Difference between revisions of "Team:ASIJ TOKYO/Description"

 
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{{ASIJ_TOKYO}}
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<h1>Description</h1>
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<li>Colorectal cancer remains the second most lethal cancer in the United States, often beginning as benign polyps in the colon and rectum. Despite relative ease of treatment, cases of CRC are usually detected in its late stages, rendering care difficult. CRC results from the mutation of multiple genes involved with the regulation of cell proliferation and DNA repair, with the ASIJ iGEM team focusing primarily on the Wnt pathway. The activation of the Wnt pathway specifically inhibits the degradation of beta-catenin, a protein that triggers the mutation of oncogenes and TSG’s. Through detection of these mutated genes and their subsequent downstream proteins, our team aims to develop an early screening method that can be adapted to a CRC detecting home-kit. </li>
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  <a href="https://2017.igem.org/Team:ASIJ_TOKYO">Home</a>
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  <div class="dropdown">
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  <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Team">Team</a>
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    <div class="dropdown-content">
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Team">Team</a>
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Collaborations">Collaborations</a>
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Attributions">Attributions</a>
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  <div class="dropdown">
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      <a href="#">Project</a>
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    <div class="dropdown-content">
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Description">Description</a>
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Design">Design</a>
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Experiments">Experiments</a>
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Notebook">Notebook</a>
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Results">Results</a>
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    </div>
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  </div>
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  <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Parts">Parts</a>
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  <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Safety">Safety</a>
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  <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Engagement">Human Practices</a>
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<a href="#" class="image"><img src="https://static.igem.org/mediawiki/2017/3/31/Anchiegg.png" alt="" /></a>
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<div class="content">
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<h2 class="major"style="color:#ffffff;">Description</h2>
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<h2 class="major">Construct Model</h2>
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<p>Building off of a rapamycin induced split-luciferase system characterized by the 2015 Peking iGEM team, our construct consists of a promoter reporter system that looks at two downstream products, c-Myc and COX-2 (Peking iGEM Team 2015, 2015). These products are assembled into a construct composed of fusion proteins as well as split luciferase fragments (COX-2 - FRB - nLuc and c-Myc - FKBP - cLuc). In the presence of rapamycin, the interacting protein partners dimerize and subsequently cause luciferase to activate. In order to test this model, we created vectors of our constructs and inserted them into E. coli cells. </p>
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<article>
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<a href="#" class="image"><img src="https://static.igem.org/mediawiki/2017/c/cc/Diagram_Models_%283%29-1.jpg" /></a>
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<h3 class="major">Figure 1</h3>
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<p>Our gene production construct is modeled to produce COX-2 and c-Myc, which we used to simulate conditions in human bodies when these proteins are overproduced, in the case of CRC. The construct consists of an Anderson promoter, a ribosomal binding site, a COX-2 gene/c-Myc gene, and a terminator.</p>
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<article>
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<a href="#" class="image"><img src="https://static.igem.org/mediawiki/2017/9/90/P-Rsystemanchiegg.jpg" title="Click to return back to the top." /></a>
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<h3 class="major">Figure 2</h3>
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<p>Our promoter-reporter construct is built so that only when there is both COX-2 and c-Myc will the binding sites be able to come together and glow with the addition of rapamycin. The construct built to bind with COX-2 consists of a COX-2 promoter, FRB, n-Luc, and terminator. The construct built to bind with c-Myc consists of a c-Myc promoter, FKBP, c-Luc, and terminator.</p>
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</article>
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<article>
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<a href="#" class="image"><img src="https://static.igem.org/mediawiki/2017/a/a5/P-Rsystemanchiegg2.jpg" title="Click to return back to the top." /></a>
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<h3 class="major">Figure 3</h3>
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<p>Our promoter-reporter system consists of two separate constructs each with a gene-specific promoter attached to a non-specific binding site fused to a domain of split luciferase. One construct consists of a COX-2 promoter, a FRB domain, and n-Luc, and the other consists of a c-Myc promoter, a FKBP domain, and c-Luc. The split system is built so that only when the presence of both COX-2 and c-Myc is detected will the binding sites be able to come together with the addition of rapamycin and cause glowing.</p>
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<article>
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<a href="#" class="image"><img src="https://static.igem.org/mediawiki/2017/e/ec/Insolutionanchiegg.jpg" title="Click to return back to the top." /></a>
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<h3 class="major">Figure 4</h3>
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<p>In solution, our two gene constructs are able to simulate the conditions in the human body by producing proteins COX-2 and c-Myc. These proteins then interact with the promoter-reporter constructs by connecting to the non- specific binding sites, allowing the dimerization of the FKBP-Rapamycin-FRB complex. This then orients the split- luciferase so they can come together.</p>
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margin-left: 0;
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width: 33.3333333333%;
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clear: none;
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margin-left: 0;
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}
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width: 25%;
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clear: none;
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margin-left: 0;
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}
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width: 16.6666666667%;
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clear: none;
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margin-left: 0;
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}
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.\31 u\28xlarge\29, .\31 u\24\28xlarge\29 {
 +
width: 8.3333333333%;
 +
clear: none;
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margin-left: 0;
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}
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.\31 2u\24\28xlarge\29 + *,
 +
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.\31 0u\24\28xlarge\29 + *,
 +
.\39 u\24\28xlarge\29 + *,
 +
.\38 u\24\28xlarge\29 + *,
 +
.\37 u\24\28xlarge\29 + *,
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.\36 u\24\28xlarge\29 + *,
 +
.\35 u\24\28xlarge\29 + *,
 +
.\34 u\24\28xlarge\29 + *,
 +
.\33 u\24\28xlarge\29 + *,
 +
.\32 u\24\28xlarge\29 + *,
 +
.\31 u\24\28xlarge\29 + * {
 +
clear: left;
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}
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.\-11u\28xlarge\29 {
 +
margin-left: 91.66667%;
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}
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 +
margin-left: 83.33333%;
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}
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.\-9u\28xlarge\29 {
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margin-left: 75%;
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}
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.\-8u\28xlarge\29 {
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margin-left: 66.66667%;
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}
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.\-7u\28xlarge\29 {
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margin-left: 58.33333%;
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}
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margin-left: 50%;
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}
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.\-5u\28xlarge\29 {
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margin-left: 41.66667%;
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}
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margin-left: 33.33333%;
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}
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.\-3u\28xlarge\29 {
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margin-left: 25%;
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}
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margin-left: 16.66667%;
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}
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margin-left: 8.33333%;
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}
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}
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@media screen and (max-width: 1280px) {
 +
 +
.row > * {
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padding: 0 0 0 1.75em;
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}
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.row {
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margin: 0 0 -1px -1.75em;
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}
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.row.uniform > * {
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padding: 1.75em 0 0 1.75em;
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}
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.row.uniform {
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margin: -1.75em 0 -1px -1.75em;
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}
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.row.\32 00\25 > * {
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padding: 0 0 0 3.5em;
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}
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.row.\32 00\25 {
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margin: 0 0 -1px -3.5em;
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}
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.row.uniform.\32 00\25 > * {
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padding: 3.5em 0 0 3.5em;
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}
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.row.uniform.\32 00\25 {
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margin: -3.5em 0 -1px -3.5em;
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}
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padding: 0 0 0 2.625em;
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}
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margin: 0 0 -1px -2.625em;
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}
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padding: 2.625em 0 0 2.625em;
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}
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.row.uniform.\31 50\25 {
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margin: -2.625em 0 -1px -2.625em;
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}
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padding: 0 0 0 0.875em;
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}
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margin: 0 0 -1px -0.875em;
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}
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padding: 0.875em 0 0 0.875em;
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}
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.row.uniform.\35 0\25 {
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margin: -0.875em 0 -1px -0.875em;
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}
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padding: 0 0 0 0.4375em;
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}
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.row.\32 5\25 {
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margin: 0 0 -1px -0.4375em;
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}
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.row.uniform.\32 5\25 > * {
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padding: 0.4375em 0 0 0.4375em;
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}
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.row.uniform.\32 5\25 {
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margin: -0.4375em 0 -1px -0.4375em;
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}
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 +
width: 100%;
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clear: none;
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margin-left: 0;
 +
}
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width: 91.6666666667%;
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clear: none;
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margin-left: 0;
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}
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width: 83.3333333333%;
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clear: none;
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margin-left: 0;
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}
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width: 75%;
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clear: none;
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margin-left: 0;
 +
}
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 +
width: 66.6666666667%;
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clear: none;
 +
margin-left: 0;
 +
}
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 +
width: 58.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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.\36 u\28large\29, .\36 u\24\28large\29 {
 +
width: 50%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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 +
width: 41.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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 +
width: 33.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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.\33 u\28large\29, .\33 u\24\28large\29 {
 +
width: 25%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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 +
width: 16.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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 +
width: 8.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 2u\24\28large\29 + *,
 +
.\31 1u\24\28large\29 + *,
 +
.\31 0u\24\28large\29 + *,
 +
.\39 u\24\28large\29 + *,
 +
.\38 u\24\28large\29 + *,
 +
.\37 u\24\28large\29 + *,
 +
.\36 u\24\28large\29 + *,
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.\35 u\24\28large\29 + *,
 +
.\34 u\24\28large\29 + *,
 +
.\33 u\24\28large\29 + *,
 +
.\32 u\24\28large\29 + *,
 +
.\31 u\24\28large\29 + * {
 +
clear: left;
 +
}
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 +
margin-left: 91.66667%;
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}
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 +
margin-left: 83.33333%;
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}
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margin-left: 75%;
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}
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margin-left: 66.66667%;
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}
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margin-left: 58.33333%;
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margin-left: 50%;
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}
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margin-left: 41.66667%;
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}
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margin-left: 33.33333%;
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}
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.\-3u\28large\29 {
 +
margin-left: 25%;
 +
}
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margin-left: 16.66667%;
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}
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.\-1u\28large\29 {
 +
margin-left: 8.33333%;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 980px) {
 +
 +
.row > * {
 +
padding: 0 0 0 1.75em;
 +
}
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.row {
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margin: 0 0 -1px -1.75em;
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}
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.row.uniform > * {
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padding: 1.75em 0 0 1.75em;
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}
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.row.uniform {
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margin: -1.75em 0 -1px -1.75em;
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}
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.row.\32 00\25 > * {
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padding: 0 0 0 3.5em;
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}
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.row.\32 00\25 {
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margin: 0 0 -1px -3.5em;
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}
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.row.uniform.\32 00\25 > * {
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padding: 3.5em 0 0 3.5em;
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}
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margin: -3.5em 0 -1px -3.5em;
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}
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padding: 0 0 0 2.625em;
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}
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.row.\31 50\25 {
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margin: 0 0 -1px -2.625em;
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}
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padding: 2.625em 0 0 2.625em;
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margin: -2.625em 0 -1px -2.625em;
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padding: 0 0 0 0.875em;
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}
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margin: 0 0 -1px -0.875em;
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}
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padding: 0.875em 0 0 0.875em;
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margin: -0.875em 0 -1px -0.875em;
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padding: 0 0 0 0.4375em;
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margin: 0 0 -1px -0.4375em;
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padding: 0.4375em 0 0 0.4375em;
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}
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.row.uniform.\32 5\25 {
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margin: -0.4375em 0 -1px -0.4375em;
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}
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 +
width: 100%;
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clear: none;
 +
margin-left: 0;
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}
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width: 91.6666666667%;
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clear: none;
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margin-left: 0;
 +
}
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width: 83.3333333333%;
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clear: none;
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margin-left: 0;
 +
}
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 +
width: 75%;
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clear: none;
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margin-left: 0;
 +
}
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 +
width: 66.6666666667%;
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clear: none;
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margin-left: 0;
 +
}
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width: 58.3333333333%;
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clear: none;
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margin-left: 0;
 +
}
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 +
width: 50%;
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clear: none;
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margin-left: 0;
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}
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width: 41.6666666667%;
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clear: none;
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margin-left: 0;
 +
}
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 +
width: 33.3333333333%;
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clear: none;
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margin-left: 0;
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}
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 +
width: 25%;
 +
clear: none;
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margin-left: 0;
 +
}
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 +
width: 16.6666666667%;
 +
clear: none;
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margin-left: 0;
 +
}
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 +
width: 8.3333333333%;
 +
clear: none;
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margin-left: 0;
 +
}
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 +
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 +
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clear: left;
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margin-left: 91.66667%;
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margin-left: 83.33333%;
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margin-left: 75%;
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margin-left: 66.66667%;
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margin-left: 58.33333%;
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margin-left: 50%;
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margin-left: 41.66667%;
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margin-left: 33.33333%;
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margin-left: 25%;
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margin-left: 16.66667%;
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}
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margin-left: 8.33333%;
 +
}
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}
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@media screen and (max-width: 736px) {
 +
 +
.row > * {
 +
padding: 0 0 0 1.25em;
 +
}
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.row {
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margin: 0 0 -1px -1.25em;
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}
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.row.uniform > * {
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padding: 1.25em 0 0 1.25em;
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}
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.row.uniform {
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margin: -1.25em 0 -1px -1.25em;
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}
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padding: 0 0 0 2.5em;
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}
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.row.\32 00\25 {
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margin: 0 0 -1px -2.5em;
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}
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.row.uniform.\32 00\25 > * {
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padding: 2.5em 0 0 2.5em;
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}
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margin: -2.5em 0 -1px -2.5em;
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padding: 0 0 0 1.875em;
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margin: 0 0 -1px -1.875em;
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}
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padding: 1.875em 0 0 1.875em;
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margin: -1.875em 0 -1px -1.875em;
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padding: 0 0 0 0.625em;
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}
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margin: 0 0 -1px -0.625em;
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padding: 0.625em 0 0 0.625em;
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margin: -0.625em 0 -1px -0.625em;
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padding: 0 0 0 0.3125em;
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margin: 0 0 -1px -0.3125em;
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padding: 0.3125em 0 0 0.3125em;
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.row.uniform.\32 5\25 {
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margin: -0.3125em 0 -1px -0.3125em;
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}
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 +
width: 100%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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 +
width: 91.6666666667%;
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clear: none;
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margin-left: 0;
 +
}
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width: 83.3333333333%;
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clear: none;
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margin-left: 0;
 +
}
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 +
width: 75%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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 +
width: 66.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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 +
width: 58.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
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 +
width: 50%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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 +
width: 41.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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 +
width: 33.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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 +
width: 25%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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 +
width: 16.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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 +
width: 8.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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.\31 2u\24\28small\29 + *,
 +
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 +
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 +
.\38 u\24\28small\29 + *,
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.\37 u\24\28small\29 + *,
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.\36 u\24\28small\29 + *,
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.\35 u\24\28small\29 + *,
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.\33 u\24\28small\29 + *,
 +
.\32 u\24\28small\29 + *,
 +
.\31 u\24\28small\29 + * {
 +
clear: left;
 +
}
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 +
margin-left: 91.66667%;
 +
}
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.\-10u\28small\29 {
 +
margin-left: 83.33333%;
 +
}
 +
 +
.\-9u\28small\29 {
 +
margin-left: 75%;
 +
}
 +
 +
.\-8u\28small\29 {
 +
margin-left: 66.66667%;
 +
}
 +
 +
.\-7u\28small\29 {
 +
margin-left: 58.33333%;
 +
}
 +
 +
.\-6u\28small\29 {
 +
margin-left: 50%;
 +
}
 +
 +
.\-5u\28small\29 {
 +
margin-left: 41.66667%;
 +
}
 +
 +
.\-4u\28small\29 {
 +
margin-left: 33.33333%;
 +
}
 +
 +
.\-3u\28small\29 {
 +
margin-left: 25%;
 +
}
 +
 +
.\-2u\28small\29 {
 +
margin-left: 16.66667%;
 +
}
 +
 +
.\-1u\28small\29 {
 +
margin-left: 8.33333%;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
.row > * {
 +
padding: 0 0 0 1.25em;
 +
}
 +
 +
.row {
 +
margin: 0 0 -1px -1.25em;
 +
}
 +
 +
.row.uniform > * {
 +
padding: 1.25em 0 0 1.25em;
 +
}
 +
 +
.row.uniform {
 +
margin: -1.25em 0 -1px -1.25em;
 +
}
 +
 +
.row.\32 00\25 > * {
 +
padding: 0 0 0 2.5em;
 +
}
 +
 +
.row.\32 00\25 {
 +
margin: 0 0 -1px -2.5em;
 +
}
 +
 +
.row.uniform.\32 00\25 > * {
 +
padding: 2.5em 0 0 2.5em;
 +
}
 +
 +
.row.uniform.\32 00\25 {
 +
margin: -2.5em 0 -1px -2.5em;
 +
}
 +
 +
.row.\31 50\25 > * {
 +
padding: 0 0 0 1.875em;
 +
}
 +
 +
.row.\31 50\25 {
 +
margin: 0 0 -1px -1.875em;
 +
}
 +
 +
.row.uniform.\31 50\25 > * {
 +
padding: 1.875em 0 0 1.875em;
 +
}
 +
 +
.row.uniform.\31 50\25 {
 +
margin: -1.875em 0 -1px -1.875em;
 +
}
 +
 +
.row.\35 0\25 > * {
 +
padding: 0 0 0 0.625em;
 +
}
 +
 +
.row.\35 0\25 {
 +
margin: 0 0 -1px -0.625em;
 +
}
 +
 +
.row.uniform.\35 0\25 > * {
 +
padding: 0.625em 0 0 0.625em;
 +
}
 +
 +
.row.uniform.\35 0\25 {
 +
margin: -0.625em 0 -1px -0.625em;
 +
}
 +
 +
.row.\32 5\25 > * {
 +
padding: 0 0 0 0.3125em;
 +
}
 +
 +
.row.\32 5\25 {
 +
margin: 0 0 -1px -0.3125em;
 +
}
 +
 +
.row.uniform.\32 5\25 > * {
 +
padding: 0.3125em 0 0 0.3125em;
 +
}
 +
 +
.row.uniform.\32 5\25 {
 +
margin: -0.3125em 0 -1px -0.3125em;
 +
}
 +
 +
.\31 2u\28xsmall\29, .\31 2u\24\28xsmall\29 {
 +
width: 100%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 1u\28xsmall\29, .\31 1u\24\28xsmall\29 {
 +
width: 91.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 0u\28xsmall\29, .\31 0u\24\28xsmall\29 {
 +
width: 83.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\39 u\28xsmall\29, .\39 u\24\28xsmall\29 {
 +
width: 75%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\38 u\28xsmall\29, .\38 u\24\28xsmall\29 {
 +
width: 66.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\37 u\28xsmall\29, .\37 u\24\28xsmall\29 {
 +
width: 58.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\36 u\28xsmall\29, .\36 u\24\28xsmall\29 {
 +
width: 50%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\35 u\28xsmall\29, .\35 u\24\28xsmall\29 {
 +
width: 41.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\34 u\28xsmall\29, .\34 u\24\28xsmall\29 {
 +
width: 33.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\33 u\28xsmall\29, .\33 u\24\28xsmall\29 {
 +
width: 25%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\32 u\28xsmall\29, .\32 u\24\28xsmall\29 {
 +
width: 16.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 u\28xsmall\29, .\31 u\24\28xsmall\29 {
 +
width: 8.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 2u\24\28xsmall\29 + *,
 +
.\31 1u\24\28xsmall\29 + *,
 +
.\31 0u\24\28xsmall\29 + *,
 +
.\39 u\24\28xsmall\29 + *,
 +
.\38 u\24\28xsmall\29 + *,
 +
.\37 u\24\28xsmall\29 + *,
 +
.\36 u\24\28xsmall\29 + *,
 +
.\35 u\24\28xsmall\29 + *,
 +
.\34 u\24\28xsmall\29 + *,
 +
.\33 u\24\28xsmall\29 + *,
 +
.\32 u\24\28xsmall\29 + *,
 +
.\31 u\24\28xsmall\29 + * {
 +
clear: left;
 +
}
 +
 +
.\-11u\28xsmall\29 {
 +
margin-left: 91.66667%;
 +
}
 +
 +
.\-10u\28xsmall\29 {
 +
margin-left: 83.33333%;
 +
}
 +
 +
.\-9u\28xsmall\29 {
 +
margin-left: 75%;
 +
}
 +
 +
.\-8u\28xsmall\29 {
 +
margin-left: 66.66667%;
 +
}
 +
 +
.\-7u\28xsmall\29 {
 +
margin-left: 58.33333%;
 +
}
 +
 +
.\-6u\28xsmall\29 {
 +
margin-left: 50%;
 +
}
 +
 +
.\-5u\28xsmall\29 {
 +
margin-left: 41.66667%;
 +
}
 +
 +
.\-4u\28xsmall\29 {
 +
margin-left: 33.33333%;
 +
}
 +
 +
.\-3u\28xsmall\29 {
 +
margin-left: 25%;
 +
}
 +
 +
.\-2u\28xsmall\29 {
 +
margin-left: 16.66667%;
 +
}
 +
 +
.\-1u\28xsmall\29 {
 +
margin-left: 8.33333%;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 360px) {
 +
 +
.row > * {
 +
padding: 0 0 0 1.25em;
 +
}
 +
 +
.row {
 +
margin: 0 0 -1px -1.25em;
 +
}
 +
 +
.row.uniform > * {
 +
padding: 1.25em 0 0 1.25em;
 +
}
 +
 +
.row.uniform {
 +
margin: -1.25em 0 -1px -1.25em;
 +
}
 +
 +
.row.\32 00\25 > * {
 +
padding: 0 0 0 2.5em;
 +
}
 +
 +
.row.\32 00\25 {
 +
margin: 0 0 -1px -2.5em;
 +
}
 +
 +
.row.uniform.\32 00\25 > * {
 +
padding: 2.5em 0 0 2.5em;
 +
}
 +
 +
.row.uniform.\32 00\25 {
 +
margin: -2.5em 0 -1px -2.5em;
 +
}
 +
 +
.row.\31 50\25 > * {
 +
padding: 0 0 0 1.875em;
 +
}
 +
 +
.row.\31 50\25 {
 +
margin: 0 0 -1px -1.875em;
 +
}
 +
 +
.row.uniform.\31 50\25 > * {
 +
padding: 1.875em 0 0 1.875em;
 +
}
 +
 +
.row.uniform.\31 50\25 {
 +
margin: -1.875em 0 -1px -1.875em;
 +
}
 +
 +
.row.\35 0\25 > * {
 +
padding: 0 0 0 0.625em;
 +
}
 +
 +
.row.\35 0\25 {
 +
margin: 0 0 -1px -0.625em;
 +
}
 +
 +
.row.uniform.\35 0\25 > * {
 +
padding: 0.625em 0 0 0.625em;
 +
}
 +
 +
.row.uniform.\35 0\25 {
 +
margin: -0.625em 0 -1px -0.625em;
 +
}
 +
 +
.row.\32 5\25 > * {
 +
padding: 0 0 0 0.3125em;
 +
}
 +
 +
.row.\32 5\25 {
 +
margin: 0 0 -1px -0.3125em;
 +
}
 +
 +
.row.uniform.\32 5\25 > * {
 +
padding: 0.3125em 0 0 0.3125em;
 +
}
 +
 +
.row.uniform.\32 5\25 {
 +
margin: -0.3125em 0 -1px -0.3125em;
 +
}
 +
 +
.\31 2u\28xxsmall\29, .\31 2u\24\28xxsmall\29 {
 +
width: 100%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 1u\28xxsmall\29, .\31 1u\24\28xxsmall\29 {
 +
width: 91.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 0u\28xxsmall\29, .\31 0u\24\28xxsmall\29 {
 +
width: 83.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\39 u\28xxsmall\29, .\39 u\24\28xxsmall\29 {
 +
width: 75%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\38 u\28xxsmall\29, .\38 u\24\28xxsmall\29 {
 +
width: 66.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\37 u\28xxsmall\29, .\37 u\24\28xxsmall\29 {
 +
width: 58.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\36 u\28xxsmall\29, .\36 u\24\28xxsmall\29 {
 +
width: 50%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\35 u\28xxsmall\29, .\35 u\24\28xxsmall\29 {
 +
width: 41.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\34 u\28xxsmall\29, .\34 u\24\28xxsmall\29 {
 +
width: 33.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\33 u\28xxsmall\29, .\33 u\24\28xxsmall\29 {
 +
width: 25%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\32 u\28xxsmall\29, .\32 u\24\28xxsmall\29 {
 +
width: 16.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 u\28xxsmall\29, .\31 u\24\28xxsmall\29 {
 +
width: 8.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 2u\24\28xxsmall\29 + *,
 +
.\31 1u\24\28xxsmall\29 + *,
 +
.\31 0u\24\28xxsmall\29 + *,
 +
.\39 u\24\28xxsmall\29 + *,
 +
.\38 u\24\28xxsmall\29 + *,
 +
.\37 u\24\28xxsmall\29 + *,
 +
.\36 u\24\28xxsmall\29 + *,
 +
.\35 u\24\28xxsmall\29 + *,
 +
.\34 u\24\28xxsmall\29 + *,
 +
.\33 u\24\28xxsmall\29 + *,
 +
.\32 u\24\28xxsmall\29 + *,
 +
.\31 u\24\28xxsmall\29 + * {
 +
clear: left;
 +
}
 +
 +
.\-11u\28xxsmall\29 {
 +
margin-left: 91.66667%;
 +
}
 +
 +
.\-10u\28xxsmall\29 {
 +
margin-left: 83.33333%;
 +
}
 +
 +
.\-9u\28xxsmall\29 {
 +
margin-left: 75%;
 +
}
 +
 +
.\-8u\28xxsmall\29 {
 +
margin-left: 66.66667%;
 +
}
 +
 +
.\-7u\28xxsmall\29 {
 +
margin-left: 58.33333%;
 +
}
 +
 +
.\-6u\28xxsmall\29 {
 +
margin-left: 50%;
 +
}
 +
 +
.\-5u\28xxsmall\29 {
 +
margin-left: 41.66667%;
 +
}
 +
 +
.\-4u\28xxsmall\29 {
 +
margin-left: 33.33333%;
 +
}
 +
 +
.\-3u\28xxsmall\29 {
 +
margin-left: 25%;
 +
}
 +
 +
.\-2u\28xxsmall\29 {
 +
margin-left: 16.66667%;
 +
}
 +
 +
.\-1u\28xxsmall\29 {
 +
margin-left: 8.33333%;
 +
}
 +
 +
}
 +
 +
/* Basic */
 +
 +
@-ms-viewport {
 +
width: device-width;
 +
}
 +
 +
body {
 +
-ms-overflow-style: scrollbar;
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
html, body {
 +
min-width: 320px;
 +
}
 +
 +
}
 +
 +
body {
 +
background-color: #dbe9d8;
 +
background-image: linear-gradient(to top, rgba(46, 49, 65, 0.8), rgba(46, 49, 65, 0.8)), url("../../images/bg.jpg");
 +
background-size: auto, cover;
 +
background-attachment: fixed, fixed;
 +
background-position: center, center;
 +
}
 +
 +
body.is-loading *, body.is-loading *:before, body.is-loading *:after {
 +
-moz-animation: none !important;
 +
-webkit-animation: none !important;
 +
-ms-animation: none !important;
 +
animation: none !important;
 +
-moz-transition: none !important;
 +
-webkit-transition: none !important;
 +
-ms-transition: none !important;
 +
transition: none !important;
 +
}
 +
 +
/* Type */
 +
 +
body, input, select, textarea {
 +
color: #ffffff;
 +
font-family: "Source Sans Pro", Helvetica, sans-serif;
 +
font-size: 16.5pt;
 +
font-weight: 300;
 +
line-height: 1.65;
 +
}
 +
 +
@media screen and (max-width: 1680px) {
 +
 +
body, input, select, textarea {
 +
font-size: 13pt;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 1280px) {
 +
 +
body, input, select, textarea {
 +
font-size: 12pt;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 980px) {
 +
 +
body, input, select, textarea {
 +
font-size: 12pt;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
body, input, select, textarea {
 +
font-size: 12pt;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
body, input, select, textarea {
 +
font-size: 12pt;
 +
}
 +
 +
}
 +
 +
a {
 +
-moz-transition: color 0.2s ease-in-out, border-bottom-color 0.2s ease-in-out;
 +
-webkit-transition: color 0.2s ease-in-out, border-bottom-color 0.2s ease-in-out;
 +
-ms-transition: color 0.2s ease-in-out, border-bottom-color 0.2s ease-in-out;
 +
transition: color 0.2s ease-in-out, border-bottom-color 0.2s ease-in-out;
 +
border-bottom: dotted 1px rgba(255, 255, 255, 0.35);
 +
color: #ffffff;
 +
text-decoration: none;
 +
}
 +
 +
a:hover {
 +
border-bottom-color: transparent;
 +
color: #ffffff !important;
 +
}
 +
 +
a.special:not(.button) {
 +
text-decoration: none;
 +
border-bottom: 0;
 +
display: block;
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-size: 0.8em;
 +
font-weight: 700;
 +
letter-spacing: 0.1em;
 +
margin: 0 0 2em 0;
 +
text-transform: uppercase;
 +
}
 +
 +
a.special:not(.button):before {
 +
-moz-osx-font-smoothing: grayscale;
 +
-webkit-font-smoothing: antialiased;
 +
font-family: FontAwesome;
 +
font-style: normal;
 +
font-weight: normal;
 +
text-transform: none !important;
 +
}
 +
 +
a.special:not(.button):before {
 +
-moz-transition: background-color 0.2s ease-in-out;
 +
-webkit-transition: background-color 0.2s ease-in-out;
 +
-ms-transition: background-color 0.2s ease-in-out;
 +
transition: background-color 0.2s ease-in-out;
 +
border-radius: 100%;
 +
border: solid 2px rgba(255, 255, 255, 0.125);
 +
content: '\f105';
 +
display: inline-block;
 +
font-size: 1.25em;
 +
height: 2em;
 +
line-height: 1.65em;
 +
margin-right: 0.85em;
 +
text-align: center;
 +
text-indent: 0.15em;
 +
vertical-align: middle;
 +
width: 2em;
 +
}
 +
 +
a.special:not(.button):hover:before {
 +
background-color: rgba(255, 255, 255, 0.025);
 +
}
 +
 +
a.special:not(.button):active:before {
 +
background-color: rgba(255, 255, 255, 0.075);
 +
}
 +
 +
strong, b {
 +
color: #ffffff;
 +
font-weight: 600;
 +
}
 +
 +
em, i {
 +
font-style: italic;
 +
}
 +
 +
p {
 +
margin: 0 0 2em 0;
 +
}
 +
 +
h1, h2, h3, h4, h5, h6 {
 +
color: #ffffff;
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-weight: 700;
 +
letter-spacing: 0.1em;
 +
margin: 0 0 1em 0;
 +
text-transform: uppercase;
 +
}
 +
 +
h1 a, h2 a, h3 a, h4 a, h5 a, h6 a {
 +
color: inherit;
 +
text-decoration: none;
 +
}
 +
 +
h1 span, h2 span, h3 span, h4 span, h5 span, h6 span {
 +
font-weight: 200;
 +
}
 +
 +
h1.major, h2.major, h3.major, h4.major, h5.major, h6.major {
 +
padding-bottom: 1em;
 +
border-bottom: solid 2px rgba(255, 255, 255, 0.125);
 +
}
 +
 +
h2 {
 +
font-size: 1.2em;
 +
}
 +
 +
h3 {
 +
font-size: 0.9em;
 +
}
 +
 +
h4 {
 +
font-size: 0.7em;
 +
}
 +
 +
h5 {
 +
font-size: 0.7em;
 +
}
 +
 +
h6 {
 +
font-size: 0.7em;
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
h2 {
 +
font-size: 1em;
 +
}
 +
 +
h3 {
 +
font-size: 0.8em;
 +
}
 +
 +
}
 +
 +
sub {
 +
font-size: 0.8em;
 +
position: relative;
 +
top: 0.5em;
 +
}
 +
 +
sup {
 +
font-size: 0.8em;
 +
position: relative;
 +
top: -0.5em;
 +
}
 +
 +
blockquote {
 +
border-left: solid 4px rgba(255, 255, 255, 0.125);
 +
font-style: italic;
 +
margin: 0 0 2em 0;
 +
padding: 0.5em 0 0.5em 2em;
 +
}
 +
 +
code {
 +
background: rgba(255, 255, 255, 0.025);
 +
border-radius: 5px;
 +
border: solid 2px rgba(255, 255, 255, 0.125);
 +
font-family: "Courier New", monospace;
 +
font-size: 0.9em;
 +
margin: 0 0.25em;
 +
padding: 0.25em 0.65em;
 +
}
 +
 +
pre {
 +
-webkit-overflow-scrolling: touch;
 +
font-family: "Courier New", monospace;
 +
font-size: 0.9em;
 +
margin: 0 0 2em 0;
 +
}
 +
 +
pre code {
 +
display: block;
 +
line-height: 1.75em;
 +
padding: 1em 1.5em;
 +
overflow-x: auto;
 +
}
 +
 +
hr {
 +
border: 0;
 +
border-bottom: solid 2px rgba(255, 255, 255, 0.125);
 +
margin: 2.5em 0;
 +
}
 +
 +
hr.major {
 +
margin: 4em 0;
 +
}
 +
 +
.align-left {
 +
text-align: left;
 +
}
 +
 +
.align-center {
 +
text-align: center;
 +
}
 +
 +
.align-right {
 +
text-align: left;
 +
}
 +
 +
/* Section/Article */
 +
 +
section.special, article.special {
 +
text-align: center;
 +
}
 +
 +
/* Form */
 +
 +
form {
 +
margin: 0 0 2em 0;
 +
}
 +
 +
form .field {
 +
margin: 0 0 2em 0;
 +
}
 +
 +
form .field label {
 +
margin-top: -1.5em;
 +
}
 +
 +
form .field:first-child label {
 +
margin-top: 0;
 +
}
 +
 +
form > :last-child {
 +
margin-bottom: 0;
 +
}
 +
 +
label {
 +
color: #ffffff;
 +
display: block;
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-size: 0.8em;
 +
font-weight: 700;
 +
letter-spacing: 0.1em;
 +
margin: 0 0 0.7em 0;
 +
text-transform: uppercase;
 +
}
 +
 +
input[type="text"],
 +
input[type="password"],
 +
input[type="email"],
 +
input[type="tel"],
 +
select,
 +
textarea {
 +
-moz-appearance: none;
 +
-webkit-appearance: none;
 +
-ms-appearance: none;
 +
appearance: none;
 +
background: rgba(255, 255, 255, 0.025);
 +
border-radius: 5px;
 +
border: none;
 +
border: solid 2px rgba(255, 255, 255, 0.125);
 +
color: inherit;
 +
display: block;
 +
outline: 0;
 +
padding: 0 1em;
 +
text-decoration: none;
 +
width: 100%;
 +
}
 +
 +
input[type="text"]:invalid,
 +
input[type="password"]:invalid,
 +
input[type="email"]:invalid,
 +
input[type="tel"]:invalid,
 +
select:invalid,
 +
textarea:invalid {
 +
box-shadow: none;
 +
}
 +
 +
input[type="text"]:focus,
 +
input[type="password"]:focus,
 +
input[type="email"]:focus,
 +
input[type="tel"]:focus,
 +
select:focus,
 +
textarea:focus {
 +
border-color: #6a588e;
 +
}
 +
 +
.select-wrapper {
 +
text-decoration: none;
 +
display: block;
 +
position: relative;
 +
}
 +
 +
.select-wrapper:before {
 +
-moz-osx-font-smoothing: grayscale;
 +
-webkit-font-smoothing: antialiased;
 +
font-family: FontAwesome;
 +
font-style: normal;
 +
font-weight: normal;
 +
text-transform: none !important;
 +
}
 +
 +
.select-wrapper:before {
 +
color: rgba(255, 255, 255, 0.125);
 +
content: '\f078';
 +
display: block;
 +
height: 2.75em;
 +
line-height: 2.75em;
 +
pointer-events: none;
 +
position: absolute;
 +
right: 0;
 +
text-align: center;
 +
top: 0;
 +
width: 2.75em;
 +
}
 +
 +
.select-wrapper select::-ms-expand {
 +
display: none;
 +
}
 +
 +
select option {
 +
color: #ffffff;
 +
background: #dbe9d8;
 +
}
 +
 +
input[type="text"],
 +
input[type="password"],
 +
input[type="email"],
 +
select {
 +
height: 2.75em;
 +
}
 +
 +
textarea {
 +
padding: 0.75em 1em;
 +
}
 +
 +
input[type="checkbox"],
 +
input[type="radio"] {
 +
-moz-appearance: none;
 +
-webkit-appearance: none;
 +
-ms-appearance: none;
 +
appearance: none;
 +
display: block;
 +
float: left;
 +
margin-right: -2em;
 +
opacity: 0;
 +
width: 1em;
 +
z-index: -1;
 +
}
 +
 +
input[type="checkbox"] + label,
 +
input[type="radio"] + label {
 +
text-decoration: none;
 +
color: #ffffff;
 +
cursor: pointer;
 +
display: inline-block;
 +
font-size: 1em;
 +
font-family: "Source Sans Pro", Helvetica, sans-serif;
 +
text-transform: none;
 +
letter-spacing: 0;
 +
font-weight: 300;
 +
padding-left: 2.4em;
 +
padding-right: 0.75em;
 +
position: relative;
 +
}
 +
 +
input[type="checkbox"] + label:before,
 +
input[type="radio"] + label:before {
 +
-moz-osx-font-smoothing: grayscale;
 +
-webkit-font-smoothing: antialiased;
 +
font-family: FontAwesome;
 +
font-style: normal;
 +
font-weight: normal;
 +
text-transform: none !important;
 +
}
 +
 +
input[type="checkbox"] + label:before,
 +
input[type="radio"] + label:before {
 +
background: rgba(255, 255, 255, 0.025);
 +
border-radius: 5px;
 +
border: solid 2px rgba(255, 255, 255, 0.125);
 +
content: '';
 +
display: inline-block;
 +
height: 1.65em;
 +
left: 0;
 +
line-height: 1.58125em;
 +
position: absolute;
 +
text-align: center;
 +
top: 0;
 +
width: 1.65em;
 +
}
 +
 +
input[type="checkbox"]:checked + label:before,
 +
input[type="radio"]:checked + label:before {
 +
background: #ffffff;
 +
border-color: #ffffff;
 +
content: '\f00c';
 +
color: #dbe9d8;
 +
}
 +
 +
input[type="checkbox"]:focus + label:before,
 +
input[type="radio"]:focus + label:before {
 +
border-color: #dbe9d8;
 +
}
 +
 +
input[type="checkbox"] + label:before {
 +
border-radius: 5px;
 +
}
 +
 +
input[type="radio"] + label:before {
 +
border-radius: 100%;
 +
}
 +
 +
::-webkit-input-placeholder {
 +
color: rgba(255, 255, 255, 0.35) !important;
 +
opacity: 1.0;
 +
}
 +
 +
:-moz-placeholder {
 +
color: rgba(255, 255, 255, 0.35) !important;
 +
opacity: 1.0;
 +
}
 +
 +
::-moz-placeholder {
 +
color: rgba(255, 255, 255, 0.35) !important;
 +
opacity: 1.0;
 +
}
 +
 +
:-ms-input-placeholder {
 +
color: rgba(255, 255, 255, 0.35) !important;
 +
opacity: 1.0;
 +
}
 +
 +
.polyfill-placeholder {
 +
color: rgba(255, 255, 255, 0.35) !important;
 +
opacity: 1.0;
 +
}
 +
 +
/* Box */
 +
 +
.box {
 +
border-radius: 5px;
 +
border: solid 2px rgba(255, 255, 255, 0.125);
 +
margin-bottom: 2em;
 +
padding: 1.5em;
 +
}
 +
 +
.box > :last-child,
 +
.box > :last-child > :last-child,
 +
.box > :last-child > :last-child > :last-child {
 +
margin-bottom: 0;
 +
}
 +
 +
.box.alt {
 +
border: 0;
 +
border-radius: 0;
 +
padding: 0;
 +
}
 +
 +
/* Icon */
 +
 +
.icon {
 +
text-decoration: none;
 +
border-bottom: none;
 +
position: relative;
 +
}
 +
 +
.icon:before {
 +
-moz-osx-font-smoothing: grayscale;
 +
-webkit-font-smoothing: antialiased;
 +
font-family: FontAwesome;
 +
font-style: normal;
 +
font-weight: normal;
 +
text-transform: none !important;
 +
}
 +
 +
.icon > .label {
 +
display: none;
 +
}
 +
 +
/* Image */
 +
 +
.image {
 +
border-radius: 5px;
 +
border: 0;
 +
display: inline-block;
 +
position: relative;
 +
}
 +
 +
.image img {
 +
border-radius: 5px;
 +
display: block;
 +
}
 +
 +
.image.left, .image.right {
 +
max-width: 40%;
 +
}
 +
 +
.image.left img, .image.right img {
 +
width: 100%;
 +
}
 +
 +
.image.left {
 +
float: left;
 +
padding: 0 1.5em 1em 0;
 +
top: 0.25em;
 +
}
 +
 +
.image.right {
 +
float: right;
 +
padding: 0 0 1em 1.5em;
 +
top: 0.25em;
 +
}
 +
 +
.image.fit {
 +
display: block;
 +
margin: 0 0 2em 0;
 +
width: 100%;
 +
}
 +
 +
.image.fit img {
 +
width: 100%;
 +
}
 +
 +
.image.main {
 +
display: block;
 +
margin: 0 0 3em 0;
 +
width: 100%;
 +
}
 +
 +
.image.main img {
 +
width: 100%;
 +
}
 +
 +
/* List */
 +
 +
ol {
 +
list-style: decimal;
 +
margin: 0 0 2em 0;
 +
padding-left: 1.25em;
 +
}
 +
 +
ol li {
 +
padding-left: 0.25em;
 +
}
 +
 +
ul {
 +
list-style: disc;
 +
margin: 0 0 2em 0;
 +
padding-left: 1em;
 +
}
 +
 +
ul li {
 +
padding-left: 0.5em;
 +
}
 +
 +
ul.alt {
 +
list-style: none;
 +
padding-left: 0;
 +
}
 +
 +
ul.alt li {
 +
border-top: solid 1px rgba(255, 255, 255, 0.125);
 +
padding: 0.5em 0;
 +
}
 +
 +
ul.alt li:first-child {
 +
border-top: 0;
 +
padding-top: 0;
 +
}
 +
 +
ul.icons {
 +
cursor: default;
 +
list-style: none;
 +
padding-left: 0;
 +
}
 +
 +
ul.icons li {
 +
display: inline-block;
 +
padding: 0 1em 0 0;
 +
}
 +
 +
ul.icons li:last-child {
 +
padding-right: 0;
 +
}
 +
 +
ul.icons li .icon:before {
 +
font-size: 1.25em;
 +
}
 +
 +
ul.actions {
 +
cursor: default;
 +
list-style: none;
 +
padding-left: 0;
 +
}
 +
 +
ul.actions li {
 +
display: inline-block;
 +
padding: 0 1em 0 0;
 +
vertical-align: middle;
 +
}
 +
 +
ul.actions li:last-child {
 +
padding-right: 0;
 +
}
 +
 +
ul.actions.small li {
 +
padding: 0 0.5em 0 0;
 +
}
 +
 +
ul.actions.vertical li {
 +
display: block;
 +
padding: 1em 0 0 0;
 +
}
 +
 +
ul.actions.vertical li:first-child {
 +
padding-top: 0;
 +
}
 +
 +
ul.actions.vertical li > * {
 +
margin-bottom: 0;
 +
}
 +
 +
ul.actions.vertical.small li {
 +
padding: 0.5em 0 0 0;
 +
}
 +
 +
ul.actions.vertical.small li:first-child {
 +
padding-top: 0;
 +
}
 +
 +
ul.actions.fit {
 +
display: table;
 +
margin-left: -1em;
 +
padding: 0;
 +
table-layout: fixed;
 +
width: calc(100% + 1em);
 +
}
 +
 +
ul.actions.fit li {
 +
display: table-cell;
 +
padding: 0 0 0 1em;
 +
}
 +
 +
ul.actions.fit li > * {
 +
margin-bottom: 0;
 +
}
 +
 +
ul.actions.fit.small {
 +
margin-left: -0.5em;
 +
width: calc(100% + 0.5em);
 +
}
 +
 +
ul.actions.fit.small li {
 +
padding: 0 0 0 0.5em;
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
ul.actions {
 +
margin: 0 0 2em 0;
 +
}
 +
 +
ul.actions li {
 +
padding: 1em 0 0 0;
 +
display: block;
 +
text-align: center;
 +
width: 100%;
 +
}
 +
 +
ul.actions li:first-child {
 +
padding-top: 0;
 +
}
 +
 +
ul.actions li > * {
 +
width: 100%;
 +
margin: 0 !important;
 +
}
 +
 +
ul.actions.small li {
 +
padding: 0.5em 0 0 0;
 +
}
 +
 +
ul.actions.small li:first-child {
 +
padding-top: 0;
 +
}
 +
 +
}
 +
 +
ul.contact {
 +
list-style: none;
 +
padding: 0;
 +
}
 +
 +
ul.contact li {
 +
text-decoration: none;
 +
margin: 2.5em 0 0 0;
 +
padding: 0 0 0 3.25em;
 +
position: relative;
 +
}
 +
 +
ul.contact li:before {
 +
-moz-osx-font-smoothing: grayscale;
 +
-webkit-font-smoothing: antialiased;
 +
font-family: FontAwesome;
 +
font-style: normal;
 +
font-weight: normal;
 +
text-transform: none !important;
 +
}
 +
 +
ul.contact li:before {
 +
border-radius: 100%;
 +
border: solid 2px rgba(255, 255, 255, 0.125);
 +
display: inline-block;
 +
font-size: 0.8em;
 +
height: 2.5em;
 +
left: 0;
 +
line-height: 2.35em;
 +
position: absolute;
 +
text-align: center;
 +
top: 0;
 +
width: 2.5em;
 +
}
 +
 +
ul.contact li:first-child {
 +
margin-top: 0;
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
ul.contact li {
 +
margin: 1.5em 0 0 0;
 +
}
 +
 +
}
 +
 +
ul.pagination {
 +
cursor: default;
 +
list-style: none;
 +
padding-left: 0;
 +
}
 +
 +
ul.pagination li {
 +
display: inline-block;
 +
padding-left: 0;
 +
vertical-align: middle;
 +
}
 +
 +
ul.pagination li > .page {
 +
-moz-transition: background-color 0.2s ease-in-out, color 0.2s ease-in-out;
 +
-webkit-transition: background-color 0.2s ease-in-out, color 0.2s ease-in-out;
 +
-ms-transition: background-color 0.2s ease-in-out, color 0.2s ease-in-out;
 +
transition: background-color 0.2s ease-in-out, color 0.2s ease-in-out;
 +
border-bottom: 0;
 +
border-radius: 5px;
 +
display: inline-block;
 +
height: 1.5em;
 +
line-height: 1.5em;
 +
margin: 0 0.125em;
 +
min-width: 1.5em;
 +
padding: 0 0.5em;
 +
text-align: center;
 +
}
 +
 +
ul.pagination li > .page:hover {
 +
background-color: rgba(255, 255, 255, 0.025);
 +
}
 +
 +
ul.pagination li > .page.active {
 +
background-color: #dbe9d8;
 +
}
 +
 +
ul.pagination li:first-child {
 +
padding-right: 0.75em;
 +
}
 +
 +
ul.pagination li:last-child {
 +
padding-left: 0.75em;
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
ul.pagination li:nth-child(n+2):nth-last-child(n+2) {
 +
display: none;
 +
}
 +
 +
ul.pagination li .button {
 +
width: 100%;
 +
}
 +
 +
ul.pagination li:first-child {
 +
width: calc(50% - 2px);
 +
text-align: left;
 +
padding-right: 0.325em;
 +
}
 +
 +
ul.pagination li:last-child {
 +
width: calc(50% - 2px);
 +
text-align: left;
 +
padding-left: 0.325em;
 +
}
 +
 +
}
 +
 +
dl {
 +
margin: 0 0 2em 0;
 +
}
 +
 +
dl dt {
 +
display: block;
 +
font-weight: 600;
 +
margin: 0 0 1em 0;
 +
}
 +
 +
dl dd {
 +
margin-left: 2em;
 +
}
 +
 +
/* Table */
 +
 +
.table-wrapper {
 +
-webkit-overflow-scrolling: touch;
 +
overflow-x: auto;
 +
}
 +
 +
table {
 +
margin: 0 0 2em 0;
 +
width: 100%;
 +
}
 +
 +
table tbody tr {
 +
border: solid 1px rgba(255, 255, 255, 0.125);
 +
border-left: 0;
 +
border-right: 0;
 +
}
 +
 +
table tbody tr:nth-child(2n + 1) {
 +
background-color: rgba(255, 255, 255, 0.025);
 +
}
 +
 +
table td {
 +
padding: 0.75em 0.75em;
 +
}
 +
 +
table th {
 +
color: #ffffff;
 +
font-size: 0.9em;
 +
font-weight: 600;
 +
padding: 0 0.75em 0.75em 0.75em;
 +
text-align: left;
 +
}
 +
 +
table thead {
 +
border-bottom: solid 2px rgba(255, 255, 255, 0.125);
 +
}
 +
 +
table tfoot {
 +
border-top: solid 2px rgba(255, 255, 255, 0.125);
 +
}
 +
 +
table.alt {
 +
border-collapse: separate;
 +
}
 +
 +
table.alt tbody tr td {
 +
border: solid 1px rgba(255, 255, 255, 0.125);
 +
border-left-width: 0;
 +
border-top-width: 0;
 +
}
 +
 +
table.alt tbody tr td:first-child {
 +
border-left-width: 1px;
 +
}
 +
 +
table.alt tbody tr:first-child td {
 +
border-top-width: 1px;
 +
}
 +
 +
table.alt thead {
 +
border-bottom: 0;
 +
}
 +
 +
table.alt tfoot {
 +
border-top: 0;
 +
}
 +
 +
/* Button */
 +
 +
input[type="submit"],
 +
input[type="reset"],
 +
input[type="button"],
 +
button,
 +
.button {
 +
-moz-appearance: none;
 +
-webkit-appearance: none;
 +
-ms-appearance: none;
 +
appearance: none;
 +
-moz-transition: background-color 0.2s ease-in-out;
 +
-webkit-transition: background-color 0.2s ease-in-out;
 +
-ms-transition: background-color 0.2s ease-in-out;
 +
transition: background-color 0.2s ease-in-out;
 +
background-color: transparent;
 +
border-radius: 5px;
 +
border: 0;
 +
box-shadow: inset 0 0 0 2px rgba(255, 255, 255, 0.125);
 +
color: #ffffff !important;
 +
cursor: pointer;
 +
display: inline-block;
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-size: 0.8em;
 +
font-weight: 700;
 +
height: 3.75em;
 +
letter-spacing: 0.1em;
 +
line-height: 3.75em;
 +
padding: 0 2.25em;
 +
text-align: center;
 +
text-decoration: none;
 +
text-transform: uppercase;
 +
white-space: nowrap;
 +
}
 +
 +
input[type="submit"]:hover,
 +
input[type="reset"]:hover,
 +
input[type="button"]:hover,
 +
button:hover,
 +
.button:hover {
 +
background-color: rgba(255, 255, 255, 0.025);
 +
}
 +
 +
input[type="submit"]:active,
 +
input[type="reset"]:active,
 +
input[type="button"]:active,
 +
button:active,
 +
.button:active {
 +
background-color: rgba(255, 255, 255, 0.075);
 +
}
 +
 +
input[type="submit"].icon:before,
 +
input[type="reset"].icon:before,
 +
input[type="button"].icon:before,
 +
button.icon:before,
 +
.button.icon:before {
 +
margin-right: 0.5em;
 +
color: rgba(255, 255, 255, 0.35);
 +
}
 +
 +
input[type="submit"].special,
 +
input[type="reset"].special,
 +
input[type="button"].special,
 +
button.special,
 +
.button.special {
 +
background-color: #dbe9d8;
 +
box-shadow: none;
 +
}
 +
 +
input[type="submit"].special:hover,
 +
input[type="reset"].special:hover,
 +
input[type="button"].special:hover,
 +
button.special:hover,
 +
.button.special:hover {
 +
background-color: #6a588e;
 +
}
 +
 +
input[type="submit"].special:active,
 +
input[type="reset"].special:active,
 +
input[type="button"].special:active,
 +
button.special:active,
 +
.button.special:active {
 +
background-color: #dbe9d8;
 +
}
 +
 +
input[type="submit"].special.icon:before,
 +
input[type="reset"].special.icon:before,
 +
input[type="button"].special.icon:before,
 +
button.special.icon:before,
 +
.button.special.icon:before {
 +
color: #7985b0;
 +
}
 +
 +
input[type="submit"].fit,
 +
input[type="reset"].fit,
 +
input[type="button"].fit,
 +
button.fit,
 +
.button.fit {
 +
display: block;
 +
margin: 0 0 1em 0;
 +
width: 100%;
 +
}
 +
 +
input[type="submit"].small,
 +
input[type="reset"].small,
 +
input[type="button"].small,
 +
button.small,
 +
.button.small {
 +
font-size: 0.6em;
 +
}
 +
 +
input[type="submit"].big,
 +
input[type="reset"].big,
 +
input[type="button"].big,
 +
button.big,
 +
.button.big {
 +
font-size: 1em;
 +
}
 +
 +
input[type="submit"].disabled, input[type="submit"]:disabled,
 +
input[type="reset"].disabled,
 +
input[type="reset"]:disabled,
 +
input[type="button"].disabled,
 +
input[type="button"]:disabled,
 +
button.disabled,
 +
button:disabled,
 +
.button.disabled,
 +
.button:disabled {
 +
opacity: 0.25;
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
input[type="submit"],
 +
input[type="reset"],
 +
input[type="button"],
 +
button,
 +
.button {
 +
padding: 0;
 +
}
 +
 +
}
 +
 +
/* Features */
 +
 +
.features {
 +
display: -moz-flex;
 +
display: -webkit-flex;
 +
display: -ms-flex;
 +
display: flex;
 +
-moz-flex-wrap: wrap;
 +
-webkit-flex-wrap: wrap;
 +
-ms-flex-wrap: wrap;
 +
flex-wrap: wrap;
 +
margin: 0 0 2em 0;
 +
}
 +
 +
.features article {
 +
padding: 1.75em 1.75em 0.1em 1.75em ;
 +
background-color: #f2efe8;
 +
border-radius: 5px;
 +
margin: 1.5em 3em 1.5em 0;
 +
width: calc(50% - 1.5em);
 +
}
 +
 +
.features article:nth-child(2n) {
 +
margin-right: 0;
 +
}
 +
 +
.features article .image {
 +
border-radius: 5px 5px 0 0;
 +
display: block;
 +
margin-bottom: 1.75em;
 +
margin-left: -1.75em;
 +
margin-top: -1.75em;
 +
position: relative;
 +
width: calc(100% + 3.5em);
 +
}
 +
 +
.features article .image img {
 +
border-radius: 5px 5px 0 0;
 +
width: 100%;
 +
}
 +
 +
@media screen and (max-width: 980px) {
 +
 +
.features article {
 +
margin: 1em 2em 1em 0;
 +
width: calc(50% - 1em);
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
.features article {
 +
padding: 1.5em 1.5em 0.1em 1.5em ;
 +
margin: 0.875em 1.75em 0.875em 0;
 +
width: calc(50% - 0.875em - 1px);
 +
}
 +
 +
.features article .image {
 +
margin-bottom: 1.5em;
 +
margin-left: -1.5em;
 +
margin-top: -1.5em;
 +
width: calc(100% + 3em);
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
.features {
 +
display: block;
 +
}
 +
 +
.features article {
 +
width: 100%;
 +
margin: 0 0 2em 0 !important;
 +
}
 +
 +
}
 +
 +
/* Header */
 +
 +
#header {
 +
-moz-transition: background-color 0.2s ease-in-out;
 +
-webkit-transition: background-color 0.2s ease-in-out;
 +
-ms-transition: background-color 0.2s ease-in-out;
 +
transition: background-color 0.2s ease-in-out;
 +
background-color: rgba(53, 56, 73, 0.95);
 +
height: 3.5em;
 +
left: 0;
 +
line-height: 3.5em;
 +
padding: 0 1.25em;
 +
position: fixed;
 +
top: 0;
 +
width: 100%;
 +
z-index: 10000;
 +
}
 +
 +
#header h1 {
 +
-moz-transition: opacity 0.2s ease-in-out, visibility 0.2s;
 +
-webkit-transition: opacity 0.2s ease-in-out, visibility 0.2s;
 +
-ms-transition: opacity 0.2s ease-in-out, visibility 0.2s;
 +
transition: opacity 0.2s ease-in-out, visibility 0.2s;
 +
border-bottom: 0;
 +
font-size: 0.8em;
 +
margin-bottom: 0;
 +
opacity: 1;
 +
visibility: visible;
 +
}
 +
 +
#header h1 a {
 +
border: 0;
 +
}
 +
 +
#header nav {
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-size: 0.8em;
 +
font-weight: 700;
 +
height: 3em;
 +
letter-spacing: 0.1em;
 +
line-height: 3em;
 +
position: absolute;
 +
right: 0.7em;
 +
text-transform: uppercase;
 +
top: 0.7em;
 +
}
 +
 +
#header nav a {
 +
border: 0;
 +
display: inline-block;
 +
padding: 0 1em;
 +
}
 +
 +
#header nav a:before {
 +
float: right;
 +
margin-left: 0.75em;
 +
}
 +
 +
#header nav a[href="#menu"] {
 +
text-decoration: none;
 +
-moz-transition: background-color 0.2s ease-in-out;
 +
-webkit-transition: background-color 0.2s ease-in-out;
 +
-ms-transition: background-color 0.2s ease-in-out;
 +
transition: background-color 0.2s ease-in-out;
 +
border-radius: 5px;
 +
box-shadow: inset 0 0 0 2px rgba(255, 255, 255, 0.125);
 +
padding: 0 1.35em;
 +
}
 +
 +
#header nav a[href="#menu"]:before {
 +
-moz-osx-font-smoothing: grayscale;
 +
-webkit-font-smoothing: antialiased;
 +
font-family: FontAwesome;
 +
font-style: normal;
 +
font-weight: normal;
 +
text-transform: none !important;
 +
}
 +
 +
#header nav a[href="#menu"]:before {
 +
content: '\f0c9';
 +
}
 +
 +
#header nav a[href="#menu"]:hover {
 +
background-color: rgba(255, 255, 255, 0.025);
 +
}
 +
 +
#header nav a[href="#menu"]:active {
 +
background-color: rgba(255, 255, 255, 0.075);
 +
}
 +
 +
#header.alt {
 +
background-color: transparent;
 +
}
 +
 +
#header.alt h1 {
 +
opacity: 0;
 +
visibility: hidden;
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
#header {
 +
height: 2.75em;
 +
line-height: 2.75em;
 +
}
 +
 +
#header nav {
 +
top: 0;
 +
right: 0;
 +
height: inherit;
 +
line-height: inherit;
 +
}
 +
 +
#header nav a {
 +
height: inherit;
 +
line-height: inherit;
 +
}
 +
 +
#header nav a[href="#menu"] {
 +
box-shadow: none;
 +
padding: 0 1em;
 +
border-radius: 0;
 +
}
 +
 +
#header nav a[href="#menu"]:hover, #header nav a[href="#menu"]:active {
 +
background-color: inherit;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
#header nav a[href="#menu"] {
 +
width: 4em;
 +
white-space: nowrap;
 +
text-indent: 4em;
 +
position: relative;
 +
}
 +
 +
#header nav a[href="#menu"]:before {
 +
width: inherit;
 +
position: absolute;
 +
top: 0;
 +
left: 0;
 +
text-indent: 0;
 +
text-align: left;
 +
margin-left: 0;
 +
padding-right: 1.25em;
 +
}
 +
 +
}
 +
 +
/* Menu */
 +
 +
#page-wrapper {
 +
-moz-transition: -moz-filter 0.25s ease;
 +
-webkit-transition: -webkit-filter 0.25s ease;
 +
-ms-transition: -ms-filter 0.25s ease;
 +
transition: filter 0.25s ease;
 +
}
 +
 +
#menu {
 +
-moz-align-items: center;
 +
-webkit-align-items: center;
 +
-ms-align-items: center;
 +
align-items: center;
 +
display: -moz-flex;
 +
display: -webkit-flex;
 +
display: -ms-flex;
 +
display: flex;
 +
-moz-justify-content: center;
 +
-webkit-justify-content: center;
 +
-ms-justify-content: center;
 +
justify-content: center;
 +
-moz-pointer-events: none;
 +
-webkit-pointer-events: none;
 +
-ms-pointer-events: none;
 +
pointer-events: none;
 +
-moz-transition: opacity 0.35s ease, visibility 0.35s;
 +
-webkit-transition: opacity 0.35s ease, visibility 0.35s;
 +
-ms-transition: opacity 0.35s ease, visibility 0.35s;
 +
transition: opacity 0.35s ease, visibility 0.35s;
 +
-moz-user-select: none;
 +
-webkit-user-select: none;
 +
-ms-user-select: none;
 +
user-select: none;
 +
-webkit-tap-highlight-color: transparent;
 +
background: rgba(46, 49, 65, 0.8);
 +
cursor: default;
 +
height: 100%;
 +
left: 0;
 +
opacity: 0;
 +
position: fixed;
 +
text-align: center;
 +
top: 0;
 +
visibility: hidden;
 +
width: 100%;
 +
}
 +
 +
#menu .inner {
 +
padding: 2.5em 1.5em 0.5em 1.5em ;
 +
-moz-transform: translateY(0.5em);
 +
-webkit-transform: translateY(0.5em);
 +
-ms-transform: translateY(0.5em);
 +
transform: translateY(0.5em);
 +
-moz-transition: opacity 0.35s ease, -moz-transform 0.35s ease;
 +
-webkit-transition: opacity 0.35s ease, -webkit-transform 0.35s ease;
 +
-ms-transition: opacity 0.35s ease, -ms-transform 0.35s ease;
 +
transition: opacity 0.35s ease, transform 0.35s ease;
 +
-webkit-overflow-scrolling: touch;
 +
background: #dbe9d8;
 +
border-radius: 5px;
 +
display: block;
 +
max-width: 100%;
 +
opacity: 0;
 +
position: relative;
 +
width: 18em;
 +
}
 +
 +
#menu h2 {
 +
border-bottom: solid 2px rgba(255, 255, 255, 0.125);
 +
padding-bottom: 1em;
 +
}
 +
 +
#menu .close {
 +
background-image: url("images/close.svg");
 +
background-position: 75% 25%;
 +
background-repeat: no-repeat;
 +
background-size: 2em 2em;
 +
border: 0;
 +
content: '';
 +
display: block;
 +
height: 4em;
 +
overflow: hidden;
 +
position: absolute;
 +
right: 0;
 +
text-align: center;
 +
text-indent: 4em;
 +
top: 0;
 +
width: 4em;
 +
}
 +
 +
#menu .links {
 +
list-style: none;
 +
margin-bottom: 1.5em;
 +
padding: 0;
 +
}
 +
 +
#menu .links li {
 +
padding: 0;
 +
}
 +
 +
#menu .links li a {
 +
border-radius: 5px;
 +
border: 0;
 +
display: block;
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-size: 0.8em;
 +
font-weight: 200;
 +
letter-spacing: 0.1em;
 +
line-height: 1.85em;
 +
padding: 0.75em 0;
 +
text-transform: uppercase;
 +
}
 +
 +
#menu .links li a:hover {
 +
background: #dbe9d8;
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
#menu .inner {
 +
max-height: 100%;
 +
overflow-y: auto;
 +
overflow-x: hidden;
 +
}
 +
 +
#menu .inner .close {
 +
background-size: 1.5em 1.5em;
 +
}
 +
 +
}
 +
 +
body.is-menu-visible #page-wrapper {
 +
-moz-filter: blur(1.5px);
 +
-webkit-filter: blur(1.5px);
 +
-ms-filter: blur(1.5px);
 +
filter: blur(1.5px);
 +
}
 +
 +
body.is-menu-visible #menu {
 +
-moz-pointer-events: auto;
 +
-webkit-pointer-events: auto;
 +
-ms-pointer-events: auto;
 +
pointer-events: auto;
 +
opacity: 1;
 +
visibility: visible;
 +
}
 +
 +
body.is-menu-visible #menu .inner {
 +
-moz-transform: translateY(0);
 +
-webkit-transform: translateY(0);
 +
-ms-transform: translateY(0);
 +
transform: translateY(0);
 +
opacity: 1;
 +
}
 +
 +
/* Banner */
 +
 +
#banner {
 +
padding: 10em 0 4.75em 0 ;
 +
}
 +
 +
#banner .inner {
 +
margin: 0 auto;
 +
width: 55em;
 +
}
 +
 +
#banner .logo {
 +
-moz-transition: opacity 2s ease, -moz-transform 1s ease;
 +
-webkit-transition: opacity 2s ease, -webkit-transform 1s ease;
 +
-ms-transition: opacity 2s ease, -ms-transform 1s ease;
 +
transition: opacity 2s ease, transform 1s ease;
 +
-moz-transform: translateY(0);
 +
-webkit-transform: translateY(0);
 +
-ms-transform: translateY(0);
 +
transform: translateY(0);
 +
opacity: 1;
 +
margin: 0 0 1.3em 0;
 +
}
 +
 +
#banner .logo .icon {
 +
border-radius: 100%;
 +
border: solid 2px rgba(255, 255, 255, 0.125);
 +
cursor: default;
 +
display: inline-block;
 +
font-size: 2em;
 +
height: 2.25em;
 +
line-height: 2.25em;
 +
text-align: center;
 +
width: 2.25em;
 +
}
 +
 +
#banner h2 {
 +
-moz-transition: opacity 0.5s ease, -moz-transform 0.5s ease, -moz-filter 0.25s ease;
 +
-webkit-transition: opacity 0.5s ease, -webkit-transform 0.5s ease, -webkit-filter 0.25s ease;
 +
-ms-transition: opacity 0.5s ease, -ms-transform 0.5s ease, -ms-filter 0.25s ease;
 +
transition: opacity 0.5s ease, transform 0.5s ease, filter 0.25s ease;
 +
-moz-transform: translateX(0);
 +
-webkit-transform: translateX(0);
 +
-ms-transform: translateX(0);
 +
transform: translateX(0);
 +
-moz-transition-delay: 0.65s;
 +
-webkit-transition-delay: 0.65s;
 +
-ms-transition-delay: 0.65s;
 +
transition-delay: 0.65s;
 +
-moz-filter: blur(0);
 +
-webkit-filter: blur(0);
 +
-ms-filter: blur(0);
 +
filter: blur(0);
 +
opacity: 1;
 +
border-bottom: solid 2px rgba(255, 255, 255, 0.125);
 +
font-size: 2.25em;
 +
margin-bottom: 0.8em;
 +
padding-bottom: 0.4em;
 +
}
 +
 +
#banner p {
 +
-moz-transition: opacity 0.5s ease, -moz-transform 0.5s ease, -moz-filter 0.25s ease;
 +
-webkit-transition: opacity 0.5s ease, -webkit-transform 0.5s ease, -webkit-filter 0.25s ease;
 +
-ms-transition: opacity 0.5s ease, -ms-transform 0.5s ease, -ms-filter 0.25s ease;
 +
transition: opacity 0.5s ease, transform 0.5s ease, filter 0.25s ease;
 +
-moz-transform: translateX(0);
 +
-webkit-transform: translateX(0);
 +
-ms-transform: translateX(0);
 +
transform: translateX(0);
 +
-moz-transition-delay: 0.8s;
 +
-webkit-transition-delay: 0.8s;
 +
-ms-transition-delay: 0.8s;
 +
transition-delay: 0.8s;
 +
-moz-filter: blur(0);
 +
-webkit-filter: blur(0);
 +
-ms-filter: blur(0);
 +
filter: blur(0);
 +
opacity: 1;
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-size: 1em;
 +
font-weight: 200;
 +
letter-spacing: 0.1em;
 +
line-height: 2;
 +
text-transform: uppercase;
 +
}
 +
 +
@media screen and (max-width: 1280px) {
 +
 +
#banner {
 +
padding: 7em 0 8.25em 0 ;
 +
background-color: #dbe9d8;
 +
background-image: linear-gradient(to top, rgba(46, 49, 65, 0.8), rgba(46, 49, 65, 0.8)), url("../../images/bg.jpg");
 +
background-size: auto, cover;
 +
background-position: center, center;
 +
margin-bottom: -6.5em;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 980px) {
 +
 +
#banner {
 +
padding: 12em 3em 12.375em 3em ;
 +
margin-bottom: -4.75em;
 +
}
 +
 +
#banner .inner {
 +
width: 100%;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
#banner {
 +
padding: 5em 2em 4.25em 2em ;
 +
margin-bottom: -2.5em;
 +
}
 +
 +
#banner .logo {
 +
margin: 0 0 1em 0;
 +
}
 +
 +
#banner .logo .icon {
 +
font-size: 1.5em;
 +
}
 +
 +
#banner h2 {
 +
font-size: 1.5em;
 +
}
 +
 +
#banner p {
 +
font-size: 0.8em;
 +
}
 +
 +
}
 +
 +
body.is-loading #banner .logo {
 +
-moz-transform: translateY(0.5em);
 +
-webkit-transform: translateY(0.5em);
 +
-ms-transform: translateY(0.5em);
 +
transform: translateY(0.5em);
 +
opacity: 0;
 +
}
 +
 +
body.is-loading #banner h2 {
 +
opacity: 0;
 +
-moz-transform: translateX(0.25em);
 +
-webkit-transform: translateX(0.25em);
 +
-ms-transform: translateX(0.25em);
 +
transform: translateX(0.25em);
 +
-moz-filter: blur(2px);
 +
-webkit-filter: blur(2px);
 +
-ms-filter: blur(2px);
 +
filter: blur(2px);
 +
}
 +
 +
body.is-loading #banner p {
 +
opacity: 0;
 +
-moz-transform: translateX(0.5em);
 +
-webkit-transform: translateX(0.5em);
 +
-ms-transform: translateX(0.5em);
 +
transform: translateX(0.5em);
 +
-moz-filter: blur(2px);
 +
-webkit-filter: blur(2px);
 +
-ms-filter: blur(2px);
 +
filter: blur(2px);
 +
}
 +
 +
/* Wrapper */
 +
 +
#wrapper > header {
 +
padding: 11em 0 2.25em 0 ;
 +
}
 +
 +
#wrapper > header .inner {
 +
margin: 0 auto;
 +
width: 55em;
 +
}
 +
 +
#wrapper > header h2 {
 +
border-bottom: solid 2px rgba(255, 255, 255, 0.125);
 +
font-size: 2em;
 +
margin-bottom: 0.8em;
 +
padding-bottom: 0.4em;
 +
}
 +
 +
#wrapper > header p {
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-size: 1em;
 +
font-weight: 200;
 +
letter-spacing: 0.1em;
 +
line-height: 2;
 +
text-transform: uppercase;
 +
}
 +
 +
@media screen and (max-width: 1280px) {
 +
 +
#wrapper > header {
 +
padding: 9em 0 6.25em 0 ;
 +
background-color: #dbe9d8;
 +
background-image: linear-gradient(to top, rgba(46, 49, 65, 0.8), rgba(46, 49, 65, 0.8)), url("../../images/bg.jpg");
 +
background-size: auto, cover;
 +
background-position: center, 0% 30%;
 +
margin-bottom: -6.5em;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 980px) {
 +
 +
#wrapper > header {
 +
padding: 11em 3em 7.375em 3em ;
 +
background-size: auto, cover;
 +
background-position: center, 0% 0%;
 +
margin-bottom: -4.75em;
 +
}
 +
 +
#wrapper > header .inner {
 +
width: 100%;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
#wrapper > header {
 +
padding: 6.5em 2em 3em 2em ;
 +
background-size: auto, 125%;
 +
margin-bottom: -2.5em;
 +
}
 +
 +
#wrapper > header h2 {
 +
font-size: 1.25em;
 +
}
 +
 +
#wrapper > header p {
 +
font-size: 0.8em;
 +
}
 +
 +
}
 +
 +
.wrapper {
 +
background-color: #dbe9d8;
 +
margin: 6.5em 0;
 +
position: relative;
 +
}
 +
 +
.wrapper:before, .wrapper:after {
 +
 +
}
 +
 +
.wrapper:before {
 +
box-shadow: inset 0 -1px 0 0 #dbe9d8, 0 1px 0 0 #dbe9d8;
 +
}
 +
 +
.wrapper:after {
 +
box-shadow: inset 0 -1px 0 0 #dbe9d8, 0 1px 0 0 #dbe9d8;
 +
}
 +
 +
.wrapper:before, .wrapper:after {
 +
background-repeat: no-repeat;
 +
background-size: 100% 100%;
 +
content: '';
 +
display: block;
 +
height: 6.5em;
 +
position: absolute;
 +
width: 100%;
 +
}
 +
 +
.wrapper:before {
 +
left: 0;
 +
top: -6.5em;
 +
}
 +
 +
.wrapper:after {
 +
-moz-transform: scaleY(-1);
 +
-webkit-transform: scaleY(-1);
 +
-ms-transform: scaleY(-1);
 +
transform: scaleY(-1);
 +
bottom: -6.5em;
 +
left: 0;
 +
}
 +
 +
.wrapper.alt:before {
 +
-moz-transform: scaleX(-1);
 +
-webkit-transform: scaleX(-1);
 +
-ms-transform: scaleX(-1);
 +
transform: scaleX(-1);
 +
}
 +
 +
.wrapper.alt:after {
 +
-moz-transform: scaleY(-1) scaleX(-1);
 +
-webkit-transform: scaleY(-1) scaleX(-1);
 +
-ms-transform: scaleY(-1) scaleX(-1);
 +
transform: scaleY(-1) scaleX(-1);
 +
}
 +
 +
.wrapper .inner {
 +
padding: 3em 0 1em 0 ;
 +
margin: 0 auto;
 +
width: 55em;
 +
}
 +
 +
.wrapper.style2 {
 +
background-color: #f2efe8;
 +
background-image: url("https://static.igem.org/mediawiki/2017/3/32/Descriptionthingasij.png")
 +
}
 +
 +
.wrapper.style2:before, .wrapper.style2:after {
 +
 +
}
 +
 +
.wrapper.style2:before {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.style2:after {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.style3 {
 +
background-color: #f2efe8;
 +
}
 +
 +
.wrapper.style3:before, .wrapper.style3:after {
 +
 +
}
 +
 +
.wrapper.style3:before {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.style3:after {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.style4 {
 +
background-color: #dbe9d8;
 +
}
 +
 +
.wrapper.style4:before, .wrapper.style4:after {
 +
 +
}
 +
 +
.wrapper.style4:before {
 +
box-shadow: inset 0 -1px 0 0 #dbe9d8, 0 1px 0 0 #dbe9d8;
 +
}
 +
 +
.wrapper.style4:after {
 +
box-shadow: inset 0 -1px 0 0 #dbe9d8, 0 1px 0 0 #dbe9d8;
 +
}
 +
 +
.wrapper.style5 {
 +
background-color: #dbe9d8;
 +
}
 +
 +
.wrapper.style5:before, .wrapper.style5:after {
 +
 +
}
 +
 +
.wrapper.style5:before {
 +
box-shadow: inset 0 -1px 0 0 #dbe9d8, 0 1px 0 0 #dbe9d8;
 +
}
 +
 +
.wrapper.style5:after {
 +
box-shadow: inset 0 -1px 0 0 #dbe9d8, 0 1px 0 0 #dbe9d8;
 +
}
 +
 +
.wrapper.style6 {
 +
background-color: #555867;
 +
}
 +
 +
.wrapper.style6:before, .wrapper.style6:after {
 +
 +
}
 +
 +
.wrapper.style6:before {
 +
box-shadow: inset 0 -1px 0 0 #555867, 0 1px 0 0 #555867;
 +
}
 +
 +
.wrapper.style6:after {
 +
box-shadow: inset 0 -1px 0 0 #555867, 0 1px 0 0 #555867;
 +
}
 +
 +
.wrapper.spotlight {
 +
background-color: #dbe9d8;
 +
}
 +
 +
.wrapper.spotlight:before, .wrapper.spotlight:after {
 +
 +
}
 +
 +
.wrapper.spotlight:before {
 +
box-shadow: inset 0 -1px 0 0 #dbe9d8, 0 1px 0 0 #dbe9d8;
 +
}
 +
 +
.wrapper.spotlight:after {
 +
box-shadow: inset 0 -1px 0 0 #dbe9d8, 0 1px 0 0 #dbe9d8;
 +
}
 +
 +
.wrapper.spotlight .inner {
 +
display: -moz-flex;
 +
display: -webkit-flex;
 +
display: -ms-flex;
 +
display: flex;
 +
-moz-align-items: center;
 +
-webkit-align-items: center;
 +
-ms-align-items: center;
 +
align-items: center;
 +
-moz-flex-direction: row;
 +
-webkit-flex-direction: row;
 +
-ms-flex-direction: row;
 +
flex-direction: row;
 +
}
 +
 +
.wrapper.spotlight .image {
 +
border-radius: 100%;
 +
margin: 0 3em 2em 0;
 +
width: 22em;
 +
overflow: hidden;
 +
-ms-flex: 1;
 +
}
 +
 +
.wrapper.spotlight .image img {
 +
border-radius: 100%;
 +
width: 100%;
 +
}
 +
 +
.wrapper.spotlight .content {
 +
width: 100%;
 +
-ms-flex: 2;
 +
}
 +
 +
.wrapper.spotlight:nth-child(2n - 1) .inner {
 +
-moz-flex-direction: row-reverse;
 +
-webkit-flex-direction: row-reverse;
 +
-ms-flex-direction: row-reverse;
 +
flex-direction: row-reverse;
 +
text-align: right;
 +
}
 +
 +
.wrapper.spotlight:nth-child(2n - 1) .image {
 +
margin: 0 0 2em 3em;
 +
}
 +
 +
.wrapper.spotlight.style2 {
 +
background-color: #dbe9d8;
 +
}
 +
 +
.wrapper.spotlight.style2:before, .wrapper.spotlight.style2:after {
 +
 +
}
 +
 +
.wrapper.spotlight.style2:before {
 +
box-shadow: inset 0 -1px 0 0 #dbe9d8, 0 1px 0 0 #dbe9d8;
 +
}
 +
 +
.wrapper.spotlight.style2:after {
 +
box-shadow: inset 0 -1px 0 0 #dbe9d8, 0 1px 0 0 #dbe9d8;
 +
}
 +
 +
.wrapper.spotlight.style3 {
 +
background-color: #f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style3:before, .wrapper.spotlight.style3:after {
 +
 +
}
 +
 +
.wrapper.spotlight.style3:before {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style3:after {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style4 {
 +
background-color: #f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style4:before, .wrapper.spotlight.style4:after {
 +
 +
}
 +
 +
.wrapper.spotlight.style4:before {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style4:after {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style5 {
 +
background-color: #f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style5:before, .wrapper.spotlight.style5:after {
 +
 +
}
 +
 +
.wrapper.spotlight.style5:before {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style5:after {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style6 {
 +
background-color: #2d3a69;
 +
}
 +
 +
.wrapper.spotlight.style6:before, .wrapper.spotlight.style6:after {
 +
 +
}
 +
 +
.wrapper.spotlight.style6:before {
 +
box-shadow: inset 0 -1px 0 0 #2d3a69, 0 1px 0 0 #2d3a69;
 +
}
 +
 +
.wrapper.spotlight.style6:after {
 +
box-shadow: inset 0 -1px 0 0 #2d3a69, 0 1px 0 0 #2d3a69;
 +
}
 +
 +
@media screen and (max-width: 980px) {
 +
 +
.wrapper {
 +
margin: 4.75em 0;
 +
}
 +
 +
.wrapper:before, .wrapper:after {
 +
height: 4.75em;
 +
}
 +
 +
.wrapper:before {
 +
top: -4.75em;
 +
}
 +
 +
.wrapper:after {
 +
bottom: -4.75em;
 +
left: 0;
 +
}
 +
 +
.wrapper .inner {
 +
padding: 3em 3em 1em 3em ;
 +
width: 100%;
 +
}
 +
 +
.wrapper.spotlight .image {
 +
margin: 0 2em 2em 0;
 +
width: 32em;
 +
}
 +
 +
.wrapper.spotlight:nth-child(2n - 1) .image {
 +
margin: 0 0 2em 2em;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
.wrapper {
 +
margin: 2.5em 0;
 +
}
 +
 +
.wrapper:before, .wrapper:after {
 +
height: 2.5em;
 +
}
 +
 +
.wrapper:before {
 +
top: -2.5em;
 +
}
 +
 +
.wrapper:after {
 +
bottom: -2.5em;
 +
left: 0;
 +
}
 +
 +
.wrapper .inner {
 +
padding: 2em 2em 0.1em 2em ;
 +
}
 +
 +
.wrapper.spotlight .inner {
 +
-moz-align-items: -moz-flex-start;
 +
-webkit-align-items: -webkit-flex-start;
 +
-ms-align-items: -ms-flex-start;
 +
align-items: flex-start;
 +
}
 +
 +
.wrapper.spotlight .image {
 +
width: 19em;
 +
margin: 0 1.75em 2em 0;
 +
}
 +
 +
.wrapper.spotlight:nth-child(2n - 1) .image {
 +
margin: 0 0 2em 1.75em;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
.wrapper.spotlight .inner {
 +
display: block;
 +
}
 +
 +
.wrapper.spotlight .image {
 +
margin: 0 0 1em 0 !important;
 +
max-width: 85%;
 +
width: 12em;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 360px) {
 +
 +
.wrapper .inner {
 +
padding: 2em 1.5em 0.1em 1.5em ;
 +
}
 +
 +
}
 +
 +
/* Footer */
 +
 +
#footer .inner {
 +
padding: 5em 0 3em 0 ;
 +
display: -moz-flex;
 +
display: -webkit-flex;
 +
display: -ms-flex;
 +
display: flex;
 +
-moz-flex-direction: row;
 +
-webkit-flex-direction: row;
 +
-ms-flex-direction: row;
 +
flex-direction: row;
 +
-moz-flex-wrap: wrap;
 +
-webkit-flex-wrap: wrap;
 +
-ms-flex-wrap: wrap;
 +
flex-wrap: wrap;
 +
margin: 0 auto;
 +
width: 55em;
 +
}
 +
 +
#footer .inner > * {
 +
width: 100%;
 +
}
 +
 +
#footer .inner form {
 +
margin: 0 3em 0 0;
 +
width: calc(50% - 1.5em);
 +
}
 +
 +
#footer .inner .contact {
 +
width: calc(50% - 1.5em);
 +
}
 +
 +
#footer .inner .copyright {
 +
border-top: solid 2px rgba(255, 255, 255, 0.125);
 +
list-style: none;
 +
margin: 4em 0 2em 0;
 +
padding: 2em 0 0 0;
 +
width: 100%;
 +
}
 +
 +
#footer .inner .copyright li {
 +
border-left: solid 2px rgba(255, 255, 255, 0.125);
 +
color: rgba(255, 255, 255, 0.35);
 +
display: inline-block;
 +
font-size: 0.9em;
 +
line-height: 1;
 +
margin-left: 1em;
 +
padding: 0;
 +
padding-left: 1em;
 +
}
 +
 +
#footer .inner .copyright li:first-child {
 +
border-left: 0;
 +
margin-left: 0;
 +
padding-left: 0;
 +
}
 +
 +
#footer .inner .copyright li a {
 +
color: inherit;
 +
}
 +
 +
@media screen and (max-width: 1280px) {
 +
 +
#footer {
 +
background-color: #dbe9d8;
 +
background-image: linear-gradient(to top, rgba(46, 49, 65, 0.8), rgba(46, 49, 65, 0.8)), url("../../images/bg.jpg");
 +
background-size: auto, cover;
 +
background-position: center, center;
 +
margin-top: -6.5em;
 +
padding-top: 6.5em;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 980px) {
 +
 +
#footer {
 +
margin-top: -4.75em;
 +
padding-top: 4.75em;
 +
}
 +
 +
#footer .inner {
 +
padding: 3em 3em 1em 3em ;
 +
display: block;
 +
width: 100%;
 +
}
 +
 +
#footer .inner form {
 +
width: 100%;
 +
margin: 0 0 4em 0;
 +
}
 +
 +
#footer .inner .contact {
 +
width: 100%;
 +
margin: 0 0 4em 0;
 +
}
 +
 +
#footer .inner .copyright {
 +
margin: 4em 0 2em 0;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
#footer {
 +
margin-top: -2.5em;
 +
padding-top: 2.5em;
 +
}
 +
 +
#footer .inner {
 +
padding: 2em 2em 0.1em 2em ;
 +
}
 +
 +
#footer .inner form {
 +
margin: 0 0 3em 0;
 +
}
 +
 +
#footer .inner .contact {
 +
margin: 0 0 3em 0;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
#footer .inner .copyright li {
 +
border-left: 0;
 +
display: block;
 +
margin: 1em 0 0 0;
 +
padding-left: 0;
 +
}
 +
 +
#footer .inner .copyright li:first-child {
 +
margin-top: 0;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 360px) {
 +
 +
#footer .inner {
 +
padding: 2em 1.5em 0.1em 1.5em ;
 +
}
 +
 +
}
 +
</style>
 +
<style>
 +
/*
 +
Solid State by HTML5 UP
 +
html5up.net | @ajlkn
 +
Free for personal and commercial use under the CCA 3.0 license (html5up.net/license)
 +
*/
 +
 +
/* Basic */
 +
 +
body {
 +
background-color: #dbe9d8;
 +
background-image: url("../../images/bg.jpg");
 +
background-size: cover;
 +
background-attachment: fixed;
 +
background-position: center;
 +
}
 +
 +
body:before {
 +
background: rgba(46, 49, 65, 0.8);
 +
content: '';
 +
display: block;
 +
height: 100%;
 +
left: 0;
 +
position: fixed;
 +
top: 0;
 +
width: 100%;
 +
}
 +
 +
body > * {
 +
position: relative;
 +
z-index: 1;
 +
}
 +
 +
/* Features */
 +
 +
.features article {
 +
display: inline-block;
 +
width: 45%;
 +
}
 +
 +
/* Menu */
 +
 +
#menu .inner {
 +
margin: 4em auto;
 +
}
 +
 +
/* Wrapper */
 +
 +
#wrapper > header {
 +
background: none !important;
 +
}
 +
 +
.wrapper.spotlight .inner {
 +
text-align: left !important;
 +
}
 +
 +
.wrapper.spotlight .image {
 +
display: inline-block;
 +
margin: 0 3em 2em 0 !important;
 +
vertical-align: middle;
 +
width: 24%;
 +
}
 +
 +
.wrapper.spotlight .content {
 +
display: inline-block;
 +
vertical-align: middle;
 +
width: 70%;
 +
}
 +
 +
/* Banner */
 +
 +
#banner {
 +
background: none !important;
 +
}
 +
 +
/* Footer */
 +
 +
#footer {
 +
background: none !important;
 +
}
 +
 +
#footer .inner form {
 +
display: inline-block;
 +
width: 45%;
 +
}
 +
 +
#footer .inner .contact {
 +
display: inline-block;
 +
width: 45%;
 +
}
 +
</style>
 +
<style>
 +
/*
 +
Solid State by HTML5 UP
 +
html5up.net | @ajlkn
 +
Free for personal and commercial use under the CCA 3.0 license (html5up.net/license)
 +
*/
 +
 +
/* Basic */
 +
 +
body {
 +
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Latest revision as of 15:53, 1 November 2017

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Description

Construct Model

Building off of a rapamycin induced split-luciferase system characterized by the 2015 Peking iGEM team, our construct consists of a promoter reporter system that looks at two downstream products, c-Myc and COX-2 (Peking iGEM Team 2015, 2015). These products are assembled into a construct composed of fusion proteins as well as split luciferase fragments (COX-2 - FRB - nLuc and c-Myc - FKBP - cLuc). In the presence of rapamycin, the interacting protein partners dimerize and subsequently cause luciferase to activate. In order to test this model, we created vectors of our constructs and inserted them into E. coli cells.

Figure 1

Our gene production construct is modeled to produce COX-2 and c-Myc, which we used to simulate conditions in human bodies when these proteins are overproduced, in the case of CRC. The construct consists of an Anderson promoter, a ribosomal binding site, a COX-2 gene/c-Myc gene, and a terminator.

Figure 2

Our promoter-reporter construct is built so that only when there is both COX-2 and c-Myc will the binding sites be able to come together and glow with the addition of rapamycin. The construct built to bind with COX-2 consists of a COX-2 promoter, FRB, n-Luc, and terminator. The construct built to bind with c-Myc consists of a c-Myc promoter, FKBP, c-Luc, and terminator.

Figure 3

Our promoter-reporter system consists of two separate constructs each with a gene-specific promoter attached to a non-specific binding site fused to a domain of split luciferase. One construct consists of a COX-2 promoter, a FRB domain, and n-Luc, and the other consists of a c-Myc promoter, a FKBP domain, and c-Luc. The split system is built so that only when the presence of both COX-2 and c-Myc is detected will the binding sites be able to come together with the addition of rapamycin and cause glowing.

Figure 4

In solution, our two gene constructs are able to simulate the conditions in the human body by producing proteins COX-2 and c-Myc. These proteins then interact with the promoter-reporter constructs by connecting to the non- specific binding sites, allowing the dimerization of the FKBP-Rapamycin-FRB complex. This then orients the split- luciferase so they can come together.

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