pointer-events: auto;
 +
opacity: 1;
 +
visibility: visible;
 +
}
 +
 +
body.is-menu-visible #menu .inner {
 +
-moz-transform: translateY(0);
 +
-webkit-transform: translateY(0);
 +
-ms-transform: translateY(0);
 +
transform: translateY(0);
 +
opacity: 1;
 +
}
 +
 +
/* Banner */
 +
 +
#banner {
 +
padding: 10em 0 4.75em 0 ;
 +
}
 +
 +
#banner .inner {
 +
margin: 0 auto;
 +
width: 55em;
 +
}
 +
 +
#banner .logo {
 +
-moz-transition: opacity 2s ease, -moz-transform 1s ease;
 +
-webkit-transition: opacity 2s ease, -webkit-transform 1s ease;
 +
-ms-transition: opacity 2s ease, -ms-transform 1s ease;
 +
transition: opacity 2s ease, transform 1s ease;
 +
-moz-transform: translateY(0);
 +
-webkit-transform: translateY(0);
 +
-ms-transform: translateY(0);
 +
transform: translateY(0);
 +
opacity: 1;
 +
margin: 0 0 1.3em 0;
 +
}
 +
 +
#banner .logo .icon {
 +
border-radius: 100%;
 +
border: solid 2px rgba(255, 255, 255, 0.125);
 +
cursor: default;
 +
display: inline-block;
 +
font-size: 2em;
 +
height: 2.25em;
 +
line-height: 2.25em;
 +
text-align: center;
 +
width: 2.25em;
 +
}
 +
 +
#banner h2 {
 +
-moz-transition: opacity 0.5s ease, -moz-transform 0.5s ease, -moz-filter 0.25s ease;
 +
-webkit-transition: opacity 0.5s ease, -webkit-transform 0.5s ease, -webkit-filter 0.25s ease;
 +
-ms-transition: opacity 0.5s ease, -ms-transform 0.5s ease, -ms-filter 0.25s ease;
 +
transition: opacity 0.5s ease, transform 0.5s ease, filter 0.25s ease;
 +
-moz-transform: translateX(0);
 +
-webkit-transform: translateX(0);
 +
-ms-transform: translateX(0);
 +
transform: translateX(0);
 +
-moz-transition-delay: 0.65s;
 +
-webkit-transition-delay: 0.65s;
 +
-ms-transition-delay: 0.65s;
 +
transition-delay: 0.65s;
 +
-moz-filter: blur(0);
 +
-webkit-filter: blur(0);
 +
-ms-filter: blur(0);
 +
filter: blur(0);
 +
opacity: 1;
 +
border-bottom: solid 2px rgba(255, 255, 255, 0.125);
 +
font-size: 2.25em;
 +
margin-bottom: 0.8em;
 +
padding-bottom: 0.4em;
 +
}
 +
 +
#banner p {
 +
-moz-transition: opacity 0.5s ease, -moz-transform 0.5s ease, -moz-filter 0.25s ease;
 +
-webkit-transition: opacity 0.5s ease, -webkit-transform 0.5s ease, -webkit-filter 0.25s ease;
 +
-ms-transition: opacity 0.5s ease, -ms-transform 0.5s ease, -ms-filter 0.25s ease;
 +
transition: opacity 0.5s ease, transform 0.5s ease, filter 0.25s ease;
 +
-moz-transform: translateX(0);
 +
-webkit-transform: translateX(0);
 +
-ms-transform: translateX(0);
 +
transform: translateX(0);
 +
-moz-transition-delay: 0.8s;
 +
-webkit-transition-delay: 0.8s;
 +
-ms-transition-delay: 0.8s;
 +
transition-delay: 0.8s;
 +
-moz-filter: blur(0);
 +
-webkit-filter: blur(0);
 +
-ms-filter: blur(0);
 +
filter: blur(0);
 +
opacity: 1;
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-size: 1em;
 +
font-weight: 200;
 +
letter-spacing: 0.1em;
 +
line-height: 2;
 +
text-transform: uppercase;
 +
}
 +
 +
@media screen and (max-width: 1280px) {
 +
 +
#banner {
 +
padding: 7em 0 8.25em 0 ;
 +
background-color: #dbe9d8;
 +
background-image: linear-gradient(to top, rgba(46, 49, 65, 0.8), rgba(46, 49, 65, 0.8)), url("../../images/bg.jpg");
 +
background-size: auto, cover;
 +
background-position: center, center;
 +
margin-bottom: -6.5em;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 980px) {
 +
 +
#banner {
 +
padding: 12em 3em 12.375em 3em ;
 +
margin-bottom: -4.75em;
 +
}
 +
 +
#banner .inner {
 +
width: 100%;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
#banner {
 +
padding: 5em 2em 4.25em 2em ;
 +
margin-bottom: -2.5em;
 +
}
 +
 +
#banner .logo {
 +
margin: 0 0 1em 0;
 +
}
 +
 +
#banner .logo .icon {
 +
font-size: 1.5em;
 +
}
 +
 +
#banner h2 {
 +
font-size: 1.5em;
 +
}
 +
 +
#banner p {
 +
font-size: 0.8em;
 +
}
 +
 +
}
 +
 +
body.is-loading #banner .logo {
 +
-moz-transform: translateY(0.5em);
 +
-webkit-transform: translateY(0.5em);
 +
-ms-transform: translateY(0.5em);
 +
transform: translateY(0.5em);
 +
opacity: 0;
 +
}
 +
 +
body.is-loading #banner h2 {
 +
opacity: 0;
 +
-moz-transform: translateX(0.25em);
 +
-webkit-transform: translateX(0.25em);
 +
-ms-transform: translateX(0.25em);
 +
transform: translateX(0.25em);
 +
-moz-filter: blur(2px);
 +
-webkit-filter: blur(2px);
 +
-ms-filter: blur(2px);
 +
filter: blur(2px);
 +
}
 +
 +
body.is-loading #banner p {
 +
opacity: 0;
 +
-moz-transform: translateX(0.5em);
 +
-webkit-transform: translateX(0.5em);
 +
-ms-transform: translateX(0.5em);
 +
transform: translateX(0.5em);
 +
-moz-filter: blur(2px);
 +
-webkit-filter: blur(2px);
 +
-ms-filter: blur(2px);
 +
filter: blur(2px);
 +
}
 +
 +
/* Wrapper */
 +
 +
#wrapper > header {
 +
padding: 11em 0 2.25em 0 ;
 +
}
 +
 +
#wrapper > header .inner {
 +
margin: 0 auto;
 +
width: 55em;
 +
}
 +
 +
#wrapper > header h2 {
 +
border-bottom: solid 2px rgba(255, 255, 255, 0.125);
 +
font-size: 2em;
 +
margin-bottom: 0.8em;
 +
padding-bottom: 0.4em;
 +
}
 +
 +
#wrapper > header p {
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-size: 1em;
 +
font-weight: 200;
 +
letter-spacing: 0.1em;
 +
line-height: 2;
 +
text-transform: uppercase;
 +
}
 +
 +
@media screen and (max-width: 1280px) {
 +
 +
#wrapper > header {
 +
padding: 9em 0 6.25em 0 ;
 +
background-color: #dbe9d8;
 +
background-image: linear-gradient(to top, rgba(46, 49, 65, 0.8), rgba(46, 49, 65, 0.8)), url("../../images/bg.jpg");
 +
background-size: auto, cover;
 +
background-position: center, 0% 30%;
 +
margin-bottom: -6.5em;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 980px) {
 +
 +
#wrapper > header {
 +
padding: 11em 3em 7.375em 3em ;
 +
background-size: auto, cover;
 +
background-position: center, 0% 0%;
 +
margin-bottom: -4.75em;
 +
}
 +
 +
#wrapper > header .inner {
 +
width: 100%;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
#wrapper > header {
 +
padding: 6.5em 2em 3em 2em ;
 +
background-size: auto, 125%;
 +
margin-bottom: -2.5em;
 +
}
 +
 +
#wrapper > header h2 {
 +
font-size: 1.25em;
 +
}
 +
 +
#wrapper > header p {
 +
font-size: 0.8em;
 +
}
 +
 +
}
 +
 +
.wrapper {
 +
background-color: #dbe9d8;
 +
margin: 6.5em 0;
 +
position: relative;
 +
}
 +
 +
.wrapper:before, .wrapper:after {
 +
 +
}
 +
 +
.wrapper:before {
 +
box-shadow: inset 0 -1px 0 0 #dbe9d8, 0 1px 0 0 #dbe9d8;
 +
}
 +
 +
.wrapper:after {
 +
box-shadow: inset 0 -1px 0 0 #dbe9d8, 0 1px 0 0 #dbe9d8;
 +
}
 +
 +
.wrapper:before, .wrapper:after {
 +
background-repeat: no-repeat;
 +
background-size: 100% 100%;
 +
content: '';
 +
display: block;
 +
height: 6.5em;
 +
position: absolute;
 +
width: 100%;
 +
}
 +
 +
.wrapper:before {
 +
left: 0;
 +
top: -6.5em;
 +
}
 +
 +
.wrapper:after {
 +
-moz-transform: scaleY(-1);
 +
-webkit-transform: scaleY(-1);
 +
-ms-transform: scaleY(-1);
 +
transform: scaleY(-1);
 +
bottom: -6.5em;
 +
left: 0;
 +
}
 +
 +
.wrapper.alt:before {
 +
-moz-transform: scaleX(-1);
 +
-webkit-transform: scaleX(-1);
 +
-ms-transform: scaleX(-1);
 +
transform: scaleX(-1);
 +
}
 +
 +
.wrapper.alt:after {
 +
-moz-transform: scaleY(-1) scaleX(-1);
 +
-webkit-transform: scaleY(-1) scaleX(-1);
 +
-ms-transform: scaleY(-1) scaleX(-1);
 +
transform: scaleY(-1) scaleX(-1);
 +
}
 +
 +
.wrapper .inner {
 +
padding: 3em 0 1em 0 ;
 +
margin: 0 auto;
 +
width: 55em;
 +
}
 +
 +
.wrapper.style2 {
 +
background-color: #f2efe8;
 +
background-image: url("https://static.igem.org/mediawiki/2017/3/32/Descriptionthingasij.png")
 +
}
 +
 +
.wrapper.style2:before, .wrapper.style2:after {
 +
 +
}
 +
 +
.wrapper.style2:before {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.style2:after {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.style3 {
 +
background-color: #f2efe8;
 +
}
 +
 +
.wrapper.style3:before, .wrapper.style3:after {
 +
 +
}
 +
 +
.wrapper.style3:before {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.style3:after {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.style4 {
 +
background-color: #dbe9d8;
 +
}
 +
 +
.wrapper.style4:before, .wrapper.style4:after {
 +
 +
}
 +
 +
.wrapper.style4:before {
 +
box-shadow: inset 0 -1px 0 0 #dbe9d8, 0 1px 0 0 #dbe9d8;
 +
}
 +
 +
.wrapper.style4:after {
 +
box-shadow: inset 0 -1px 0 0 #dbe9d8, 0 1px 0 0 #dbe9d8;
 +
}
 +
 +
.wrapper.style5 {
 +
background-color: #dbe9d8;
 +
}
 +
 +
.wrapper.style5:before, .wrapper.style5:after {
 +
 +
}
 +
 +
.wrapper.style5:before {
 +
box-shadow: inset 0 -1px 0 0 #dbe9d8, 0 1px 0 0 #dbe9d8;
 +
}
 +
 +
.wrapper.style5:after {
 +
box-shadow: inset 0 -1px 0 0 #dbe9d8, 0 1px 0 0 #dbe9d8;
 +
}
 +
 +
.wrapper.style6 {
 +
background-color: #555867;
 +
}
 +
 +
.wrapper.style6:before, .wrapper.style6:after {
 +
 +
}
 +
 +
.wrapper.style6:before {
 +
box-shadow: inset 0 -1px 0 0 #555867, 0 1px 0 0 #555867;
 +
}
 +
 +
.wrapper.style6:after {
 +
box-shadow: inset 0 -1px 0 0 #555867, 0 1px 0 0 #555867;
 +
}
 +
 +
.wrapper.spotlight {
 +
background-color: #dbe9d8;
 +
}
 +
 +
.wrapper.spotlight:before, .wrapper.spotlight:after {
 +
 +
}
 +
 +
.wrapper.spotlight:before {
 +
box-shadow: inset 0 -1px 0 0 #dbe9d8, 0 1px 0 0 #dbe9d8;
 +
}
 +
 +
.wrapper.spotlight:after {
 +
box-shadow: inset 0 -1px 0 0 #dbe9d8, 0 1px 0 0 #dbe9d8;
 +
}
 +
 +
.wrapper.spotlight .inner {
 +
display: -moz-flex;
 +
display: -webkit-flex;
 +
display: -ms-flex;
 +
display: flex;
 +
-moz-align-items: center;
 +
-webkit-align-items: center;
 +
-ms-align-items: center;
 +
align-items: center;
 +
-moz-flex-direction: row;
 +
-webkit-flex-direction: row;
 +
-ms-flex-direction: row;
 +
flex-direction: row;
 +
}
 +
 +
.wrapper.spotlight .image {
 +
border-radius: 100%;
 +
margin: 0 3em 2em 0;
 +
width: 22em;
 +
overflow: hidden;
 +
-ms-flex: 1;
 +
}
 +
 +
.wrapper.spotlight .image img {
 +
border-radius: 100%;
 +
width: 100%;
 +
}
 +
 +
.wrapper.spotlight .content {
 +
width: 100%;
 +
-ms-flex: 2;
 +
}
 +
 +
.wrapper.spotlight:nth-child(2n - 1) .inner {
 +
-moz-flex-direction: row-reverse;
 +
-webkit-flex-direction: row-reverse;
 +
-ms-flex-direction: row-reverse;
 +
flex-direction: row-reverse;
 +
text-align: right;
 +
}
 +
 +
.wrapper.spotlight:nth-child(2n - 1) .image {
 +
margin: 0 0 2em 3em;
 +
}
 +
 +
.wrapper.spotlight.style2 {
 +
background-color: #dbe9d8;
 +
}
 +
 +
.wrapper.spotlight.style2:before, .wrapper.spotlight.style2:after {
 +
 +
}
 +
 +
.wrapper.spotlight.style2:before {
 +
box-shadow: inset 0 -1px 0 0 #dbe9d8, 0 1px 0 0 #dbe9d8;
 +
}
 +
 +
.wrapper.spotlight.style2:after {
 +
box-shadow: inset 0 -1px 0 0 #dbe9d8, 0 1px 0 0 #dbe9d8;
 +
}
 +
 +
.wrapper.spotlight.style3 {
 +
background-color: #f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style3:before, .wrapper.spotlight.style3:after {
 +
 +
}
 +
 +
.wrapper.spotlight.style3:before {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style3:after {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style4 {
 +
background-color: #f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style4:before, .wrapper.spotlight.style4:after {
 +
 +
}
 +
 +
.wrapper.spotlight.style4:before {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style4:after {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style5 {
 +
background-color: #f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style5:before, .wrapper.spotlight.style5:after {
 +
 +
}
 +
 +
.wrapper.spotlight.style5:before {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style5:after {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style6 {
 +
background-color: #2d3a69;
 +
}
 +
 +
.wrapper.spotlight.style6:before, .wrapper.spotlight.style6:after {
 +
 +
}
 +
 +
.wrapper.spotlight.style6:before {
 +
box-shadow: inset 0 -1px 0 0 #2d3a69, 0 1px 0 0 #2d3a69;
 +
}
 +
 +
.wrapper.spotlight.style6:after {
 +
box-shadow: inset 0 -1px 0 0 #2d3a69, 0 1px 0 0 #2d3a69;
 +
}
 +
 +
@media screen and (max-width: 980px) {
 +
 +
.wrapper {
 +
margin: 4.75em 0;
 +
}
 +
 +
.wrapper:before, .wrapper:after {
 +
height: 4.75em;
 +
}
 +
 +
.wrapper:before {
 +
top: -4.75em;
 +
}
 +
 +
.wrapper:after {
 +
bottom: -4.75em;
 +
left: 0;
 +
}
 +
 +
.wrapper .inner {
 +
padding: 3em 3em 1em 3em ;
 +
width: 100%;
 +
}
 +
 +
.wrapper.spotlight .image {
 +
margin: 0 2em 2em 0;
 +
width: 32em;
 +
}
 +
 +
.wrapper.spotlight:nth-child(2n - 1) .image {
 +
margin: 0 0 2em 2em;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
.wrapper {
 +
margin: 2.5em 0;
 +
}
 +
 +
.wrapper:before, .wrapper:after {
 +
height: 2.5em;
 +
}
 +
 +
.wrapper:before {
 +
top: -2.5em;
 +
}
 +
 +
.wrapper:after {
 +
bottom: -2.5em;
 +
left: 0;
 +
}
 +
 +
.wrapper .inner {
 +
padding: 2em 2em 0.1em 2em ;
 +
}
 +
 +
.wrapper.spotlight .inner {
 +
-moz-align-items: -moz-flex-start;
 +
-webkit-align-items: -webkit-flex-start;
 +
-ms-align-items: -ms-flex-start;
 +
align-items: flex-start;
 +
}
 +
 +
.wrapper.spotlight .image {
 +
width: 19em;
 +
margin: 0 1.75em 2em 0;
 +
}
 +
 +
.wrapper.spotlight:nth-child(2n - 1) .image {
 +
margin: 0 0 2em 1.75em;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
.wrapper.spotlight .inner {
 +
display: block;
 +
}
 +
 +
.wrapper.spotlight .image {
 +
margin: 0 0 1em 0 !important;
 +
max-width: 85%;
 +
width: 12em;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 360px) {
 +
 +
.wrapper .inner {
 +
padding: 2em 1.5em 0.1em 1.5em ;
 +
}
 +
 +
}
 +
 +
/* Footer */
 +
 +
#footer .inner {
 +
padding: 5em 0 3em 0 ;
 +
display: -moz-flex;
 +
display: -webkit-flex;
 +
display: -ms-flex;
 +
display: flex;
 +
-moz-flex-direction: row;
 +
-webkit-flex-direction: row;
 +
-ms-flex-direction: row;
 +
flex-direction: row;
 +
-moz-flex-wrap: wrap;
 +
-webkit-flex-wrap: wrap;
 +
-ms-flex-wrap: wrap;
 +
flex-wrap: wrap;
 +
margin: 0 auto;
 +
width: 55em;
 +
}
 +
 +
#footer .inner > * {
 +
width: 100%;
 +
}
 +
 +
#footer .inner form {
 +
margin: 0 3em 0 0;
 +
width: calc(50% - 1.5em);
 +
}
 +
 +
#footer .inner .contact {
 +
width: calc(50% - 1.5em);
 +
}
 +
 +
#footer .inner .copyright {
 +
border-top: solid 2px rgba(255, 255, 255, 0.125);
 +
list-style: none;
 +
margin: 4em 0 2em 0;
 +
padding: 2em 0 0 0;
 +
width: 100%;
 +
}
 +
 +
#footer .inner .copyright li {
 +
border-left: solid 2px rgba(255, 255, 255, 0.125);
 +
color: rgba(255, 255, 255, 0.35);
 +
display: inline-block;
 +
font-size: 0.9em;
 +
line-height: 1;
 +
margin-left: 1em;
 +
padding: 0;
 +
padding-left: 1em;
 +
}
 +
 +
#footer .inner .copyright li:first-child {
 +
border-left: 0;
 +
margin-left: 0;
 +
padding-left: 0;
 +
}
 +
 +
#footer .inner .copyright li a {
 +
color: inherit;
 +
}
 +
 +
@media screen and (max-width: 1280px) {
 +
 +
#footer {
 +
background-color: #dbe9d8;
 +
background-image: linear-gradient(to top, rgba(46, 49, 65, 0.8), rgba(46, 49, 65, 0.8)), url("../../images/bg.jpg");
 +
background-size: auto, cover;
 +
background-position: center, center;
 +
margin-top: -6.5em;
 +
padding-top: 6.5em;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 980px) {
 +
 +
#footer {
 +
margin-top: -4.75em;
 +
padding-top: 4.75em;
 +
}
 +
 +
#footer .inner {
 +
padding: 3em 3em 1em 3em ;
 +
display: block;
 +
width: 100%;
 +
}
 +
 +
#footer .inner form {
 +
width: 100%;
 +
margin: 0 0 4em 0;
 +
}
 +
 +
#footer .inner .contact {
 +
width: 100%;
 +
margin: 0 0 4em 0;
 +
}
 +
 +
#footer .inner .copyright {
 +
margin: 4em 0 2em 0;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
#footer {
 +
margin-top: -2.5em;
 +
padding-top: 2.5em;
 +
}
 +
 +
#footer .inner {
 +
padding: 2em 2em 0.1em 2em ;
 +
}
 +
 +
#footer .inner form {
 +
margin: 0 0 3em 0;
 +
}
 +
 +
#footer .inner .contact {
 +
margin: 0 0 3em 0;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
#footer .inner .copyright li {
 +
border-left: 0;
 +
display: block;
 +
margin: 1em 0 0 0;
 +
padding-left: 0;
 +
}
 +
 +
#footer .inner .copyright li:first-child {
 +
margin-top: 0;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 360px) {
 +
 +
#footer .inner {
 +
padding: 2em 1.5em 0.1em 1.5em ;
 +
}
 +
 +
}
 +
</style>
 +
<style>
 +
/*
 +
Solid State by HTML5 UP
 +
html5up.net | @ajlkn
 +
Free for personal and commercial use under the CCA 3.0 license (html5up.net/license)
 +
*/
 +
 +
/* Basic */
 +
 +
body {
 +
background-color: #dbe9d8;
 +
background-image: url("../../images/bg.jpg");
 +
background-size: cover;
 +
background-attachment: fixed;
 +
background-position: center;
 +
}
 +
 +
body:before {
 +
background: rgba(46, 49, 65, 0.8);
 +
content: '';
 +
display: block;
 +
height: 100%;
 +
left: 0;
 +
position: fixed;
 +
top: 0;
 +
width: 100%;
 +
}
 +
 +
body > * {
 +
position: relative;
 +
z-index: 1;
 +
}
 +
 +
/* Features */
 +
 +
.features article {
 +
display: inline-block;
 +
width: 45%;
 +
}
 +
 +
/* Menu */
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p

Latest revision as of 15:53, 1 November 2017

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Description

Construct Model

Building off of a rapamycin induced split-luciferase system characterized by the 2015 Peking iGEM team, our construct consists of a promoter reporter system that looks at two downstream products, c-Myc and COX-2 (Peking iGEM Team 2015, 2015). These products are assembled into a construct composed of fusion proteins as well as split luciferase fragments (COX-2 - FRB - nLuc and c-Myc - FKBP - cLuc). In the presence of rapamycin, the interacting protein partners dimerize and subsequently cause luciferase to activate. In order to test this model, we created vectors of our constructs and inserted them into E. coli cells.

Figure 1

Our gene production construct is modeled to produce COX-2 and c-Myc, which we used to simulate conditions in human bodies when these proteins are overproduced, in the case of CRC. The construct consists of an Anderson promoter, a ribosomal binding site, a COX-2 gene/c-Myc gene, and a terminator.

Figure 2

Our promoter-reporter construct is built so that only when there is both COX-2 and c-Myc will the binding sites be able to come together and glow with the addition of rapamycin. The construct built to bind with COX-2 consists of a COX-2 promoter, FRB, n-Luc, and terminator. The construct built to bind with c-Myc consists of a c-Myc promoter, FKBP, c-Luc, and terminator.

Figure 3

Our promoter-reporter system consists of two separate constructs each with a gene-specific promoter attached to a non-specific binding site fused to a domain of split luciferase. One construct consists of a COX-2 promoter, a FRB domain, and n-Luc, and the other consists of a c-Myc promoter, a FKBP domain, and c-Luc. The split system is built so that only when the presence of both COX-2 and c-Myc is detected will the binding sites be able to come together with the addition of rapamycin and cause glowing.

Figure 4

In solution, our two gene constructs are able to simulate the conditions in the human body by producing proteins COX-2 and c-Myc. These proteins then interact with the promoter-reporter constructs by connecting to the non- specific binding sites, allowing the dimerization of the FKBP-Rapamycin-FRB complex. This then orients the split- luciferase so they can come together.

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