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<h1 class="bottomborder">The most neglected tropical disease</h1>
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<h3 class="rmvpadmarg">What is the problem</h3>
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<p>Some very informative text that will make the user click the link and learn more about our project</p>
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                                <p>Some very informative text that will make the user click the link and learn more about our project</p>
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<h2 class="bottomborder">Project description</h2>
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Envenomation by snakebite is one of the most neglected diseases with an estimated 5 million bites each year. These result in about 100,000 deaths and 400,000 disabilities annually. The only effective treatment is animal derived antivenoms, which frequently causes adverse reactions. As a result they are often only administered as a last resort.
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        <p>Envenomation by snakebite is one of the most neglected diseases with an estimated 5 million bites each year. These result in about 100,000 deaths and 400,000 disabilities annually. The only effective treatment is animal derived antivenoms, which frequently causes adverse reactions. As a result they are often only administered as a last resort.
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We aim to develop a detection-assay that enables us to determine what type of snake a snake bite patient is envenomed by. The strategy is to target distinguishable enzymatic features in the different snake venoms by developing suitable substrate-based diagnostic. We hope our diagnostic tool can be useful in identifying the relative composition of specific venom components in a blood sample and thereby allow for the safest course of treatment.
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See our <a href=https://2017.igem.org/Team:DTU-Denmark/Description>Project Description<a/>
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        <p>We aim to develop a detection-assay that enables us to determine what type of snake a snake bite patient is envenomed by. The strategy is to target distinguishable enzymatic features in the different snake venoms by developing suitable substrate-based diagnostic. We hope our diagnostic tool can be useful in identifying the relative composition of specific venom components in a blood sample and thereby allow for the safest course of treatment. See our <a href=https://2017.igem.org/Team:DTU-Denmark/Description>Project Description<a/>
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<!-- <p>Envenomation by snakebite is one of the most neglected diseases with an estimated 5 million bites. These result in about 100,000 deaths and 400,000 disabilities annually [1]. The only effective treatment is animal derived antivenoms, which frequently causes adverse reactions [2]. As a result they are often only administered as a last resort.</p>
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<!-- <p>Envenomation by snakebite is one of the most neglected diseases with an estimated 5 million bites. These result in about 100,000 deaths and 400,000 disabilities annually [1]. The only effective treatment is animal derived antivenoms, which frequently causes adverse reactions [2]. As a result they are often only administered as a last resort.</p>
 
<p>One of the major problems related to treatment of snake bites concerns the lack of identification of the snake. When bitten, it is difficult for most people to remember details about the snake, which makes it almost impossible to confidently administer the correct specific antivenom. Currently, if the snake cannot be identified, multispecies antivenom is used in a consequently higher dose leading to more severe side effects. By solving the venom identification problem it could potentially increase the survival rate of snake bite victims. This is due to decreased diagnosis time and less amount of antivenom necessary for treatment, thereby causing fewer adverse reactions in the patient [3].</p>
 
<p>One of the major problems related to treatment of snake bites concerns the lack of identification of the snake. When bitten, it is difficult for most people to remember details about the snake, which makes it almost impossible to confidently administer the correct specific antivenom. Currently, if the snake cannot be identified, multispecies antivenom is used in a consequently higher dose leading to more severe side effects. By solving the venom identification problem it could potentially increase the survival rate of snake bite victims. This is due to decreased diagnosis time and less amount of antivenom necessary for treatment, thereby causing fewer adverse reactions in the patient [3].</p>
 
<p>We aim to create a novel diagnostic platform by using synthetic biology derived protease activity assay to identify specific venom enzymes that, by developing suitable substrates, can investigate the relative composition of specific venom components in a blood sample. Our goal is to create a diagnostic tool that would make it possible for a clinician to quickly determine which antivenom is necessary, or if it is necessary at all.</p><br /><br />
 
<p>We aim to create a novel diagnostic platform by using synthetic biology derived protease activity assay to identify specific venom enzymes that, by developing suitable substrates, can investigate the relative composition of specific venom components in a blood sample. Our goal is to create a diagnostic tool that would make it possible for a clinician to quickly determine which antivenom is necessary, or if it is necessary at all.</p><br /><br />
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[1] Chippaux JP (1998). <em>Snake-bites: appraisal of the global situation.</em> Bulletin of the World Health Organization, 76(5),515-24.<br />
 
[1] Chippaux JP (1998). <em>Snake-bites: appraisal of the global situation.</em> Bulletin of the World Health Organization, 76(5),515-24.<br />
 
[2] Gutiérrez JM, León G, Lomonte B, Angulo Y (2011). <em>Antivenoms for Snakebite Envenomings. Inflammation and Allergy.</em> Drug Targets 10(5), 369–80.<br />
 
[2] Gutiérrez JM, León G, Lomonte B, Angulo Y (2011). <em>Antivenoms for Snakebite Envenomings. Inflammation and Allergy.</em> Drug Targets 10(5), 369–80.<br />
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[3] Warrell D, Gutierrez JM, Padilla A (2007). <em>Rabies and Envenomings: a Neglected Public Health Issue: Report of a Consultative Meeting.</em> World Health Organization, Geneva.</p> -->
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[3] Warrell D, Gutierrez JM, Padilla A (2007). <em>Rabies and Envenomings: a Neglected Public Health Issue: Report of a Consultative Meeting.</em> World Health Organization, Geneva.</p>-->
  
 
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Revision as of 19:58, 16 July 2017

Snakebite Detectives

iGEM 2017

The most neglected tropical disease

What is the problem

Some very informative text that will make the user click the link and learn more about our project

Where is the problem

Some more very informative text that will make the user click the link and learn more about our project

Project description

Envenomation by snakebite is one of the most neglected diseases with an estimated 5 million bites each year. These result in about 100,000 deaths and 400,000 disabilities annually. The only effective treatment is animal derived antivenoms, which frequently causes adverse reactions. As a result they are often only administered as a last resort.

We aim to develop a detection-assay that enables us to determine what type of snake a snake bite patient is envenomed by. The strategy is to target distinguishable enzymatic features in the different snake venoms by developing suitable substrate-based diagnostic. We hope our diagnostic tool can be useful in identifying the relative composition of specific venom components in a blood sample and thereby allow for the safest course of treatment. See our Project Description