Difference between revisions of "Team:ColumbiaNYC"

 
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                 <h1>
 
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                     <mark>SilenshR</mark><br>
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                     <u> &nbsp;SilenshR</u><br>
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                 </h1>
 
                 </h1>
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                 <h3><mark>a Bacteria-Mediated Oncogene Silencing as Living Cancer Therapeutic</mark></h3>
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                 <h3> <u> Bacteria-Mediated Oncogene Silencing as a Living Cancer Therapeutic </u> </h3>
 
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        <!-- First Featurette -->
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        <div class="featurette" id="about">
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            <img class="featurette-image img-circle img-responsive pull-right" src="http://placehold.it/500x500">
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            <h2 class="featurette-heading">The Advantages to a
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                <span class="text-muted">Synthetic Biology Approach</span>
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            </h2>
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            <p class="lead">A cornerstone in synthetic biology is the connection of distinct biological functions to create useful system
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                level behavior. We can take advantage of how bacteria naturally localize in tumors while failing to survive
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                in healthy tissue in the body to use bacteria as a cancer-specific delivery mechanism. Also, bacteria can
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                mass produce products, invade cells, and release the products directly into the cells. This allows easily-degraded
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                compounds to be effective delivered into cancer cells. It also prevents these compounds from affecting healthy
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                cells. The combination of these mechanisms creates a powerful, cancer-specific circuit for gene therapy.</p>
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            <h2 class="featurette-heading">Expanding the Possibilities of
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                <span class="text-muted">Gene Therapy</span>
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            </h2>
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            <p class="lead">Anticipating the applications of synthetic biology to healthcare, Columbia iGEM 2017 is devising a therapeutic
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                approach to modulate mammalian gene expression at the post-transcriptional level. Recombinant E. coli with
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                the capacity to invade mammalian cells will deliver an shRNA payload against an aberrantly expressed gene,
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                for example an oncogene in cancer or proinflammatory cytokine in inflammation, to the host cytoplasm. This
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                shRNA payload will then inhibit protein function, which can combat mutations that confer resistance to traditional
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                therapies, as with the tyrosine kinase inhibitors gefitinib and imatinib. </p>
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            <h2 class="featurette-heading">The Future
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                <span class="text-muted">Outlook</span>
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            </h2>
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            <p class="lead">Our mechanism to modulate mammalian gene expression can have a variety of applications, extending throughout
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                as well beyond healthcare. The engineered bacteria would have a significant application to human health particularly
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                in conditions characterized by aberrant gene expression, such as with oncogenes in cancer, cytokines in inflammation,
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                and many others. For cancer applications, the engineered bacteria can be taken as an oral probiotic, which
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                will then selectively localize in tumor cells to prove gene therapy.</p>
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Latest revision as of 05:05, 15 December 2017

 SilenshR

Bacteria-Mediated Oncogene Silencing as a Living Cancer Therapeutic