Difference between revisions of "Team:Bordeaux/HP/Silver"

 
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<div class="title" style="margin-top:-30px" >Integrated Human Practices</div>
  
 
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     <p>As we worked on C.elegans in the context of the Stargate WCC project, we wanted to focus on it as a safe and very relevant model organism. C.elegans  is subject to many researches and great discoveries.  
 
     <p>As we worked on C.elegans in the context of the Stargate WCC project, we wanted to focus on it as a safe and very relevant model organism. C.elegans  is subject to many researches and great discoveries.  
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It is also a relevant model to study processes in many human diseases. As we studied unc-60, a gene involved in the muscular development in C.elegans, it was very important to see if the phenomenon observed in worms could have perspectives in medical research linked to muscular deficiency for exemple.
 
It is also a relevant model to study processes in many human diseases. As we studied unc-60, a gene involved in the muscular development in C.elegans, it was very important to see if the phenomenon observed in worms could have perspectives in medical research linked to muscular deficiency for exemple.
 
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<strong>Why is C.elegans such an outstanding experimental model ?</strong>
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<h4>Why is C.elegans such an outstanding experimental model ?</h4>
  
 
<h1>I. What should we know about C.elegans ?</h1>
 
<h1>I. What should we know about C.elegans ?</h1>
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<b>Sydney Brenner</b> brought this organism in the lab in 1974. He decided to study it because of the ease of <b>genetic manipulation</b>.
 
<b>Sydney Brenner</b> brought this organism in the lab in 1974. He decided to study it because of the ease of <b>genetic manipulation</b>.
 
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<strong>What are the properties that allow easy genetic manipulations? Is there any limit to these properties ?</strong>
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<h4>What are the properties that allow easy genetic manipulations? Is there any limit to these properties ?</h4>
  
 
<h2>1. Advantages to study C.elegans<h2>
 
<h2>1. Advantages to study C.elegans<h2>
  
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<h3>Self fertilization</h3>
 
<h3>Self fertilization</h3>
  
 
<p>Among the C.elegans, we can find hermaphrodites and males. Hermaphrodites allow self-fertilization. This way, when an hermaphrodite worm is mutagenized, the mutation can be maintained through self propagation in following progenies without mating with males.</p>
 
<p>Among the C.elegans, we can find hermaphrodites and males. Hermaphrodites allow self-fertilization. This way, when an hermaphrodite worm is mutagenized, the mutation can be maintained through self propagation in following progenies without mating with males.</p>
  
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<h3>Rapid growth</h3>
 
<h3>Rapid growth</h3>
  
 
<p>C.elegans takes around 3 days at 25° to develop from fertilized aggs to adult worms that can produce their own fertilized eggs.</p>
 
<p>C.elegans takes around 3 days at 25° to develop from fertilized aggs to adult worms that can produce their own fertilized eggs.</p>
  
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<h3>The ability to freeze and recover, cryopreservation</h3>
 
<h3>The ability to freeze and recover, cryopreservation</h3>
  
 
<p>We can preserve C.elegans mutant strains.</p>
 
<p>We can preserve C.elegans mutant strains.</p>
  
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<h3>Transparency</h3>
 
<h3>Transparency</h3>
  
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Thanks to transparency, optogenetic tools can also be effective in C.elegans, with many applications in the nervous system.</p>
 
Thanks to transparency, optogenetic tools can also be effective in C.elegans, with many applications in the nervous system.</p>
  
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<h3>A benign organism to humans</h3>
 
<h3>A benign organism to humans</h3>
  
 
<p>They cannot grow in humans because our body temperature is to high</p>
 
<p>They cannot grow in humans because our body temperature is to high</p>
  
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<h2>2. Limitations</h2>
 
<h2>2. Limitations</h2>
 
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<p>The community of C.elegans researchers is another reason why the field flourished besides the outstanding opportunities to study biological questions with this model organism</p>
 
<p>The community of C.elegans researchers is another reason why the field flourished besides the outstanding opportunities to study biological questions with this model organism</p>
  
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<h2>1. What are the main features of this community?<h2>
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<h2>1. What are the main features of this community?</h2>
 
<p>The C.elegans community has been characterised by a unique sharing spirit since the introduction of C.elegans in research labs.
 
<p>The C.elegans community has been characterised by a unique sharing spirit since the introduction of C.elegans in research labs.
 
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This large community supplies few databases about nematodes.</p>
 
This large community supplies few databases about nematodes.</p>
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     <h3>Wormbook</h3>
 
     <h3>Wormbook</h3>
 
     <p><a href="www.wormbook.org"> WormBook </a> provides reviews on many topics of C. elegans biology. WormBook is an open-access collection of chapters covering topics related to the biology of nematodes It contains:
 
     <p><a href="www.wormbook.org"> WormBook </a> provides reviews on many topics of C. elegans biology. WormBook is an open-access collection of chapters covering topics related to the biology of nematodes It contains:
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<h3>Wormbase</h3>
 
<h3>Wormbase</h3>
 
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WormBase is an international consortium of biologists and computer scientists dedicated to providing the research community with accurate, current, accessible information concerning the genetics, genomics and biology of C. elegans and related nematodes.” (from Mission Statement of Wormbase).
 
WormBase is an international consortium of biologists and computer scientists dedicated to providing the research community with accurate, current, accessible information concerning the genetics, genomics and biology of C. elegans and related nematodes.” (from Mission Statement of Wormbase).
 
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<h3>Wormatlas</h3>
 
<h3>Wormatlas</h3>
 
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<a href="www.wormatlas.org/">Wormatalas</a> database features behavioural and structural anatomy of C.elegans.
 
<a href="www.wormatlas.org/">Wormatalas</a> database features behavioural and structural anatomy of C.elegans.
 
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<h3>The Caenorhabditis Genetics Centre</h3>
 
<h3>The Caenorhabditis Genetics Centre</h3>
 
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<h2>2. Meeting with Asako Sugimoto, member of the <I style="color: #d8b700">C.elegans</I> Community</h2>
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<img align="center" src="https://static.igem.org/mediawiki/2017/thumb/6/6d/T--Bordeaux--pictureAsakoSugimoto.png/337px-T--Bordeaux--pictureAsakoSugimoto.png.jpeg" alt="img" style="width:200px; margin:auto; display:block"/>
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<p>Asako Sugimoto is currently a Professor in Life Sciences in Tohoku University in Sendai. She is a member of several scientific societies and communities such as the Molecular Biology Society of Japan, the Japanese Society of Developmental Biologists, the Japan Society for Cell Biology and the Japanese <I>C. elegans</I> Community.</p>
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<p>Pr. Sugimoto used to work for the first time on <I>C.elegans</I> as a postdoctoral fellow in the department of Biochimistry, in the University of Wisconsin-Madison. She did not work on this model by any chance. Indeed, she chose to work on it when she scarcely finished her PhD about “Characterization of genes involved in the initiation of sexual reproduction process in fission yeast” in the University of Tokyo.</p>
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<p>In her lab, her team works on <I>Caenorhabditis elegans</I> as an experimental model. They aim to understand developmentally important mechanisms. To do so, her lab uses RNAi in a high-throughput system to interfere with gene functions. Through this experimental technique, they can identify individual genes and gene groups with important functions during the development and determine phenotypes resulting from their loss of function.</p>
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<p>Once these sets of genes are detected, they can proceed to live imaging and other studies. They currently focus on mitosis and meiosis in the context of development.
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Finally Pr. Sugimoto talked about studying other nematodes in order to compare similar phenomenon in different species.</p>
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<p>It was such a pleasure to meet Asako Sugimoto and to learn about other fields that we can study with <I>C.elegans</I>. This interview was very interesting and inspiring. Pr. Sugimoto’s career path is impressive and she seems passionate and invested in the <I>C.elegans</I> Community.</p>
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<h1> III. Guide for C. elegans </h1>
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<p> In order to help igemers who wants to use <i> C.elegans</i> for their experimentations, we have created a guide that resume some informations about C.elegans, why it is a good model, and how to use it. </p>
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<a href="https://static.igem.org/mediawiki/2017/8/86/Bordeaux2017_CelegansGuide.pdf" target="_blank">
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      --> CLICK HERE <-- </a>
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<h1 style="text-align:center;color:#d8b700">How to find us ?</h1>
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<p style="font-size:1.5em; text-align:center; color:#E0E0E0">Feel free to email us to provide some feedback on our project, have some information on the team and our work, or to just say hello !</p>
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<h5 style="text-align:right ; color:#E0E0E0"><i>Copyright &#169; iGEM Bordeaux 2017</i></h5>
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Latest revision as of 01:41, 2 November 2017

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