Our project combines the functionality of computational logic - powered by toehold switch driven recombinases - with the efficiency and simplicity of the Cell-Free transcription translation system to detect RNA and produce an input specific response. We anticipate applications in point-of-care diagnostic technologies such as those for Zika and Ebola developed by the Collins group at MIT, targeted at diseases with RNA profiles that are more computationally demanding, such as cancer. Now we understand that description is rather dense, but click on the links to learn more about each section of our project.
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