Team:UPMC PARIS

Impact UPMC

Project Description: The BioMaker Factory, Synthetic biology for access to care

The biomarker factory project began from the alarming observation that over 150 000 people around the word die from venomous snakebites. Yet, there already exists safe and effective treatments which lead to a complete recovery. Unfortunately, those accidents mainly occur in developing countries in which the population cannot easily afford such expensive treatments. Therefore, through our first project called “Antivenom box”, we wanted to facilitate the antivenom access to the people in need that are often far from any hospital or facility providing these treatments. However, it became obvious to us that the lack of antivenom in these countries was in fact part of a much bigger problem: the lack of access to health care. Thus, we decided to adapt our project according to this issue and renamed it “The Biomarker Factory”. The BioMaker Factory is a miniaturized mobile factory able to produce therapeutic molecules for multiple diseases. To do so, we have used a heterologous recombinant protein expression system, which synthesizes the active ingredients within a completely automated smart box that can manage the expression of the active ingredients as well as their purification. Hence, our project can be split in two facets: On one hand, it’s an efficient and innovative biological system that can make E. coli bacteria express Fab antibodies. This expression would be accurately regulated by the light through an optogenetic system. On another hand, it’s a complex engineering system. Indeed, our smart box will contain a bioreactor and all the needed elements to purify the Fab antibodies. Everything will be under computer control thanks to a software specially designed for our box. Our final purpose for “The Biomaker Factory” is to be as simple as possible to operate so it can easily and safely be used by everyone, maybe even by kids! Thus, we consider to make it available to humanitarian organizations and local facilities to tackle the lack of health care in areas in need. Thanks to the Biobrick system and the work currently done by searchers and industries to develop the bioproduction, we are confident that “The Biomaker Factory” will offer a large range of applications. By easing the access to synthetic biology, it could stimulate everyone’s creativity and may even lead to new discoveries!

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