Difference between revisions of "Team:ASIJ TOKYO/Experiments"
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Revision as of 07:36, 31 October 2017
What is CRC?
Colorectal cancer (CRC), or colon/bowel cancer, is a common form of cancer that most frequently develops starting with polyps. In 2014, an estimated 1.3 million people lived with colon and rectum cancer in the United States. In fact, about 1 in 20 men and women are expected to have colon cancer at some point in their life. CRC is caused by the APC gene, or activating mutation in β-catenin, which results in the accumulation of β-catenin and subsequent complex formation with TCF/LEF transcription factors. Excessive β-catenin can interact with TCF to activate the transcription of proliferative genes, such as c-MYC and cyclin D1, in the colon.
Pictures
Project Motivations
After speaking to Minako Abe, an immunologist, we became aware of the immense prevalence and impact--especially in Japan--of colorectal cancer. In Japan alone, in 2015, there were almost 50,000 deaths from colorectal cancer, marking a sudden, sharp spike in the number of young adults that were diagnosed with this cancer. Finding out that two faculty members at our school were survivors of this disease further cemented our belief in the importance of addressing it at its root. The issue is especially prevalent in Japan mostly because the younger generation is not fully aware on how common colorectal cancer is becoming and because they are not checking up on their bodies as frequently as they should be. This motivated us to not limit our project on only addressing early detection of CRC, but also raising awareness.
