Difference between revisions of "Team:TU-Eindhoven"

 
(290 intermediate revisions by 3 users not shown)
Line 1: Line 1:
−
{{TU-Eindhoven}}
+
<!--{{TU-Eindhoven}}-->
 
{{TU-Eindhoven_menu}}
 
{{TU-Eindhoven_menu}}
−
{{TU-Eindhoven_footer}}
 
  
−
  <div class="content">
+
<html>
−
    <h1>Lorem Ipsum</h1>
+
<head>
−
<p>Lorem ipsum dolor sit amet, consectetur adipiscing elit. Etiam nec dolor sed elit pretium tempus non quis nibh. Nullam felis diam, mattis sit amet tortor vitae, pulvinar faucibus leo. Suspendisse eu mattis ante, in commodo diam. Cras nec tristique neque, ut egestas felis. Nunc feugiat ligula a ante tempor dictum. Donec pharetra ligula ante. Nulla placerat, nulla ac ultrices iaculis, urna elit bibendum quam, id rutrum nisl dolor vel lorem. Phasellus sit amet sapien sit amet enim consequat finibus a eu lorem. Nunc non dui eu lacus feugiat egestas at in lacus. Fusce hendrerit rutrum nisi, vel tristique ante dictum eget. Proin tempor massa dui, at scelerisque massa accumsan eget. Fusce venenatis ipsum ut porttitor mollis. Fusce sagittis erat non ante ultricies facilisis in et purus.</p>
+
<meta charset="utf-8">
 +
<title>Menu</title>
 +
<style type="text/css">
  
−
<p>Nulla sit amet turpis ac urna condimentum auctor ac ut diam. Suspendisse potenti. Donec lobortis risus id felis porttitor fringilla. In convallis interdum dolor, sed commodo lorem posuere ac. Quisque non diam lacinia, facilisis odio non, laoreet neque. Quisque congue sapien at vulputate ullamcorper. Donec sit amet est hendrerit, hendrerit massa in, suscipit eros. Fusce condimentum urna nisi, eget dignissim metus tincidunt ut. Curabitur vel mi id nisl ornare molestie. Curabitur ut iaculis leo. Maecenas gravida, dui sit amet tincidunt fermentum, dui erat semper velit, pellentesque placerat augue mauris rhoncus sem. Mauris odio leo, pretium sit amet ante in, placerat gravida lorem. In tristique, sapien ac auctor posuere, nibh metus placerat sem, at porttitor nibh nulla quis nibh.</p>
+
<!--
  
−
<p>Morbi suscipit, mi et eleifend venenatis, purus erat venenatis lacus, eu congue neque lacus et lorem. Integer in facilisis nunc. Fusce et tellus venenatis, egestas tellus luctus, elementum mi. Vestibulum in nibh vel nisi bibendum porttitor. Etiam et semper nunc. Vivamus efficitur vehicula tortor. Nam ullamcorper malesuada cursus.</p>
+
h1{
  
−
<p>Ut ut felis nibh. Phasellus lobortis turpis sit amet libero maximus congue. Morbi vitae leo at felis rhoncus feugiat ut eget ipsum. Fusce id vestibulum lorem, sed sodales enim. Maecenas posuere eros ligula, at varius ex venenatis eget. Nam hendrerit nibh ac nulla ultrices, semper venenatis velit feugiat. Sed sit amet felis bibendum, placerat eros ut, aliquam nibh. Cras dictum diam sed odio faucibus iaculis.</p>
+
      width:1000px;
 +
      text-align: center;
 +
      color: #000080;
 +
}
 +
h6{
 +
      text-align: justify;
 +
      width:1000px;
 +
      height:250px;
 +
      color: #34363A;
 +
}
 +
.logo{
 +
      margin-left:400px;
 +
      height:500px;
 +
      align:center;}
 +
table{
 +
    font-family: Verdana, Geneva, sans-serif;
 +
    line-height:normal;
 +
    color: #34363A;
 +
    font-weight:bold;
 +
    font-size:17px;
 +
    align:center;}
 +
table, tr, td, th{
 +
    border: 2px solid #B0E0E6;}
  
−
<p>Sed pharetra magna eros, sit amet ornare arcu commodo eu. Nunc sed ex porta, pharetra risus quis, placerat erat. Morbi augue purus, pharetra ac nulla eget, consectetur blandit elit. Etiam ornare dolor et nunc sollicitudin dapibus. Integer eget orci purus. Vestibulum sit amet viverra risus, ut convallis nibh. Ut purus diam, vulputate in tristique a, gravida sed risus. Maecenas elementum laoreet orci id lacinia. Suspendisse feugiat consequat risus, quis sagittis dui tristique semper. Integer congue mattis tempor. Phasellus ut volutpat est. Nunc ac egestas neque. Integer suscipit eros sed mi eleifend sagittis.</p>
+
.hoek{background-color:#B0E0E6;}
−
    <!-- end .footer --></div>
+
 
 +
video{margin-left:221px;}
 +
 
 +
.text{
 +
    height:200px;}
 +
.team{margin-left:408px;}
 +
-->
 +
</style></head>
 +
 
 +
<body>
 +
<ul class="topbar">
 +
<li class="picture"><a href="#"><img src="https://static.igem.org/mediawiki/2017/e/e3/T--TU-Eindhoven--HomeFinal.png " width="128" height="60" alt="Home_Icon" /></a></li>
 +
    <li><a href="#">Home</a></li>
 +
</ul>
 +
<br/><br/><br/><br/><br/><br/><br/><br/>
 +
<h1>GUPPI: Gelation Using Protein Protein Interactions</h1>
 +
 
 +
<div class="team">
 +
<img src="https://static.igem.org/mediawiki/2017/4/48/T--TU-Eindhoven--team.png" width="642" height="482" alt="Team_Picture" />
 +
</div><br/>
 +
<h2>The TU Eindhoven team of 2017 has won a golden medal and was nominated for Best New Application!</h2>
 +
<div class="logo">
 +
<table>
 +
<tr>
 +
<td class="hoek"></td>
 +
<td align="center"><a href="https://2017.igem.org/Team:TU-Eindhoven/Human_Practices">Human Practices</a></td>
 +
<td class="hoek"></td>
 +
<tr>
 +
<td><a href="https://2017.igem.org/Team:TU-Eindhoven/Safety">Safety</a>
 +
    </td>
 +
<td rowspan="2"><img src="https://static.igem.org/mediawiki/2017/7/7e/T--TU-Eindhoven--Logo_home.png" width="440" height="400" alt="1" /></td>
 +
<td><a href="https://2017.igem.org/Team:TU-Eindhoven/Project">Project</a></td>
 +
<tr>
 +
<td><a href="https://2017.igem.org/Team:TU-Eindhoven/Results">Results<br/><br/><br/><br/><br/><br/><br/><br/><br/><br/></a></td>
 +
<td><a href="https://2017.igem.org/Team:TU-Eindhoven/Team">Team</a></td>
 +
</tr>
 +
<tr>
 +
<td class="hoek"></td>
 +
<td align="center"><a href="https://2017.igem.org/Team:TU-Eindhoven/Model">Model</a></td>
 +
<td class="hoek"></td>
 +
</tr>
 +
</table>
 +
</div>
 +
 
 +
<br/><br/><br/>
 +
 
 +
<div class="text">
 +
<h6>
 +
Cancer is a major cause of death worldwide. With our project, GUPPI, we hope to set the basics of a system that can encapsulate the cancerous tissue to prevent metastasis in an early stage. GUPPI utilizes Protein Protein Interactions and is inspired by the formation of membraneless organelles by multivalent interactions. A designed protein scaffold and its binding partner, both having sequential repeating units, will respond to an inducer and form a gel-like structure. We envision that later on, GUPPI can respond to extracellular conditions that will act as an inducer of the gelation to specifically target and encapsulate the desired tissue. The GUPPI system has some major advantages, such as the tunability of the protein’s multivalency and the possible adaptation of interactions. Furthermore, a rule-base-model is developed to predict, verify and characterize the wet-lab experiments and act as an additional support.<br/><br/>
 +
Below, an animation is shown which shows the formation of the gel-like structure. The scaffold protein is depicted in light-blue and its binding partner is depicted in orange.<br/><br/>
 +
</h6>
 +
</div>
 +
 
 +
 
 +
<video width="1000" height="600" controls>
 +
<source src="https://static.igem.org/mediawiki/2017/7/74/Construct720c.mp4" type="video/mp4">
 +
</video>
 +
 
 +
 
 +
 
 +
 
 +
</body>
 +
 
 +
 
 +
 
 +
</html>
 +
 
 +
{{TU-Eindhoven_footer}}

Latest revision as of 10:35, 15 December 2017

Menu

Menu









GUPPI: Gelation Using Protein Protein Interactions

Team_Picture

The TU Eindhoven team of 2017 has won a golden medal and was nominated for Best New Application!




Cancer is a major cause of death worldwide. With our project, GUPPI, we hope to set the basics of a system that can encapsulate the cancerous tissue to prevent metastasis in an early stage. GUPPI utilizes Protein Protein Interactions and is inspired by the formation of membraneless organelles by multivalent interactions. A designed protein scaffold and its binding partner, both having sequential repeating units, will respond to an inducer and form a gel-like structure. We envision that later on, GUPPI can respond to extracellular conditions that will act as an inducer of the gelation to specifically target and encapsulate the desired tissue. The GUPPI system has some major advantages, such as the tunability of the protein’s multivalency and the possible adaptation of interactions. Furthermore, a rule-base-model is developed to predict, verify and characterize the wet-lab experiments and act as an additional support.

Below, an animation is shown which shows the formation of the gel-like structure. The scaffold protein is depicted in light-blue and its binding partner is depicted in orange.

Footer







  • Logo TUe
  • Logo IBA
  • Logo PAMM
  • Logo ICMS