Team:Vilnius-Lithuania/Solution
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Our Solution: the SynORI Framework
Multi-plasmid framework would not be much without multiple plasmids. The synthetic origin of replication allows to co-maintain different unique plasmid groups in a single cell.
With the SynORI system you can adjust your plasmids' copy number in constitutive and inducible manner or virtually any signal pattern.
With the SynORI we introduce the world’s first inducible precise copy number plasmids. You may choose any particular plasmid to be low or high copy number.
Would you like to globally control your plasmid groups’ copy number, we have optimized the effects of Rop protein. By inducing the expression of Rop you can lower the copy number of all plasmid groups universally.
Five different plasmids equals to five different antibiotics for external selection? Not anymore. SynORI contains a five-part self-assembling selection system which uses only one antibiotic resistance gene.
SynORI also contains an active partitioning device, which ensures stable specific plasmid group inheritance and can be used for low copy number plasmids.
A framework for multi-plasmid sytems
It is time to make the work with plasmid systems more precise, convenient and extend its possibilities.
Your personal SynORI system is now ready. It is as simple as that.
Explore synori system in detail
Please select plasmid number that will appear in a cell.
Preview of Rop induction
Choose level of ROP induction
Do you want to add ROP protein to your SynORI system?
This might be helpful:
If your copy number is lower than 30, we recommend checking the box.
