Difference between revisions of "Team:ColumbiaNYC"

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               <h2>shRNA-induced Oncogene Silencing as a Therapeutic Avenue for Cancer</h2>
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               <h1>shRNA</h1>
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               <h2>Columbia iGEM</h2>
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               <h2>developing an shRNA-induced Silencing Therapy for Cancer</h2>
 
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           <h2 class="featurette-heading">The Advantages to a
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           <h2 class="featurette-heading">This First Heading
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               <span class="text-muted">Synthetic Biology Approach</span>
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               <span class="text-muted">Will Catch Your Eye</span>
 
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           <p class="lead">A cornerstone in synthetic biology is the connection of distinct biological functions to create useful system level behavior. We can take advantage of how bacteria naturally localizes in tumors while failing to survive in healthy tissue in the body to use bacteria as a cancer-specific delivery mechanism. Also, bacteria can mass produce products, invade cells, and release the products directly into the cells. This allows easily-degraded compounds to be effective delivered into cancer cells. It also prevents these compounds from affecting healthy cells. The combination of these mechanisms creates a powerful, cancer-specific circuit for gene therapy. </p>
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           <h2 class="featurette-heading">Expanding the Possibilities of
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           <h2 class="featurette-heading">The Second Heading
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               <span class="text-muted">Gene Therapy</span>
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               <span class="text-muted">Is Pretty Cool Too.</span>
 
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           <p class="lead">Anticipating the applications of synthetic biology to healthcare, Columbia iGEM 2017 is devising a therapeutic approach to modulate mammalian gene expression at the post-transcriptional level. Recombinant E. coli with the capacity to invade mammalian cells will deliver an shRNA payload against an aberrantly expressed gene, for example an oncogene in cancer or proinflammatory cytokine in inflammation, to the host cytoplasm. This shRNA payload will then inhibit protein function, which can combat mutations that confer resistance to traditional therapies, as with the tyrosine kinase inhibitors gefitinib and imatinib.  
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           <h2 class="featurette-heading">The  
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           <h2 class="featurette-heading">The Third Heading
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               <span class="text-muted">Future Outlook</span>
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               <span class="text-muted">Will Seal the Deal.</span>
 
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           <p class="lead">Our mechanism to modulate mammalian gene expression can have a variety of applications, extending throughout as well as well beyond healthcare. The engineered bacteria would have a significant application to human health particularly in conditions characterized by aberrant gene expression, such as with oncogenes in cancer, cytokines in inflammation, and many others. For cancer applications, the engineered bacteria can be taken as an oral probiotic, which will then selectively localize in tumor cells to prove gene therapy.
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Revision as of 15:45, 13 July 2017

shRNA

developing an shRNA-induced Silencing Therapy for Cancer

This First Heading Will Catch Your Eye

Donec ullamcorper nulla non metus auctor fringilla. Vestibulum id ligula porta felis euismod semper. Praesent commodo cursus magna, vel scelerisque nisl consectetur. Fusce dapibus, tellus ac cursus commodo.

The Second Heading Is Pretty Cool Too.

Donec ullamcorper nulla non metus auctor fringilla. Vestibulum id ligula porta felis euismod semper. Praesent commodo cursus magna, vel scelerisque nisl consectetur. Fusce dapibus, tellus ac cursus commodo.

The Third Heading Will Seal the Deal.

Donec ullamcorper nulla non metus auctor fringilla. Vestibulum id ligula porta felis euismod semper. Praesent commodo cursus magna, vel scelerisque nisl consectetur. Fusce dapibus, tellus ac cursus commodo.