Difference between revisions of "Team:NTNU Trondheim/Description"

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{{NTNU_Trondheim}}
 
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<h1>Description</h1>
 
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<p>Tell us about your project, describe what moves you and why this is something important for your team.</p>
 
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<h5>What should this page contain?</h5>
 
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<ul>
 
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<li> A clear and concise description of your project.</li>
 
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<li>A detailed explanation of why your team chose to work on this particular project.</li>
 
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<li>References and sources to document your research.</li>
 
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<li>Use illustrations and other visual resources to explain your project.</li>
 
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<h5>Advice on writing your Project Description</h5>
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    <div class="content">
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        <div class="break_header">
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            <img src="../SVG/splitter_header.svg">
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<p>
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        <div class="paragraph_img_right">
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We encourage you to put up a lot of information and content on your wiki, but we also encourage you to include summaries as much as possible. If you think of the sections in your project description as the sections in a publication, you should try to be consist, accurate and unambiguous in your achievements.  
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            <h1>Why phages?</h1>
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</p>
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            <div>
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                <img src="../PNG/fag.png">
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            </div>
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            <p>
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              Antibiotic resistance is poised to become one of the greatest dangers of our time.
 +
  Ever since the discovery of penicillin in 1928, antibiotics have been our first line
 +
  of defense against bacterial infections. However, widespread overuse of antibiotics,
 +
  coupled with minimal investment in new treatments have allowed pathogenic bacteria to
 +
  develop resistances to many antibiotics. Fortunately, there is more than one way to  
 +
  kill bacteria. Bacteriophages (phages for short) are bacteria-specific viruses capable
 +
  of killing select bacteria while leaving animal cells unharmed. For this reason, phages
 +
  could potentially synergize with, or even replace antibiotics. This type of treatment is
 +
  called phage therapy.
 +
            </p>
 +
        </div>
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<p>
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        <div class="break_2">
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Judges like to read your wiki and know exactly what you have achieved. This is how you should think about these sections; from the point of view of the judge evaluating you at the end of the year.
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            <img src="../SVG/splitter_2.svg">
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</p>
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        </div>
  
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</div>
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        <div class="paragraph_img_left">
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            <h1>Why not yet?</h1> <!-- Don't work properly -->
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            <div class="image" style="width: 30%;margin-top: -3em">
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                <img src="../PNG/Phage_specifficity.png">
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            </div>
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            <p>
 +
                Phage therapy does however have several issues to be ironed out before becoming a
 +
mainstream medical treatment. One major stumbling block for phage therapy is the high
 +
host specificity of phages. Many phages can only infect certain strains of a bacterial
 +
species. This creates the need for either large libraries of potential phages, or a
 +
quick method of developing a phage capable of fighting a given bacterial infection.
 +
In order to solve this problem, our project attempts the latter method.
  
 +
            </p>
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        </div>
  
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<div class="column half_size" >
 
  
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<h5>References</h5>
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        <div class="break_1">
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<p>iGEM teams are encouraged to record references you use during the course of your research. They should be posted somewhere on your wiki so that judges and other visitors can see how you thought about your project and what works inspired you.</p>
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            <img src="../SVG/splitter_1.svg">
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        </div>
  
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</div>
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        <div class="image" style="width: 50%;margin-top: 5em">
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            <img src="../PNG/Phage_evolution.png">
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        </div>
  
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        <div class="paragraph_no_img">
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            <h1>Our project</h1>
 +
            <p>
 +
                For our project, we aim to develop a method of evolving phages capable of infecting
 +
a target bacteria strain. We plan to first harvest a catalogue of phages and identify
 +
their host bacteria. Phages are plentiful in nature, and by taking different water and
 +
soil samples, we will collect a variety of phages capable of infecting different
 +
bacteria.  By genetically modifying host bacteria, we will accelerate the natural
 +
mutation rate of our respective phages. We plan to set up a controlled environment that
 +
favorizes phages capable of also infecting the target bacteria. We believe this method will
 +
be capable of quickly producing tailored phages, keeping us one step ahead of the resistant
 +
bacteria.
  
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<div class="column half_size" >
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            </p>
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<h5>Inspiration</h5>
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        </div>
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<p>See how other teams have described and presented their projects: </p>
+
 +
        <div class="footer">
 +
            <img src="../SVG/splitter_footer.svg">
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            <div class="footer_content">
 +
                <div class="sponsors">
 +
                    <a href="https://digitallifenorway.org/gb/" target="_blank">
 +
                        <img src="../PNG/SDL_LOGO_ENG_confirmed_version2.png">
 +
                    </a>
 +
                    <a href="http://aquagen.no/en/" target="_blank">
 +
                        <img src="../PNG/AquaGen_forslag1_transparent.png">
 +
                    </a>
 +
                    <a href="http://www.biokjemisk.no/" target="_blank">
 +
                        <img src="../PNG/NBS_forslag1_transparent.png">
 +
                    </a>
 +
                    <a href="http://www.ntnu.edu/ibt" target="_blank">
 +
                        <img src="../PNG/Instituttlogo_english_white.png">
 +
                    </a>
 +
                    <a href="http://www.vectronbiosolutions.com/" target="_blank">
 +
                        <img src="../PNG/Vectron_forslag1_transparent.png">
 +
                    </a>
 +
                </div>
 +
                <div class="sosial_media">
 +
                    <a href="mailto:igem-team@ntnu.no" >
 +
                        <img src="../PNG/mail.png">
 +
                    </a>
 +
                    <a href="https://www.facebook.com/igemntnu2017/" target="_blank">
 +
                        <img src="../PNG/facebook.png">
 +
                    </a>
 +
                    <a href="https://twitter.com/ntnuigem?lang=en/" target="_blank">
 +
                        <img src="../PNG/twitter.png">
 +
                    </a>
 +
                    <a href="https://www.instagram.com/ntnu_igem/" target="_blank">
 +
                        <img src="../PNG/instagram.png">
 +
                    </a>
 +
                    <p>
 +
                        Email: igem-team@ntnu.no
 +
                    </p>
 +
                </div>
 +
            </div>
 +
        </div>
 +
    </div>
  
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<ul>
 
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<li><a href="https://2016.igem.org/Team:Imperial_College/Description">2016 Imperial College</a></li>
 
−
<li><a href="https://2016.igem.org/Team:Wageningen_UR/Description">2016 Wageningen UR</a></li>
 
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<li><a href="https://2014.igem.org/Team:UC_Davis/Project_Overview"> 2014 UC Davis</a></li>
 
−
<li><a href="https://2014.igem.org/Team:SYSU-Software/Overview">2014 SYSU Software</a></li>
 
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</ul>
 
 
</div>
 
</div>
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</body>
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Revision as of 11:24, 30 June 2017

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Why phages?

Antibiotic resistance is poised to become one of the greatest dangers of our time. Ever since the discovery of penicillin in 1928, antibiotics have been our first line of defense against bacterial infections. However, widespread overuse of antibiotics, coupled with minimal investment in new treatments have allowed pathogenic bacteria to develop resistances to many antibiotics. Fortunately, there is more than one way to kill bacteria. Bacteriophages (phages for short) are bacteria-specific viruses capable of killing select bacteria while leaving animal cells unharmed. For this reason, phages could potentially synergize with, or even replace antibiotics. This type of treatment is called phage therapy.

Why not yet?

Phage therapy does however have several issues to be ironed out before becoming a mainstream medical treatment. One major stumbling block for phage therapy is the high host specificity of phages. Many phages can only infect certain strains of a bacterial species. This creates the need for either large libraries of potential phages, or a quick method of developing a phage capable of fighting a given bacterial infection. In order to solve this problem, our project attempts the latter method.

Our project

For our project, we aim to develop a method of evolving phages capable of infecting a target bacteria strain. We plan to first harvest a catalogue of phages and identify their host bacteria. Phages are plentiful in nature, and by taking different water and soil samples, we will collect a variety of phages capable of infecting different bacteria. By genetically modifying host bacteria, we will accelerate the natural mutation rate of our respective phages. We plan to set up a controlled environment that favorizes phages capable of also infecting the target bacteria. We believe this method will be capable of quickly producing tailored phages, keeping us one step ahead of the resistant bacteria.

Email: igem-team@ntnu.no