Difference between revisions of "Team:ASIJ TOKYO/Design"

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html5up.net | @ajlkn
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Free for personal and commercial use under the CCA 3.0 license (html5up.net/license)
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<h1>Design</h1>
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Design is the first step in the design-build-test cycle in engineering and synthetic biology. Use this page to describe the process that you used in the design of your parts. You should clearly explain the engineering principles used to design your project.
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This page is different to the "Applied Design Award" page. Please see the <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Applied_Design">Applied Design</a> page for more information on how to compete for that award.
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<h5>What should this page contain?</h5>
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<li>Explanation of the engineering principles your team used in your design</li>
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<li>Discussion of the design iterations your team went through</li>
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<li>Experimental plan to test your designs</li>
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<h5>Inspiration</h5>
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<ul>
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<li><a href="https://2016.igem.org/Team:MIT/Experiments/Promoters">2016 MIT</a></li>
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<li><a href="https://2016.igem.org/Team:BostonU/Proof">2016 BostonU</a></li>
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<li><a href="https://2016.igem.org/Team:NCTU_Formosa/Design">2016 NCTU Formosa</a></li>
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  <a href="https://2017.igem.org/Team:ASIJ_TOKYO">Home</a>
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  <div class="dropdown">
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  <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Team">Team</a>
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    <div class="dropdown-content">
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Team">Team</a>
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Collaborations">Collaborations</a>
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Attributions">Attributions</a>
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      <a href="#">Project</a>
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Description">Description</a>
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Design">Design</a>
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Experiments">Experiments</a>
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Notebook">Notebook</a>
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      <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Results">Results</a>
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    </div>
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  </div>
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  <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Parts">Parts</a>
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  <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Safety">Safety</a>
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  <a href="https://2017.igem.org/Team:ASIJ_TOKYO/Engagement">Human Practices</a>
 
</div>
 
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<head>
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<title>IGEM ASIJ TOKYO</title>
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<!-- Two -->
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<section id="three" class="wrapper spotlight style2">
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<div class="inner">
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<a href="#" class="image"><img src="https://static.igem.org/mediawiki/2017/7/71/Asijigem-designegg.jpg"></a>
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<div class="content">
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<h2 class="major">Design</h2>
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<p>In the course of our experimentation, perhaps the most crucial step was the design of our experiment, prior to its actual carrying out. Below, we detail the steps we took and the ideas we came up with in order to reach our final goal.</p>
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<h2 class="major">Our Process</h2>
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<p>We began our experiments with a competent cell check to find the optimal concentration of DNA for working with NEB 5-alpha Competent E. coli. Next, we found the ideal promoter strength for the growth of COX-2 and c-Myc by performing the Gibson Assembly with three different Anderson promoters of different strengths. In order to observe phenotypic proof of these results the competent cells were transformed and plated, as well as expanded into solution so both the number of colonies, as well as the optical density of the solutions were used to support the optimal promoter strength. </p>
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<p>We then moved on to find the most efficient promoter-to-binding domain combinations for both the c-Myc and COX-2 genes by testing a variety of them and seeing which produced the most glowing colonies in the presence of rapamycin. We also utilized this phase to make sure that the combinations glowed only when rapamycin was present. We concluded this test with the combinations of the COX-2 promoter with the FRB domain, and the c-Myc promoter with the FKBP domain being the most efficient combinations. The last step was to ensure that the construct glowed only when all parts were present, and to prove that the promoters had altered the shape of the nonspecific binding domains to become specific to the corresponding proteins. We did this by expanding incomplete combinations into tubes and observing whether they glowed or not. We found that none of the tubes glowed, no matter if they were missing a gene, or one of the promoter-reporter systems. The only tube that glowed was the one containing both COX-2 and c-Myc promoter-reporter systems, both respective genes, as well as rapamycin.
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.</p>
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<div class="content">
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<h2 class="major">Future Directions</h2>
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<p> With more time, we would like to implement our current model into a yeast system. This would prove advantageous as it will confirm the working of our model in an eukaryotic  organism. Using yeast, followed by flow cytometry, would allow us to collect quantitative data that could be better analyzed. Additionally, we would work on the upregulation of c-Myc production for the effectiveness of our experiment. This was a limiting factor in our experiment and continues to be a weak point in our design and planning. Most importantly, our team would like to develop a 3D prototype for a home-kit that would diagnose CRC. Our goal would be to develop a home-diagnosis kit similar in method and design to the home-pregnancy kit, where the product would be commercially approved and easily available. Our model would consist of two solutions that would be combined with the addition of a sample of fecal matter. This would address a major component of our project goal in developing a more convenient treatment and detection method for colorectal cancer. </p>
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clear: none;
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margin-left: 0;
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}
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width: 66.6666666667%;
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clear: none;
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margin-left: 0;
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width: 58.3333333333%;
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clear: none;
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margin-left: 0;
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}
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width: 50%;
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clear: none;
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margin-left: 0;
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}
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width: 41.6666666667%;
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clear: none;
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margin-left: 0;
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}
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width: 33.3333333333%;
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clear: none;
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margin-left: 0;
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}
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width: 25%;
 +
clear: none;
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margin-left: 0;
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}
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width: 16.6666666667%;
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clear: none;
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margin-left: 0;
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}
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.\31 u\28xlarge\29, .\31 u\24\28xlarge\29 {
 +
width: 8.3333333333%;
 +
clear: none;
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margin-left: 0;
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}
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.\31 2u\24\28xlarge\29 + *,
 +
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.\31 0u\24\28xlarge\29 + *,
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 +
.\38 u\24\28xlarge\29 + *,
 +
.\37 u\24\28xlarge\29 + *,
 +
.\36 u\24\28xlarge\29 + *,
 +
.\35 u\24\28xlarge\29 + *,
 +
.\34 u\24\28xlarge\29 + *,
 +
.\33 u\24\28xlarge\29 + *,
 +
.\32 u\24\28xlarge\29 + *,
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.\31 u\24\28xlarge\29 + * {
 +
clear: left;
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}
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.\-11u\28xlarge\29 {
 +
margin-left: 91.66667%;
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}
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.\-10u\28xlarge\29 {
 +
margin-left: 83.33333%;
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}
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.\-9u\28xlarge\29 {
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margin-left: 75%;
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}
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.\-8u\28xlarge\29 {
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margin-left: 66.66667%;
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}
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.\-7u\28xlarge\29 {
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margin-left: 58.33333%;
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}
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.\-6u\28xlarge\29 {
 +
margin-left: 50%;
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}
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.\-5u\28xlarge\29 {
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margin-left: 41.66667%;
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}
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margin-left: 33.33333%;
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.\-3u\28xlarge\29 {
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margin-left: 25%;
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}
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margin-left: 16.66667%;
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}
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.\-1u\28xlarge\29 {
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margin-left: 8.33333%;
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}
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}
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@media screen and (max-width: 1280px) {
 +
 +
.row > * {
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padding: 0 0 0 1.75em;
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}
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.row {
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margin: 0 0 -1px -1.75em;
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}
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.row.uniform > * {
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padding: 1.75em 0 0 1.75em;
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}
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.row.uniform {
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margin: -1.75em 0 -1px -1.75em;
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}
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.row.\32 00\25 > * {
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padding: 0 0 0 3.5em;
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}
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.row.\32 00\25 {
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margin: 0 0 -1px -3.5em;
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}
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.row.uniform.\32 00\25 > * {
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padding: 3.5em 0 0 3.5em;
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}
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.row.uniform.\32 00\25 {
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margin: -3.5em 0 -1px -3.5em;
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}
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padding: 0 0 0 2.625em;
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}
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margin: 0 0 -1px -2.625em;
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}
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.row.uniform.\31 50\25 > * {
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padding: 2.625em 0 0 2.625em;
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}
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.row.uniform.\31 50\25 {
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margin: -2.625em 0 -1px -2.625em;
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}
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padding: 0 0 0 0.875em;
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}
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margin: 0 0 -1px -0.875em;
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}
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padding: 0.875em 0 0 0.875em;
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}
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.row.uniform.\35 0\25 {
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margin: -0.875em 0 -1px -0.875em;
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}
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padding: 0 0 0 0.4375em;
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}
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.row.\32 5\25 {
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margin: 0 0 -1px -0.4375em;
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}
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.row.uniform.\32 5\25 > * {
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padding: 0.4375em 0 0 0.4375em;
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}
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.row.uniform.\32 5\25 {
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margin: -0.4375em 0 -1px -0.4375em;
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}
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 +
width: 100%;
 +
clear: none;
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margin-left: 0;
 +
}
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 +
width: 91.6666666667%;
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clear: none;
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margin-left: 0;
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}
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width: 83.3333333333%;
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clear: none;
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margin-left: 0;
 +
}
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width: 75%;
 +
clear: none;
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margin-left: 0;
 +
}
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.\38 u\28large\29, .\38 u\24\28large\29 {
 +
width: 66.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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.\37 u\28large\29, .\37 u\24\28large\29 {
 +
width: 58.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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.\36 u\28large\29, .\36 u\24\28large\29 {
 +
width: 50%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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 +
width: 41.6666666667%;
 +
clear: none;
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margin-left: 0;
 +
}
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 +
width: 33.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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.\33 u\28large\29, .\33 u\24\28large\29 {
 +
width: 25%;
 +
clear: none;
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margin-left: 0;
 +
}
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 +
width: 16.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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.\31 u\28large\29, .\31 u\24\28large\29 {
 +
width: 8.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 2u\24\28large\29 + *,
 +
.\31 1u\24\28large\29 + *,
 +
.\31 0u\24\28large\29 + *,
 +
.\39 u\24\28large\29 + *,
 +
.\38 u\24\28large\29 + *,
 +
.\37 u\24\28large\29 + *,
 +
.\36 u\24\28large\29 + *,
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.\35 u\24\28large\29 + *,
 +
.\34 u\24\28large\29 + *,
 +
.\33 u\24\28large\29 + *,
 +
.\32 u\24\28large\29 + *,
 +
.\31 u\24\28large\29 + * {
 +
clear: left;
 +
}
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 +
margin-left: 91.66667%;
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}
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.\-10u\28large\29 {
 +
margin-left: 83.33333%;
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}
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.\-9u\28large\29 {
 +
margin-left: 75%;
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}
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.\-8u\28large\29 {
 +
margin-left: 66.66667%;
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}
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.\-7u\28large\29 {
 +
margin-left: 58.33333%;
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}
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.\-6u\28large\29 {
 +
margin-left: 50%;
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}
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margin-left: 41.66667%;
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}
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.\-4u\28large\29 {
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margin-left: 33.33333%;
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}
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.\-3u\28large\29 {
 +
margin-left: 25%;
 +
}
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.\-2u\28large\29 {
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margin-left: 16.66667%;
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}
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.\-1u\28large\29 {
 +
margin-left: 8.33333%;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 980px) {
 +
 +
.row > * {
 +
padding: 0 0 0 1.75em;
 +
}
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.row {
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margin: 0 0 -1px -1.75em;
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}
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.row.uniform > * {
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padding: 1.75em 0 0 1.75em;
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}
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.row.uniform {
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margin: -1.75em 0 -1px -1.75em;
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}
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.row.\32 00\25 > * {
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padding: 0 0 0 3.5em;
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}
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.row.\32 00\25 {
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margin: 0 0 -1px -3.5em;
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}
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.row.uniform.\32 00\25 > * {
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padding: 3.5em 0 0 3.5em;
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}
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.row.uniform.\32 00\25 {
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margin: -3.5em 0 -1px -3.5em;
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}
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padding: 0 0 0 2.625em;
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}
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.row.\31 50\25 {
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margin: 0 0 -1px -2.625em;
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}
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padding: 2.625em 0 0 2.625em;
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}
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margin: -2.625em 0 -1px -2.625em;
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padding: 0 0 0 0.875em;
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}
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margin: 0 0 -1px -0.875em;
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}
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padding: 0.875em 0 0 0.875em;
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}
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margin: -0.875em 0 -1px -0.875em;
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padding: 0 0 0 0.4375em;
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}
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margin: 0 0 -1px -0.4375em;
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}
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.row.uniform.\32 5\25 > * {
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padding: 0.4375em 0 0 0.4375em;
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}
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.row.uniform.\32 5\25 {
 +
margin: -0.4375em 0 -1px -0.4375em;
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}
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 +
width: 100%;
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clear: none;
 +
margin-left: 0;
 +
}
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width: 91.6666666667%;
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clear: none;
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margin-left: 0;
 +
}
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width: 83.3333333333%;
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clear: none;
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margin-left: 0;
 +
}
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 +
width: 75%;
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clear: none;
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margin-left: 0;
 +
}
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 +
width: 66.6666666667%;
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clear: none;
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margin-left: 0;
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}
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width: 58.3333333333%;
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clear: none;
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margin-left: 0;
 +
}
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 +
width: 50%;
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clear: none;
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margin-left: 0;
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}
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 +
width: 41.6666666667%;
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clear: none;
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margin-left: 0;
 +
}
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 +
width: 33.3333333333%;
 +
clear: none;
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margin-left: 0;
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}
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 +
width: 25%;
 +
clear: none;
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margin-left: 0;
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}
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 +
width: 16.6666666667%;
 +
clear: none;
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margin-left: 0;
 +
}
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 +
width: 8.3333333333%;
 +
clear: none;
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margin-left: 0;
 +
}
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.\31 2u\24\28medium\29 + *,
 +
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 +
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 +
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.\31 u\24\28medium\29 + * {
 +
clear: left;
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 +
margin-left: 91.66667%;
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 +
margin-left: 83.33333%;
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margin-left: 75%;
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margin-left: 66.66667%;
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margin-left: 58.33333%;
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margin-left: 50%;
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margin-left: 41.66667%;
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margin-left: 33.33333%;
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 +
margin-left: 25%;
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 +
margin-left: 16.66667%;
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}
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 +
margin-left: 8.33333%;
 +
}
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}
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@media screen and (max-width: 736px) {
 +
 +
.row > * {
 +
padding: 0 0 0 1.25em;
 +
}
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.row {
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margin: 0 0 -1px -1.25em;
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}
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.row.uniform > * {
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padding: 1.25em 0 0 1.25em;
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}
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.row.uniform {
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margin: -1.25em 0 -1px -1.25em;
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}
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padding: 0 0 0 2.5em;
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}
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.row.\32 00\25 {
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margin: 0 0 -1px -2.5em;
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}
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.row.uniform.\32 00\25 > * {
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padding: 2.5em 0 0 2.5em;
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}
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margin: -2.5em 0 -1px -2.5em;
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padding: 0 0 0 1.875em;
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margin: 0 0 -1px -1.875em;
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}
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padding: 1.875em 0 0 1.875em;
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}
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margin: -1.875em 0 -1px -1.875em;
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padding: 0 0 0 0.625em;
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}
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margin: 0 0 -1px -0.625em;
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padding: 0.625em 0 0 0.625em;
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margin: -0.625em 0 -1px -0.625em;
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padding: 0 0 0 0.3125em;
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margin: 0 0 -1px -0.3125em;
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padding: 0.3125em 0 0 0.3125em;
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.row.uniform.\32 5\25 {
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margin: -0.3125em 0 -1px -0.3125em;
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}
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 +
width: 100%;
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clear: none;
 +
margin-left: 0;
 +
}
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 +
width: 91.6666666667%;
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clear: none;
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margin-left: 0;
 +
}
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 +
width: 83.3333333333%;
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clear: none;
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margin-left: 0;
 +
}
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 +
width: 75%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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 +
width: 66.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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 +
width: 58.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
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 +
width: 50%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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 +
width: 41.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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 +
width: 33.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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 +
width: 25%;
 +
clear: none;
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margin-left: 0;
 +
}
 +
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 +
width: 16.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
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 +
width: 8.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 2u\24\28small\29 + *,
 +
.\31 1u\24\28small\29 + *,
 +
.\31 0u\24\28small\29 + *,
 +
.\39 u\24\28small\29 + *,
 +
.\38 u\24\28small\29 + *,
 +
.\37 u\24\28small\29 + *,
 +
.\36 u\24\28small\29 + *,
 +
.\35 u\24\28small\29 + *,
 +
.\34 u\24\28small\29 + *,
 +
.\33 u\24\28small\29 + *,
 +
.\32 u\24\28small\29 + *,
 +
.\31 u\24\28small\29 + * {
 +
clear: left;
 +
}
 +
 +
.\-11u\28small\29 {
 +
margin-left: 91.66667%;
 +
}
 +
 +
.\-10u\28small\29 {
 +
margin-left: 83.33333%;
 +
}
 +
 +
.\-9u\28small\29 {
 +
margin-left: 75%;
 +
}
 +
 +
.\-8u\28small\29 {
 +
margin-left: 66.66667%;
 +
}
 +
 +
.\-7u\28small\29 {
 +
margin-left: 58.33333%;
 +
}
 +
 +
.\-6u\28small\29 {
 +
margin-left: 50%;
 +
}
 +
 +
.\-5u\28small\29 {
 +
margin-left: 41.66667%;
 +
}
 +
 +
.\-4u\28small\29 {
 +
margin-left: 33.33333%;
 +
}
 +
 +
.\-3u\28small\29 {
 +
margin-left: 25%;
 +
}
 +
 +
.\-2u\28small\29 {
 +
margin-left: 16.66667%;
 +
}
 +
 +
.\-1u\28small\29 {
 +
margin-left: 8.33333%;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
.row > * {
 +
padding: 0 0 0 1.25em;
 +
}
 +
 +
.row {
 +
margin: 0 0 -1px -1.25em;
 +
}
 +
 +
.row.uniform > * {
 +
padding: 1.25em 0 0 1.25em;
 +
}
 +
 +
.row.uniform {
 +
margin: -1.25em 0 -1px -1.25em;
 +
}
 +
 +
.row.\32 00\25 > * {
 +
padding: 0 0 0 2.5em;
 +
}
 +
 +
.row.\32 00\25 {
 +
margin: 0 0 -1px -2.5em;
 +
}
 +
 +
.row.uniform.\32 00\25 > * {
 +
padding: 2.5em 0 0 2.5em;
 +
}
 +
 +
.row.uniform.\32 00\25 {
 +
margin: -2.5em 0 -1px -2.5em;
 +
}
 +
 +
.row.\31 50\25 > * {
 +
padding: 0 0 0 1.875em;
 +
}
 +
 +
.row.\31 50\25 {
 +
margin: 0 0 -1px -1.875em;
 +
}
 +
 +
.row.uniform.\31 50\25 > * {
 +
padding: 1.875em 0 0 1.875em;
 +
}
 +
 +
.row.uniform.\31 50\25 {
 +
margin: -1.875em 0 -1px -1.875em;
 +
}
 +
 +
.row.\35 0\25 > * {
 +
padding: 0 0 0 0.625em;
 +
}
 +
 +
.row.\35 0\25 {
 +
margin: 0 0 -1px -0.625em;
 +
}
 +
 +
.row.uniform.\35 0\25 > * {
 +
padding: 0.625em 0 0 0.625em;
 +
}
 +
 +
.row.uniform.\35 0\25 {
 +
margin: -0.625em 0 -1px -0.625em;
 +
}
 +
 +
.row.\32 5\25 > * {
 +
padding: 0 0 0 0.3125em;
 +
}
 +
 +
.row.\32 5\25 {
 +
margin: 0 0 -1px -0.3125em;
 +
}
 +
 +
.row.uniform.\32 5\25 > * {
 +
padding: 0.3125em 0 0 0.3125em;
 +
}
 +
 +
.row.uniform.\32 5\25 {
 +
margin: -0.3125em 0 -1px -0.3125em;
 +
}
 +
 +
.\31 2u\28xsmall\29, .\31 2u\24\28xsmall\29 {
 +
width: 100%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 1u\28xsmall\29, .\31 1u\24\28xsmall\29 {
 +
width: 91.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 0u\28xsmall\29, .\31 0u\24\28xsmall\29 {
 +
width: 83.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\39 u\28xsmall\29, .\39 u\24\28xsmall\29 {
 +
width: 75%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\38 u\28xsmall\29, .\38 u\24\28xsmall\29 {
 +
width: 66.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\37 u\28xsmall\29, .\37 u\24\28xsmall\29 {
 +
width: 58.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\36 u\28xsmall\29, .\36 u\24\28xsmall\29 {
 +
width: 50%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\35 u\28xsmall\29, .\35 u\24\28xsmall\29 {
 +
width: 41.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\34 u\28xsmall\29, .\34 u\24\28xsmall\29 {
 +
width: 33.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\33 u\28xsmall\29, .\33 u\24\28xsmall\29 {
 +
width: 25%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\32 u\28xsmall\29, .\32 u\24\28xsmall\29 {
 +
width: 16.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 u\28xsmall\29, .\31 u\24\28xsmall\29 {
 +
width: 8.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 2u\24\28xsmall\29 + *,
 +
.\31 1u\24\28xsmall\29 + *,
 +
.\31 0u\24\28xsmall\29 + *,
 +
.\39 u\24\28xsmall\29 + *,
 +
.\38 u\24\28xsmall\29 + *,
 +
.\37 u\24\28xsmall\29 + *,
 +
.\36 u\24\28xsmall\29 + *,
 +
.\35 u\24\28xsmall\29 + *,
 +
.\34 u\24\28xsmall\29 + *,
 +
.\33 u\24\28xsmall\29 + *,
 +
.\32 u\24\28xsmall\29 + *,
 +
.\31 u\24\28xsmall\29 + * {
 +
clear: left;
 +
}
 +
 +
.\-11u\28xsmall\29 {
 +
margin-left: 91.66667%;
 +
}
 +
 +
.\-10u\28xsmall\29 {
 +
margin-left: 83.33333%;
 +
}
 +
 +
.\-9u\28xsmall\29 {
 +
margin-left: 75%;
 +
}
 +
 +
.\-8u\28xsmall\29 {
 +
margin-left: 66.66667%;
 +
}
 +
 +
.\-7u\28xsmall\29 {
 +
margin-left: 58.33333%;
 +
}
 +
 +
.\-6u\28xsmall\29 {
 +
margin-left: 50%;
 +
}
 +
 +
.\-5u\28xsmall\29 {
 +
margin-left: 41.66667%;
 +
}
 +
 +
.\-4u\28xsmall\29 {
 +
margin-left: 33.33333%;
 +
}
 +
 +
.\-3u\28xsmall\29 {
 +
margin-left: 25%;
 +
}
 +
 +
.\-2u\28xsmall\29 {
 +
margin-left: 16.66667%;
 +
}
 +
 +
.\-1u\28xsmall\29 {
 +
margin-left: 8.33333%;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 360px) {
 +
 +
.row > * {
 +
padding: 0 0 0 1.25em;
 +
}
 +
 +
.row {
 +
margin: 0 0 -1px -1.25em;
 +
}
 +
 +
.row.uniform > * {
 +
padding: 1.25em 0 0 1.25em;
 +
}
 +
 +
.row.uniform {
 +
margin: -1.25em 0 -1px -1.25em;
 +
}
 +
 +
.row.\32 00\25 > * {
 +
padding: 0 0 0 2.5em;
 +
}
 +
 +
.row.\32 00\25 {
 +
margin: 0 0 -1px -2.5em;
 +
}
 +
 +
.row.uniform.\32 00\25 > * {
 +
padding: 2.5em 0 0 2.5em;
 +
}
 +
 +
.row.uniform.\32 00\25 {
 +
margin: -2.5em 0 -1px -2.5em;
 +
}
 +
 +
.row.\31 50\25 > * {
 +
padding: 0 0 0 1.875em;
 +
}
 +
 +
.row.\31 50\25 {
 +
margin: 0 0 -1px -1.875em;
 +
}
 +
 +
.row.uniform.\31 50\25 > * {
 +
padding: 1.875em 0 0 1.875em;
 +
}
 +
 +
.row.uniform.\31 50\25 {
 +
margin: -1.875em 0 -1px -1.875em;
 +
}
 +
 +
.row.\35 0\25 > * {
 +
padding: 0 0 0 0.625em;
 +
}
 +
 +
.row.\35 0\25 {
 +
margin: 0 0 -1px -0.625em;
 +
}
 +
 +
.row.uniform.\35 0\25 > * {
 +
padding: 0.625em 0 0 0.625em;
 +
}
 +
 +
.row.uniform.\35 0\25 {
 +
margin: -0.625em 0 -1px -0.625em;
 +
}
 +
 +
.row.\32 5\25 > * {
 +
padding: 0 0 0 0.3125em;
 +
}
 +
 +
.row.\32 5\25 {
 +
margin: 0 0 -1px -0.3125em;
 +
}
 +
 +
.row.uniform.\32 5\25 > * {
 +
padding: 0.3125em 0 0 0.3125em;
 +
}
 +
 +
.row.uniform.\32 5\25 {
 +
margin: -0.3125em 0 -1px -0.3125em;
 +
}
 +
 +
.\31 2u\28xxsmall\29, .\31 2u\24\28xxsmall\29 {
 +
width: 100%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 1u\28xxsmall\29, .\31 1u\24\28xxsmall\29 {
 +
width: 91.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 0u\28xxsmall\29, .\31 0u\24\28xxsmall\29 {
 +
width: 83.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\39 u\28xxsmall\29, .\39 u\24\28xxsmall\29 {
 +
width: 75%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\38 u\28xxsmall\29, .\38 u\24\28xxsmall\29 {
 +
width: 66.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\37 u\28xxsmall\29, .\37 u\24\28xxsmall\29 {
 +
width: 58.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\36 u\28xxsmall\29, .\36 u\24\28xxsmall\29 {
 +
width: 50%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\35 u\28xxsmall\29, .\35 u\24\28xxsmall\29 {
 +
width: 41.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\34 u\28xxsmall\29, .\34 u\24\28xxsmall\29 {
 +
width: 33.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\33 u\28xxsmall\29, .\33 u\24\28xxsmall\29 {
 +
width: 25%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\32 u\28xxsmall\29, .\32 u\24\28xxsmall\29 {
 +
width: 16.6666666667%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 u\28xxsmall\29, .\31 u\24\28xxsmall\29 {
 +
width: 8.3333333333%;
 +
clear: none;
 +
margin-left: 0;
 +
}
 +
 +
.\31 2u\24\28xxsmall\29 + *,
 +
.\31 1u\24\28xxsmall\29 + *,
 +
.\31 0u\24\28xxsmall\29 + *,
 +
.\39 u\24\28xxsmall\29 + *,
 +
.\38 u\24\28xxsmall\29 + *,
 +
.\37 u\24\28xxsmall\29 + *,
 +
.\36 u\24\28xxsmall\29 + *,
 +
.\35 u\24\28xxsmall\29 + *,
 +
.\34 u\24\28xxsmall\29 + *,
 +
.\33 u\24\28xxsmall\29 + *,
 +
.\32 u\24\28xxsmall\29 + *,
 +
.\31 u\24\28xxsmall\29 + * {
 +
clear: left;
 +
}
 +
 +
.\-11u\28xxsmall\29 {
 +
margin-left: 91.66667%;
 +
}
 +
 +
.\-10u\28xxsmall\29 {
 +
margin-left: 83.33333%;
 +
}
 +
 +
.\-9u\28xxsmall\29 {
 +
margin-left: 75%;
 +
}
 +
 +
.\-8u\28xxsmall\29 {
 +
margin-left: 66.66667%;
 +
}
 +
 +
.\-7u\28xxsmall\29 {
 +
margin-left: 58.33333%;
 +
}
 +
 +
.\-6u\28xxsmall\29 {
 +
margin-left: 50%;
 +
}
 +
 +
.\-5u\28xxsmall\29 {
 +
margin-left: 41.66667%;
 +
}
 +
 +
.\-4u\28xxsmall\29 {
 +
margin-left: 33.33333%;
 +
}
 +
 +
.\-3u\28xxsmall\29 {
 +
margin-left: 25%;
 +
}
 +
 +
.\-2u\28xxsmall\29 {
 +
margin-left: 16.66667%;
 +
}
 +
 +
.\-1u\28xxsmall\29 {
 +
margin-left: 8.33333%;
 +
}
 +
 +
}
 +
 +
/* Basic */
 +
 +
@-ms-viewport {
 +
width: device-width;
 +
}
 +
 +
body {
 +
-ms-overflow-style: scrollbar;
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
html, body {
 +
min-width: 320px;
 +
}
 +
 +
}
 +
 +
body {
 +
background-color: #5d48a0;
 +
background-image: linear-gradient(to top, rgba(46, 49, 65, 0.8), rgba(46, 49, 65, 0.8)), url("../../images/bg.jpg");
 +
background-size: auto, cover;
 +
background-attachment: fixed, fixed;
 +
background-position: center, center;
 +
}
 +
 +
body.is-loading *, body.is-loading *:before, body.is-loading *:after {
 +
-moz-animation: none !important;
 +
-webkit-animation: none !important;
 +
-ms-animation: none !important;
 +
animation: none !important;
 +
-moz-transition: none !important;
 +
-webkit-transition: none !important;
 +
-ms-transition: none !important;
 +
transition: none !important;
 +
}
 +
 +
/* Type */
 +
 +
body, input, select, textarea {
 +
color: #ffffff;
 +
font-family: "Source Sans Pro", Helvetica, sans-serif;
 +
font-size: 16.5pt;
 +
font-weight: 300;
 +
line-height: 1.65;
 +
}
 +
 +
@media screen and (max-width: 1680px) {
 +
 +
body, input, select, textarea {
 +
font-size: 13pt;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 1280px) {
 +
 +
body, input, select, textarea {
 +
font-size: 12pt;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 980px) {
 +
 +
body, input, select, textarea {
 +
font-size: 12pt;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
body, input, select, textarea {
 +
font-size: 12pt;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
body, input, select, textarea {
 +
font-size: 12pt;
 +
}
 +
 +
}
 +
 +
a {
 +
-moz-transition: color 0.2s ease-in-out, border-bottom-color 0.2s ease-in-out;
 +
-webkit-transition: color 0.2s ease-in-out, border-bottom-color 0.2s ease-in-out;
 +
-ms-transition: color 0.2s ease-in-out, border-bottom-color 0.2s ease-in-out;
 +
transition: color 0.2s ease-in-out, border-bottom-color 0.2s ease-in-out;
 +
border-bottom: dotted 1px rgba(255, 255, 255, 0.35);
 +
color: #ffffff;
 +
text-decoration: none;
 +
}
 +
 +
a:hover {
 +
border-bottom-color: transparent;
 +
color: #ffffff !important;
 +
}
 +
 +
a.special:not(.button) {
 +
text-decoration: none;
 +
border-bottom: 0;
 +
display: block;
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-size: 0.8em;
 +
font-weight: 700;
 +
letter-spacing: 0.1em;
 +
margin: 0 0 2em 0;
 +
text-transform: uppercase;
 +
}
 +
 +
a.special:not(.button):before {
 +
-moz-osx-font-smoothing: grayscale;
 +
-webkit-font-smoothing: antialiased;
 +
font-family: FontAwesome;
 +
font-style: normal;
 +
font-weight: normal;
 +
text-transform: none !important;
 +
}
 +
 +
a.special:not(.button):before {
 +
-moz-transition: background-color 0.2s ease-in-out;
 +
-webkit-transition: background-color 0.2s ease-in-out;
 +
-ms-transition: background-color 0.2s ease-in-out;
 +
transition: background-color 0.2s ease-in-out;
 +
border-radius: 100%;
 +
border: solid 2px rgba(255, 255, 255, 0.125);
 +
content: '\f105';
 +
display: inline-block;
 +
font-size: 1.25em;
 +
height: 2em;
 +
line-height: 1.65em;
 +
margin-right: 0.85em;
 +
text-align: center;
 +
text-indent: 0.15em;
 +
vertical-align: middle;
 +
width: 2em;
 +
}
 +
 +
a.special:not(.button):hover:before {
 +
background-color: rgba(255, 255, 255, 0.025);
 +
}
 +
 +
a.special:not(.button):active:before {
 +
background-color: rgba(255, 255, 255, 0.075);
 +
}
 +
 +
strong, b {
 +
color: #ffffff;
 +
font-weight: 600;
 +
}
 +
 +
em, i {
 +
font-style: italic;
 +
}
 +
 +
p {
 +
margin: 0 0 2em 0;
 +
}
 +
 +
h1, h2, h3, h4, h5, h6 {
 +
color: #ffffff;
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-weight: 700;
 +
letter-spacing: 0.1em;
 +
margin: 0 0 1em 0;
 +
text-transform: uppercase;
 +
}
 +
 +
h1 a, h2 a, h3 a, h4 a, h5 a, h6 a {
 +
color: inherit;
 +
text-decoration: none;
 +
}
 +
 +
h1 span, h2 span, h3 span, h4 span, h5 span, h6 span {
 +
font-weight: 200;
 +
}
 +
 +
h1.major, h2.major, h3.major, h4.major, h5.major, h6.major {
 +
padding-bottom: 1em;
 +
border-bottom: solid 2px rgba(255, 255, 255, 0.125);
 +
}
 +
 +
h2 {
 +
font-size: 1.2em;
 +
}
 +
 +
h3 {
 +
font-size: 0.9em;
 +
}
 +
 +
h4 {
 +
font-size: 0.7em;
 +
}
 +
 +
h5 {
 +
font-size: 0.7em;
 +
}
 +
 +
h6 {
 +
font-size: 0.7em;
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
h2 {
 +
font-size: 1em;
 +
}
 +
 +
h3 {
 +
font-size: 0.8em;
 +
}
 +
 +
}
 +
 +
sub {
 +
font-size: 0.8em;
 +
position: relative;
 +
top: 0.5em;
 +
}
 +
 +
sup {
 +
font-size: 0.8em;
 +
position: relative;
 +
top: -0.5em;
 +
}
 +
 +
blockquote {
 +
border-left: solid 4px rgba(255, 255, 255, 0.125);
 +
font-style: italic;
 +
margin: 0 0 2em 0;
 +
padding: 0.5em 0 0.5em 2em;
 +
}
 +
 +
code {
 +
background: rgba(255, 255, 255, 0.025);
 +
border-radius: 5px;
 +
border: solid 2px rgba(255, 255, 255, 0.125);
 +
font-family: "Courier New", monospace;
 +
font-size: 0.9em;
 +
margin: 0 0.25em;
 +
padding: 0.25em 0.65em;
 +
}
 +
 +
pre {
 +
-webkit-overflow-scrolling: touch;
 +
font-family: "Courier New", monospace;
 +
font-size: 0.9em;
 +
margin: 0 0 2em 0;
 +
}
 +
 +
pre code {
 +
display: block;
 +
line-height: 1.75em;
 +
padding: 1em 1.5em;
 +
overflow-x: auto;
 +
}
 +
 +
hr {
 +
border: 0;
 +
border-bottom: solid 2px rgba(255, 255, 255, 0.125);
 +
margin: 2.5em 0;
 +
}
 +
 +
hr.major {
 +
margin: 4em 0;
 +
}
 +
 +
.align-left {
 +
text-align: left;
 +
}
 +
 +
.align-center {
 +
text-align: center;
 +
}
 +
 +
.align-right {
 +
text-align: right;
 +
}
 +
 +
/* Section/Article */
 +
 +
section.special, article.special {
 +
text-align: center;
 +
}
 +
 +
/* Form */
 +
 +
form {
 +
margin: 0 0 2em 0;
 +
}
 +
 +
form .field {
 +
margin: 0 0 2em 0;
 +
}
 +
 +
form .field label {
 +
margin-top: -1.5em;
 +
}
 +
 +
form .field:first-child label {
 +
margin-top: 0;
 +
}
 +
 +
form > :last-child {
 +
margin-bottom: 0;
 +
}
 +
 +
label {
 +
color: #ffffff;
 +
display: block;
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-size: 0.8em;
 +
font-weight: 700;
 +
letter-spacing: 0.1em;
 +
margin: 0 0 0.7em 0;
 +
text-transform: uppercase;
 +
}
 +
 +
input[type="text"],
 +
input[type="password"],
 +
input[type="email"],
 +
input[type="tel"],
 +
select,
 +
textarea {
 +
-moz-appearance: none;
 +
-webkit-appearance: none;
 +
-ms-appearance: none;
 +
appearance: none;
 +
background: rgba(255, 255, 255, 0.025);
 +
border-radius: 5px;
 +
border: none;
 +
border: solid 2px rgba(255, 255, 255, 0.125);
 +
color: inherit;
 +
display: block;
 +
outline: 0;
 +
padding: 0 1em;
 +
text-decoration: none;
 +
width: 100%;
 +
}
 +
 +
input[type="text"]:invalid,
 +
input[type="password"]:invalid,
 +
input[type="email"]:invalid,
 +
input[type="tel"]:invalid,
 +
select:invalid,
 +
textarea:invalid {
 +
box-shadow: none;
 +
}
 +
 +
input[type="text"]:focus,
 +
input[type="password"]:focus,
 +
input[type="email"]:focus,
 +
input[type="tel"]:focus,
 +
select:focus,
 +
textarea:focus {
 +
border-color: #5b6ba6;
 +
}
 +
 +
.select-wrapper {
 +
text-decoration: none;
 +
display: block;
 +
position: relative;
 +
}
 +
 +
.select-wrapper:before {
 +
-moz-osx-font-smoothing: grayscale;
 +
-webkit-font-smoothing: antialiased;
 +
font-family: FontAwesome;
 +
font-style: normal;
 +
font-weight: normal;
 +
text-transform: none !important;
 +
}
 +
 +
.select-wrapper:before {
 +
color: rgba(255, 255, 255, 0.125);
 +
content: '\f078';
 +
display: block;
 +
height: 2.75em;
 +
line-height: 2.75em;
 +
pointer-events: none;
 +
position: absolute;
 +
right: 0;
 +
text-align: center;
 +
top: 0;
 +
width: 2.75em;
 +
}
 +
 +
.select-wrapper select::-ms-expand {
 +
display: none;
 +
}
 +
 +
select option {
 +
color: #ffffff;
 +
background: #5d48a0;
 +
}
 +
 +
input[type="text"],
 +
input[type="password"],
 +
input[type="email"],
 +
select {
 +
height: 2.75em;
 +
}
 +
 +
textarea {
 +
padding: 0.75em 1em;
 +
}
 +
 +
input[type="checkbox"],
 +
input[type="radio"] {
 +
-moz-appearance: none;
 +
-webkit-appearance: none;
 +
-ms-appearance: none;
 +
appearance: none;
 +
display: block;
 +
float: left;
 +
margin-right: -2em;
 +
opacity: 0;
 +
width: 1em;
 +
z-index: -1;
 +
}
 +
 +
input[type="checkbox"] + label,
 +
input[type="radio"] + label {
 +
text-decoration: none;
 +
color: #ffffff;
 +
cursor: pointer;
 +
display: inline-block;
 +
font-size: 1em;
 +
font-family: "Source Sans Pro", Helvetica, sans-serif;
 +
text-transform: none;
 +
letter-spacing: 0;
 +
font-weight: 300;
 +
padding-left: 2.4em;
 +
padding-right: 0.75em;
 +
position: relative;
 +
}
 +
 +
input[type="checkbox"] + label:before,
 +
input[type="radio"] + label:before {
 +
-moz-osx-font-smoothing: grayscale;
 +
-webkit-font-smoothing: antialiased;
 +
font-family: FontAwesome;
 +
font-style: normal;
 +
font-weight: normal;
 +
text-transform: none !important;
 +
}
 +
 +
input[type="checkbox"] + label:before,
 +
input[type="radio"] + label:before {
 +
background: rgba(255, 255, 255, 0.025);
 +
border-radius: 5px;
 +
border: solid 2px rgba(255, 255, 255, 0.125);
 +
content: '';
 +
display: inline-block;
 +
height: 1.65em;
 +
left: 0;
 +
line-height: 1.58125em;
 +
position: absolute;
 +
text-align: center;
 +
top: 0;
 +
width: 1.65em;
 +
}
 +
 +
input[type="checkbox"]:checked + label:before,
 +
input[type="radio"]:checked + label:before {
 +
background: #ffffff;
 +
border-color: #ffffff;
 +
content: '\f00c';
 +
color: #5d48a0;
 +
}
 +
 +
input[type="checkbox"]:focus + label:before,
 +
input[type="radio"]:focus + label:before {
 +
border-color: #f2efe8;
 +
}
 +
 +
input[type="checkbox"] + label:before {
 +
border-radius: 5px;
 +
}
 +
 +
input[type="radio"] + label:before {
 +
border-radius: 100%;
 +
}
 +
 +
::-webkit-input-placeholder {
 +
color: rgba(255, 255, 255, 0.35) !important;
 +
opacity: 1.0;
 +
}
 +
 +
:-moz-placeholder {
 +
color: rgba(255, 255, 255, 0.35) !important;
 +
opacity: 1.0;
 +
}
 +
 +
::-moz-placeholder {
 +
color: rgba(255, 255, 255, 0.35) !important;
 +
opacity: 1.0;
 +
}
 +
 +
:-ms-input-placeholder {
 +
color: rgba(255, 255, 255, 0.35) !important;
 +
opacity: 1.0;
 +
}
 +
 +
.polyfill-placeholder {
 +
color: rgba(255, 255, 255, 0.35) !important;
 +
opacity: 1.0;
 +
}
 +
 +
/* Box */
 +
 +
.box {
 +
border-radius: 5px;
 +
border: solid 2px rgba(255, 255, 255, 0.125);
 +
margin-bottom: 2em;
 +
padding: 1.5em;
 +
}
 +
 +
.box > :last-child,
 +
.box > :last-child > :last-child,
 +
.box > :last-child > :last-child > :last-child {
 +
margin-bottom: 0;
 +
}
 +
 +
.box.alt {
 +
border: 0;
 +
border-radius: 0;
 +
padding: 0;
 +
}
 +
 +
/* Icon */
 +
 +
.icon {
 +
text-decoration: none;
 +
border-bottom: none;
 +
position: relative;
 +
}
 +
 +
.icon:before {
 +
-moz-osx-font-smoothing: grayscale;
 +
-webkit-font-smoothing: antialiased;
 +
font-family: FontAwesome;
 +
font-style: normal;
 +
font-weight: normal;
 +
text-transform: none !important;
 +
}
 +
 +
.icon > .label {
 +
display: none;
 +
}
 +
 +
/* Image */
 +
 +
.image {
 +
border-radius: 5px;
 +
border: 0;
 +
display: inline-block;
 +
position: relative;
 +
}
 +
 +
.image img {
 +
border-radius: 5px;
 +
display: block;
 +
}
 +
 +
.image.left, .image.right {
 +
max-width: 40%;
 +
}
 +
 +
.image.left img, .image.right img {
 +
width: 100%;
 +
}
 +
 +
.image.left {
 +
float: left;
 +
padding: 0 1.5em 1em 0;
 +
top: 0.25em;
 +
}
 +
 +
.image.right {
 +
float: right;
 +
padding: 0 0 1em 1.5em;
 +
top: 0.25em;
 +
}
 +
 +
.image.fit {
 +
display: block;
 +
margin: 0 0 2em 0;
 +
width: 100%;
 +
}
 +
 +
.image.fit img {
 +
width: 100%;
 +
}
 +
 +
.image.main {
 +
display: block;
 +
margin: 0 0 3em 0;
 +
width: 100%;
 +
}
 +
 +
.image.main img {
 +
width: 100%;
 +
}
 +
 +
/* List */
 +
 +
ol {
 +
list-style: decimal;
 +
margin: 0 0 2em 0;
 +
padding-left: 1.25em;
 +
}
 +
 +
ol li {
 +
padding-left: 0.25em;
 +
}
 +
 +
ul {
 +
list-style: disc;
 +
margin: 0 0 2em 0;
 +
padding-left: 1em;
 +
}
 +
 +
ul li {
 +
padding-left: 0.5em;
 +
}
 +
 +
ul.alt {
 +
list-style: none;
 +
padding-left: 0;
 +
}
 +
 +
ul.alt li {
 +
border-top: solid 1px rgba(255, 255, 255, 0.125);
 +
padding: 0.5em 0;
 +
}
 +
 +
ul.alt li:first-child {
 +
border-top: 0;
 +
padding-top: 0;
 +
}
 +
 +
ul.icons {
 +
cursor: default;
 +
list-style: none;
 +
padding-left: 0;
 +
}
 +
 +
ul.icons li {
 +
display: inline-block;
 +
padding: 0 1em 0 0;
 +
}
 +
 +
ul.icons li:last-child {
 +
padding-right: 0;
 +
}
 +
 +
ul.icons li .icon:before {
 +
font-size: 1.25em;
 +
}
 +
 +
ul.actions {
 +
cursor: default;
 +
list-style: none;
 +
padding-left: 0;
 +
}
 +
 +
ul.actions li {
 +
display: inline-block;
 +
padding: 0 1em 0 0;
 +
vertical-align: middle;
 +
}
 +
 +
ul.actions li:last-child {
 +
padding-right: 0;
 +
}
 +
 +
ul.actions.small li {
 +
padding: 0 0.5em 0 0;
 +
}
 +
 +
ul.actions.vertical li {
 +
display: block;
 +
padding: 1em 0 0 0;
 +
}
 +
 +
ul.actions.vertical li:first-child {
 +
padding-top: 0;
 +
}
 +
 +
ul.actions.vertical li > * {
 +
margin-bottom: 0;
 +
}
 +
 +
ul.actions.vertical.small li {
 +
padding: 0.5em 0 0 0;
 +
}
 +
 +
ul.actions.vertical.small li:first-child {
 +
padding-top: 0;
 +
}
 +
 +
ul.actions.fit {
 +
display: table;
 +
margin-left: -1em;
 +
padding: 0;
 +
table-layout: fixed;
 +
width: calc(100% + 1em);
 +
}
 +
 +
ul.actions.fit li {
 +
display: table-cell;
 +
padding: 0 0 0 1em;
 +
}
 +
 +
ul.actions.fit li > * {
 +
margin-bottom: 0;
 +
}
 +
 +
ul.actions.fit.small {
 +
margin-left: -0.5em;
 +
width: calc(100% + 0.5em);
 +
}
 +
 +
ul.actions.fit.small li {
 +
padding: 0 0 0 0.5em;
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
ul.actions {
 +
margin: 0 0 2em 0;
 +
}
 +
 +
ul.actions li {
 +
padding: 1em 0 0 0;
 +
display: block;
 +
text-align: center;
 +
width: 100%;
 +
}
 +
 +
ul.actions li:first-child {
 +
padding-top: 0;
 +
}
 +
 +
ul.actions li > * {
 +
width: 100%;
 +
margin: 0 !important;
 +
}
 +
 +
ul.actions.small li {
 +
padding: 0.5em 0 0 0;
 +
}
 +
 +
ul.actions.small li:first-child {
 +
padding-top: 0;
 +
}
 +
 +
}
 +
 +
ul.contact {
 +
list-style: none;
 +
padding: 0;
 +
}
 +
 +
ul.contact li {
 +
text-decoration: none;
 +
margin: 2.5em 0 0 0;
 +
padding: 0 0 0 3.25em;
 +
position: relative;
 +
}
 +
 +
ul.contact li:before {
 +
-moz-osx-font-smoothing: grayscale;
 +
-webkit-font-smoothing: antialiased;
 +
font-family: FontAwesome;
 +
font-style: normal;
 +
font-weight: normal;
 +
text-transform: none !important;
 +
}
 +
 +
ul.contact li:before {
 +
border-radius: 100%;
 +
border: solid 2px rgba(255, 255, 255, 0.125);
 +
display: inline-block;
 +
font-size: 0.8em;
 +
height: 2.5em;
 +
left: 0;
 +
line-height: 2.35em;
 +
position: absolute;
 +
text-align: center;
 +
top: 0;
 +
width: 2.5em;
 +
}
 +
 +
ul.contact li:first-child {
 +
margin-top: 0;
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
ul.contact li {
 +
margin: 1.5em 0 0 0;
 +
}
 +
 +
}
 +
 +
ul.pagination {
 +
cursor: default;
 +
list-style: none;
 +
padding-left: 0;
 +
}
 +
 +
ul.pagination li {
 +
display: inline-block;
 +
padding-left: 0;
 +
vertical-align: middle;
 +
}
 +
 +
ul.pagination li > .page {
 +
-moz-transition: background-color 0.2s ease-in-out, color 0.2s ease-in-out;
 +
-webkit-transition: background-color 0.2s ease-in-out, color 0.2s ease-in-out;
 +
-ms-transition: background-color 0.2s ease-in-out, color 0.2s ease-in-out;
 +
transition: background-color 0.2s ease-in-out, color 0.2s ease-in-out;
 +
border-bottom: 0;
 +
border-radius: 5px;
 +
display: inline-block;
 +
height: 1.5em;
 +
line-height: 1.5em;
 +
margin: 0 0.125em;
 +
min-width: 1.5em;
 +
padding: 0 0.5em;
 +
text-align: center;
 +
}
 +
 +
ul.pagination li > .page:hover {
 +
background-color: rgba(255, 255, 255, 0.025);
 +
}
 +
 +
ul.pagination li > .page.active {
 +
background-color: #f2efe8;
 +
}
 +
 +
ul.pagination li:first-child {
 +
padding-right: 0.75em;
 +
}
 +
 +
ul.pagination li:last-child {
 +
padding-left: 0.75em;
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
ul.pagination li:nth-child(n+2):nth-last-child(n+2) {
 +
display: none;
 +
}
 +
 +
ul.pagination li .button {
 +
width: 100%;
 +
}
 +
 +
ul.pagination li:first-child {
 +
width: calc(50% - 2px);
 +
text-align: left;
 +
padding-right: 0.325em;
 +
}
 +
 +
ul.pagination li:last-child {
 +
width: calc(50% - 2px);
 +
text-align: right;
 +
padding-left: 0.325em;
 +
}
 +
 +
}
 +
 +
dl {
 +
margin: 0 0 2em 0;
 +
}
 +
 +
dl dt {
 +
display: block;
 +
font-weight: 600;
 +
margin: 0 0 1em 0;
 +
}
 +
 +
dl dd {
 +
margin-left: 2em;
 +
}
 +
 +
/* Table */
 +
 +
.table-wrapper {
 +
-webkit-overflow-scrolling: touch;
 +
overflow-x: auto;
 +
}
 +
 +
table {
 +
margin: 0 0 2em 0;
 +
width: 100%;
 +
}
 +
 +
table tbody tr {
 +
border: solid 1px rgba(255, 255, 255, 0.125);
 +
border-left: 0;
 +
border-right: 0;
 +
}
 +
 +
table tbody tr:nth-child(2n + 1) {
 +
background-color: rgba(255, 255, 255, 0.025);
 +
}
 +
 +
table td {
 +
padding: 0.75em 0.75em;
 +
}
 +
 +
table th {
 +
color: #ffffff;
 +
font-size: 0.9em;
 +
font-weight: 600;
 +
padding: 0 0.75em 0.75em 0.75em;
 +
text-align: left;
 +
}
 +
 +
table thead {
 +
border-bottom: solid 2px rgba(255, 255, 255, 0.125);
 +
}
 +
 +
table tfoot {
 +
border-top: solid 2px rgba(255, 255, 255, 0.125);
 +
}
 +
 +
table.alt {
 +
border-collapse: separate;
 +
}
 +
 +
table.alt tbody tr td {
 +
border: solid 1px rgba(255, 255, 255, 0.125);
 +
border-left-width: 0;
 +
border-top-width: 0;
 +
}
 +
 +
table.alt tbody tr td:first-child {
 +
border-left-width: 1px;
 +
}
 +
 +
table.alt tbody tr:first-child td {
 +
border-top-width: 1px;
 +
}
 +
 +
table.alt thead {
 +
border-bottom: 0;
 +
}
 +
 +
table.alt tfoot {
 +
border-top: 0;
 +
}
 +
 +
/* Button */
 +
 +
input[type="submit"],
 +
input[type="reset"],
 +
input[type="button"],
 +
button,
 +
.button {
 +
-moz-appearance: none;
 +
-webkit-appearance: none;
 +
-ms-appearance: none;
 +
appearance: none;
 +
-moz-transition: background-color 0.2s ease-in-out;
 +
-webkit-transition: background-color 0.2s ease-in-out;
 +
-ms-transition: background-color 0.2s ease-in-out;
 +
transition: background-color 0.2s ease-in-out;
 +
background-color: transparent;
 +
border-radius: 5px;
 +
border: 0;
 +
box-shadow: inset 0 0 0 2px rgba(255, 255, 255, 0.125);
 +
color: #ffffff !important;
 +
cursor: pointer;
 +
display: inline-block;
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-size: 0.8em;
 +
font-weight: 700;
 +
height: 3.75em;
 +
letter-spacing: 0.1em;
 +
line-height: 3.75em;
 +
padding: 0 2.25em;
 +
text-align: center;
 +
text-decoration: none;
 +
text-transform: uppercase;
 +
white-space: nowrap;
 +
}
 +
 +
input[type="submit"]:hover,
 +
input[type="reset"]:hover,
 +
input[type="button"]:hover,
 +
button:hover,
 +
.button:hover {
 +
background-color: rgba(255, 255, 255, 0.025);
 +
}
 +
 +
input[type="submit"]:active,
 +
input[type="reset"]:active,
 +
input[type="button"]:active,
 +
button:active,
 +
.button:active {
 +
background-color: rgba(255, 255, 255, 0.075);
 +
}
 +
 +
input[type="submit"].icon:before,
 +
input[type="reset"].icon:before,
 +
input[type="button"].icon:before,
 +
button.icon:before,
 +
.button.icon:before {
 +
margin-right: 0.5em;
 +
color: rgba(255, 255, 255, 0.35);
 +
}
 +
 +
input[type="submit"].special,
 +
input[type="reset"].special,
 +
input[type="button"].special,
 +
button.special,
 +
.button.special {
 +
background-color: #f2efe8;
 +
box-shadow: none;
 +
}
 +
 +
input[type="submit"].special:hover,
 +
input[type="reset"].special:hover,
 +
input[type="button"].special:hover,
 +
button.special:hover,
 +
.button.special:hover {
 +
background-color:#f2efe8;
 +
}
 +
 +
input[type="submit"].special:active,
 +
input[type="reset"].special:active,
 +
input[type="button"].special:active,
 +
button.special:active,
 +
.button.special:active {
 +
background-color:#f2efe8;
 +
}
 +
 +
input[type="submit"].special.icon:before,
 +
input[type="reset"].special.icon:before,
 +
input[type="button"].special.icon:before,
 +
button.special.icon:before,
 +
.button.special.icon:before {
 +
color: #7985b0;
 +
}
 +
 +
input[type="submit"].fit,
 +
input[type="reset"].fit,
 +
input[type="button"].fit,
 +
button.fit,
 +
.button.fit {
 +
display: block;
 +
margin: 0 0 1em 0;
 +
width: 100%;
 +
}
 +
 +
input[type="submit"].small,
 +
input[type="reset"].small,
 +
input[type="button"].small,
 +
button.small,
 +
.button.small {
 +
font-size: 0.6em;
 +
}
 +
 +
input[type="submit"].big,
 +
input[type="reset"].big,
 +
input[type="button"].big,
 +
button.big,
 +
.button.big {
 +
font-size: 1em;
 +
}
 +
 +
input[type="submit"].disabled, input[type="submit"]:disabled,
 +
input[type="reset"].disabled,
 +
input[type="reset"]:disabled,
 +
input[type="button"].disabled,
 +
input[type="button"]:disabled,
 +
button.disabled,
 +
button:disabled,
 +
.button.disabled,
 +
.button:disabled {
 +
opacity: 0.25;
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
input[type="submit"],
 +
input[type="reset"],
 +
input[type="button"],
 +
button,
 +
.button {
 +
padding: 0;
 +
}
 +
 +
}
 +
 +
/* Features */
 +
 +
.features {
 +
display: -moz-flex;
 +
display: -webkit-flex;
 +
display: -ms-flex;
 +
display: flex;
 +
-moz-flex-wrap: wrap;
 +
-webkit-flex-wrap: wrap;
 +
-ms-flex-wrap: wrap;
 +
flex-wrap: wrap;
 +
margin: 0 0 2em 0;
 +
}
 +
 +
.features article {
 +
padding: 1.75em 1.75em 0.1em 1.75em ;
 +
background-color: #f2efe8;
 +
border-radius: 5px;
 +
margin: 1.5em 3em 1.5em 0;
 +
width: calc(50% - 1.5em);
 +
}
 +
 +
.features article:nth-child(2n) {
 +
margin-right: 0;
 +
}
 +
 +
.features article .image {
 +
border-radius: 5px 5px 0 0;
 +
display: block;
 +
margin-bottom: 1.75em;
 +
margin-left: -1.75em;
 +
margin-top: -1.75em;
 +
position: relative;
 +
width: calc(100% + 3.5em);
 +
}
 +
 +
.features article .image img {
 +
border-radius: 5px 5px 0 0;
 +
width: 100%;
 +
}
 +
 +
@media screen and (max-width: 980px) {
 +
 +
.features article {
 +
margin: 1em 2em 1em 0;
 +
width: calc(50% - 1em);
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
.features article {
 +
padding: 1.5em 1.5em 0.1em 1.5em ;
 +
margin: 0.875em 1.75em 0.875em 0;
 +
width: calc(50% - 0.875em - 1px);
 +
}
 +
 +
.features article .image {
 +
margin-bottom: 1.5em;
 +
margin-left: -1.5em;
 +
margin-top: -1.5em;
 +
width: calc(100% + 3em);
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
.features {
 +
display: block;
 +
}
 +
 +
.features article {
 +
width: 100%;
 +
margin: 0 0 2em 0 !important;
 +
}
 +
 +
}
 +
 +
/* Header */
 +
 +
#header {
 +
-moz-transition: background-color 0.2s ease-in-out;
 +
-webkit-transition: background-color 0.2s ease-in-out;
 +
-ms-transition: background-color 0.2s ease-in-out;
 +
transition: background-color 0.2s ease-in-out;
 +
background-color: rgba(53, 56, 73, 0.95);
 +
height: 3.5em;
 +
left: 0;
 +
line-height: 3.5em;
 +
padding: 0 1.25em;
 +
position: fixed;
 +
top: 0;
 +
width: 100%;
 +
z-index: 10000;
 +
}
 +
 +
#header h1 {
 +
-moz-transition: opacity 0.2s ease-in-out, visibility 0.2s;
 +
-webkit-transition: opacity 0.2s ease-in-out, visibility 0.2s;
 +
-ms-transition: opacity 0.2s ease-in-out, visibility 0.2s;
 +
transition: opacity 0.2s ease-in-out, visibility 0.2s;
 +
border-bottom: 0;
 +
font-size: 0.8em;
 +
margin-bottom: 0;
 +
opacity: 1;
 +
visibility: visible;
 +
}
 +
 +
#header h1 a {
 +
border: 0;
 +
}
 +
 +
#header nav {
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-size: 0.8em;
 +
font-weight: 700;
 +
height: 3em;
 +
letter-spacing: 0.1em;
 +
line-height: 3em;
 +
position: absolute;
 +
right: 0.7em;
 +
text-transform: uppercase;
 +
top: 0.7em;
 +
}
 +
 +
#header nav a {
 +
border: 0;
 +
display: inline-block;
 +
padding: 0 1em;
 +
}
 +
 +
#header nav a:before {
 +
float: right;
 +
margin-left: 0.75em;
 +
}
 +
 +
#header nav a[href="#menu"] {
 +
text-decoration: none;
 +
-moz-transition: background-color 0.2s ease-in-out;
 +
-webkit-transition: background-color 0.2s ease-in-out;
 +
-ms-transition: background-color 0.2s ease-in-out;
 +
transition: background-color 0.2s ease-in-out;
 +
border-radius: 5px;
 +
box-shadow: inset 0 0 0 2px rgba(255, 255, 255, 0.125);
 +
padding: 0 1.35em;
 +
}
 +
 +
#header nav a[href="#menu"]:before {
 +
-moz-osx-font-smoothing: grayscale;
 +
-webkit-font-smoothing: antialiased;
 +
font-family: FontAwesome;
 +
font-style: normal;
 +
font-weight: normal;
 +
text-transform: none !important;
 +
}
 +
 +
#header nav a[href="#menu"]:before {
 +
content: '\f0c9';
 +
}
 +
 +
#header nav a[href="#menu"]:hover {
 +
background-color: rgba(255, 255, 255, 0.025);
 +
}
 +
 +
#header nav a[href="#menu"]:active {
 +
background-color: rgba(255, 255, 255, 0.075);
 +
}
 +
 +
#header.alt {
 +
background-color: transparent;
 +
}
 +
 +
#header.alt h1 {
 +
opacity: 0;
 +
visibility: hidden;
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
#header {
 +
height: 2.75em;
 +
line-height: 2.75em;
 +
}
 +
 +
#header nav {
 +
top: 0;
 +
right: 0;
 +
height: inherit;
 +
line-height: inherit;
 +
}
 +
 +
#header nav a {
 +
height: inherit;
 +
line-height: inherit;
 +
}
 +
 +
#header nav a[href="#menu"] {
 +
box-shadow: none;
 +
padding: 0 1em;
 +
border-radius: 0;
 +
}
 +
 +
#header nav a[href="#menu"]:hover, #header nav a[href="#menu"]:active {
 +
background-color: inherit;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
#header nav a[href="#menu"] {
 +
width: 4em;
 +
white-space: nowrap;
 +
text-indent: 4em;
 +
position: relative;
 +
}
 +
 +
#header nav a[href="#menu"]:before {
 +
width: inherit;
 +
position: absolute;
 +
top: 0;
 +
left: 0;
 +
text-indent: 0;
 +
text-align: right;
 +
margin-left: 0;
 +
padding-right: 1.25em;
 +
}
 +
 +
}
 +
 +
/* Menu */
 +
 +
#page-wrapper {
 +
-moz-transition: -moz-filter 0.25s ease;
 +
-webkit-transition: -webkit-filter 0.25s ease;
 +
-ms-transition: -ms-filter 0.25s ease;
 +
transition: filter 0.25s ease;
 +
}
 +
 +
#menu {
 +
-moz-align-items: center;
 +
-webkit-align-items: center;
 +
-ms-align-items: center;
 +
align-items: center;
 +
display: -moz-flex;
 +
display: -webkit-flex;
 +
display: -ms-flex;
 +
display: flex;
 +
-moz-justify-content: center;
 +
-webkit-justify-content: center;
 +
-ms-justify-content: center;
 +
justify-content: center;
 +
-moz-pointer-events: none;
 +
-webkit-pointer-events: none;
 +
-ms-pointer-events: none;
 +
pointer-events: none;
 +
-moz-transition: opacity 0.35s ease, visibility 0.35s;
 +
-webkit-transition: opacity 0.35s ease, visibility 0.35s;
 +
-ms-transition: opacity 0.35s ease, visibility 0.35s;
 +
transition: opacity 0.35s ease, visibility 0.35s;
 +
-moz-user-select: none;
 +
-webkit-user-select: none;
 +
-ms-user-select: none;
 +
user-select: none;
 +
-webkit-tap-highlight-color: transparent;
 +
background: rgba(46, 49, 65, 0.8);
 +
cursor: default;
 +
height: 100%;
 +
left: 0;
 +
opacity: 0;
 +
position: fixed;
 +
text-align: center;
 +
top: 0;
 +
visibility: hidden;
 +
width: 100%;
 +
}
 +
 +
#menu .inner {
 +
padding: 2.5em 1.5em 0.5em 1.5em ;
 +
-moz-transform: translateY(0.5em);
 +
-webkit-transform: translateY(0.5em);
 +
-ms-transform: translateY(0.5em);
 +
transform: translateY(0.5em);
 +
-moz-transition: opacity 0.35s ease, -moz-transform 0.35s ease;
 +
-webkit-transition: opacity 0.35s ease, -webkit-transform 0.35s ease;
 +
-ms-transition: opacity 0.35s ease, -ms-transform 0.35s ease;
 +
transition: opacity 0.35s ease, transform 0.35s ease;
 +
-webkit-overflow-scrolling: touch;
 +
background: #f2efe8;
 +
border-radius: 5px;
 +
display: block;
 +
max-width: 100%;
 +
opacity: 0;
 +
position: relative;
 +
width: 18em;
 +
}
 +
 +
#menu h2 {
 +
border-bottom: solid 2px rgba(255, 255, 255, 0.125);
 +
padding-bottom: 1em;
 +
}
 +
 +
#menu .close {
 +
background-image: url("images/close.svg");
 +
background-position: 75% 25%;
 +
background-repeat: no-repeat;
 +
background-size: 2em 2em;
 +
border: 0;
 +
content: '';
 +
display: block;
 +
height: 4em;
 +
overflow: hidden;
 +
position: absolute;
 +
right: 0;
 +
text-align: center;
 +
text-indent: 4em;
 +
top: 0;
 +
width: 4em;
 +
}
 +
 +
#menu .links {
 +
list-style: none;
 +
margin-bottom: 1.5em;
 +
padding: 0;
 +
}
 +
 +
#menu .links li {
 +
padding: 0;
 +
}
 +
 +
#menu .links li a {
 +
border-radius: 5px;
 +
border: 0;
 +
display: block;
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-size: 0.8em;
 +
font-weight: 200;
 +
letter-spacing: 0.1em;
 +
line-height: 1.85em;
 +
padding: 0.75em 0;
 +
text-transform: uppercase;
 +
}
 +
 +
#menu .links li a:hover {
 +
background:#f2efe8;
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
#menu .inner {
 +
max-height: 100%;
 +
overflow-y: auto;
 +
overflow-x: hidden;
 +
}
 +
 +
#menu .inner .close {
 +
background-size: 1.5em 1.5em;
 +
}
 +
 +
}
 +
 +
body.is-menu-visible #page-wrapper {
 +
-moz-filter: blur(1.5px);
 +
-webkit-filter: blur(1.5px);
 +
-ms-filter: blur(1.5px);
 +
filter: blur(1.5px);
 +
}
 +
 +
body.is-menu-visible #menu {
 +
-moz-pointer-events: auto;
 +
-webkit-pointer-events: auto;
 +
-ms-pointer-events: auto;
 +
pointer-events: auto;
 +
opacity: 1;
 +
visibility: visible;
 +
}
 +
 +
body.is-menu-visible #menu .inner {
 +
-moz-transform: translateY(0);
 +
-webkit-transform: translateY(0);
 +
-ms-transform: translateY(0);
 +
transform: translateY(0);
 +
opacity: 1;
 +
}
 +
 +
/* Banner */
 +
 +
#banner {
 +
padding: 20em 0 15em 0 ;
 +
}
 +
 +
#banner .inner {
 +
margin: 0 auto;
 +
width: 55em;
 +
}
 +
 +
#banner .logo {
 +
-moz-transition: opacity 2s ease, -moz-transform 1s ease;
 +
-webkit-transition: opacity 2s ease, -webkit-transform 1s ease;
 +
-ms-transition: opacity 2s ease, -ms-transform 1s ease;
 +
transition: opacity 2s ease, transform 1s ease;
 +
-moz-transform: translateY(0);
 +
-webkit-transform: translateY(0);
 +
-ms-transform: translateY(0);
 +
transform: translateY(0);
 +
opacity: 1;
 +
margin: 0 0 1.3em 0;
 +
}
 +
 +
#banner .logo .icon {
 +
border-radius: 100%;
 +
border: solid 2px rgba(255, 255, 255, 0.125);
 +
cursor: default;
 +
display: inline-block;
 +
font-size: 2em;
 +
height: 2.25em;
 +
line-height: 2.25em;
 +
text-align: center;
 +
width: 2.25em;
 +
}
 +
 +
#banner h2 {
 +
-moz-transition: opacity 0.5s ease, -moz-transform 0.5s ease, -moz-filter 0.25s ease;
 +
-webkit-transition: opacity 0.5s ease, -webkit-transform 0.5s ease, -webkit-filter 0.25s ease;
 +
-ms-transition: opacity 0.5s ease, -ms-transform 0.5s ease, -ms-filter 0.25s ease;
 +
transition: opacity 0.5s ease, transform 0.5s ease, filter 0.25s ease;
 +
-moz-transform: translateX(0);
 +
-webkit-transform: translateX(0);
 +
-ms-transform: translateX(0);
 +
transform: translateX(0);
 +
-moz-transition-delay: 0.65s;
 +
-webkit-transition-delay: 0.65s;
 +
-ms-transition-delay: 0.65s;
 +
transition-delay: 0.65s;
 +
-moz-filter: blur(0);
 +
-webkit-filter: blur(0);
 +
-ms-filter: blur(0);
 +
filter: blur(0);
 +
opacity: 1;
 +
border-bottom: solid 2px rgba(255, 255, 255, 0.125);
 +
font-size: 2.25em;
 +
margin-bottom: 0.8em;
 +
padding-bottom: 0.4em;
 +
}
 +
 +
#banner p {
 +
-moz-transition: opacity 0.5s ease, -moz-transform 0.5s ease, -moz-filter 0.25s ease;
 +
-webkit-transition: opacity 0.5s ease, -webkit-transform 0.5s ease, -webkit-filter 0.25s ease;
 +
-ms-transition: opacity 0.5s ease, -ms-transform 0.5s ease, -ms-filter 0.25s ease;
 +
transition: opacity 0.5s ease, transform 0.5s ease, filter 0.25s ease;
 +
-moz-transform: translateX(0);
 +
-webkit-transform: translateX(0);
 +
-ms-transform: translateX(0);
 +
transform: translateX(0);
 +
-moz-transition-delay: 0.8s;
 +
-webkit-transition-delay: 0.8s;
 +
-ms-transition-delay: 0.8s;
 +
transition-delay: 0.8s;
 +
-moz-filter: blur(0);
 +
-webkit-filter: blur(0);
 +
-ms-filter: blur(0);
 +
filter: blur(0);
 +
opacity: 1;
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-size: 1em;
 +
font-weight: 200;
 +
letter-spacing: 0.1em;
 +
line-height: 2;
 +
text-transform: uppercase;
 +
}
 +
 +
@media screen and (max-width: 1280px) {
 +
 +
#banner {
 +
padding: 7em 0 8.25em 0 ;
 +
background-color: #5d48a0;
 +
background-image: linear-gradient(to top, rgba(46, 49, 65, 0.8), rgba(46, 49, 65, 0.8)), url("../../images/bg.jpg");
 +
background-size: auto, cover;
 +
background-position: center, center;
 +
margin-bottom: -6.5em;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 980px) {
 +
 +
#banner {
 +
padding: 12em 3em 12.375em 3em ;
 +
margin-bottom: -4.75em;
 +
}
 +
 +
#banner .inner {
 +
width: 100%;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
#banner {
 +
padding: 5em 2em 4.25em 2em ;
 +
margin-bottom: -2.5em;
 +
}
 +
 +
#banner .logo {
 +
margin: 0 0 1em 0;
 +
}
 +
 +
#banner .logo .icon {
 +
font-size: 1.5em;
 +
}
 +
 +
#banner h2 {
 +
font-size: 1.5em;
 +
}
 +
 +
#banner p {
 +
font-size: 0.8em;
 +
}
 +
 +
}
 +
 +
body.is-loading #banner .logo {
 +
-moz-transform: translateY(0.5em);
 +
-webkit-transform: translateY(0.5em);
 +
-ms-transform: translateY(0.5em);
 +
transform: translateY(0.5em);
 +
opacity: 0;
 +
}
 +
 +
body.is-loading #banner h2 {
 +
opacity: 0;
 +
-moz-transform: translateX(0.25em);
 +
-webkit-transform: translateX(0.25em);
 +
-ms-transform: translateX(0.25em);
 +
transform: translateX(0.25em);
 +
-moz-filter: blur(2px);
 +
-webkit-filter: blur(2px);
 +
-ms-filter: blur(2px);
 +
filter: blur(2px);
 +
}
 +
 +
body.is-loading #banner p {
 +
opacity: 0;
 +
-moz-transform: translateX(0.5em);
 +
-webkit-transform: translateX(0.5em);
 +
-ms-transform: translateX(0.5em);
 +
transform: translateX(0.5em);
 +
-moz-filter: blur(2px);
 +
-webkit-filter: blur(2px);
 +
-ms-filter: blur(2px);
 +
filter: blur(2px);
 +
}
 +
 +
/* Wrapper */
 +
 +
#wrapper > header {
 +
padding: 11em 0 2.25em 0 ;
 +
}
 +
 +
#wrapper > header .inner {
 +
margin: 0 auto;
 +
width: 55em;
 +
}
 +
 +
#wrapper > header h2 {
 +
border-bottom: solid 2px rgba(255, 255, 255, 0.125);
 +
font-size: 2em;
 +
margin-bottom: 0.8em;
 +
padding-bottom: 0.4em;
 +
}
 +
 +
#wrapper > header p {
 +
font-family: Raleway, Helvetica, sans-serif;
 +
font-size: 1em;
 +
font-weight: 200;
 +
letter-spacing: 0.1em;
 +
line-height: 2;
 +
text-transform: uppercase;
 +
}
 +
 +
@media screen and (max-width: 1280px) {
 +
 +
#wrapper > header {
 +
padding: 9em 0 6.25em 0 ;
 +
background-color: #5d48a0;
 +
background-image: linear-gradient(to top, rgba(46, 49, 65, 0.8), rgba(46, 49, 65, 0.8)), url("../../images/bg.jpg");
 +
background-size: auto, cover;
 +
background-position: center, 0% 30%;
 +
margin-bottom: -6.5em;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 980px) {
 +
 +
#wrapper > header {
 +
padding: 11em 3em 7.375em 3em ;
 +
background-size: auto, cover;
 +
background-position: center, 0% 0%;
 +
margin-bottom: -4.75em;
 +
}
 +
 +
#wrapper > header .inner {
 +
width: 100%;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
#wrapper > header {
 +
padding: 6.5em 2em 3em 2em ;
 +
background-size: auto, 125%;
 +
margin-bottom: -2.5em;
 +
}
 +
 +
#wrapper > header h2 {
 +
font-size: 1.25em;
 +
}
 +
 +
#wrapper > header p {
 +
font-size: 0.8em;
 +
}
 +
 +
}
 +
 +
.wrapper {
 +
background-color: #5d48a0;
 +
margin: 6.5em 0;
 +
position: relative;
 +
}
 +
 +
.wrapper:before, .wrapper:after {
 +
background-image: url("data:image/svg+xml;charset=utf8,%3Csvg xmlns='http://www.w3.org/2000/svg' width='100' height='100' viewBox='0 0 100 100' preserveAspectRatio='none'%3E%3Cpolygon points='0,100 100,0 100,100' style='fill:%232e3141%3B' /%3E%3C/svg%3E");
 +
}
 +
 +
.wrapper:before {
 +
box-shadow: inset 0 -1px 0 0 #5d48a0, 0 1px 0 0 #5d48a0;
 +
}
 +
 +
.wrapper:after {
 +
box-shadow: inset 0 -1px 0 0 #5d48a0, 0 1px 0 0 #5d48a0;
 +
}
 +
 +
.wrapper:before, .wrapper:after {
 +
background-repeat: no-repeat;
 +
background-size: 100% 100%;
 +
content: '';
 +
display: block;
 +
height: 6.5em;
 +
position: absolute;
 +
width: 100%;
 +
}
 +
 +
.wrapper:before {
 +
left: 0;
 +
top: -6.5em;
 +
}
 +
 +
.wrapper:after {
 +
-moz-transform: scaleY(-1);
 +
-webkit-transform: scaleY(-1);
 +
-ms-transform: scaleY(-1);
 +
transform: scaleY(-1);
 +
bottom: -6.5em;
 +
left: 0;
 +
}
 +
 +
.wrapper.alt:before {
 +
-moz-transform: scaleX(-1);
 +
-webkit-transform: scaleX(-1);
 +
-ms-transform: scaleX(-1);
 +
transform: scaleX(-1);
 +
}
 +
 +
.wrapper.alt:after {
 +
-moz-transform: scaleY(-1) scaleX(-1);
 +
-webkit-transform: scaleY(-1) scaleX(-1);
 +
-ms-transform: scaleY(-1) scaleX(-1);
 +
transform: scaleY(-1) scaleX(-1);
 +
}
 +
 +
.wrapper .inner {
 +
padding: 3em 0 1em 0 ;
 +
margin: 0 auto;
 +
width: 55em;
 +
}
 +
 +
.wrapper.style2 {
 +
background-color: #f2efe8;
 +
background-image: url("https://static.igem.org/mediawiki/2017/9/92/Asijigem-designbanner.png")
 +
}
 +
 +
.wrapper.style2:before, .wrapper.style2:after {
 +
 +
}
 +
 +
.wrapper.style2:before {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.style2:after {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.style3 {
 +
background-color: #c2d4d8;
 +
}
 +
 +
.wrapper.style3:before, .wrapper.style3:after {
 +
 +
}
 +
 +
.wrapper.style3:before {
 +
box-shadow: inset 0 -1px 0 0 #c2d4d8, 0 1px 0 0 #c2d4d8;
 +
}
 +
 +
.wrapper.style3:after {
 +
box-shadow: inset 0 -1px 0 0 #c2d4d8, 0 1px 0 0 #c2d4d8;
 +
}
 +
 +
.wrapper.style4 {
 +
background-color: #454858;
 +
}
 +
 +
.wrapper.style4:before, .wrapper.style4:after {
 +
 +
}
 +
 +
.wrapper.style4:before {
 +
box-shadow: inset 0 -1px 0 0 #454858, 0 1px 0 0 #454858;
 +
}
 +
 +
.wrapper.style4:after {
 +
box-shadow: inset 0 -1px 0 0 #454858, 0 1px 0 0 #454858;
 +
}
 +
 +
.wrapper.style5 {
 +
background-color: #4d5060;
 +
}
 +
 +
.wrapper.style5:before, .wrapper.style5:after {
 +
 +
}
 +
 +
.wrapper.style5:before {
 +
box-shadow: inset 0 -1px 0 0 #4d5060, 0 1px 0 0 #4d5060;
 +
}
 +
 +
.wrapper.style5:after {
 +
box-shadow: inset 0 -1px 0 0 #4d5060, 0 1px 0 0 #4d5060;
 +
}
 +
 +
.wrapper.style6 {
 +
background-color: #555867;
 +
}
 +
 +
.wrapper.style6:before, .wrapper.style6:after {
 +
 +
}
 +
 +
.wrapper.style6:before {
 +
box-shadow: inset 0 -1px 0 0 #555867, 0 1px 0 0 #555867;
 +
}
 +
 +
.wrapper.style6:after {
 +
box-shadow: inset 0 -1px 0 0 #555867, 0 1px 0 0 #555867;
 +
}
 +
 +
.wrapper.spotlight {
 +
background-color: #f2efe8;
 +
}
 +
 +
.wrapper.spotlight:before, .wrapper.spotlight:after {
 +
 +
}
 +
 +
.wrapper.spotlight:before {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.spotlight:after {
 +
box-shadow: inset 0 -1px 0 0 #f2efe8, 0 1px 0 0 #f2efe8;
 +
}
 +
 +
.wrapper.spotlight .inner {
 +
display: -moz-flex;
 +
display: -webkit-flex;
 +
display: -ms-flex;
 +
display: flex;
 +
-moz-align-items: center;
 +
-webkit-align-items: center;
 +
-ms-align-items: center;
 +
align-items: center;
 +
-moz-flex-direction: row;
 +
-webkit-flex-direction: row;
 +
-ms-flex-direction: row;
 +
flex-direction: row;
 +
}
 +
 +
.wrapper.spotlight .image {
 +
border-radius: 100%;
 +
margin: 0 3em 2em 0;
 +
width: 22em;
 +
overflow: hidden;
 +
-ms-flex: 1;
 +
}
 +
 +
.wrapper.spotlight .image img {
 +
border-radius: 100%;
 +
width: 100%;
 +
}
 +
 +
.wrapper.spotlight .content {
 +
width: 100%;
 +
-ms-flex: 2;
 +
}
 +
 +
.wrapper.spotlight:nth-child(2n - 1) .inner {
 +
-moz-flex-direction: row-reverse;
 +
-webkit-flex-direction: row-reverse;
 +
-ms-flex-direction: row-reverse;
 +
flex-direction: row-reverse;
 +
text-align: right;
 +
}
 +
 +
.wrapper.spotlight:nth-child(2n - 1) .image {
 +
margin: 0 0 2em 3em;
 +
}
 +
 +
.wrapper.spotlight.style2 {
 +
background-color:#f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style2:before, .wrapper.spotlight.style2:after {
 +
 +
}
 +
 +
.wrapper.spotlight.style2:before {
 +
box-shadow: inset 0 -1px 0 0#f2efe8, 0 1px 0 0#f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style2:after {
 +
box-shadow: inset 0 -1px 0 0#f2efe8, 0 1px 0 0#f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style3 {
 +
 +
text-align: left;
 +
width: 1440px;
 +
padding: 0px;
 +
margin: 0 auto;
 +
height: 100%;
 +
overflow-x:hidden;
 +
}
 +
 +
.wrapper.spotlight.style3:before, .wrapper.spotlight.style3:after {
 +
 +
}
 +
 +
.wrapper.spotlight.style3:before {
 +
box-shadow: inset 0 -1px 0 0#f2efe8, 0 1px 0 0#f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style3:after {
 +
box-shadow: inset 0 -1px 0 0#f2efe8, 0 1px 0 0#f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style4 {
 +
background-color:#f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style4:before, .wrapper.spotlight.style4:after {
 +
 +
}
 +
 +
.wrapper.spotlight.style4:before {
 +
box-shadow: inset 0 -1px 0 0#f2efe8, 0 1px 0 0#f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style4:after {
 +
box-shadow: inset 0 -1px 0 0#f2efe8, 0 1px 0 0#f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style5 {
 +
background-color:#f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style5:before, .wrapper.spotlight.style5:after {
 +
 +
}
 +
 +
.wrapper.spotlight.style5:before {
 +
box-shadow: inset 0 -1px 0 0#f2efe8, 0 1px 0 0#f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style5:after {
 +
box-shadow: inset 0 -1px 0 0#f2efe8, 0 1px 0 0#f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style6 {
 +
background-color:#f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style6:before, .wrapper.spotlight.style6:after {
 +
 +
}
 +
 +
.wrapper.spotlight.style6:before {
 +
box-shadow: inset 0 -1px 0 0#f2efe8, 0 1px 0 0#f2efe8;
 +
}
 +
 +
.wrapper.spotlight.style6:after {
 +
box-shadow: inset 0 -1px 0 0#f2efe8, 0 1px 0 0#f2efe8;
 +
}
 +
 +
@media screen and (max-width: 980px) {
 +
 +
.wrapper {
 +
margin: 4.75em 0;
 +
}
 +
 +
.wrapper:before, .wrapper:after {
 +
height: 4.75em;
 +
}
 +
 +
.wrapper:before {
 +
top: -4.75em;
 +
}
 +
 +
.wrapper:after {
 +
bottom: -4.75em;
 +
left: 0;
 +
}
 +
 +
.wrapper .inner {
 +
padding: 3em 3em 1em 3em ;
 +
width: 100%;
 +
}
 +
 +
.wrapper.spotlight .image {
 +
margin: 0 2em 2em 0;
 +
width: 32em;
 +
}
 +
 +
.wrapper.spotlight:nth-child(2n - 1) .image {
 +
margin: 0 0 2em 2em;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
.wrapper {
 +
margin: 2.5em 0;
 +
}
 +
 +
.wrapper:before, .wrapper:after {
 +
height: 2.5em;
 +
}
 +
 +
.wrapper:before {
 +
top: -2.5em;
 +
}
 +
 +
.wrapper:after {
 +
bottom: -2.5em;
 +
left: 0;
 +
}
 +
 +
.wrapper .inner {
 +
padding: 2em 2em 0.1em 2em ;
 +
}
 +
 +
.wrapper.spotlight .inner {
 +
-moz-align-items: -moz-flex-start;
 +
-webkit-align-items: -webkit-flex-start;
 +
-ms-align-items: -ms-flex-start;
 +
align-items: flex-start;
 +
}
 +
 +
.wrapper.spotlight .image {
 +
width: 19em;
 +
margin: 0 1.75em 2em 0;
 +
}
 +
 +
.wrapper.spotlight:nth-child(2n - 1) .image {
 +
margin: 0 0 2em 1.75em;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
.wrapper.spotlight .inner {
 +
display: block;
 +
}
 +
 +
.wrapper.spotlight .image {
 +
margin: 0 0 1em 0 !important;
 +
max-width: 85%;
 +
width: 12em;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 360px) {
 +
 +
.wrapper .inner {
 +
padding: 2em 1.5em 0.1em 1.5em ;
 +
}
 +
 +
}
 +
 +
/* Footer */
 +
 +
#footer .inner {
 +
padding: 5em 0 3em 0 ;
 +
display: -moz-flex;
 +
display: -webkit-flex;
 +
display: -ms-flex;
 +
display: flex;
 +
-moz-flex-direction: row;
 +
-webkit-flex-direction: row;
 +
-ms-flex-direction: row;
 +
flex-direction: row;
 +
-moz-flex-wrap: wrap;
 +
-webkit-flex-wrap: wrap;
 +
-ms-flex-wrap: wrap;
 +
flex-wrap: wrap;
 +
margin: 0 auto;
 +
width: 55em;
 +
}
 +
 +
#footer .inner > * {
 +
width: 100%;
 +
}
 +
 +
#footer .inner form {
 +
margin: 0 3em 0 0;
 +
width: calc(50% - 1.5em);
 +
}
 +
 +
#footer .inner .contact {
 +
width: calc(50% - 1.5em);
 +
}
 +
 +
#footer .inner .copyright {
 +
border-top: solid 2px rgba(255, 255, 255, 0.125);
 +
list-style: none;
 +
margin: 4em 0 2em 0;
 +
padding: 2em 0 0 0;
 +
width: 100%;
 +
}
 +
 +
#footer .inner .copyright li {
 +
border-left: solid 2px rgba(255, 255, 255, 0.125);
 +
color: rgba(255, 255, 255, 0.35);
 +
display: inline-block;
 +
font-size: 0.9em;
 +
line-height: 1;
 +
margin-left: 1em;
 +
padding: 0;
 +
padding-left: 1em;
 +
}
 +
 +
#footer .inner .copyright li:first-child {
 +
border-left: 0;
 +
margin-left: 0;
 +
padding-left: 0;
 +
}
 +
 +
#footer .inner .copyright li a {
 +
color: inherit;
 +
}
 +
 +
@media screen and (max-width: 1280px) {
 +
 +
#footer {
 +
background-color: #5d48a0;
 +
background-image: linear-gradient(to top, rgba(46, 49, 65, 0.8), rgba(46, 49, 65, 0.8)), url("../../images/bg.jpg");
 +
background-size: auto, cover;
 +
background-position: center, center;
 +
margin-top: -6.5em;
 +
padding-top: 6.5em;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 980px) {
 +
 +
#footer {
 +
margin-top: -4.75em;
 +
padding-top: 4.75em;
 +
}
 +
 +
#footer .inner {
 +
padding: 3em 3em 1em 3em ;
 +
display: block;
 +
width: 100%;
 +
}
 +
 +
#footer .inner form {
 +
width: 100%;
 +
margin: 0 0 4em 0;
 +
}
 +
 +
#footer .inner .contact {
 +
width: 100%;
 +
margin: 0 0 4em 0;
 +
}
 +
 +
#footer .inner .copyright {
 +
margin: 4em 0 2em 0;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 736px) {
 +
 +
#footer {
 +
margin-top: -2.5em;
 +
padding-top: 2.5em;
 +
}
 +
 +
#footer .inner {
 +
padding: 2em 2em 0.1em 2em ;
 +
}
 +
 +
#footer .inner form {
 +
margin: 0 0 3em 0;
 +
}
 +
 +
#footer .inner .contact {
 +
margin: 0 0 3em 0;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 640px) {
 +
 +
#footer .inner .copyright li {
 +
border-left: 0;
 +
display: block;
 +
margin: 1em 0 0 0;
 +
padding-left: 0;
 +
}
 +
 +
#footer .inner .copyright li:first-child {
 +
margin-top: 0;
 +
}
 +
 +
}
 +
 +
@media screen and (max-width: 360px) {
 +
 +
#footer .inner {
 +
padding: 2em 1.5em 0.1em 1.5em ;
 +
}
 +
 +
}
 +
</style>
 +
<style>
 +
/*
 +
Solid State by HTML5 UP
 +
html5up.net | @ajlkn
 +
Free for personal and commercial use under the CCA 3.0 license (html5up.net/license)
 +
*/
 +
 +
/* Basic */
 +
 +
body {
 +
background-color: #5d48a0;
 +
background-image: url("../../images/bg.jpg");
 +
background-size: cover;
 +
background-attachment: fixed;
 +
background-position: center;
 +
}
 +
 +
body:before {
 +
background: rgba(46, 49, 65, 0.8);
 +
content: '';
 +
display: block;
 +
height: 100%;
 +
left: 0;
 +
position: fixed;
 +
top: 0;
 +
width: 100%;
 +
}
 +
 +
body > * {
 +
position: relative;
 +
z-index: 1;
 +
}
 +
 +
/* Features */
 +
 +
.features article {
 +
display: inline-block;
 +
width: 45%;
 +
}
 +
 +
/* Menu */
 +
 +
#menu .inner {
 +
margin: 4em auto;
 +
}
 +
 +
/* Wrapper */
 +
 +
#wrapper > header {
 +
background: none !important;
 +
}
 +
 +
.wrapper.spotlight .inner {
 +
text-align: left !important;
 +
}
 +
 +
.wrapper.spotlight .image {
 +
display: inline-block;
 +
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Latest revision as of 15:58, 1 November 2017

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IGEM ASIJ TOKYO

Design

In the course of our experimentation, perhaps the most crucial step was the design of our experiment, prior to its actual carrying out. Below, we detail the steps we took and the ideas we came up with in order to reach our final goal.

Our Process

We began our experiments with a competent cell check to find the optimal concentration of DNA for working with NEB 5-alpha Competent E. coli. Next, we found the ideal promoter strength for the growth of COX-2 and c-Myc by performing the Gibson Assembly with three different Anderson promoters of different strengths. In order to observe phenotypic proof of these results the competent cells were transformed and plated, as well as expanded into solution so both the number of colonies, as well as the optical density of the solutions were used to support the optimal promoter strength.

We then moved on to find the most efficient promoter-to-binding domain combinations for both the c-Myc and COX-2 genes by testing a variety of them and seeing which produced the most glowing colonies in the presence of rapamycin. We also utilized this phase to make sure that the combinations glowed only when rapamycin was present. We concluded this test with the combinations of the COX-2 promoter with the FRB domain, and the c-Myc promoter with the FKBP domain being the most efficient combinations. The last step was to ensure that the construct glowed only when all parts were present, and to prove that the promoters had altered the shape of the nonspecific binding domains to become specific to the corresponding proteins. We did this by expanding incomplete combinations into tubes and observing whether they glowed or not. We found that none of the tubes glowed, no matter if they were missing a gene, or one of the promoter-reporter systems. The only tube that glowed was the one containing both COX-2 and c-Myc promoter-reporter systems, both respective genes, as well as rapamycin. .

Future Directions

With more time, we would like to implement our current model into a yeast system. This would prove advantageous as it will confirm the working of our model in an eukaryotic  organism. Using yeast, followed by flow cytometry, would allow us to collect quantitative data that could be better analyzed. Additionally, we would work on the upregulation of c-Myc production for the effectiveness of our experiment. This was a limiting factor in our experiment and continues to be a weak point in our design and planning. Most importantly, our team would like to develop a 3D prototype for a home-kit that would diagnose CRC. Our goal would be to develop a home-diagnosis kit similar in method and design to the home-pregnancy kit, where the product would be commercially approved and easily available. Our model would consist of two solutions that would be combined with the addition of a sample of fecal matter. This would address a major component of our project goal in developing a more convenient treatment and detection method for colorectal cancer.