Difference between revisions of "Team:JNFLS/Demonstrate"

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<h3>★  ALERT! </h3>
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<p>This page is used by the judges to evaluate your team for the <a href="https://2017.igem.org/Judging/Medals">medal criterion</a> or <a href="https://2017.igem.org/Judging/Awards"> award listed above</a>. </p>
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<p> Delete this box in order to be evaluated for this medal criterion and/or award. See more information at <a href="https://2017.igem.org/Judging/Pages_for_Awards"> Instructions for Pages for awards</a>.</p>
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<h1>Demonstrate</h1>
 
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<h3>Gold Medal Criterion #4</h3>
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<h2>Fighting colon cancer with yogurt?</h2>
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<p>Yes, polish your eyes, it is not a joke but a reality in our project. As we know, many kinds of tumors have characteristic anaerobic and necrotic areas, which is one of important reasons that tumors are resistant to radiotherapy and chemotherapy. The fdhF promoter is an hypoxia induced promoter that initiates expression only in an oxygen-deficient environment, which is used for initiation the expression of invasin gene and hyl gene to invade, consequently induce apoptosis of colon cancer.</p>
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Teams that can show their system working under real world conditions are usually good at impressing the judges in iGEM. To achieve gold medal criterion #4, convince the judges that your project works. There are many ways in which your project working could be demonstrated, so there is more than one way to meet this requirement. This gold medal criterion was introduced in 2016, so check our what 2016 teams did to achieve a their gold medals!
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<p>In order to realize our dreams, firstly, we have systematically learned the safety requirements of experimtents and operations. before we went to lab (<a href="https://2017.igem.org/Team:JNFLS/Safety">https://2017.igem.org/Team:JNFLS/Safety</a>). And in our project design, we also considered the biosafety problem, so we introduced the plasmid suicide system into the project. (<a href="https://2017.igem.org/Team:JNFLS/Design">https://2017.igem.org/Team:JNFLS/Design)</a></p>
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<p>In HP, we interviewed the doctor working in Qilu Hospital, knowing that current effective and relative safe treatment of colon cancer is surgery. But some patients are not willing to accept it because the surgery needs to cut out anus, and sometimes consequent infections may be lethal. Doctors never tried gene therapy. Molecular targeted anti-tumor agents are sometimes used. Nonetheless, the price of drugs is very high, most of the patients can not afford it. So we were going to develop a gene therapy for colon cancer with cheap and convenient way. In order to know the public understanding and acceptance for gene therapy, we did public propaganda and survey in some community and Science Museum. From the survey we found that safety and cost of gene therapy are widely concerned problems. So we modified our project to introduce the plasmid suicide system and probiotics Nissle 1917 as plasmid delivery in our project for more safety and less cost. This propaganda and survey improved well our project. （<a href="https://2017.igem.org/Team:JNFLS/HP/Gold_Integrated">https://2017.igem.org/Team:JNFLS/HP/Gold_Integrated</a>）</p>
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<p>In our project, we have completed the sensitivity detection of fdhF promoter and tetR repressible promoter. Also, We verified the TAT plasmid actually have the effect of inducing apoptosis in colon cancer cell line LOVO. Since our project aimed to use Nissle 1917 as the plasmid delivery, we also explored if Nissle 1917 is used for making yogurt in laboratory. The result indicated that it is possible because its character and pH value are very similar with the yogurt bought from store.
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(<a href="https://2017.igem.org/Team:JNFLS/Results">https://2017.igem.org/Team:JNFLS/Results</a>)</p>
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Please see the <a href="https://2017.igem.org/Judging/Medals">2017 Medals Page</a> for more information.
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<div class="top_text">In a conclusion , although we have not finished the whole project, the present results indicated that fighting colon cancer with yogurt will become reality, and it has a very promising prospect!</div>
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<h4> What should we do for our demonstration?</h4>
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<h5> Standard teams </h5>
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If you have built a proof of concept system, you can demonstrate it working under real world conditions. If you have built a biological device that is intended to be a sensor, can you show it detecting whatever it is intended to sense. If it is intended to work in the field, you can show how this might work using a simulated version in the lab, or a simulation of your device in the field.<strong> Please note biological materials must not be taken out of the lab</strong>.
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<h5> Special track teams </h5>
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Special track teams can achieve this medal criterion by bringing their work to the Jamboree and showcasing it in the track event. Art & Design, Measurement, Hardware and Software tracks will all have showcase events at the Giant Jamboree.<strong> Please note biological materials must not be taken out of the lab</strong>.
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Latest revision as of 20:30, 1 March 2018

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JNFLS

★ ALERT!

This page is used by the judges to evaluate your team for the medal criterion or award listed above.

Delete this box in order to be evaluated for this medal criterion and/or award. See more information at Instructions for Pages for awards.

Demonstrate

Gold Medal Criterion #4

Teams that can show their system working under real world conditions are usually good at impressing the judges in iGEM. To achieve gold medal criterion #4, convince the judges that your project works. There are many ways in which your project working could be demonstrated, so there is more than one way to meet this requirement. This gold medal criterion was introduced in 2016, so check our what 2016 teams did to achieve a their gold medals!

Please see the 2017 Medals Page for more information.

What should we do for our demonstration?

Standard teams

If you have built a proof of concept system, you can demonstrate it working under real world conditions. If you have built a biological device that is intended to be a sensor, can you show it detecting whatever it is intended to sense. If it is intended to work in the field, you can show how this might work using a simulated version in the lab, or a simulation of your device in the field. Please note biological materials must not be taken out of the lab.


Special track teams

Special track teams can achieve this medal criterion by bringing their work to the Jamboree and showcasing it in the track event. Art & Design, Measurement, Hardware and Software tracks will all have showcase events at the Giant Jamboree. Please note biological materials must not be taken out of the lab.