Team:Westminster UK/markdown-test
Biomaterials Group Project
|
NAME |
INITIALS |
STUDENT NUMBER |
|
Oran Maguire |
OM |
|
|
Mohammed Ali Amin Banani |
MB |
|
|
Rebecca Varley |
RV |
|
|
Komal Ramsahye |
KR |
|
SPION-carrying polymersomes in cancer theranostics.
*** We envisage specifying our study to a cancer type or a class of class of cancer types.
Contents
Introduction
Definition of SPIONs
Definition of polymersomes
Generic treatment in (?class of?) cancer theranostics.
Clinical Benefits of SPION-loaded polymersome theranostics
Superparamagnetic Iron Oxide Nanoparticles
Clinically approved SPIONs
SPIONs with enhanced magnetism
SPION-Loaded Polymersome Material Characteristisation
Structure
Polymer Characteristics
Figure: Polymersome structures in comparison
Production Methods
Consistency of magnetic properties vs in situ production.
Table: Production methods vs function
Cell Interactions in vitro.
Cell Targeting
Degradation
Toxicity and compatibility
Cell interactions in vivo.
Imaging
Delivery to target tissue
Heat therapy
Table: Smart Drug delivery
Summary
Future Clinical Applications
Imaging
Smart Drug release
Heat therapy
Commercialisation and limitations.
To consider with SPION-loaded polymersomes.
Important Material Properties
Biomaterial Design Considerations.
Bio... inertness, resorbability, bioactivity, functionalisation, (inflammation, immune response, toxicity)
Topography / Surface Chemistry of a changeable structure? How to attach?
What are the adsorbtion / degradation mechanisms for the polymers and NPs. Byproducts?
Micro polymersome properties vs Nano SPION properties.
Cellular interaction (and functionalisation?) wrt physical / chemical attributes and biofunctionalisation? Surface patterning?
