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− | {{HZAU-China}}
| + | <!DOCTYPE html> |
| <html> | | <html> |
− |
| |
| <head> | | <head> |
− | <meta charset="UTF-8">
| + | <meta charset="utf-8"> |
− | <!--内容的样式-->
| + | <title>Bootstrap 实例</title> |
− | <style>
| + | <meta name="viewport" content="width=device-width, initial-scale=1"> |
− | body {
| + | <link rel="stylesheet" href="http://cdn.static.runoob.com/libs/bootstrap/3.3.7/css/bootstrap.min.css"> |
− | font-family: "Arial", Helvetica, sans-serif;
| + | <script src="http://cdn.static.runoob.com/libs/jquery/2.1.1/jquery.min.js"></script> |
− | text-align: justify;
| + | <script src="http://cdn.static.runoob.com/libs/bootstrap/3.3.7/js/bootstrap.min.js"></script> |
− | margin: 0px;
| + | <style> |
− | background-color: #ffffff;
| + | body { |
− | }
| + | position: relative; |
| + | } |
| + | ul.nav-pills { |
| + | top: 20px; |
| + | position: fixed; |
| + | } |
| + | div.col-sm-9 div { |
| + | height: 250px; |
| + | font-size: 28px; |
| + | } |
| + | #section1 {color: #fff; background-color: #1E88E5;} |
| + | #section2 {color: #fff; background-color: #673ab7;} |
| + | #section3 {color: #fff; background-color: #ff9800;} |
| + | #section41 {color: #fff; background-color: #00bcd4;} |
| + | #section42 {color: #fff; background-color: #009688;} |
| | | |
− | .HZAU_content a:hover {
| + | @media screen and (max-width: 810px) { |
− | color: black;
| + | #section1, #section2, #section3, #section41, #section42 { |
− | text-decoration: none;
| + | margin-left: 150px; |
− | }
| + | } |
| + | } |
| + | </style> |
| + | </head> |
| + | <body data-spy="scroll" data-target="#myScrollspy" data-offset="20"> |
| | | |
− | .HZAU_content a {
| + | <div class="container"> |
− | color: black;
| + | <div class="row"> |
− | }
| + | <nav class="col-sm-3" id="myScrollspy"> |
| + | <div class="container-fluid"> |
| + | <div class="container-fluid"> |
| + | <ul class="nav nav-pills nav-stacked"> |
| + | <li class="active"><a href="#section1">Section 1</a></li> |
| + | <li><a href="#section2">Section 2</a></li> |
| + | <li><a href="#section3">Section 3</a></li> |
| + | <li class="dropdown"> |
| + | <a class="dropdown-toggle" data-toggle="dropdown" href="#">Section 4 <span class="caret"></span></a> |
| + | <ul class="dropdown-menu"> |
| + | <li><a href="#section41">Section 4-1</a></li> |
| + | <li><a href="#section42">Section 4-2</a></li> |
| + | </ul> |
| + | </li> |
| + | </ul> |
| + | </div> |
| + | </div> |
| + | </nav> |
| + | <div class="col-sm-9"> |
| + | <div id="section1"> |
| + | <h1>Section 1</h1> |
| + | <p>Try to scroll this section and look at the navigation list while scrolling!</p> |
| + | </div> |
| + | <div id="section2"> |
| + | <h1>Section 2</h1> |
| + | <p>Try to scroll this section and look at the navigation list while scrolling!</p> |
| + | </div> |
| + | <div id="section3"> |
| + | <h1>Section 3</h1> |
| + | <p>Try to scroll this section and look at the navigation list while scrolling!</p> |
| + | </div> |
| + | <div id="section41"> |
| + | <h1>Section 4-1</h1> |
| + | <p>Try to scroll this section and look at the navigation list while scrolling!</p> |
| + | </div> |
| + | <div id="section42"> |
| + | <h1>Section 4-2</h1> |
| + | <p>Try to scroll this section and look at the navigation list while scrolling!</p> |
| + | </div> |
| + | </div> |
| + | </div> |
| + | </div> |
| | | |
− | .HZAU_content {
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− | position: absolute;
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− | top: 43px;
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− | left: 250px;
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− | width: 1000px;
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− | height: 2100px;
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− | z-index: -1;
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− | }
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− |
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− | .HZAU_2017_menu {
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− | display: block;
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− | position: fixed;
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− | left: 15px;
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− | top: 100px;
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− | height: 337px;
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− | width: 233px;
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− | overflow: hidden;
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− | }
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− |
| |
− | .beijin {
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− | height: 337px;
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− | width: 233px;
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− | }
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− |
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− | .HZAU_2017_menu ul {
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− | position: absolute;
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− | top: 50%;
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− | margin-top: -80px;
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− | margin-left: 0px;
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− | left: 0px;
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− | width: 100%;
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− | padding-left: 0px;
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− | font-size: 16px;
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− | }
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− |
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− | .HZAU_2017_menu li {
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− | width: 100%;
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− | }
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− |
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− | .HZAU_2017_menu li a {
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− | display: inline-block;
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− | width: 100%;
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− | height: 100%;
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− | padding: 20px 0px 20px 0px;
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− | margin-left: 13px;
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− | text-align: left;
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− | color: rgb(249, 228, 137);
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− | text-decoration: none;
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− | font-style: arial;
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− | line-height: 90%;
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− | }
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− |
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− | .HZAU_2017_menu li:hover {
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− | background: rgb(249, 228, 137);
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− | }
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− |
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− | .HZAU_2017_menu li a:hover {
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− | color: #000;
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− | }
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− |
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− | .HZAU_item {
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− | position: absolute;
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− | width: 100%;
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− | padding-left: 40px;
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− | }
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− |
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− | .biaoti {
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− | font-size: 50px;
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− | font-weight: bold;
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− | text-align: center;
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− | width: 100%;
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− | display: block;
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− | padding-bottom: 50px;
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− | padding-top: 50px;
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− | color: rgb(63, 59, 58);
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− | }
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− |
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− | .zhengwen {
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− | display: block;
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− | font-style: arial;
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− | font-size: 18px;
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− | line-height: 34px;
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− | text-align: justify;
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− | color: #000;
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− | margin-bottom: 9px;
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− | margin-left: 0px;
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− | margin-right: 0px;
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− | margin-top: 7.2px
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− | }
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− |
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− | .jiaozheng {
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− | position: relative;
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− | }
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− |
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− | .jiaozheng a {
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− | position: absolute;
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− | top: -66px;
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− | }
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− |
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− | .HZAU_content img {
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− | margin: 0 auto;
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− | display: block;
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− | }
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− |
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− | .tu_1 {
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− | width: 666px;
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− | }
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− |
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− | .tu_2 {
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− | width: 555px;
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− | }
| |
− | </style>
| |
− | <style>
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− | span.caret_black {
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− | display: inline-block;
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− | margin-left: 6px;
| |
− | vertical-align: middle;
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− | width: 0;
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− | height: 0;
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− | border-left: 6px solid transparent;
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− | border-right: 6px solid transparent;
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− | border-top: 6px solid black;
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− | }
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− |
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− | label {
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− | cursor: pointer;
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− | }
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− |
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− | #menu-toggle {
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− | display: none;
| |
− | /* hide the checkbox */
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− | }
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− |
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− | #menu {
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− | display: none;
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− | font-size: 17.5px;
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− | margin-left: 0px;
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− | padding-left: 25px;
| |
− | }
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− |
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− | #menu-toggle:checked+#menu {
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− | display: block;
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− | }
| |
− | </style>
| |
− | </head>
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− |
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− | <body>
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− | <div class="HZAU_2017_menu">
| |
− | <img src="https://static.igem.org/mediawiki/2017/8/8e/HZAU_2017_background_1.png" class="beijin">
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− | <ul class="daohang">
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− | <li id="HZAU_menu_1">
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− | <a href="#" id="bianse_1">Background</a>
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− | </li>
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− | <li id="HZAU_menu_2">
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− | <a href="#item2_1" id="bianse_2">Information</a>
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− | </li>
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− | <li id="HZAU_menu_3">
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− | <a href="#item3_1" id="bianse_3">Why light control</a>
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− | </li>
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− | </ul>
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− | </div>
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− | <div class="HZAU_content">
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− | <div class="HZAU_item">
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− | <a class="biaoti">Description</a>
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− | <a class="zhengwen">The replication of prokaryotes can be divided into three phases, B C and D, while there are multi-rounds of replication
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− | happened in one cell. So both the phase and the copy number of genome is various in a culture.</a>
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− | <div>
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− | <label for="menu-toggle" class="zhengwen" style="color:blue">To know more about replication
| |
− | <span class="caret_black"></span>
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− | </label>
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− | <input type="checkbox" id="menu-toggle" />
| |
− | <ul id="menu">
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− | <a>The replication process of E.coli can be divided into three phases, phase B, phase C and phase D. B is also called
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− | pre-replication phase in which cells are preparing for DNA replication, like G1 phase of eukaryotes. C is also
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− | called replication phase in which the genome is under replication corresponding to phase S in eukaryotic cell
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− | cycle. The last D phase, of course, is called post-replication phase, in which chromosome separates and one cell
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− | divides into two corresponding to G2 and M phase in eukaryotes. Among the three phases, C and D are relatively
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− | constant, about 40 min and 20 min separately, so when to initiate a replication determines the whole cell cycle.
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− | Recent research reveals a relationship between replication initiation and cell volume, but many details are still
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− | remain unknown. But what we know is that a protein, DnaA, plays an important role in this process.
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− | <br> DnaA is a versatile protein possessing many different functions related to cell cycle, among which the most
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− | important one is to attached to the OriC, the origins of chromosome replication, and initiates replication. So
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− | controlling cell cycle by interrupting the attachment of DnaA and corresponding DNA sequence with dCas9 is an
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− | efficient approach.
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− | <br> The whole cell cycle of eukaryotes and prokaryotes show a certain similarity, but there is difference between
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− | them. The cell cycle of prokaryotes can overlap, which means the next round of replication initiates before the
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− | last replication complete, while eukaryotic cell cycle initiates one after another. Experiments have shown that
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− | even an isogenetic bacteria grown in the same culture show a difference in both replication phase and genome
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− | copy numbers and this becomes a huge noise when constructing the 3D genome structure and building up a circuit
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− | related to genome gene. Besides, the development of synthetic biology requires a system to control the reproduction
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− | of engineered organisms. So we believe that our project would be a useful tool no matter in theoretical areas
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− | or application areas.
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− | </a>
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− | </ul>
| |
− | </div>
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− | <img src="https://static.igem.org/mediawiki/2017/f/f1/HZAU_2017_BCDperiod.png" class="tu_1">
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− | <div class="jiaozheng">
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− | <a id="item2_1"></a>
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− | </div>
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− | <a class="zhengwen">Our problem arises from a research about constructing 4D genome of eukaryote. So we begin to wonder why there isn’t
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− | a 4D genome project of prokaryote. After research we find that due to its complicated replication mechanism, there
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− | will be a huge noise while detecting its structure, which hinder the research on prokaryotic genome.
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− | <br>Besides, the heterogenicity of cells are gathering importance recently in different fields.</a>
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− | <img src="https://static.igem.org/mediawiki/2017/d/d2/HZAU_2017_computorHand.png" class="tu_2">
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− | <div class="jiaozheng">
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− | <a id="item3_1"></a>
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− | </div>
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− | <a class="zhengwen">Therefore we begin to think if there could be a methods to eliminate the heterogeneity. While thinking deeper into
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− | this problem, it becomes interesting that what would happen if all the cells are synchronized, will there be a new
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− | phenomenon that can change the traditional statements?
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− | <br>So in our mind the ideal synchronization methods should be not only simply inhibit the cell cycle but at the same
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− | time can free the inhibition according to our decision. As we all know, the manipulation of machine is much more
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− | accurate than hum beings, and there is a trend to let machine help us to control the organisms, so we want our synchronization
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− | system can also be controlled by machine, by program.</a>
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− | </div>
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− | </div>
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| </body> | | </body> |
− | <script>
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− |
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− | </script>
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| </html> | | </html> |