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The aim of the project is to optimize the expression of the proteins amyloid-beta and tau in the bacteria Escherichia coli. These proteins are known to be linked to the development of Alzheimer's disease, though the cause of the disease is still unknown [1]. They are both found in the brain in and around our neurons, and during Alzheimer's disease they accumulate to form plaques and tangles [2, 3]. Because these proteins are prone to misfolding and aggregate they are hard to study in a laboratory environment, which has slowed down research. It’s here our project comes in, trying to facilitate the production of these proteins. | The aim of the project is to optimize the expression of the proteins amyloid-beta and tau in the bacteria Escherichia coli. These proteins are known to be linked to the development of Alzheimer's disease, though the cause of the disease is still unknown [1]. They are both found in the brain in and around our neurons, and during Alzheimer's disease they accumulate to form plaques and tangles [2, 3]. Because these proteins are prone to misfolding and aggregate they are hard to study in a laboratory environment, which has slowed down research. It’s here our project comes in, trying to facilitate the production of these proteins. | ||
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+ | To optimize the expression of the proteins we will be using chaperones. Chaperones are proteins that can help other proteins to fold into their native three-dimensional shape, by dissolving aggregates and guiding both unfolded and misfolded proteins to their correctly folded form. During our project we will be using four different chaperones and we will see how different combinations of these affect the expression of Amyloid-beta and Tau respectively. | ||
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To optimize the expression of the proteins we will be using chaperones. Chaperones are proteins that can help other proteins to fold into their native three-dimensional shape, by dissolving aggregates and guiding both unfolded and misfolded proteins to their correctly folded form. During our project we will be using four different chaperones and we will see how different combinations of these affect the expression of Amyloid-beta and Tau respectively. | To optimize the expression of the proteins we will be using chaperones. Chaperones are proteins that can help other proteins to fold into their native three-dimensional shape, by dissolving aggregates and guiding both unfolded and misfolded proteins to their correctly folded form. During our project we will be using four different chaperones and we will see how different combinations of these affect the expression of Amyloid-beta and Tau respectively. | ||
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Revision as of 18:06, 22 October 2017