Difference between revisions of "Team:NUS Singapore"

 
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{{NUS_Singapore}}
 
{{NUS_Singapore}}
 
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<div class="column full_size">
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</head>
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<img src="https://static.igem.org/mediawiki/2017/2/27/NUS_IGEM_Logo.jpeg" width="2000" height="300"></div>
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</div>
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<style>
  
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<div class="column full_size" >
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<h1> Probiome </h1>
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/************************************************** Image Carousel Section **************************************************/
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<h5> National University of Singapore</h5>
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/**************************************** Sponsor and Social Connact Link Cover  ****************************************/
 +
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*/
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 +
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 +
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 +
    background-color: white;
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 +
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<body>
 +
<!--***********************************************  Image Carousel Section ***********************************************-->
 +
<div id="slide">
 +
  <div class="slideshow-container">
 +
    <div class="mySlides fade"> <img src="https://static.igem.org/mediawiki/2017/0/0c/NUS_2017_IGEM_slideshow.png"> </div>
 +
    <div class="mySlides fade"> <img src="https://static.igem.org/mediawiki/2017/d/d1/NUS_2017_IGEM_Group_Eng.jpeg"> </div>
 +
    <div class="mySlides fade"> <img src="https://static.igem.org/mediawiki/2017/0/04/NUS_IGEM_Groupphoto_1_tailored.jpeg"> </div>
 +
    <a class="prev" onclick="plusSlides(-1)">&#10094;</a> <a class="next" onclick="plusSlides(1)">&#10095;</a>
 +
  </div>
 +
  <br>
 +
  <div style="text-align:center">
 +
      <span class="dot" onclick="currentSlide(1)"></span>
 +
      <span class="dot" onclick="currentSlide(2)"></span>
 +
      <span class="dot" onclick="currentSlide(3)"></span>
 +
  </div>
 +
</div> 
 +
 
 +
<!--**************************************** Project Description with Image Section ****************************************-->
 +
  <h1>Making Engineering of Customised Kill Switches Easier</h1>  
 +
<div class="column larger_section">
 +
  <p>Many SynBio groups are engineering microbes that could one day be useful in detecting diseases, fighting cancer and monitoring heavy metals in rivers. However, engineered microbes may leak into the non-designated environment, posing threats to our natural ecosystem. This is a major hurdle towards the commercialization of engineered microbes. To address this, we need effective kill switches to prevent engineered microbes from escaping into the environment. However, existing kill switches have limitations and, more importantly, it is difficult to readily tailor make kill switches for different applications.</p><br>
 +
<p>
 +
Currently, there is no harmonized framework for kill switch design and construction. Team NUSgem aims to make engineering of such customised, effective kill switches easier. To this end, we are developing a library of characterized sensors, a killing and verification module which can be used in computer-aided design and modelling tool (such as <a href ="http://www.cellocad.org/"> CELLO</a> and <a href="http://advancesyn.com/"> AdvanceSyn Studio </a>) and can be readily modelled. As a proof of concept, we will focus on developing a kill switch for engineered probiotics for human health.</p>
 +
 
 +
<p>
 +
We are a team of 6 undergraduates and 1 recent graduate student from different disciplines including Biomedical Engineering, Electrical Engineering, Science and Economics.</p>
 +
</div>
 +
 
 +
<div class="column smaller_section">
 +
    <img src="https://static.igem.org/mediawiki/2017/3/31/NUS_2017_IGEM_badbacteria.png">
 +
    <img src="https://static.igem.org/mediawiki/2017/6/6b/NUS_2017_IGEM_goodbacteria.png">
 +
</div>
  
 
<div class="clear"></div>
 
<div class="clear"></div>
 +
<!--**************************************** Video with Explanation Section ****************************************-->
 +
<div class="video_container">
 +
    <video controls poster="https://static.igem.org/mediawiki/2017/9/91/NUS_2017_IGEM_outline_cover.png">
 +
      <source src="https://static.igem.org/mediawiki/2017/6/6f/NUS_2017_IGEM_Videooverview.mp4" type="video/mp4">
 +
    </video>
 +
</div>
  
−
<div class="column full_size" >
+
<!--********** Make seperation between two different sections **********-->
−
<h2>Project Abstract </h2>
+
−
<p> Recent advancements in engineered probiotics have enabled a host of novel whole-cell-mediated medical therapeutics and diagnostics. One such example is scientists using engineered microbes to successfully target tumours in the gastrointestinal tract with minimal collateral damage and invasion. Critical to the function of many such applications are control systems that allow for spatial and temporal activation of the engineered microbe at specific target sites. However, since many existing control systems rely on single input triggers such as temperature or auxotrophy, their reliability is often limited because of evolutionary mutations and environmental perturbations. <br><br>
+
  
−
Team NUSgem proposes a novel active biocontainment system for the human gut with enhanced specificity and safeguard. Our cascaded toxin-antitoxin killswitch is configured to achieve an OR gate logic upon detection of a physical (temperature) and chemical (phosphate) input. Upon detection of a wastewater environment outside of the human body, the system will inhibit the expression of anti-toxin IM2, thereby allowing the toxin E2 to destroy the engineered microbe. Moreover, we use the bidirectional properties of the pTlpA36 promoter to express the verification of engineered microbe death. <br>
+
<!--**************************************** Homepage Gallery ****************************************-->
−
</p>  
+
  <h1>Learn More</h1>
 +
<!--1st image_INTERLAB STUDY-->
 +
<div class="polaroid"> 
 +
 
 +
  <img src="https://static.igem.org/mediawiki/2017/5/56/NUS_2017_IGEM_home_interlab.png" alt="#" style="width:100%;display: block;height:180px">
 +
 
 +
  <div class="gallery-intro-container">
 +
    <a href="https://2017.igem.org/Team:NUS_Singapore/InterLab">INTERLAB STUDY</a>
 +
  </div>
 +
 
 +
  <div class="gallery-overlay" style="background-color: #ffccbc">
 +
    <div class="gallery-overlay-text"><a href="https://2017.igem.org/Team:NUS_Singapore/InterLab">Interlab Study</a></div>
 +
  </div>
  
 
</div>
 
</div>
  
−
<div class="column half_size">
+
<!--2nd image_MODELLING-->
−
<img src="https://files.slack.com/files-tmb/T4FFUCVE3-F5RFNHZJM-06c4c709c0/img_20170522_154132_1024.jpg" width="300" height="200" margin-right:10px;></div>
+
<div class="polaroid">
 +
 
 +
  <img src="https://static.igem.org/mediawiki/2017/c/cc/NUS_2017_IGEM_home_modelling.png" alt="modelling" style="width:100%;display: block;height:180px">
 +
 
 +
  <div class="gallery-intro-container">
 +
    <a href="https://2017.igem.org/Team:NUS_Singapore/Model">MODELLING</a>
 +
  </div>
  
−
<div class="column half_size">
+
  <div class="gallery-overlay" style="background-color: #b2dfdb">
−
<img src="https://files.slack.com/files-tmb/T4FFUCVE3-F5WVBHXD0-13d3a0a8da/image_uploaded_from_ios_720.jpg" width="300" height="200" margin-left:10px;></div>
+
    <div class="gallery-overlay-text"><a href="https://2017.igem.org/Team:NUS_Singapore/Model">Modelling</a></div>
 +
  </div>
  
 +
</div>
  
−
<div class="column full_size" >
+
<!--3rd image_COLLABORATION-->
−
<h3 style="clear:both"> Awards Criteria </h3>
+
<div class="polaroid">
−
<p style="text-align:center"><a href="https://2017.igem.org/Judging/Pages_for_Awards">Pages for awards</a></p>
+
 
−
</div>  
+
  <img src="https://static.igem.org/mediawiki/2017/b/be/NUS_2017_IGEM_home_collaboration.png" alt="Collaboration" style="width:100%;display: block;height:180px">
 +
 
 +
  <div class="gallery-intro-container">
 +
    <a href="https://2017.igem.org/Team:NUS_Singapore/Collaborations" >COLLABORATION</a>
 +
  </div>
  
 +
  <div class="gallery-overlay" style="background-color: #c5cae9">
 +
    <div class="gallery-overlay-text"><a href="https://2017.igem.org/Team:NUS_Singapore/Collaborations" >Collaboration</a></div>
 +
  </div>
 +
 +
</div>
 +
 +
<!--4th image_GALLERY-->
 +
<div class="polaroid">
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Latest revision as of 16:07, 1 November 2017

Measurement Modelling Medal Check List
Team Member Attributions
Collaboration
Silver Up Gold Integrated
Overview Methodology Kill Switch for Probiotics Kill Switch for BeeT
Description Interlab Study Parts Experiment Documentation Improvement Demonstrate Safety Future Works
Home

Making Engineering of Customised Kill Switches Easier

Many SynBio groups are engineering microbes that could one day be useful in detecting diseases, fighting cancer and monitoring heavy metals in rivers. However, engineered microbes may leak into the non-designated environment, posing threats to our natural ecosystem. This is a major hurdle towards the commercialization of engineered microbes. To address this, we need effective kill switches to prevent engineered microbes from escaping into the environment. However, existing kill switches have limitations and, more importantly, it is difficult to readily tailor make kill switches for different applications.


Currently, there is no harmonized framework for kill switch design and construction. Team NUSgem aims to make engineering of such customised, effective kill switches easier. To this end, we are developing a library of characterized sensors, a killing and verification module which can be used in computer-aided design and modelling tool (such as CELLO and AdvanceSyn Studio ) and can be readily modelled. As a proof of concept, we will focus on developing a kill switch for engineered probiotics for human health.

We are a team of 6 undergraduates and 1 recent graduate student from different disciplines including Biomedical Engineering, Electrical Engineering, Science and Economics.

Learn More

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INTERLAB STUDY
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