Difference between revisions of "Team:TU-Eindhoven"

 
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     <h1>Instructions</h1>
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    <p>Be aware that the CSS for these layouts is heavily commented. If you do most of your work in Design view, have a peek at the code to get tips on working with the CSS for the fixed layouts. You can remove these comments before you launch your site. To learn more about the techniques used in these CSS Layouts, read this article at Adobe's Developer Center - <a href="http://www.adobe.com/go/adc_css_layouts">http://www.adobe.com/go/adc_css_layouts</a>.</p>
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<title>Menu</title>
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    <p>Since this is a one-column layout, the .content is not floated. </p>
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    <p>An image placeholder was used in this layout in the .header where you'll likely want to place  a logo. It is recommended that you remove the placeholder and replace it with your own linked logo. </p>
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    <p> Be aware that if you use the Property inspector to navigate to your logo image using the SRC field (instead of removing and replacing the placeholder), you should remove the inline background and display properties. These inline styles are only used to make the logo placeholder show up in browsers for demonstration purposes. </p>
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    <p>To remove the inline styles, make sure your CSS Styles panel is set to Current. Select the image, and in the Properties pane of the CSS Styles panel, right click and delete the display and background properties. (Of course, you can always go directly into the code and delete the inline styles from the image or placeholder there.)</p>
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<ul class="topbar">
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<li class="picture"><a href="#"><img src="https://static.igem.org/mediawiki/2017/e/e3/T--TU-Eindhoven--HomeFinal.png " width="128" height="60" alt="Home_Icon" /></a></li>
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     <li><a href="#">Home</a></li>
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</ul>
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<br/><br/><br/><br/><br/><br/><br/><br/>
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<h1>GUPPI: Gelation Using Protein Protein Interactions</h1>
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<div class="team">
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<img src="https://static.igem.org/mediawiki/2017/4/48/T--TU-Eindhoven--team.png" width="642" height="482" alt="Team_Picture" />
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</div><br/>
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<h2>The TU Eindhoven team of 2017 has won a golden medal and was nominated for Best New Application!</h2>
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<div class="logo">
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<table>
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<td class="hoek"></td>
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<td align="center"><a href="https://2017.igem.org/Team:TU-Eindhoven/Human_Practices">Human Practices</a></td>
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<td><a href="https://2017.igem.org/Team:TU-Eindhoven/Safety">Safety</a>
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    </td>
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<td rowspan="2"><img src="https://static.igem.org/mediawiki/2017/7/7e/T--TU-Eindhoven--Logo_home.png" width="440" height="400" alt="1" /></td>
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<td><a href="https://2017.igem.org/Team:TU-Eindhoven/Project">Project</a></td>
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<tr>
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<td><a href="https://2017.igem.org/Team:TU-Eindhoven/Results">Results<br/><br/><br/><br/><br/><br/><br/><br/><br/><br/></a></td>
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<td><a href="https://2017.igem.org/Team:TU-Eindhoven/Team">Team</a></td>
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<td align="center"><a href="https://2017.igem.org/Team:TU-Eindhoven/Model">Model</a></td>
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<h6>
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Cancer is a major cause of death worldwide. With our project, GUPPI, we hope to set the basics of a system that can encapsulate the cancerous tissue to prevent metastasis in an early stage. GUPPI utilizes Protein Protein Interactions and is inspired by the formation of membraneless organelles by multivalent interactions. A designed protein scaffold and its binding partner, both having sequential repeating units, will respond to an inducer and form a gel-like structure. We envision that later on, GUPPI can respond to extracellular conditions that will act as an inducer of the gelation to specifically target and encapsulate the desired tissue. The GUPPI system has some major advantages, such as the tunability of the protein’s multivalency and the possible adaptation of interactions. Furthermore, a rule-base-model is developed to predict, verify and characterize the wet-lab experiments and act as an additional support.<br/><br/>
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Below, an animation is shown which shows the formation of the gel-like structure. The scaffold protein is depicted in light-blue and its binding partner is depicted in orange.<br/><br/>
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</h6>
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<video width="1000" height="600" controls>
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<source src="https://static.igem.org/mediawiki/2017/7/74/Construct720c.mp4" type="video/mp4">
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Latest revision as of 10:35, 15 December 2017

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GUPPI: Gelation Using Protein Protein Interactions

Team_Picture

The TU Eindhoven team of 2017 has won a golden medal and was nominated for Best New Application!




Cancer is a major cause of death worldwide. With our project, GUPPI, we hope to set the basics of a system that can encapsulate the cancerous tissue to prevent metastasis in an early stage. GUPPI utilizes Protein Protein Interactions and is inspired by the formation of membraneless organelles by multivalent interactions. A designed protein scaffold and its binding partner, both having sequential repeating units, will respond to an inducer and form a gel-like structure. We envision that later on, GUPPI can respond to extracellular conditions that will act as an inducer of the gelation to specifically target and encapsulate the desired tissue. The GUPPI system has some major advantages, such as the tunability of the protein’s multivalency and the possible adaptation of interactions. Furthermore, a rule-base-model is developed to predict, verify and characterize the wet-lab experiments and act as an additional support.

Below, an animation is shown which shows the formation of the gel-like structure. The scaffold protein is depicted in light-blue and its binding partner is depicted in orange.

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