Team:ColumbiaNYC/Entrepreneurship
Entrepreneurship
Our first steps towards a business model
Our Product
SilenshR is a synthetic biology solution that leverages the innate capacity of bacteria to colonize the hypoxic and immune-privileged cores of tumors conferring specificity to a systemic therapeutic approach. Once the SilenshR E. coli reach a cell density of 2*10^11 colony forming units (cfu) per milliliter within the tumor, genetic circuits are activated allowing SilenshR recombinants to invade cancer cells and release a short hairpin RNA (shRNA) targeting an expressed oncogene thereby halting the unchecked cellular proliferation of cancer. By circumventing the need for systemic delivery of chemotherapy and the inevitable off-target cytotoxicity, SilenshR keeps the immune system intact, spares the digestive epithelial lining from damage and relieves anxiety surrounding hair loss.
Mission Statement
We are committed to being curious and improving medicine by applying synthetic biology to enhance health and well-being.
