Difference between revisions of "Team:XJTLU-CHINA"

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<h1 style="font-weight:900;text-align:center;">Overview</h1>
 
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    <h1 style="color:#428bca;"><i>S. aureus</i> Intestinal Colonization</h1>
 
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<p>Human intestine is a highly complex microbial ecosystem. It accommodates commensal microflora species, various types of secretory fluids, fermentation metabolites and host defense molecules that promote colonization resistance to pathogenic bacteria. However, <i>Staphylococcus aureus</i>, one of the most opportunistic and invasive pathogens, is capable of disrupting this colonization resistance and infecting the intestine. Patients with <i>S. aureus</i> intestinal colonization suffer from fecal incontinence, diarrhea, pseudomembranous colitis and so on.
 
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<h1 style="font-weight:bolder;font-family: 'PT Serif', serif;color:#006934; ">Collaborators and Supporters</h1>
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        <a href="http://www.synbio-tech.com.cn"><img class="" src="https://static.igem.org/mediawiki/2017/3/38/Synbio_tech_logo.png"></a>
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<h1 style="color:#f0ad4e;">Antibiotic Overuse and Superbacteria</h1>
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<p>Due to antibiotic overuse, <i>Staphylococcus aureus</i> develops resistance to various antibiotics and it becomes increasingly difficult to be eliminated. As a leading cause of hospital-acquired infections, methicillin-resistant <i>S. aureus</i> (MRSA) strains are multi-antibiotic resistant. Even the use of vancomycin — one of the last therapeutic resorts against <i>S. aureus</i>, becomes futile. Worse still, community-acquired MRSA strains are much more virulent and cause more morbidity and mortality than hospital-acquired MRSA.
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        <a href="http://www.wx2h.com/web/index.php"><img src="https://static.igem.org/mediawiki/2017/f/f7/Wuxi_no2_hospital_logo.png"></a>
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        <a href="http://www.chinapeptides.qianyan.biz"><img src="https://static.igem.org/mediawiki/2017/7/7d/Qiangyao_logo.png"></a>
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<h1 style="color:#d9534f">Antimicrobial Peptides — A Promising Alternative To Antibiotics</h1>
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<p>Antimicrobial peptides (AMPs) have a reputation for their efficient antimicrobial activity against bacteria, fungi and protozoa. Despite of some promising results in clinical trials, AMPs have difficulties to be made into drugs due to their poor metabolic stability in human body. Therefore, our project aims to genetically engineer <i>Lactococcus lactis</i> (Grenadier Guards) to closely detect <i>S. aureus</i> and throw AMPs (grenades) to eradicate them within a short time after infection.
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        <a href="https://www.snapgene.com"><img src="https://static.igem.org/mediawiki/2017/c/cb/Snapgene_logo.png"></a>
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<h1 style="color:#5bc0de;">Further Applications</h1>
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<p>Our genetically engineered <i>Lactococcus lactis</i> can be made into medicines, such as enteric coated tablets, together with anti-diarrheal medicines, to cure enteritis. In addition, as an important industrial microorganism, <i>L. lactis</i> can be used as food additives in fermented dairy products such as cheese, and yogurt. When they inhabit in the intestinal tract, not only do they regulate micro-ecological balance, but also prevent or reduce the chance of infection.
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              <h4>Loaction</h4>
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              <p  style="text-align:center;">Rm 363, Science Building<br>
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              Xi'an Jiaotong-Liverpool University<br>
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              111 Ren'ai Road, Suzhou, China<br>
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              215123
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              <h4>Get in touch</h4>
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              <img src="https://static.igem.org/mediawiki/2017/1/19/XJTLU_email.png" alt="emali" width=30 height=30>
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              <p style="text-align:center;">igem@xjtlu.edu.cn</p>
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        <p style="text-align:center; color:white;">XJTLU-CHINA iGEM 2017</p>
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Revision as of 13:22, 5 August 2017

Home

Responsive image

Overview

Collaborators and Supporters

Loaction

Rm 363, Science Building
Xi'an Jiaotong-Liverpool University
111 Ren'ai Road, Suzhou, China
215123

Get in touch

emali

igem@xjtlu.edu.cn

XJTLU-CHINA iGEM 2017