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− | The aim of the project is to optimize the expression of the proteins amyloid-beta and tau in the bacteria Escherichia coli. These proteins are known to be linked to the development of Alzheimer's disease, though the cause of the disease is still unknown [1]. They are both found in the brain in and around our neurons, and during Alzheimer's disease they accumulate to form plaques and tangles [ | + | The aim of the project is to optimize the expression of the proteins amyloid-beta and tau in the bacteria Escherichia coli. These proteins are known to be linked to the development of Alzheimer's disease, though the cause of the disease is still unknown [1]. They are both found in the brain in and around our neurons, and during Alzheimer's disease they accumulate to form plaques and tangles [2, 3]. Because these proteins are prone to misfolding and aggregate they are hard to study in a laboratory environment, which has slowed down research. It’s here our project comes in, trying to facilitate the production of these proteins. |
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1. Alzheimerfonden. Alzheimers sjukdom [Internet]. Cited 2017-06-15. Available from: http://www.alzheimerfonden.se/om_demens/alzheimers_sjukdom [in swedish] | 1. Alzheimerfonden. Alzheimers sjukdom [Internet]. Cited 2017-06-15. Available from: http://www.alzheimerfonden.se/om_demens/alzheimers_sjukdom [in swedish] | ||
− | </br> 2. Alzheimer´s Disease International. Dementia statistics [Internet]. Cited 2017-06-27. Available from: https://www.alz.co.uk/research/statistics | + | <!--</br> 2. Alzheimer´s Disease International. Dementia statistics [Internet]. Cited 2017-06-27. Available from: https://www.alz.co.uk/research/statistics--> |
− | </br> | + | </br> 2. Alzheimerfonden. Lexikon för Alzheimers sjukdom och andra demenssjukdomar [Internet]. Cited 2017-06-15. Available from: http://www.alzheimerfonden.se/om_demens/lexikon [in swedish] |
− | </br> | + | </br> 3. Bloom GS. Amyloid-β and TauThe Trigger and Bullet in Alzheimer Disease Pathogenesis. JAMA Neurol. 2014;71(4):505-508. doi:10.1001/jamaneurol.2013.5847 |
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Revision as of 14:57, 9 September 2017