Difference between revisions of "Team:AFCM-Egypt"

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<h3 class="text-center" style="text-align: center;"><br /><br /><span style="font-size: 14pt; color: #ffffff;">Abstract</span></h3>
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<p><span style="font-size: 14pt; color: #ffffff;">&nbsp;</span></p>
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<h3 style="text-align: left;"><span style="font-size: 14pt; color: #ffffff;">Competing endogenous RNA network : Potential entrants to gene editing in Hepatocellular Carcinoma</span><br /><br /><br /><span style="font-size: 14pt; color: #ffffff;">Hepatocellular Carcinoma (HCC) is the leading cause of cancer deaths worldwide &amp; ranked first among cancers in males and next to breast cancer among females in Egypt - based upon results of National Cancer Registry Program of Egypt-. "Grabbing the problem from the roots" is the best way to decently describe the use of CRISPR, a special gene editing technique that we will be using to modulate a certain circRNA and adjust its gene expression, which is down-regulated in hepatocellular carcinoma. This in consequence modifies miRNA expression thus amending the mRNA gene expression; which is the visible problem in our trials. This will lead us to adopt a novel strategy for miRNA suppression by using circRNAs. This is accomplished by utilizing a synthetic circuit to give rise to a springboard in our battle against cancer.</span><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /></h3>
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                <h3>Competing endogenous RNA network : Potential entrants to gene editing in Hepatocellular Carcinoma </h4>
 
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Hepatocellular Carcinoma (HCC) is the leading cause of cancer deaths worldwide & ranked first among cancers
 
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in males and next to breast cancer among females in Egypt - based upon results of National Cancer Registry Program of Egypt-.
 
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"Grabbing the problem from the roots" is the best way to decently describe the use of CRISPR, a special gene editing technique
 
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that we will be using to modulate a certain circRNA and adjust its gene expression, which is down-regulated in hepatocellular carcinoma.
 
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This in consequence modifies miRNA expression thus amending the mRNA gene expression; which is the visible problem in our trials.
 
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This will lead us to adopt a novel strategy for miRNA suppression by using circRNAs. This is accomplished by utilizing a synthetic circuit to give rise to a springboard in our battle against cancer.
 
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Revision as of 13:42, 25 October 2017

A F C M



Abstract

 

Competing endogenous RNA network : Potential entrants to gene editing in Hepatocellular Carcinoma


Hepatocellular Carcinoma (HCC) is the leading cause of cancer deaths worldwide & ranked first among cancers in males and next to breast cancer among females in Egypt - based upon results of National Cancer Registry Program of Egypt-. "Grabbing the problem from the roots" is the best way to decently describe the use of CRISPR, a special gene editing technique that we will be using to modulate a certain circRNA and adjust its gene expression, which is down-regulated in hepatocellular carcinoma. This in consequence modifies miRNA expression thus amending the mRNA gene expression; which is the visible problem in our trials. This will lead us to adopt a novel strategy for miRNA suppression by using circRNAs. This is accomplished by utilizing a synthetic circuit to give rise to a springboard in our battle against cancer.















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