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| + | <h1>Modeling on the sensing device</h1> |
| − | <div class="col-sm-6">
| + | <p>In the mathematical modeling of quorum sensing, we formulated a system of ordinary equations representing the intracellular and extracellular interactions between the two Agr proteins and AIP (auto-inducing peptide) molecules. Along with numerical simulations, we performed an asymptotic analysis of the time-dependent model in order to characterize whether the AIP molecules produced by <i>Staphylococcus aureus</i> in the intestine would activate our sensing device.</p> |
| − | <h1>About Xi'an Jiaotong-Liverpool University</h1>
| + | <p>To build the model, we first proposed the following assumptions:</p> |
| − | <p> Xi'an Jiaotong-Liverpool University (XJTLU) is a young international university situated at Suzhou, a vigorous Chinese city bound with both modern technology and classic cultural atmosphere. XJTLU has been experiencing a vast speed of advancement since its establishment in 2006. The education style of XJTLU is distinctive from that of other traditional Chinese universities in that it combines the best of both Western and Chinese education systems to cultivate students' learning interests, independent and critical thinking abilities, writing skills as well as their innovation awareness, and to prepare them fully for the future world challenges and real life problems.< /p> | + | <ul> |
| − | </div>
| + | <li>The agr mRNA contains all the information required for the translation of AgrC and AgrA. There are plentiful ribosomes for translation within the cells and the rates of translations of AgrC and AgrA are the same, and are proportional to the concentrations of their mRNA.</li> |
| − | <div class="col-sm-6">
| + | <li>Proteins and mRNA inside the cells are limited by natural degradation.</li> |
| − | <img class="img-responsive center-block img-thumbnail school" src="https://static.igem.org/mediawiki/2017/2/28/XJTLU.jpg">
| + | <li>Housekeeping phosphatases are able to dephosphorylate AgrA at rate α<sb>pidi</sub>.</li> |
| − | </div>
| + | <li>Receptor-bound AIP can dissociate spontaneously at rate α<sub>unbind</sub>.</li> |
| − | </div> | + | <li>When an AIP binds to AgrC, we assume that auto-phosphorylation of AgrC happens simultaneously because this process is sufficiently fast. When AgrC transfers its phosphate group to AgrA at rate α<sub>pi</sub>, it is able to re-auto-phosphorylate.</li> |
| − | <hr class="member-divider"> | + | </ul> |
| − | <div class="row"> | + | <p>The resulting equations, together with the definitions of the parameters and variables are shown below. </p> |
| − | <div class="col-sm-6 col-sm-push-6">
| + | <img class="img-responsive center-block" src="https://static.igem.org/mediawiki/2017/7/70/Modeling_on_the_sensing_device.png" height=700 width=700> |
| − | <h1>About us</h1>
| + | <h1>Modelling on peptide synthesis and cell lysis</h1> |
| − | <p>With an explicit aim to utilize knowledge to benefit public welfare, we, students with strong social responsibility and curiosity for synthetic biology, decided to organize our own team to strive for participating in the 2017 iGEM competition. Team members of 2017 iGEM are from diverse backgrounds, but all of us are very industrious, cooperative and have the same goal. Each of us does our best to make contributions to the progression of this year's iGEM project. Not only do we reap academic knowledge and skills, but we also gain precious friendships through this meaningful competition experience. [We expect to meet more people during the competition from all over the world.]</p>
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| − | </div>
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| − | <div class="col-sm-6 col-sm-pull-6">
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| − | <img class="img-responsive center-block img-thumbnail us" src="https://static.igem.org/mediawiki/2017/e/e1/Lab_picture.jpg">
| + | |
| − | </div>
| + | |
| − | </div> | + | |
| − | <hr class="member-divider"> | + | |
| − | <!--Team member introduction--!> | + | |
| − | <!--Wangtianjun--!> | + | |
| − | <div class="row member"> | + | |
| − | <div class="col-sm-7 text-center">
| + | |
| − | <h1 class="member-heading">Tianjun Wang</h1>
| + | |
| − | <h1 class="text-muted">Year 2 Bioinformatics</h2>
| + | |
| − | <h2 class="lead" style="text-align:center;">Personality: Be hardworking than others, but don't tell them so</br>
| + | |
| − | Hobbies: Animation & Cycling</br>
| + | |
| − | One word to iGEM: Persistence
| + | |
| − | </h2>
| + | |
| − | </div>
| + | |
| − | <div class="col-sm-5">
| + | |
| − | <img class=" member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/7/ 7e/ Wangtianjun. jpg" height= 400 width= 400> | + | |
| − | </div>
| + | |
| − | </div> | + | |
| | | | |
| − | <hr class="member-divider">
| |
| − | <!--Gongyijing--!>
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| − | <div class="row member">
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| − | <div class="col-sm-7 col-sm-push-5 text-center">
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| − | <h1 class="member-heading">Yijing Gong</h1>
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| − | <h1 class="text-muted">Year 2 Biological Sciences</h1>
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| − | <h2 class="lead" style="text-align:center;">Personality: Creative, Crazy & Naive</br>
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| − | Hobbies: Everything that I prefer to do</br>
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| − | One word to iGEM: Intelligence
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| − | </h2>
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| − | </div>
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| − | <div class="col-sm-5 col-sm-pull-7">
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| − | <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/2/23/Gongyijing.jpg" height=400 width=400>
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| − | </div>
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| − | </div>
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| − |
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| − | <hr class="member-divider">
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| − | <!--Fanghaohui--!>
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| − | <div class="row member">
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| − | <div class="col-sm-7 text-center">
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| − | <h1 class="member-heading">Haohui Fang</h1>
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| − | <h1 class="text-muted">Year 1 Applied Chemistry</h2>
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| − | <h2 class="lead" style="text-align:center;">Personality: Curious, Friendly, Positive & Active, Highly adaptive but slack off sometimes</br>
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| − | Hobbies: Table tennis, Music & Watching sports games</br>
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| − | One word to iGEM: Hobby
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| − | </h2>
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| − | </div>
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| − | <div class="col-sm-5">
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| − | <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/c/c4/Fanghaohui.jpg" height=400 width=400>
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| − | </div>
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| − | </div>
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| − |
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| − | <hr class="member-divider">
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| − | <!--Lihuiting--!>
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| − | <div class="row member">
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| − | <div class="col-sm-7 col-sm-push-5 text-center">
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| − | <h1 class="member-heading">Huiting Li</h1>
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| − | <h1 class="text-muted">Year 2 Biological Sciences</h1>
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| − | <h2 class="lead" style="text-align:center;">Personality: Liberalist</br>
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| − | Hobbies: Imagining & Dreaming</br>
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| − | One word to iGEM: Cooperation
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| − | </h2>
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| − | </div>
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| − | <div class="col-sm-5 col-sm-pull-7">
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| − | <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/0/03/Lihuiting.jpg" height=400 width=400>
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| − | </div>
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| − | </div>
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| − |
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| − | <hr class="member-divider">
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| − | <!--Jinziyin--!>
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| − | <div class="row member">
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| − | <div class="col-sm-7 text-center">
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| − | <h1 class="member-heading">Zinyin Jin</h1>
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| − | <h1 class="text-muted">Year 3 Biological Sciences</h2>
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| − | <h2 class="lead" style="text-align:center;">Personality: Optimistic</br>
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| − | Hobbies: Urheen & Calligraphy</br>
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| − | One word to iGEM: Innovation
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| − | </h2>
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| − | </div>
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| − | <div class="col-sm-5">
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| | <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/0/06/Jinziyin.jpg" height=400 width=400> | | <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/0/06/Jinziyin.jpg" height=400 width=400> |
| − | </div>
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| − | </div>
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| − |
| |
| − | <hr class="member-divider">
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| − | <!--Songyiyou--!>
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| − | <div class="row member">
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| − | <div class="col-sm-7 col-sm-push-5 text-center">
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| − | <h1 class="member-heading">Yiyou Song</h1>
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| − | <h1 class="text-muted">Year 2 Bioinformatics</h1>
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| − | <h2 class="lead" style="text-align:center;">Personality: Complex</br>
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| − | Hobbies: Game</br>
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| − | One word to iGEM: Creativity
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| − | </h2>
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| − | </div>
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| − | <div class="col-sm-5 col-sm-pull-7">
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| − | <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/a/ac/Songyiyou.jpg" height=400 width=400>
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| − | </div>
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| − | </div>
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| − |
| |
| − | <hr class="member-divider">
| |
| − | <!--Rongzixin--!>
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| − | <div class="row member">
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| − | <div class="col-sm-7 text-center">
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| − | <h1 class="member-heading">Zixin Rong</h1>
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| − | <h1 class="text-muted">Year 2 Biological Sciences</h2>
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| − | <h2 class="lead" style="text-align:center;">Personality: Introverted</br>
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| − | Hobbies: Daydreaming & Instrument</br>
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| − | One word to iGEM: Imagination
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| − | </h2>
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| − | </div>
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| − | <div class="col-sm-5">
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| − | <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/d/dd/Rongzixin.jpg" height=400 width=400>
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| − | </div>
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| − | </div>
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| − |
| |
| − | <hr class="member-divider">
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| − | <!--Panwenlan--!>
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| − | <div class="row member">
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| − | <div class="col-sm-7 col-sm-push-5 text-center">
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| − | <h1 class="member-heading">Wenlan Pan</h1>
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| − | <h1 class="text-muted">Year 2 Bioinformatics</h1>
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| − | <h2 class="lead" style="text-align:center;">Personality: Emotional & Perfectionist</br>
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| − | Hobbies: Reading, Sleeping & Eating</br>
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| − | One word to iGEM: Motivated
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| − | </h2>
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| − | </div>
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| − | <div class="col-sm-5 col-sm-pull-7">
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| − | <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/b/ba/Panwenlan.jpg" height=400 width=400>
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| − | </div>
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| − | </div>
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| − |
| |
| − | <hr class="member-divider">
| |
| − | <!--Zhangxidan--!>
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| − | <div class="row member">
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| − | <div class="col-sm-7 text-center">
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| − | <h1 class="member-heading">Xidan Zhang</h1>
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| − | <h1 class="text-muted">Year 2 Biological Sciences</h2>
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| − | <h2 class="lead" style="text-align:center;">Personality: Curious & Persistent</br>
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| − | Hobbies: Puzzle games & Reading novels</br>
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| − | One word to iGEM: Challenge
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| − | </h2>
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| − | </div>
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| − | <div class="col-sm-5">
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| − | <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/f/f7/Zhangxidan.jpg" height=400 width=400>
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| − | </div>
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| − | </div>
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| − |
| |
| − | <hr class="member-divider">
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| − | <!--Hangyuqi--!>
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| − | <div class="row member">
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| − | <div class="col-sm-7 col-sm-push-5 text-center">
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| − | <h1 class="member-heading">Yuqi Hang</h1>
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| − | <h1 class="text-muted">Year 1 Biological Sciences</h1>
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| − | <h2 class="lead" style="text-align:center;">Personality: Curious & Passionate</br>
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| − | Hobbies: Neuroscience & Philosophy</br>
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| − | One word to iGEM: Opportunity
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| − | </h2>
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| − | </div>
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| − | <div class="col-sm-5 col-sm-pull-7">
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| − | <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/1/17/Hangyuqi.jpg" height=400 width=400>
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| − | </div>
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| − | </div>
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| − |
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| − | <hr class="member-divider">
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| − | <!--Gongzhiyun--!>
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| − | <div class="row member">
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| − | <div class="col-sm-7 text-center">
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| − | <h1 class="member-heading">Zhiyun Gong</h1>
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| − | <h1 class="text-muted">Year 2 Bioinformatics</h2>
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| − | <h2 class="lead" style="text-align:center;">Personality: Always digging deeper in my own personality and depicting the true self </br>
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| − | Hobbies: Switching between deliberating and wandering without destination</br>
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| − | One word to iGEM: Youth
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| − | </h2>
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| − | </div>
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| − | <div class="col-sm-5">
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| − | <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/5/59/Gongzhiyun.jpg" height=400 width=400>
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| − | </div>
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| − | </div>
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| − |
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| − | <hr class="member-divider">
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| − | <!--Fengsijie--!>
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| − | <div class="row member">
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| − | <div class="col-sm-7 col-sm-push-5 text-center">
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| − | <h1 class="member-heading">Sijie Feng</h1>
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| − | <h1 class="text-muted">Year 2 Biological Sciences</h1>
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| − | <h2 class="lead" style="text-align:center;">Personality: Practical & Open-minded</br>
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| − | Hobbies: Anime tennis</br>
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| − | One word to iGEM: Test
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| − | </h2>
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| − | </div>
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| − | <div class="col-sm-5 col-sm-pull-7">
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| − | <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/6/6e/Fengsijie.jpg" height=400 width=400>
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| − | </div>
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| − | </div>
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| − |
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| − | <hr class="member-divider">
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| − |
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| − |
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| | | | |
| − | <!--supervisors and advisers--!>
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| − | <div class="text-center" style="margin-bottom:30px;">
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| − | <h1 style="text-align: center;">The Back-up Team</h1>
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| − | <h2 class="text-muted lead" style="text-align:center;">In addition, we want to express our sincere thanks to supervisors and advisers for all the help.</h2>
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| − | </div>
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| − | <div class="row text-center">
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| − | <div class="col-sm-6 col-md-3">
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| − | <img class="img-circle center-block" src="https://static.igem.org/mediawiki/2017/e/ed/Hanguoxia.jpg" width="200" height="200">
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| − | <h2>Dr. Guoxia Han</h2>
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| − | </div><!--/.col-sm-6 col-md-3-->
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| − | <div class="col-sm-6 col-md-3">
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| − | <img class="img-circle center-block" src="https://static.igem.org/mediawiki/2017/7/7b/Chiu.jpg" width="200" height="200">
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| − | <h2>Dr. David Chiu</h2>
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| − | </div><!--/.col-sm-6 col-md-3-->
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| − | <div class="col-sm-6 col-md-3">
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| − | <img class="img-circle center-block" src="https://static.igem.org/mediawiki/2017/6/6e/Dechang_Xu.jpg" width="200" height="200">
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| − | <h2>Prof. Dechang Xu</h2>
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| − | </div><!--/.col-sm-6 col-md-3-->
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| − | <div class="col-sm-6 col-md-3">
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| − | <img class="img-circle center-block" src="https://static.igem.org/mediawiki/2017/9/9c/Yunpeng_Zhong.jpg" width="200" height="200">
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| − | <h2>Mr. Yunpeng Zhong (MSc)</h2>
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| − | </div><!--/.col-sm-6 col-md-3-->
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| − | </div> <!--/.row-->
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| | </div><!--container--!> | | </div><!--container--!> |
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