Difference between revisions of "Team:Hong Kong-CUHK/HP/Gold Integrated"

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<h3>★  ALERT! </h3>
 
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<p>This page is used by the judges to evaluate your team for the <a href="https://2017.igem.org/Judging/Medals">medal criterion</a> or <a href="https://2017.igem.org/Judging/Awards"> award listed above</a>. </p>
 
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<p> Delete this box in order to be evaluated for this medal criterion and/or award. See more information at <a href="https://2017.igem.org/Judging/Pages_for_Awards"> Instructions for Pages for awards</a>.</p>
 
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<h1><b><u>Integrated Human Practice</u></b></h1>
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<p><b>Interview and questionnaire of different skateholders<b>
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<br>
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<b>influenza</b>is an infectious disease caused by influenza virus, we usually simply call it &quot;flu&quot;. There
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is usually an outbreak every year in the world, Hong kong is not excluded:
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<br>
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<br>
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According to the latest figures (up to 17 August 2017) from the Department of Health, HKSAR,
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536 cases of severe illness and 388 deaths were recorded, affecting Hong Kong a lot every year
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undoubtedly in terms of public healthcare system, economy. In order to let our design suit the
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real needs of potential users, it is necessary to understand their concerns except only focusing
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on the construction of biobricks.
  
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<h1>Gold Medal and Integrated Human Practices</h1>
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</p>
  
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<p>This page will contain information for your Gold medal Human Practices work, which you can also use to nominate your team for the Best Integrated Human Practices page. To make things easier, we have combined the Gold medal page with the Best Integrated Human Practices page since we expect the work to overlap considerably. </p>
 
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<p>iGEM teams are unique and leading the field because they "go beyond the lab" to imagine their projects in a social/environmental context, to better understand issues that might influence the design and use of their technologies.</p>
 
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<p>Teams work with students and advisors from the humanities and social sciences to explore topics concerning ethical, legal, social, economic, safety or security issues related to their work. Consideration of these Human Practices is crucial for building safe and sustainable projects that serve the public interest. </p>
 
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<p>For more information, please see the <a href="https://2017.igem.org/Competition/Human_Practices">Human Practices page</a>.</p>
 
 
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There are 4 major potential users: medical expert, chicken farmer, government, general public.
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<h2><b><u>Medical Expert</u></b></h2>
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<p><b>1. Professor Chan Kay Sheung, Paul</b>
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<br>
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We interviewed Professor Paul Chan at the department of Microbiology, Prince of Wales Hospital. Professor Paul Chan is an <b><u>Honorary Consultant in Microbiology of the Hong Kong Hospital Authority</u><b>. He is also a <b><u>member of the Global Outbreak Alert and Response Network of World Health Organization</u></b>.He is an <b><u>expert of molecular methods for rapid diagnosis and strain characterization (conducted research in?)</u></b>.
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<br>
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The conversation with Prof. Chan was fruitful. He had explained the whole process of influenza detection, from sample collection to standard diagnosis procedures in very detail, which set a clearer direction on what we should focus more. For example, there is a verity of sources of sample can be collected from patient: <u>Nasopharyngeal aspirate is the most sensitive source</u> to be examined, however, <u>assistance of nurse is required</u>, while <u>throat swab</u> is the common method adopted in clinic due to its <u>easier manipulation and collection</u>, but lower amount of virus can be found here, leading to lower accuracy. Thus, He emphasized the importance of the sensitivity: if the product we designed is sensitive enough (sensitivity performance similar to PCR reaction (molecular assay)), the source limitation is no longer an obstacle and it can then be applied in the clinic without the help of profession of collecting human specimens.
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<br>
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Thus, we decided to package our design as <h5><u>“point of care”</u></h5>, can be applied in both hospital and clinic, especially useful in nightshift and peak season. Besides, as suggested by Prof Chan, <h5><u>distinguishing the subtype of influenza is not very significant in tackling flu</u></h5>, because currently available medicine can already defeat all types of influenza. Reversely, <b><u>subtyping is relatively important to be the parameter of deciding the release of chicken to the market</u></b>. Thus, two directions of detection are proposed: for human, identification of the <h8><u>presence of influenza(Avian?)</u></h8> is enough; as for subtyping, it is more suitable to be applied in <h8><u>chicken detection</u></h8>.
  
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<h3>Gold Medal Criterion #1</h3>
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<p>Expand on your silver medal activity by demonstrating how you have integrated the investigated issues into the design and/or execution of your project.</p>
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<h3>Best Integrated Human Practices Special Prize</h3>
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To compete for the <a href="https://2017.igem.org/Judging/Awards">Best Integrated Human Practices prize</a>, please describe your work on this page and also fill out the description on the <a href="https://2017.igem.org/Judging/Judging_Form">judging form</a>.
 
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You must also delete the message box on the top of this page to be eligible for this prize.
 
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Revision as of 18:03, 15 September 2017





Integrated Human Practice

Interview and questionnaire of different skateholders
influenzais an infectious disease caused by influenza virus, we usually simply call it "flu". There is usually an outbreak every year in the world, Hong kong is not excluded:

According to the latest figures (up to 17 August 2017) from the Department of Health, HKSAR, 536 cases of severe illness and 388 deaths were recorded, affecting Hong Kong a lot every year undoubtedly in terms of public healthcare system, economy. In order to let our design suit the real needs of potential users, it is necessary to understand their concerns except only focusing on the construction of biobricks.

There are 4 major potential users: medical expert, chicken farmer, government, general public.

Medical Expert

1. Professor Chan Kay Sheung, Paul
We interviewed Professor Paul Chan at the department of Microbiology, Prince of Wales Hospital. Professor Paul Chan is an Honorary Consultant in Microbiology of the Hong Kong Hospital Authority. He is also a member of the Global Outbreak Alert and Response Network of World Health Organization.He is an expert of molecular methods for rapid diagnosis and strain characterization (conducted research in?).

The conversation with Prof. Chan was fruitful. He had explained the whole process of influenza detection, from sample collection to standard diagnosis procedures in very detail, which set a clearer direction on what we should focus more. For example, there is a verity of sources of sample can be collected from patient: Nasopharyngeal aspirate is the most sensitive source to be examined, however, assistance of nurse is required, while throat swab is the common method adopted in clinic due to its easier manipulation and collection, but lower amount of virus can be found here, leading to lower accuracy. Thus, He emphasized the importance of the sensitivity: if the product we designed is sensitive enough (sensitivity performance similar to PCR reaction (molecular assay)), the source limitation is no longer an obstacle and it can then be applied in the clinic without the help of profession of collecting human specimens.

Thus, we decided to package our design as

“point of care”
, can be applied in both hospital and clinic, especially useful in nightshift and peak season. Besides, as suggested by Prof Chan,
distinguishing the subtype of influenza is not very significant in tackling flu
, because currently available medicine can already defeat all types of influenza. Reversely, subtyping is relatively important to be the parameter of deciding the release of chicken to the market. Thus, two directions of detection are proposed: for human, identification of the presence of influenza(Avian?) is enough; as for subtyping, it is more suitable to be applied in chicken detection.

Inspiration

Here are a few examples of excellent Integrated Human Practices work: