Difference between revisions of "Team:AFCM-Egypt"
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<section class="section-wrapper add container"> | <section class="section-wrapper add container"> | ||
<div class="slider-wrapper theme-mi-slider"> | <div class="slider-wrapper theme-mi-slider"> | ||
| − | <div id=" | + | |
| − | + | <div class="afcmslider-holder"> | |
| − | + | <button class="afcmcontrols" id="afcmcontrols-left">❮</button> | |
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| − | + | <li class="afcmslide afcmshowing"> | |
| − | + | <img src="https://static.igem.org/mediawiki/2017/b/bb/2-AFCM-Egypt-sponsers-EFIA_LOGO.png"> | |
| − | + | <img src="https://static.igem.org/mediawiki/2017/b/bd/3-AFCM-Egypt-sponsers-Pharco_Logo.png"> | |
| − | + | <img src="https://static.igem.org/mediawiki/2017/3/3b/4-AFCM-Egypt-sponsers-Nationel_Research.png"> | |
| − | + | <img src="https://static.igem.org/mediawiki/2017/f/f1/1-AFCM-Egypt-sponsers-vitabiotics.png"> | |
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| + | <img src="https://static.igem.org/mediawiki/2017/3/37/5-AFCM-Egypt-sponsers-IDT.png"> | ||
| + | <img src="https://static.igem.org/mediawiki/2017/6/60/9-AFCM-Egypt-sponsers-Benchling.png"> | ||
| + | <img src="https://static.igem.org/mediawiki/2017/b/b4/8-AFCM-Egypt-sponsers-Zewail_logo.png"></li> | ||
| + | </ul> | ||
| + | |||
| + | </div> | ||
</div> | </div> | ||
</section> | </section> | ||
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<script> | <script> | ||
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Revision as of 00:32, 17 October 2017
Abstract
Knock-in of Circular RNA gene in Hepatocellular Carcinoma cells via CRISPR/Cas9
Hepatocellular Carcinoma (HCC) is the leading cause of cancer deaths worldwide & ranked first among cancers
in males and next to breast cancer among females in Egypt - based upon results of National Cancer Registry Program of Egypt-.
"Grabbing the problem from the roots" is the best way to decently describe the use of CRISPR, a special gene editing technique
that we will be using to modulate a certain circRNA and adjust its gene expression, which is down-regulated in hepatocellular carcinoma.
This in consequence modifies miRNA expression thus amending the mRNA gene expression; which is the visible problem in our trials.
This will lead us to adopt a novel strategy for miRNA suppression by using circRNAs. This is accomplished by utilizing a synthetic circuit to give rise to a springboard in our battle against cancer.
Hepatocellular Carcinoma (HCC) is the leading cause of cancer deaths worldwide & ranked first among cancers in males and next to breast cancer among females in Egypt - based upon results of National Cancer Registry Program of Egypt-. "Grabbing the problem from the roots" is the best way to decently describe the use of CRISPR, a special gene editing technique that we will be using to modulate a certain circRNA and adjust its gene expression, which is down-regulated in hepatocellular carcinoma. This in consequence modifies miRNA expression thus amending the mRNA gene expression; which is the visible problem in our trials. This will lead us to adopt a novel strategy for miRNA suppression by using circRNAs. This is accomplished by utilizing a synthetic circuit to give rise to a springboard in our battle against cancer.
AFCM-Egypt
We strive to excel
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