Difference between revisions of "Team:BGIC-Union"

Line 1: Line 1:
−
<HTML>
+
 
 +
<html>
 +
  <head>
 +
  <html>
 +
  <head>
 
     <meta charset="utf-8">
 
     <meta charset="utf-8">
 
    
 
    
Line 5: Line 9:
  
  
−
     <title>Safety</title>
+
     <title>Team：BGIC-Union</title>
  
 
   <head>
 
   <head>
 
    
 
    
−
        <link href='http://fonts.googleapis.com/css?family=Lato:400,300' rel='stylesheet' type='text/css'>
 
−
        <link href='http://fonts.googleapis.com/css?family=Raleway:400,300,500' rel='stylesheet' type='text/css'>
 
  
 
   <!-- Bootstrap core CSS -->
 
   <!-- Bootstrap core CSS -->
Line 19: Line 21:
 
   <link href="https://2017.igem.org/Template:BGIC-Union/owlcarousel-css?action=raw&amp;ctype=text/css" rel="stylesheet">
 
   <link href="https://2017.igem.org/Template:BGIC-Union/owlcarousel-css?action=raw&amp;ctype=text/css" rel="stylesheet">
 
   <link href=" https://2017.igem.org/Template:BGIC-Union/fontawesomemin2-css?action=raw&amp;ctype=text/css" rel="stylesheet">
 
   <link href=" https://2017.igem.org/Template:BGIC-Union/fontawesomemin2-css?action=raw&amp;ctype=text/css" rel="stylesheet">
−
    
+
   <!-- light -->
 +
<style type="text/css">
 +
/* fixed line holder */
 +
.timelineLight .timeline_line {c
 +
margin-top:50px;
 +
margin-bottom:10px;
 +
width:900px;
 +
}
 +
.timelineLight
 +
{color: #fff;
 +
background: #ffe4e1;}
 +
/* full (including months that are not shown) line holder */
 +
.timelineLight .t_line_holder {
 +
height:80px;
 +
background:url('https://static.igem.org/mediawiki/2017/3/35/Line.jpg') repeat-x 0px 39px;
 +
}
 +
 
 +
/* 2 months are stored in one view */
 +
.timelineLight .t_line_view {
 +
height:20px;
 +
width:900px;
 +
}
 +
 
 +
/* holder for year number */
 +
.timelineLight h3.t_line_year {
 +
margin:0;
 +
color:#545454;
 +
}
 +
 
 +
/* holder for 1 month (constist of nodes and month caption) - we use borders to separate months thats why it has width 2px less then 50% */
 +
.timelineLight .t_line_m {
 +
margin-top:35px;
 +
height:10px;
 +
border-left:1px solid #545454;
 +
border-right:1px solid #545454;
 +
width:448px;
 +
}
 +
 
 +
/* month on the right side - has left set at 459 so border would overlap border from first element (to evade duplicated borders) */
 +
.timelineLight .t_line_m.right {
 +
left:449px;
 +
width:449px;
 +
}
 +
 
 +
/* month caption */
 +
.timelineLight h4.t_line_month {
 +
margin:-30px 0 0;
 +
color:#545454;
 +
}
 +
 
 +
/* used in responsive layout when only one month is shown (it is span containing year) */
 +
.t_line_month_year {
 +
display:none;
 +
}
 +
 
 +
/* node on the timeline */
 +
.timelineLight a.t_line_node {
 +
text-decoration:none;
 +
padding:38px 0 4px;
 +
height:10px;
 +
font-size:12px;
 +
top:-25px;
 +
background:url('https://static.igem.org/mediawiki/2017/2/2a/Dot.png') no-repeat center 24px;
 +
color:#141817;
 +
}
 +
.timelineLight a.t_line_node:hover {
 +
background:url('https://static.igem.org/mediawiki/2017/6/65/Dot-rollover.png') no-repeat center 24px;
 +
}
 +
.timelineLight a.t_line_node.active {
 +
background:url('https://static.igem.org/mediawiki/2017/d/d7/Dot-selected.png') no-repeat center 24px;
 +
}
 +
 
 +
/* node description */
 +
.timelineLight .t_node_desc {
 +
background: rgba(26,134,172,0.9);
 +
top:0;
 +
color:#fff;
 +
padding:1px 5px;
 +
}
 +
 
 +
/* descriptions on right side go from right to left */
 +
.timelineLight .t_node_desc.pos_right {
 +
right:0;
 +
}
 +
 
 +
/* line arrow left */
 +
.timelineLight #t_line_left {
 +
cursor:pointer;
 +
left:-30px;
 +
top:30px;
 +
width:14px;
 +
height:19px;
 +
background:url('https://static.igem.org/mediawiki/2017/9/95/Bgic-arrow.png') no-repeat left top;
 +
}
 +
 
 +
.timelineLight #t_line_left:hover {
 +
background:url('https://static.igem.org/mediawiki/2017/9/95/Bgic-arrow.png') no-repeat left bottom;
 +
}
 +
 
 +
/* line arrow right */
 +
.timelineLight #t_line_right {
 +
cursor:pointer;
 +
right:-30px;
 +
top:30px;
 +
width:14px;
 +
height:19px;
 +
background:url('https://static.igem.org/mediawiki/2017/9/95/Bgic-arrow.png') no-repeat right top;
 +
}
 +
 
 +
.timelineLight #t_line_right:hover {
 +
background:url('https://static.igem.org/mediawiki/2017/9/95/Bgic-arrow.png') no-repeat right bottom;
 +
}
 +
.timelineLight {
 +
display:none;
 +
}
 +
 
 +
/* items container */
 +
.timelineLight .timeline_items {
 +
padding:10px 0;
 +
}
 +
 
 +
/* single item (margines set from javascript) */
 +
.timelineLight .item {
 +
height:380px;
 +
text-align:center;
 +
 +
color: #fff;
 +
background: #f7dae7;
 +
 +
-moz-box-shadow: -3px 1px 6px rgba(0,0,0,0.4);
 +
-webkit-box-shadow: -3px 1px 6px rgba(0,0,0,0.4);
 +
box-shadow: -3px 1px 6px rgba(0,0,0,0.4);
 +
width:200px;
 +
}
 +
 
 +
/* ----- content - non-plugin elements ----- */
 +
.timelineLight .item img class="center"{
 +
margin-top:0;
 +
width:200px;
 +
}
 +
 
 +
.timelineLight .item span{
 +
display:block;
 +
margin:0px 20px 10px;
 +
height:150px;
 +
}
 +
.timelineLight .item .read_more {
 +
padding:2px 8px 2px 10px;
 +
font-family:Comic Sans MS;
 +
font-size:20px;
 +
float:right;
 +
color:#ffffff;
 +
background: rgba(0,0,0,0.35);
 +
cursor:pointer;
 +
}
 +
.timelineLight .item .read_more:hover {
 +
background:rgb(26,134,172);
 +
}
 +
/* ----------------------------------------- */
 +
 
 +
/* item details (margines set from javascript) */
 +
.timelineLight .item_open {
 +
height:380px;
 +
background:url('../images/timeline/light/background.jpg') repeat;
 +
position:relative;
 +
color:#545454;
 +
z-index:2;
 +
-moz-box-shadow: 0px 0px 6px rgba(0,0,0,0.4);
 +
-webkit-box-shadow: 0px 0px 6px rgba(0,0,0,0.4);
 +
box-shadow: 0px 0px 6px rgba(0,0,0,0.4);
 +
width:490px;
 +
 +
}
 +
 
 +
/* item details content wrapper (used for animation - shuld have same width as .item_open) */
 +
.timelineLight .item_open_cwrapper {
 +
width:490px;
 +
}
 +
 
 +
/* ----- content - non-plugin elements ----- */
 +
.timelineLight .timeline_open_content {
 +
padding:20px;
 +
}
 +
 
 +
.timelineLight .item_open h2 {
 +
margin-top:10px;
 +
padding-top:0;
 +
font-size:28px;
 +
}
 +
.timelineLight .item_open .t_close {
 +
position:absolute;
 +
top:10px;
 +
right:10px;
 +
padding:2px 8px 2px 10px;
 +
font-family: Comic Sans MS;
 +
font-size:20px;
 +
color:#ffffff;
 +
background: rgba(0,0,0,0.25);
 +
cursor:pointer;
 +
}
 +
.timelineLight .item_open .t_close:hover {
 +
background:rgb(26,134,172);
 +
}
 +
/* ----------------------------------------- */
 +
 
 +
/* left/right controles */
 +
.timelineLight .t_controles {
 +
margin:10px auto;
 +
text-align:center;
 +
}
 +
.timelineLight .t_left,
 +
.timelineLight .t_right {
 +
display:inline-block;
 +
height:50px;
 +
width:29px;
 +
margin:10px;
 +
cursor:pointer;
 +
}
 +
.timelineLight .t_left, 
 +
.timelineLight .t_left:hover:active {
 +
background: url('https://static.igem.org/mediawiki/2017/b/ba/Big-arrow.png') no-repeat left top;
 +
}
 +
.timelineLight .t_left:hover {
 +
background: url('https://static.igem.org/mediawiki/2017/b/ba/Big-arrow.png') no-repeat left bottom;
 +
}
 +
 
 +
.timelineLight .t_right,
 +
.timelineLight .t_right:hover:active{
 +
background: url('https://static.igem.org/mediawiki/2017/b/ba/Big-arrow.png') no-repeat right top;
 +
}
 +
 
 +
.timelineLight .t_right:hover {
 +
background: url('https://static.igem.org/mediawiki/2017/b/ba/Big-arrow.png') no-repeat right bottom;
 +
}
 +
 
 +
/* -----------------------------------------------------------------------*/
 +
/* ------------------------------ RESPONSIVE -----------------------------*/
 +
/* -----------------------------------------------------------------------*/
 +
 
 +
 
 +
 
 +
/* --- 768px --- */
 +
@media screen and (max-width:980px) {
 +
 +
.timelineLight .timeline_line {
 +
width:680px;
 +
}
 +
 +
.timelineLight .t_line_view {
 +
width:680px;
 +
}
 +
 +
.timelineLight .t_line_m {
 +
width: 338px;
 +
}
 +
.timelineLight .t_line_m.right {
 +
left: 339px;
 +
width: 339px;
 +
}
 +
}
 +
 
 +
 
 +
/* --- 610px --- */
 +
@media screen and (max-width:767px) {
 +
 +
.timelineLight .timeline_line {
 +
width:530px;
 +
}
 +
 +
.timelineLight .t_line_view {
 +
width:1060px;
 +
}
 +
 +
.timelineLight .t_line_m {
 +
width: 528px;
 +
}
 +
.timelineLight .t_line_m.right {
 +
left: 530px;
 +
width: 528px;
 +
}
 +
.timelineLight .t_line_year {
 +
opacity:0;
 +
filter:alpha(opacity=0)
 +
}
 +
.timelineLight .t_line_month_year {
 +
display:inline;
 +
}
 +
 +
.timelineLight .t_line_node span {
 +
 +
}
 +
.timelineLight .t_node_desc {
 +
font-size:8px;
 +
}
 +
.timelineLight .t_node_desc.pos_right {
 +
right:auto;
 +
left:0;
 +
}
 +
}
 +
 
 +
 
 +
/* --- 300px --- */
 +
@media screen and (max-width:
 +
 
 +
) {
 +
.timelineLight .timeline_line {
 +
width:240px;
 +
}
 +
 +
.timelineLight .t_line_view {
 +
width:480px;
 +
}
 +
 +
.timelineLight .t_line_m {
 +
width: 238px;
 +
}
 +
.timelineLight .t_line_m.right {
 +
left: 240px;
 +
width: 238px;
 +
}
 +
 +
.timelineLight .item_open {
 +
width:280px;
 +
height:390px;
 +
}
 +
.timelineLight .item_open_cwrapper {
 +
width:280px;
 +
}
 +
}
 +
 
 +
 
 +
 
 +
 
 +
</style>
  
 
   <!-- main -->
 
   <!-- main -->
 
   <style type="text/css">
 
   <style type="text/css">
 
    
 
    
−
@import url(http://fonts.googleapis.com/css?family=Montserrat:400,700);
+
 
 
#top_title,#sideMenu { display: none !important; }
 
#top_title,#sideMenu { display: none !important; }
 
         #content {
 
         #content {
Line 33: Line 368:
 
         }
 
         }
  
−
 
+
#bodyContent
 +
{
 +
margin-top：0px !important;
 +
}
  
  
Line 41: Line 379:
  
  
−
+
.mainstyle
 +
{
 +
font-family: Comic Sans MS;
 +
}
 
html, body {
 
html, body {
−
     margin: 0 !important;
+
     margin: 0 ;
−
     padding: 0 !important;
+
     padding: 0 ;
 
}
 
}
 
body {
 
body {
−
   background-color: #FFe4e1;
+
   background-color: #ffa07a;
−
   font-family: 'Montserrat', sans-serif;
+
  
 
     font-weight: 400;
 
     font-weight: 400;
 
     font-size: 14px;
 
     font-size: 14px;
Line 59: Line 400:
 
/* Titles */
 
/* Titles */
 
h1, h2, h3, h4, h5, h6 {
 
h1, h2, h3, h4, h5, h6 {
−
font-family: 'Montserrat', sans-serif;
+
font-family: Comic Sans MS;
 
     font-weight: 700;
 
     font-weight: 700;
 
     color: #333;
 
     color: #333;
Line 72: Line 413:
  
  
−
/* Paragraph &amp; Typographic */
+
 
 
p {
 
p {
 
     line-height: 28px;
 
     line-height: 28px;
 
     margin-bottom: 25px;
 
     margin-bottom: 25px;
 
     font-size: 16px;
 
     font-size: 16px;
 +
font-family: Comic Sans MS;
 
}
 
}
  
Line 134: Line 476:
  
 
.navbar-inverse {
 
.navbar-inverse {
−
padding-bottom: 70px;
+
padding-bottom: 30px;
−
padding-top: 70px;
+
padding-top: 0;
 
}
 
}
  
Line 145: Line 487:
 
.navbar-inverse .navbar-nav > li > a {
 
.navbar-inverse .navbar-nav > li > a {
 
color: white;
 
color: white;
 +
 
}
 
}
 +
  
 
.navbar-inverse .navbar-nav > li > a:hover {
 
.navbar-inverse .navbar-nav > li > a:hover {
Line 153: Line 497:
 
.navbar-brand {
 
.navbar-brand {
 
font-weight: 700;
 
font-weight: 700;
−
font-size: 20px;
+
font-size: 40px;
 
letter-spacing: 2px;
 
letter-spacing: 2px;
 +
backgroud: white;
 
}
 
}
  
 
.navbar-inverse .navbar-brand {
 
.navbar-inverse .navbar-brand {
 
color: white;
 
color: white;
 +
background-color: #FFA07A;
 +
 
}
 
}
  
 
.navbar-inverse .navbar-toggle {
 
.navbar-inverse .navbar-toggle {
 
border-color: transparent;
 
border-color: transparent;
 +
font-size: 12px;
 
}
 
}
  
Line 200: Line 548:
 
#footer p {
 
#footer p {
 
color: white;
 
color: white;
 +
font-family: Comic Sans MS;
 
}
 
}
  
Line 286: Line 635:
 
   </style>
 
   </style>
 
    
 
    
 +
  <!-- script -->
 +
  <script src="https://code.jquery.com/jquery-1.10.2.min.js"></script>
 +
  <script type="text/javascript">
 +
  /*
 +
* jQuery Easing v1.3 - http://gsgd.co.uk/sandbox/jquery/easing/
 +
*
 +
* Uses the built in easing capabilities added In jQuery 1.1
 +
* to offer multiple easing options
 +
*
 +
* TERMS OF USE - jQuery Easing
 +
*
 +
* Open source under the BSD License.
 +
*
 +
* Copyright © 2008 George McGinley Smith
 +
* All rights reserved.
 +
*
 +
* Redistribution and use in source and binary forms, with or without modification,
 +
* are permitted provided that the following conditions are met:
 +
*
 +
* Redistributions of source code must retain the above copyright notice, this list of
 +
* conditions and the following disclaimer.
 +
* Redistributions in binary form must reproduce the above copyright notice, this list
 +
* of conditions and the following disclaimer in the documentation and/or other materials
 +
* provided with the distribution.
 +
*
 +
* Neither the name of the author nor the names of contributors may be used to endorse
 +
* or promote products derived from this software without specific prior written permission.
 +
*
 +
* THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND ANY
 +
* EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF
 +
* MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE
 +
*  COPYRIGHT OWNER OR CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL,
 +
*  EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE
 +
*  GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED
 +
* AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING
 +
*  NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED
 +
* OF THE POSSIBILITY OF SUCH DAMAGE.
 +
*
 +
*/
 +
 +
// t: current time, b: begInnIng value, c: change In value, d: duration
 +
jQuery.easing['jswing'] = jQuery.easing['swing'];
 +
 +
jQuery.extend( jQuery.easing,
 +
{
 +
def: 'easeOutQuad',
 +
swing: function (x, t, b, c, d) {
 +
//alert(jQuery.easing.default);
 +
return jQuery.easing[jQuery.easing.def](x, t, b, c, d);
 +
},
 +
easeInQuad: function (x, t, b, c, d) {
 +
return c*(t/=d)*t + b;
 +
},
 +
easeOutQuad: function (x, t, b, c, d) {
 +
return -c *(t/=d)*(t-2) + b;
 +
},
 +
easeInOutQuad: function (x, t, b, c, d) {
 +
if ((t/=d/2) < 1) return c/2*t*t + b;
 +
return -c/2 * ((--t)*(t-2) - 1) + b;
 +
},
 +
easeInCubic: function (x, t, b, c, d) {
 +
return c*(t/=d)*t*t + b;
 +
},
 +
easeOutCubic: function (x, t, b, c, d) {
 +
return c*((t=t/d-1)*t*t + 1) + b;
 +
},
 +
easeInOutCubic: function (x, t, b, c, d) {
 +
if ((t/=d/2) < 1) return c/2*t*t*t + b;
 +
return c/2*((t-=2)*t*t + 2) + b;
 +
},
 +
easeInQuart: function (x, t, b, c, d) {
 +
return c*(t/=d)*t*t*t + b;
 +
},
 +
easeOutQuart: function (x, t, b, c, d) {
 +
return -c * ((t=t/d-1)*t*t*t - 1) + b;
 +
},
 +
easeInOutQuart: function (x, t, b, c, d) {
 +
if ((t/=d/2) < 1) return c/2*t*t*t*t + b;
 +
return -c/2 * ((t-=2)*t*t*t - 2) + b;
 +
},
 +
easeInQuint: function (x, t, b, c, d) {
 +
return c*(t/=d)*t*t*t*t + b;
 +
},
 +
easeOutQuint: function (x, t, b, c, d) {
 +
return c*((t=t/d-1)*t*t*t*t + 1) + b;
 +
},
 +
easeInOutQuint: function (x, t, b, c, d) {
 +
if ((t/=d/2) < 1) return c/2*t*t*t*t*t + b;
 +
return c/2*((t-=2)*t*t*t*t + 2) + b;
 +
},
 +
easeInSine: function (x, t, b, c, d) {
 +
return -c * Math.cos(t/d * (Math.PI/2)) + c + b;
 +
},
 +
easeOutSine: function (x, t, b, c, d) {
 +
return c * Math.sin(t/d * (Math.PI/2)) + b;
 +
},
 +
easeInOutSine: function (x, t, b, c, d) {
 +
return -c/2 * (Math.cos(Math.PI*t/d) - 1) + b;
 +
},
 +
easeInExpo: function (x, t, b, c, d) {
 +
return (t==0) ? b : c * Math.pow(2, 10 * (t/d - 1)) + b;
 +
},
 +
easeOutExpo: function (x, t, b, c, d) {
 +
return (t==d) ? b+c : c * (-Math.pow(2, -10 * t/d) + 1) + b;
 +
},
 +
easeInOutExpo: function (x, t, b, c, d) {
 +
if (t==0) return b;
 +
if (t==d) return b+c;
 +
if ((t/=d/2) < 1) return c/2 * Math.pow(2, 10 * (t - 1)) + b;
 +
return c/2 * (-Math.pow(2, -10 * --t) + 2) + b;
 +
},
 +
easeInCirc: function (x, t, b, c, d) {
 +
return -c * (Math.sqrt(1 - (t/=d)*t) - 1) + b;
 +
},
 +
easeOutCirc: function (x, t, b, c, d) {
 +
return c * Math.sqrt(1 - (t=t/d-1)*t) + b;
 +
},
 +
easeInOutCirc: function (x, t, b, c, d) {
 +
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/*
 +
*
 +
* TERMS OF USE - EASING EQUATIONS
 +
*
 +
* Open source under the BSD License.
 +
*
 +
* Copyright © 2001 Robert Penner
 +
* All rights reserved.
 +
*
 +
* Redistribution and use in source and binary forms, with or without modification,
 +
* are permitted provided that the following conditions are met:
 +
*
 +
* Redistributions of source code must retain the above copyright notice, this list of
 +
* conditions and the following disclaimer.
 +
* Redistributions in binary form must reproduce the above copyright notice, this list
 +
* of conditions and the following disclaimer in the documentation and/or other materials
 +
* provided with the distribution.
 +
*
 +
* Neither the name of the author nor the names of contributors may be used to endorse
 +
* or promote products derived from this software without specific prior written permission.
 +
*
 +
* THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND ANY
 +
* EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF
 +
* MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE
 +
*  COPYRIGHT OWNER OR CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL,
 +
*  EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE
 +
*  GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED
 +
* AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING
 +
*  NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED
 +
* OF THE POSSIBILITY OF SUCH DAMAGE.
 +
*
 +
*/
 +
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</div><h1 class="center">Hi, I am dCasentry,</h1>
 
</div><h1 class="center">Hi, I am dCasentry,</h1>
−
<div>a T7—dCas9 multi-output DNA sensor designed to detect ctDNA!</h2>
+
−
Cancer is a leading cause of death worldwide, accounting for 8.8 million deaths in 2015, and the most common cause of cancer death is lung cancer (1.69 million deaths). Nowadays, multiple lung cancer detection methods are developed, one of them being liquid biopsy. The technique of liquid biopsy is much better than the popular biopsy as it obviates pain and complication incurred to patients by detecting various tumor markup, including short strand circulating tumor DNA (CtDNA) in the blood. However, it still requires laboratory apparatus such as PCR instrument.
+
<div>dCasentry: A guardian against Lung Cancer</br>
−
</br>
+
Lung cancer is one of the deadliest malignant tumors in the world, with highest death rate in China. The most widely used lung cancer detection method nowadays remains biopsy, which may cause pain infection and bruising. However, the technic of liquid biopsy obviates this problem by detecting various factors including circulating tumor DNA (ctDNA) in the blood. ctDNA is a short strand of DNA released from tumor cells that can be deemed as the sign of cancer. Although traditional liquid biopsy avoids many side effects, it requires laboratory apparatus such as PCR instrument during detection. Also, some other ctDNA detection systems fail to overcome the difficulty of the extremely low concentration of ctDNA in the blood. To solve those problems, we developed a new liquid biopsy method using dCas9 protein with a much simple procedure while increase the signal with various kinds of output. We hope to adopt free-dried paper chip as our vector of detecting system to simplify its operation as well as storage. Finally, the product will be presented as a kit that contains all the items you needed for convenient machine-free detection.
−
Thus our primary task is to devise a more efficient, rapid and convenient lung cancer prognosis method. We construct a paper chip containing powerful biosensor capable of detecting the fusion gene, EML4-ALK, which only exists only in NSCLC (non small cell lung cancer) patients’ blood. Specific targeted drug for this mutation has been produced, which means patients can receive precise treatment as soon as possible when the detection result is positive. </br>
+
 
−
+
−
The biosensor, dCasentry, consists of paired dCas9 protein guided by sgRNA and linked with split T7 RNA polymerase that serves as a switch. When the targeting lung cancer mutation gene is detected, visible signal will be released as the T7 RNA polymerase starts transcription. DCasentry not only deals with low ctDNA concentration in blood but also capable of producing various kinds of signal output, such as GFP and RFP.
+
−
</br>
+
−
+
−
We adopt freeze-dried paper chip as the vector of the detection system to simplify its operation as well as storage. The DNA device and proteins needed for detection are mixed with cell-free system and freeze-dried on the paper chip. During testing, the blood sample of the patient provides a liquid environment to reactivate the cell-free system. The product will be presented as a kit, containing including hemostix, a hand power centrifuge, NASBA reaction system and the paper screening chip, that can be widely used on the medical field.
+
 
<p>Please, click <a href="https://2017.igem.org/Team:BGIC-Union/Project">  here </a> and know more about me as well as the product!</p>
 
<p>Please, click <a href="https://2017.igem.org/Team:BGIC-Union/Project">  here </a> and know more about me as well as the product!</p>
 
</div><!-- /col-lg-8 -->
 
</div><!-- /col-lg-8 -->

Revision as of 03:41, 2 November 2017

Team：BGIC-Union

Hi, I am dCasentry,

dCasentry: A guardian against Lung Cancer
Lung cancer is one of the deadliest malignant tumors in the world, with highest death rate in China. The most widely used lung cancer detection method nowadays remains biopsy, which may cause pain infection and bruising. However, the technic of liquid biopsy obviates this problem by detecting various factors including circulating tumor DNA (ctDNA) in the blood. ctDNA is a short strand of DNA released from tumor cells that can be deemed as the sign of cancer. Although traditional liquid biopsy avoids many side effects, it requires laboratory apparatus such as PCR instrument during detection. Also, some other ctDNA detection systems fail to overcome the difficulty of the extremely low concentration of ctDNA in the blood. To solve those problems, we developed a new liquid biopsy method using dCas9 protein with a much simple procedure while increase the signal with various kinds of output. We hope to adopt free-dried paper chip as our vector of detecting system to simplify its operation as well as storage. Finally, the product will be presented as a kit that contains all the items you needed for convenient machine-free detection.

Please, click here and know more about me as well as the product!

Best Parts

Applied Design

Integrated Human Practice

Education & Public Engagement

Entreprenuership

Model