Team:TAS Taipei/Model

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Project

Experiment

Modeling

Prototype

Human Practice

Biosafety

About Us

Attributions

Home

Modeling

Computational Biology provides us insight on how to apply experimental data to real world applications!

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MODELING

Our model aims to facilitate the implementation of our proteorhodopsin (PR)-expressing bacteria and biofilm prototype in wastewater treatment plants (WWTPs). Using variables which are specific to any WWTP (such as flow rate and water retention time in each tank), we can determine the amount of bacteria or surface area of biofilm needed to reduce nanoparticle concentration in the treated effluent.

INTRODUCTION

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PROTEORHODOPSIN TRAPPING MODEL

Proteorhodopsin and citrate binding modeled as a ligand-receptor interaction

Determining NP binding rate (kon) and dissociation rate (koff) constants using experimental data

Example Application of Completed Model

Influent (Initial) NP Concentration in WWTP (umols/cm3)
Targeted Effluent (Initial) NP Concentration in WWTP (umols/cm3)
Volume of water in clarifier tank of WWTP (L)
Vertical velocity of water making contact with the biofilm (cm/minutes)
Time of contact between NP contaminated water and our biofilm construct (minutes)
cm2 of biofilm needed for clean up:

Calculations

BIOFILM TRAPPING MODEL

Evaluating the trapping rate through the change in substrate concentration and volumetric flow rate

Determining the significance of different factors

Surface Area

Biofilm time trial results, finding average trapping rate (per SA)

Calculator

Initial volume of clarifier tank (L)
Final volume of clarifier tank (L)
Initial concentration of NP in tank (micromolar)
Targeted final concentration on NP in tank (micromolar)
Vertical velocity of water (or velocity of water in contact with biofilm, cm/min)
Time for biofilm to be in contact with NP solution (minutes)
Surface area of biofilm needed (cm2)

REFERENCES

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