Difference between revisions of "Team:UPMC PARIS/Gold HP Biology"

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<h3>★  ALERT! </h3>
 
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<p>This page is used by the judges to evaluate your team for the <a href="https://2017.igem.org/Judging/Medals">medal criterion</a> or <a href="https://2017.igem.org/Judging/Awards"> award listed above</a>. </p>
 
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<p> Delete this box in order to be evaluated for this medal criterion and/or award. See more information at <a href="https://2017.igem.org/Judging/Pages_for_Awards"> Instructions for Pages for awards</a>.</p>
 
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<h1> Modeling</h1>
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    <h2 class="centered">HUMAN PRATICES</h2>
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<p>Mathematical models and computer simulations provide a great way to describe the function and operation of BioBrick Parts and Devices. Synthetic Biology is an engineering discipline, and part of engineering is simulation and modeling to determine the behavior of your design before you build it. Designing and simulating can be iterated many times in a computer before moving to the lab. This award is for teams who build a model of their system and use it to inform system design or simulate expected behavior in conjunction with experiments in the wetlab.</p>
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      <h4>Meeting with a Biologist</h4>
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        Our meeting with Dr. Sobzcik was very instructive. We started by presenting him the principle of the competition iGEM and our project which he found very interesting. At first we contacted him about the transformation of the cells but finally we discussed at length each point of the project. Thus, he reminded us of the basics of bacterial transformation and suggested to integrate a maximum of genes into the bacterial chromosome rather than leaving them in plasmids. We also discussed the extraction of proteins and lyses of bacteria. Finally, we rethought with him the construction of the optogenetic system of the machine - he himself had to work with a system of induction by light during his thesis. Dr. Sobzic was very patient and pedagogue, this interview was very useful!
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        When we needed advice for the synthesis of Fab, we first contacted Dr. Karim Dorgham from Pitié Salpêtrière Hospital. But we only work on mammalian cells so he kindly directed to Dr. Pablo Guardado Calvo from Pasteur Institute who quickly received us. At the end of this interview, we concluded that our project was too ambitious and that it would have taken much longer to succeed. Our discussion was very interesting and we learned a lot about the structure of antibodies, their synthesis in vitro and the production of proteins by bacteria in general.
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<h3> Gold Medal Criterion #3</h3>
 
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To complete for the gold medal criterion #3, please describe your work on this page and fill out the description on your <a href="https://2017.igem.org/Judging/Judging_Form">judging form</a>. To achieve this medal criterion, you must convince the judges that your team has gained insight into your project from modeling. You may not convince the judges if your model does not have an effect on your project design or implementation.
 
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Please see the <a href="https://2017.igem.org/Judging/Medals"> 2017 Medals Page</a> for more information.
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<h3>Best Model Special Prize</h3>
 
  
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To compete for the <a href="https://2017.igem.org/Judging/Awards">Best Model prize</a>, please describe your work on this page  and also fill out the description on the <a href="https://2017.igem.org/Judging/Judging_Form">judging form</a>. Please note you can compete for both the gold medal criterion #3 and the best model prize with this page.
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You must also delete the message box on the top of this page to be eligible for the Best Model Prize.
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          <br>
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          <h3>Sponsors</h3>
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          <br><br><br>
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              <img height="30%" width="30%" src="https://static.igem.org/mediawiki/2017/5/54/UPMC_team_2017_sponsors_Ambassade_france.jpg" alt="">
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              <img height="30%" width="30%" src="https://static.igem.org/mediawiki/2017/4/4e/UPMC_team_2017_sponsors_Bagneux.jpg" alt="">
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              <img height="30%" width="30%" src="https://static.igem.org/mediawiki/2017/d/d5/UPMC_team_2017_sponsors_ICM.png" alt="">
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              <img height="60%" width="60%" src="https://static.igem.org/mediawiki/2017/b/be/UPMC_team_2017_sponsors_UPMC.png" alt="">
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              <img height="30%" width="30%" src="https://static.igem.org/mediawiki/2017/7/70/UPMC_team_2017_sponsors_IDT.png" alt="">
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              <img height="50%" width="50%" src="https://static.igem.org/mediawiki/2017/6/6d/UPMC_team_2017_sponsors_T-Evry_Paris-Saclay-logos-sponsors-sigma.png" alt="">
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              <img src="https://static.igem.org/mediawiki/2017/d/de/UPMC_team_2017_sponsors_CFA_UPMC.png" alt="">
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              <img height="100%" width="100%" src="https://static.igem.org/mediawiki/2017/b/bf/UPMC_team_2017_sponsors_MAster_BMC.jpg" alt="">
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              <img height="100%" width="100%" src="https://static.igem.org/mediawiki/2017/8/80/UPMC_team_2017_sponsors_UFR_bio.jpg" alt="">
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<h5> Inspiration </h5>
 
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Here are a few examples from previous teams:
 
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<li><a href="https://2016.igem.org/Team:Manchester/Model">Manchester 2016</a></li>
 
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<li><a href="https://2016.igem.org/Team:TU_Delft/Model">TU Delft 2016  </li>
 
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<li><a href="https://2014.igem.org/Team:ETH_Zurich/modeling/overview">ETH Zurich 2014</a></li>
 
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<li><a href="https://2014.igem.org/Team:Waterloo/Math_Book">Waterloo 2014</a></li>
 
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Latest revision as of 00:09, 19 December 2017

Impact UPMC



HUMAN PRATICES

Meeting with a Biologist


Our meeting with Dr. Sobzcik was very instructive. We started by presenting him the principle of the competition iGEM and our project which he found very interesting. At first we contacted him about the transformation of the cells but finally we discussed at length each point of the project. Thus, he reminded us of the basics of bacterial transformation and suggested to integrate a maximum of genes into the bacterial chromosome rather than leaving them in plasmids. We also discussed the extraction of proteins and lyses of bacteria. Finally, we rethought with him the construction of the optogenetic system of the machine - he himself had to work with a system of induction by light during his thesis. Dr. Sobzic was very patient and pedagogue, this interview was very useful!

When we needed advice for the synthesis of Fab, we first contacted Dr. Karim Dorgham from Pitié Salpêtrière Hospital. But we only work on mammalian cells so he kindly directed to Dr. Pablo Guardado Calvo from Pasteur Institute who quickly received us. At the end of this interview, we concluded that our project was too ambitious and that it would have taken much longer to succeed. Our discussion was very interesting and we learned a lot about the structure of antibodies, their synthesis in vitro and the production of proteins by bacteria in general.


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