Difference between revisions of "Team:ColumbiaNYC/Model"

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         <br>
 
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         <h4 style="text-align:left">Rate of mRNA degradation/decay</h4>
 
         <h4 style="text-align:left">Rate of mRNA degradation/decay</h4>
         <p>$mRNA\xrightarrow[\text{deg_{nonspec}}]{\text{}}degmRNA$</p>
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         <p>$mRNA\xrightarrow[\text{deg_{nonspec}}]{\text{ }}$</p>
 
       </div>
 
       </div>
  

Revision as of 20:37, 6 October 2017

Modelling

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Modelling the relationship between siRNA and protein translation


$k_{m}=$ transcription rate of mRNA

$\delta([mRNA],[siRNA])=$ rate of mRNA degraded by siRNA

$\frac{d[mRNA]}{dt}=k_{m}-\delta([mRNA],[siRNA])$


$k_{T}=$ rate of protein translation

$d_{p}=$ decay rate of protein

$\frac{d[protein]}{dt}=k_{T}[mRNA]-d_{p}[protein]$

Finding $\delta([mRNA],[siRNA])$

$\lambda=$ affinity of siRNA target site for siRNA guided RISC complex

$\kappa=$ mRNA cleave + dissociation rate of bound siRNA RISC

$siRNA^{*}=$ siRNA loaded (active) RISC complex

$siRNA^{*}_{bound}=$ mRNA bound siRNA^{*} complex


Rate of mRNA degradation/decay

$mRNA\xrightarrow[\text{deg_{nonspec}}]{\text{ }}$

A tetR decay model

Bacterial growth curves