Difference between revisions of "Team:AFCM-Egypt"
Aymanshafei (Talk | contribs) |
Aymanshafei (Talk | contribs) |
||
| Line 180: | Line 180: | ||
</section> | </section> | ||
<!-- /#header --> | <!-- /#header --> | ||
| − | <div class="twitter-feed purple"> | + | <div class="twitter-feed purple" style="padding-bottom:250px"> |
<div class="container section-wrapper"> | <div class="container section-wrapper"> | ||
<div class="col-md-12 text-center"> | <div class="col-md-12 text-center"> | ||
<video width="800" height="450" controls style="border:1px solid #000;width: 800px;height: 450px;"> | <video width="800" height="450" controls style="border:1px solid #000;width: 800px;height: 450px;"> | ||
<source src="https://static.igem.org/mediawiki/2017/8/88/Final_vid.mp4" type="video/mp4"> | <source src="https://static.igem.org/mediawiki/2017/8/88/Final_vid.mp4" type="video/mp4"> | ||
| − | + | </video> | |
</div> | </div> | ||
Revision as of 14:36, 21 October 2017
Abstract
Competing endogenous RNA network : Potential entrants to gene editing in Hepatocellular Carcinoma
Hepatocellular Carcinoma (HCC) is the leading cause of cancer deaths worldwide & ranked first among cancers
in males and next to breast cancer among females in Egypt - based upon results of National Cancer Registry Program of Egypt-.
"Grabbing the problem from the roots" is the best way to decently describe the use of CRISPR, a special gene editing technique
that we will be using to modulate a certain circRNA and adjust its gene expression, which is down-regulated in hepatocellular carcinoma.
This in consequence modifies miRNA expression thus amending the mRNA gene expression; which is the visible problem in our trials.
This will lead us to adopt a novel strategy for miRNA suppression by using circRNAs. This is accomplished by utilizing a synthetic circuit to give rise to a springboard in our battle against cancer.
Hepatocellular Carcinoma (HCC) is the leading cause of cancer deaths worldwide & ranked first among cancers in males and next to breast cancer among females in Egypt - based upon results of National Cancer Registry Program of Egypt-. "Grabbing the problem from the roots" is the best way to decently describe the use of CRISPR, a special gene editing technique that we will be using to modulate a certain circRNA and adjust its gene expression, which is down-regulated in hepatocellular carcinoma. This in consequence modifies miRNA expression thus amending the mRNA gene expression; which is the visible problem in our trials. This will lead us to adopt a novel strategy for miRNA suppression by using circRNAs. This is accomplished by utilizing a synthetic circuit to give rise to a springboard in our battle against cancer.
AFCM-Egypt
We strive to excel
click here
