Difference between revisions of "Team:Utrecht/"

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<link rel='stylesheet prefetch' href='https://cdn3.devexpress.com/jslib/17.1.3/css/dx.light.css'>
 
<link rel='stylesheet prefetch' href='https://cdn3.devexpress.com/jslib/17.1.3/css/dx.light.css'>
 
 
−
<link rel="stylesheet" type="text/css" href="slick/slick.css"/>
+
<style>
−
<link rel="stylesheet" type="text/css" href="slick/slick-theme.css"/>
+
@charset 'UTF-8';
 +
/* Slider */
 +
.slick-loading .slick-list
 +
{
 +
    background: #fff url('./ajax-loader.gif') center center no-repeat;
 +
}
 +
 
 +
/* Icons */
 +
@font-face
 +
{
 +
    font-family: 'slick';
 +
    font-weight: normal;
 +
    font-style: normal;
 +
 
 +
    src: url('./fonts/slick.eot');
 +
    src: url('./fonts/slick.eot?#iefix') format('embedded-opentype'), url('./fonts/slick.woff') format('woff'), url('./fonts/slick.ttf') format('truetype'), url('./fonts/slick.svg#slick') format('svg');
 +
}
 +
/* Arrows */
 +
.slick-prev,
 +
.slick-next
 +
{
 +
    font-size: 0;
 +
    line-height: 0;
 +
 
 +
    position: absolute;
 +
    top: 50%;
 +
 
 +
    display: block;
 +
 
 +
    width: 20px;
 +
    height: 20px;
 +
    padding: 0;
 +
    -webkit-transform: translate(0, -50%);
 +
    -ms-transform: translate(0, -50%);
 +
    transform: translate(0, -50%);
 +
 
 +
    cursor: pointer;
 +
 
 +
    color: transparent;
 +
    border: none;
 +
    outline: none;
 +
    background: transparent;
 +
}
 +
.slick-prev:hover,
 +
.slick-prev:focus,
 +
.slick-next:hover,
 +
.slick-next:focus
 +
{
 +
    color: transparent;
 +
    outline: none;
 +
    background: transparent;
 +
}
 +
.slick-prev:hover:before,
 +
.slick-prev:focus:before,
 +
.slick-next:hover:before,
 +
.slick-next:focus:before
 +
{
 +
    opacity: 1;
 +
}
 +
.slick-prev.slick-disabled:before,
 +
.slick-next.slick-disabled:before
 +
{
 +
    opacity: .25;
 +
}
 +
 
 +
.slick-prev:before,
 +
.slick-next:before
 +
{
 +
    font-family: 'slick';
 +
    font-size: 20px;
 +
    line-height: 1;
 +
 
 +
    opacity: .75;
 +
    color: white;
 +
 
 +
    -webkit-font-smoothing: antialiased;
 +
    -moz-osx-font-smoothing: grayscale;
 +
}
 +
 
 +
.slick-prev
 +
{
 +
    left: -25px;
 +
}
 +
[dir='rtl'] .slick-prev
 +
{
 +
    right: -25px;
 +
    left: auto;
 +
}
 +
.slick-prev:before
 +
{
 +
    content: '←';
 +
}
 +
[dir='rtl'] .slick-prev:before
 +
{
 +
    content: '→';
 +
}
 +
 
 +
.slick-next
 +
{
 +
    right: -25px;
 +
}
 +
[dir='rtl'] .slick-next
 +
{
 +
    right: auto;
 +
    left: -25px;
 +
}
 +
.slick-next:before
 +
{
 +
    content: '→';
 +
}
 +
[dir='rtl'] .slick-next:before
 +
{
 +
    content: '←';
 +
}
 +
 
 +
/* Dots */
 +
.slick-dotted.slick-slider
 +
{
 +
    margin-bottom: 30px;
 +
}
 +
 
 +
.slick-dots
 +
{
 +
    position: absolute;
 +
    bottom: -25px;
 +
 
 +
    display: block;
 +
 
 +
    width: 100%;
 +
    padding: 0;
 +
    margin: 0;
 +
 
 +
    list-style: none;
 +
 
 +
    text-align: center;
 +
}
 +
.slick-dots li
 +
{
 +
    position: relative;
 +
 
 +
    display: inline-block;
 +
 
 +
    width: 20px;
 +
    height: 20px;
 +
    margin: 0 5px;
 +
    padding: 0;
 +
 
 +
    cursor: pointer;
 +
}
 +
.slick-dots li button
 +
{
 +
    font-size: 0;
 +
    line-height: 0;
 +
 
 +
    display: block;
 +
 
 +
    width: 20px;
 +
    height: 20px;
 +
    padding: 5px;
 +
 
 +
    cursor: pointer;
 +
 
 +
    color: transparent;
 +
    border: 0;
 +
    outline: none;
 +
    background: transparent;
 +
}
 +
.slick-dots li button:hover,
 +
.slick-dots li button:focus
 +
{
 +
    outline: none;
 +
}
 +
.slick-dots li button:hover:before,
 +
.slick-dots li button:focus:before
 +
{
 +
    opacity: 1;
 +
}
 +
.slick-dots li button:before
 +
{
 +
    font-family: 'slick';
 +
    font-size: 6px;
 +
    line-height: 20px;
 +
 
 +
    position: absolute;
 +
    top: 0;
 +
    left: 0;
 +
 
 +
    width: 20px;
 +
    height: 20px;
 +
 
 +
    content: '•';
 +
    text-align: center;
 +
 
 +
    opacity: .25;
 +
    color: black;
 +
 
 +
    -webkit-font-smoothing: antialiased;
 +
    -moz-osx-font-smoothing: grayscale;
 +
}
 +
.slick-dots li.slick-active button:before
 +
{
 +
    opacity: .75;
 +
    color: black;
 +
}
 +
 
 +
</style>
 +
 +
<style>
 +
/* Slider */
 +
.slick-slider
 +
{
 +
    position: relative;
 +
 
 +
    display: block;
 +
    box-sizing: border-box;
 +
 
 +
    -webkit-user-select: none;
 +
      -moz-user-select: none;
 +
        -ms-user-select: none;
 +
            user-select: none;
 +
 
 +
    -webkit-touch-callout: none;
 +
    -khtml-user-select: none;
 +
    -ms-touch-action: pan-y;
 +
        touch-action: pan-y;
 +
    -webkit-tap-highlight-color: transparent;
 +
}
 +
 
 +
.slick-list
 +
{
 +
    position: relative;
 +
 
 +
    display: block;
 +
    overflow: hidden;
 +
 
 +
    margin: 0;
 +
    padding: 0;
 +
}
 +
.slick-list:focus
 +
{
 +
    outline: none;
 +
}
 +
.slick-list.dragging
 +
{
 +
    cursor: pointer;
 +
    cursor: hand;
 +
}
 +
 
 +
.slick-slider .slick-track,
 +
.slick-slider .slick-list
 +
{
 +
    -webkit-transform: translate3d(0, 0, 0);
 +
      -moz-transform: translate3d(0, 0, 0);
 +
        -ms-transform: translate3d(0, 0, 0);
 +
        -o-transform: translate3d(0, 0, 0);
 +
            transform: translate3d(0, 0, 0);
 +
}
 +
 
 +
.slick-track
 +
{
 +
    position: relative;
 +
    top: 0;
 +
    left: 0;
 +
 
 +
    display: block;
 +
    margin-left: auto;
 +
    margin-right: auto;
 +
}
 +
.slick-track:before,
 +
.slick-track:after
 +
{
 +
    display: table;
 +
 
 +
    content: '';
 +
}
 +
.slick-track:after
 +
{
 +
    clear: both;
 +
}
 +
.slick-loading .slick-track
 +
{
 +
    visibility: hidden;
 +
}
 +
 
 +
.slick-slide
 +
{
 +
    display: none;
 +
    float: left;
 +
 
 +
    height: 100%;
 +
    min-height: 1px;
 +
}
 +
[dir='rtl'] .slick-slide
 +
{
 +
    float: right;
 +
}
 +
.slick-slide img
 +
{
 +
    display: block;
 +
}
 +
.slick-slide.slick-loading img
 +
{
 +
    display: none;
 +
}
 +
.slick-slide.dragging img
 +
{
 +
    pointer-events: none;
 +
}
 +
.slick-initialized .slick-slide
 +
{
 +
    display: block;
 +
}
 +
.slick-loading .slick-slide
 +
{
 +
    visibility: hidden;
 +
}
 +
.slick-vertical .slick-slide
 +
{
 +
    display: block;
 +
 
 +
    height: auto;
 +
 
 +
    border: 1px solid transparent;
 +
}
 +
.slick-arrow.slick-hidden {
 +
    display: none;
 +
}
 +
</style>
 
 
 
<style>
 
<style>
Line 1,660: Line 1,987:
 
<script src="https://ajax.googleapis.com/ajax/libs/scriptaculous/1.9.0/scriptaculous.js"></script>
 
<script src="https://ajax.googleapis.com/ajax/libs/scriptaculous/1.9.0/scriptaculous.js"></script>
  
−
<script type="text/javascript" src="slick/slick.min.js"></script>
+
<script type="text/javascript">!function(i){"use strict";"function"==typeof define&&define.amd?define(["jquery"],i):"undefined"!=typeof exports?module.exports=i(require("jquery")):i(jQuery)}(function(i){"use strict";var e=window.Slick||{};(e=function(){var e=0;return function(t,o){var s,n=this;n.defaults={accessibility:!0,adaptiveHeight:!1,appendArrows:i(t),appendDots:i(t),arrows:!0,asNavFor:null,prevArrow:'<button class="slick-prev" aria-label="Previous" type="button">Previous</button>',nextArrow:'<button class="slick-next" aria-label="Next" type="button">Next</button>',autoplay:!1,autoplaySpeed:3e3,centerMode:!1,centerPadding:"50px",cssEase:"ease",customPaging:function(e,t){return i('<button type="button" />').text(t+1)},dots:!1,dotsClass:"slick-dots",draggable:!0,easing:"linear",edgeFriction:.35,fade:!1,focusOnSelect:!1,focusOnChange:!1,infinite:!0,initialSlide:0,lazyLoad:"ondemand",mobileFirst:!1,pauseOnHover:!0,pauseOnFocus:!0,pauseOnDotsHover:!1,respondTo:"window",responsive:null,rows:1,rtl:!1,slide:"",slidesPerRow:1,slidesToShow:1,slidesToScroll:1,speed:500,swipe:!0,swipeToSlide:!1,touchMove:!0,touchThreshold:5,useCSS:!0,useTransform:!0,variableWidth:!1,vertical:!1,verticalSwiping:!1,waitForAnimate:!0,zIndex:1e3},n.initials={animating:!1,dragging:!1,autoPlayTimer:null,currentDirection:0,currentLeft:null,currentSlide:0,direction:1,$dots:null,listWidth:null,listHeight:null,loadIndex:0,$nextArrow:null,$prevArrow:null,scrolling:!1,slideCount:null,slideWidth:null,$slideTrack:null,$slides:null,sliding:!1,slideOffset:0,swipeLeft:null,swiping:!1,$list:null,touchObject:{},transformsEnabled:!1,unslicked:!1},i.extend(n,n.initials),n.activeBreakpoint=null,n.animType=null,n.animProp=null,n.breakpoints=[],n.breakpointSettings=[],n.cssTransitions=!1,n.focussed=!1,n.interrupted=!1,n.hidden="hidden",n.paused=!0,n.positionProp=null,n.respondTo=null,n.rowCount=1,n.shouldClick=!0,n.$slider=i(t),n.$slidesCache=null,n.transformType=null,n.transitionType=null,n.visibilityChange="visibilitychange",n.windowWidth=0,n.windowTimer=null,s=i(t).data("slick")||{},n.options=i.extend({},n.defaults,o,s),n.currentSlide=n.options.initialSlide,n.originalSettings=n.options,void 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if(t<0||t>=s.slideCount)return!1;s.unload(),"number"==typeof t?0===t&&0===s.$slides.length?i(e).appendTo(s.$slideTrack):o?i(e).insertBefore(s.$slides.eq(t)):i(e).insertAfter(s.$slides.eq(t)):!0===o?i(e).prependTo(s.$slideTrack):i(e).appendTo(s.$slideTrack),s.$slides=s.$slideTrack.children(this.options.slide),s.$slideTrack.children(this.options.slide).detach(),s.$slideTrack.append(s.$slides),s.$slides.each(function(e,t){i(t).attr("data-slick-index",e)}),s.$slidesCache=s.$slides,s.reinit()},e.prototype.animateHeight=function(){var i=this;if(1===i.options.slidesToShow&&!0===i.options.adaptiveHeight&&!1===i.options.vertical){var e=i.$slides.eq(i.currentSlide).outerHeight(!0);i.$list.animate({height:e},i.options.speed)}},e.prototype.animateSlide=function(e,t){var o={},s=this;s.animateHeight(),!0===s.options.rtl&&!1===s.options.vertical&&(e=-e),!1===s.transformsEnabled?!1===s.options.vertical?s.$slideTrack.animate({left:e},s.options.speed,s.options.easing,t):s.$slideTrack.animate({top:e},s.options.speed,s.options.easing,t):!1===s.cssTransitions?(!0===s.options.rtl&&(s.currentLeft=-s.currentLeft),i({animStart:s.currentLeft}).animate({animStart:e},{duration:s.options.speed,easing:s.options.easing,step:function(i){i=Math.ceil(i),!1===s.options.vertical?(o[s.animType]="translate("+i+"px, 0px)",s.$slideTrack.css(o)):(o[s.animType]="translate(0px,"+i+"px)",s.$slideTrack.css(o))},complete:function(){t&&t.call()}})):(s.applyTransition(),e=Math.ceil(e),!1===s.options.vertical?o[s.animType]="translate3d("+e+"px, 0px, 0px)":o[s.animType]="translate3d(0px,"+e+"px, 0px)",s.$slideTrack.css(o),t&&setTimeout(function(){s.disableTransition(),t.call()},s.options.speed))},e.prototype.getNavTarget=function(){var e=this,t=e.options.asNavFor;return t&&null!==t&&(t=i(t).not(e.$slider)),t},e.prototype.asNavFor=function(e){var t=this.getNavTarget();null!==t&&"object"==typeof t&&t.each(function(){var t=i(this).slick("getSlick");t.unslicked||t.slideHandler(e,!0)})},e.prototype.applyTransition=function(i){var e=this,t={};!1===e.options.fade?t[e.transitionType]=e.transformType+" "+e.options.speed+"ms "+e.options.cssEase:t[e.transitionType]="opacity "+e.options.speed+"ms "+e.options.cssEase,!1===e.options.fade?e.$slideTrack.css(t):e.$slides.eq(i).css(t)},e.prototype.autoPlay=function(){var i=this;i.autoPlayClear(),i.slideCount>i.options.slidesToShow&&(i.autoPlayTimer=setInterval(i.autoPlayIterator,i.options.autoplaySpeed))},e.prototype.autoPlayClear=function(){var i=this;i.autoPlayTimer&&clearInterval(i.autoPlayTimer)},e.prototype.autoPlayIterator=function(){var i=this,e=i.currentSlide+i.options.slidesToScroll;i.paused||i.interrupted||i.focussed||(!1===i.options.infinite&&(1===i.direction&&i.currentSlide+1===i.slideCount-1?i.direction=0:0===i.direction&&(e=i.currentSlide-i.options.slidesToScroll,i.currentSlide-1==0&&(i.direction=1))),i.slideHandler(e))},e.prototype.buildArrows=function(){var e=this;!0===e.options.arrows&&(e.$prevArrow=i(e.options.prevArrow).addClass("slick-arrow"),e.$nextArrow=i(e.options.nextArrow).addClass("slick-arrow"),e.slideCount>e.options.slidesToShow?(e.$prevArrow.removeClass("slick-hidden").removeAttr("aria-hidden tabindex"),e.$nextArrow.removeClass("slick-hidden").removeAttr("aria-hidden 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e=this;e.$slides=e.$slider.children(e.options.slide+":not(.slick-cloned)").addClass("slick-slide"),e.slideCount=e.$slides.length,e.$slides.each(function(e,t){i(t).attr("data-slick-index",e).data("originalStyling",i(t).attr("style")||"")}),e.$slider.addClass("slick-slider"),e.$slideTrack=0===e.slideCount?i('<div class="slick-track"/>').appendTo(e.$slider):e.$slides.wrapAll('<div class="slick-track"/>').parent(),e.$list=e.$slideTrack.wrap('<div class="slick-list"/>').parent(),e.$slideTrack.css("opacity",0),!0!==e.options.centerMode&&!0!==e.options.swipeToSlide||(e.options.slidesToScroll=1),i("img[data-lazy]",e.$slider).not("[src]").addClass("slick-loading"),e.setupInfinite(),e.buildArrows(),e.buildDots(),e.updateDots(),e.setSlideClasses("number"==typeof e.currentSlide?e.currentSlide:0),!0===e.options.draggable&&e.$list.addClass("draggable")},e.prototype.buildRows=function(){var i,e,t,o,s,n,r,l=this;if(o=document.createDocumentFragment(),n=l.$slider.children(),l.options.rows>1){for(r=l.options.slidesPerRow*l.options.rows,s=Math.ceil(n.length/r),i=0;i<s;i++){var d=document.createElement("div");for(e=0;e<l.options.rows;e++){var a=document.createElement("div");for(t=0;t<l.options.slidesPerRow;t++){var c=i*r+(e*l.options.slidesPerRow+t);n.get(c)&&a.appendChild(n.get(c))}d.appendChild(a)}o.appendChild(d)}l.$slider.empty().append(o),l.$slider.children().children().children().css({width:100/l.options.slidesPerRow+"%",display:"inline-block"})}},e.prototype.checkResponsive=function(e,t){var o,s,n,r=this,l=!1,d=r.$slider.width(),a=window.innerWidth||i(window).width();if("window"===r.respondTo?n=a:"slider"===r.respondTo?n=d:"min"===r.respondTo&&(n=Math.min(a,d)),r.options.responsive&&r.options.responsive.length&&null!==r.options.responsive){s=null;for(o in r.breakpoints)r.breakpoints.hasOwnProperty(o)&&(!1===r.originalSettings.mobileFirst?n<r.breakpoints[o]&&(s=r.breakpoints[o]):n>r.breakpoints[o]&&(s=r.breakpoints[o]));null!==s?null!==r.activeBreakpoint?(s!==r.activeBreakpoint||t)&&(r.activeBreakpoint=s,"unslick"===r.breakpointSettings[s]?r.unslick(s):(r.options=i.extend({},r.originalSettings,r.breakpointSettings[s]),!0===e&&(r.currentSlide=r.options.initialSlide),r.refresh(e)),l=s):(r.activeBreakpoint=s,"unslick"===r.breakpointSettings[s]?r.unslick(s):(r.options=i.extend({},r.originalSettings,r.breakpointSettings[s]),!0===e&&(r.currentSlide=r.options.initialSlide),r.refresh(e)),l=s):null!==r.activeBreakpoint&&(r.activeBreakpoint=null,r.options=r.originalSettings,!0===e&&(r.currentSlide=r.options.initialSlide),r.refresh(e),l=s),e||!1===l||r.$slider.trigger("breakpoint",[r,l])}},e.prototype.changeSlide=function(e,t){var o,s,n,r=this,l=i(e.currentTarget);switch(l.is("a")&&e.preventDefault(),l.is("li")||(l=l.closest("li")),n=r.slideCount%r.options.slidesToScroll!=0,o=n?0:(r.slideCount-r.currentSlide)%r.options.slidesToScroll,e.data.message){case"previous":s=0===o?r.options.slidesToScroll:r.options.slidesToShow-o,r.slideCount>r.options.slidesToShow&&r.slideHandler(r.currentSlide-s,!1,t);break;case"next":s=0===o?r.options.slidesToScroll:o,r.slideCount>r.options.slidesToShow&&r.slideHandler(r.currentSlide+s,!1,t);break;case"index":var d=0===e.data.index?0:e.data.index||l.index()*r.options.slidesToScroll;r.slideHandler(r.checkNavigable(d),!1,t),l.children().trigger("focus");break;default:return}},e.prototype.checkNavigable=function(i){var e,t;if(e=this.getNavigableIndexes(),t=0,i>e[e.length-1])i=e[e.length-1];else for(var o in e){if(i<e[o]){i=t;break}t=e[o]}return i},e.prototype.cleanUpEvents=function(){var e=this;e.options.dots&&null!==e.$dots&&(i("li",e.$dots).off("click.slick",e.changeSlide).off("mouseenter.slick",i.proxy(e.interrupt,e,!0)).off("mouseleave.slick",i.proxy(e.interrupt,e,!1)),!0===e.options.accessibility&&e.$dots.off("keydown.slick",e.keyHandler)),e.$slider.off("focus.slick blur.slick"),!0===e.options.arrows&&e.slideCount>e.options.slidesToShow&&(e.$prevArrow&&e.$prevArrow.off("click.slick",e.changeSlide),e.$nextArrow&&e.$nextArrow.off("click.slick",e.changeSlide),!0===e.options.accessibility&&(e.$prevArrow&&e.$prevArrow.off("keydown.slick",e.keyHandler),e.$nextArrow&&e.$nextArrow.off("keydown.slick",e.keyHandler))),e.$list.off("touchstart.slick mousedown.slick",e.swipeHandler),e.$list.off("touchmove.slick mousemove.slick",e.swipeHandler),e.$list.off("touchend.slick mouseup.slick",e.swipeHandler),e.$list.off("touchcancel.slick mouseleave.slick",e.swipeHandler),e.$list.off("click.slick",e.clickHandler),i(document).off(e.visibilityChange,e.visibility),e.cleanUpSlideEvents(),!0===e.options.accessibility&&e.$list.off("keydown.slick",e.keyHandler),!0===e.options.focusOnSelect&&i(e.$slideTrack).children().off("click.slick",e.selectHandler),i(window).off("orientationchange.slick.slick-"+e.instanceUid,e.orientationChange),i(window).off("resize.slick.slick-"+e.instanceUid,e.resize),i("[draggable!=true]",e.$slideTrack).off("dragstart",e.preventDefault),i(window).off("load.slick.slick-"+e.instanceUid,e.setPosition)},e.prototype.cleanUpSlideEvents=function(){var e=this;e.$list.off("mouseenter.slick",i.proxy(e.interrupt,e,!0)),e.$list.off("mouseleave.slick",i.proxy(e.interrupt,e,!1))},e.prototype.cleanUpRows=function(){var i,e=this;e.options.rows>1&&((i=e.$slides.children().children()).removeAttr("style"),e.$slider.empty().append(i))},e.prototype.clickHandler=function(i){!1===this.shouldClick&&(i.stopImmediatePropagation(),i.stopPropagation(),i.preventDefault())},e.prototype.destroy=function(e){var t=this;t.autoPlayClear(),t.touchObject={},t.cleanUpEvents(),i(".slick-cloned",t.$slider).detach(),t.$dots&&t.$dots.remove(),t.$prevArrow&&t.$prevArrow.length&&(t.$prevArrow.removeClass("slick-disabled slick-arrow slick-hidden").removeAttr("aria-hidden aria-disabled tabindex").css("display",""),t.htmlExpr.test(t.options.prevArrow)&&t.$prevArrow.remove()),t.$nextArrow&&t.$nextArrow.length&&(t.$nextArrow.removeClass("slick-disabled slick-arrow slick-hidden").removeAttr("aria-hidden aria-disabled tabindex").css("display",""),t.htmlExpr.test(t.options.nextArrow)&&t.$nextArrow.remove()),t.$slides&&(t.$slides.removeClass("slick-slide slick-active slick-center slick-visible slick-current").removeAttr("aria-hidden").removeAttr("data-slick-index").each(function(){i(this).attr("style",i(this).data("originalStyling"))}),t.$slideTrack.children(this.options.slide).detach(),t.$slideTrack.detach(),t.$list.detach(),t.$slider.append(t.$slides)),t.cleanUpRows(),t.$slider.removeClass("slick-slider"),t.$slider.removeClass("slick-initialized"),t.$slider.removeClass("slick-dotted"),t.unslicked=!0,e||t.$slider.trigger("destroy",[t])},e.prototype.disableTransition=function(i){var e=this,t={};t[e.transitionType]="",!1===e.options.fade?e.$slideTrack.css(t):e.$slides.eq(i).css(t)},e.prototype.fadeSlide=function(i,e){var t=this;!1===t.cssTransitions?(t.$slides.eq(i).css({zIndex:t.options.zIndex}),t.$slides.eq(i).animate({opacity:1},t.options.speed,t.options.easing,e)):(t.applyTransition(i),t.$slides.eq(i).css({opacity:1,zIndex:t.options.zIndex}),e&&setTimeout(function(){t.disableTransition(i),e.call()},t.options.speed))},e.prototype.fadeSlideOut=function(i){var e=this;!1===e.cssTransitions?e.$slides.eq(i).animate({opacity:0,zIndex:e.options.zIndex-2},e.options.speed,e.options.easing):(e.applyTransition(i),e.$slides.eq(i).css({opacity:0,zIndex:e.options.zIndex-2}))},e.prototype.filterSlides=e.prototype.slickFilter=function(i){var e=this;null!==i&&(e.$slidesCache=e.$slides,e.unload(),e.$slideTrack.children(this.options.slide).detach(),e.$slidesCache.filter(i).appendTo(e.$slideTrack),e.reinit())},e.prototype.focusHandler=function(){var e=this;e.$slider.off("focus.slick blur.slick").on("focus.slick blur.slick","*",function(t){t.stopImmediatePropagation();var o=i(this);setTimeout(function(){e.options.pauseOnFocus&&(e.focussed=o.is(":focus"),e.autoPlay())},0)})},e.prototype.getCurrent=e.prototype.slickCurrentSlide=function(){return this.currentSlide},e.prototype.getDotCount=function(){var i=this,e=0,t=0,o=0;if(!0===i.options.infinite)if(i.slideCount<=i.options.slidesToShow)++o;else for(;e<i.slideCount;)++o,e=t+i.options.slidesToScroll,t+=i.options.slidesToScroll<=i.options.slidesToShow?i.options.slidesToScroll:i.options.slidesToShow;else if(!0===i.options.centerMode)o=i.slideCount;else if(i.options.asNavFor)for(;e<i.slideCount;)++o,e=t+i.options.slidesToScroll,t+=i.options.slidesToScroll<=i.options.slidesToShow?i.options.slidesToScroll:i.options.slidesToShow;else o=1+Math.ceil((i.slideCount-i.options.slidesToShow)/i.options.slidesToScroll);return o-1},e.prototype.getLeft=function(i){var e,t,o,s,n=this,r=0;return n.slideOffset=0,t=n.$slides.first().outerHeight(!0),!0===n.options.infinite?(n.slideCount>n.options.slidesToShow&&(n.slideOffset=n.slideWidth*n.options.slidesToShow*-1,s=-1,!0===n.options.vertical&&!0===n.options.centerMode&&(2===n.options.slidesToShow?s=-1.5:1===n.options.slidesToShow&&(s=-2)),r=t*n.options.slidesToShow*s),n.slideCount%n.options.slidesToScroll!=0&&i+n.options.slidesToScroll>n.slideCount&&n.slideCount>n.options.slidesToShow&&(i>n.slideCount?(n.slideOffset=(n.options.slidesToShow-(i-n.slideCount))*n.slideWidth*-1,r=(n.options.slidesToShow-(i-n.slideCount))*t*-1):(n.slideOffset=n.slideCount%n.options.slidesToScroll*n.slideWidth*-1,r=n.slideCount%n.options.slidesToScroll*t*-1))):i+n.options.slidesToShow>n.slideCount&&(n.slideOffset=(i+n.options.slidesToShow-n.slideCount)*n.slideWidth,r=(i+n.options.slidesToShow-n.slideCount)*t),n.slideCount<=n.options.slidesToShow&&(n.slideOffset=0,r=0),!0===n.options.centerMode&&n.slideCount<=n.options.slidesToShow?n.slideOffset=n.slideWidth*Math.floor(n.options.slidesToShow)/2-n.slideWidth*n.slideCount/2:!0===n.options.centerMode&&!0===n.options.infinite?n.slideOffset+=n.slideWidth*Math.floor(n.options.slidesToShow/2)-n.slideWidth:!0===n.options.centerMode&&(n.slideOffset=0,n.slideOffset+=n.slideWidth*Math.floor(n.options.slidesToShow/2)),e=!1===n.options.vertical?i*n.slideWidth*-1+n.slideOffset:i*t*-1+r,!0===n.options.variableWidth&&(o=n.slideCount<=n.options.slidesToShow||!1===n.options.infinite?n.$slideTrack.children(".slick-slide").eq(i):n.$slideTrack.children(".slick-slide").eq(i+n.options.slidesToShow),e=!0===n.options.rtl?o[0]?-1*(n.$slideTrack.width()-o[0].offsetLeft-o.width()):0:o[0]?-1*o[0].offsetLeft:0,!0===n.options.centerMode&&(o=n.slideCount<=n.options.slidesToShow||!1===n.options.infinite?n.$slideTrack.children(".slick-slide").eq(i):n.$slideTrack.children(".slick-slide").eq(i+n.options.slidesToShow+1),e=!0===n.options.rtl?o[0]?-1*(n.$slideTrack.width()-o[0].offsetLeft-o.width()):0:o[0]?-1*o[0].offsetLeft:0,e+=(n.$list.width()-o.outerWidth())/2)),e},e.prototype.getOption=e.prototype.slickGetOption=function(i){return this.options[i]},e.prototype.getNavigableIndexes=function(){var i,e=this,t=0,o=0,s=[];for(!1===e.options.infinite?i=e.slideCount:(t=-1*e.options.slidesToScroll,o=-1*e.options.slidesToScroll,i=2*e.slideCount);t<i;)s.push(t),t=o+e.options.slidesToScroll,o+=e.options.slidesToScroll<=e.options.slidesToShow?e.options.slidesToScroll:e.options.slidesToShow;return s},e.prototype.getSlick=function(){return this},e.prototype.getSlideCount=function(){var e,t,o=this;return t=!0===o.options.centerMode?o.slideWidth*Math.floor(o.options.slidesToShow/2):0,!0===o.options.swipeToSlide?(o.$slideTrack.find(".slick-slide").each(function(s,n){if(n.offsetLeft-t+i(n).outerWidth()/2>-1*o.swipeLeft)return e=n,!1}),Math.abs(i(e).attr("data-slick-index")-o.currentSlide)||1):o.options.slidesToScroll},e.prototype.goTo=e.prototype.slickGoTo=function(i,e){this.changeSlide({data:{message:"index",index:parseInt(i)}},e)},e.prototype.init=function(e){var t=this;i(t.$slider).hasClass("slick-initialized")||(i(t.$slider).addClass("slick-initialized"),t.buildRows(),t.buildOut(),t.setProps(),t.startLoad(),t.loadSlider(),t.initializeEvents(),t.updateArrows(),t.updateDots(),t.checkResponsive(!0),t.focusHandler()),e&&t.$slider.trigger("init",[t]),!0===t.options.accessibility&&t.initADA(),t.options.autoplay&&(t.paused=!1,t.autoPlay())},e.prototype.initADA=function(){var e=this,t=Math.ceil(e.slideCount/e.options.slidesToShow),o=e.getNavigableIndexes().filter(function(i){return i>=0&&i<e.slideCount});e.$slides.add(e.$slideTrack.find(".slick-cloned")).attr({"aria-hidden":"true",tabindex:"-1"}).find("a, input, button, select").attr({tabindex:"-1"}),null!==e.$dots&&(e.$slides.not(e.$slideTrack.find(".slick-cloned")).each(function(t){var s=o.indexOf(t);i(this).attr({role:"tabpanel",id:"slick-slide"+e.instanceUid+t,tabindex:-1}),-1!==s&&i(this).attr({"aria-describedby":"slick-slide-control"+e.instanceUid+s})}),e.$dots.attr("role","tablist").find("li").each(function(s){var n=o[s];i(this).attr({role:"presentation"}),i(this).find("button").first().attr({role:"tab",id:"slick-slide-control"+e.instanceUid+s,"aria-controls":"slick-slide"+e.instanceUid+n,"aria-label":s+1+" of "+t,"aria-selected":null,tabindex:"-1"})}).eq(e.currentSlide).find("button").attr({"aria-selected":"true",tabindex:"0"}).end());for(var s=e.currentSlide,n=s+e.options.slidesToShow;s<n;s++)e.$slides.eq(s).attr("tabindex",0);e.activateADA()},e.prototype.initArrowEvents=function(){var i=this;!0===i.options.arrows&&i.slideCount>i.options.slidesToShow&&(i.$prevArrow.off("click.slick").on("click.slick",{message:"previous"},i.changeSlide),i.$nextArrow.off("click.slick").on("click.slick",{message:"next"},i.changeSlide),!0===i.options.accessibility&&(i.$prevArrow.on("keydown.slick",i.keyHandler),i.$nextArrow.on("keydown.slick",i.keyHandler)))},e.prototype.initDotEvents=function(){var e=this;!0===e.options.dots&&(i("li",e.$dots).on("click.slick",{message:"index"},e.changeSlide),!0===e.options.accessibility&&e.$dots.on("keydown.slick",e.keyHandler)),!0===e.options.dots&&!0===e.options.pauseOnDotsHover&&i("li",e.$dots).on("mouseenter.slick",i.proxy(e.interrupt,e,!0)).on("mouseleave.slick",i.proxy(e.interrupt,e,!1))},e.prototype.initSlideEvents=function(){var e=this;e.options.pauseOnHover&&(e.$list.on("mouseenter.slick",i.proxy(e.interrupt,e,!0)),e.$list.on("mouseleave.slick",i.proxy(e.interrupt,e,!1)))},e.prototype.initializeEvents=function(){var e=this;e.initArrowEvents(),e.initDotEvents(),e.initSlideEvents(),e.$list.on("touchstart.slick mousedown.slick",{action:"start"},e.swipeHandler),e.$list.on("touchmove.slick mousemove.slick",{action:"move"},e.swipeHandler),e.$list.on("touchend.slick mouseup.slick",{action:"end"},e.swipeHandler),e.$list.on("touchcancel.slick mouseleave.slick",{action:"end"},e.swipeHandler),e.$list.on("click.slick",e.clickHandler),i(document).on(e.visibilityChange,i.proxy(e.visibility,e)),!0===e.options.accessibility&&e.$list.on("keydown.slick",e.keyHandler),!0===e.options.focusOnSelect&&i(e.$slideTrack).children().on("click.slick",e.selectHandler),i(window).on("orientationchange.slick.slick-"+e.instanceUid,i.proxy(e.orientationChange,e)),i(window).on("resize.slick.slick-"+e.instanceUid,i.proxy(e.resize,e)),i("[draggable!=true]",e.$slideTrack).on("dragstart",e.preventDefault),i(window).on("load.slick.slick-"+e.instanceUid,e.setPosition),i(e.setPosition)},e.prototype.initUI=function(){var i=this;!0===i.options.arrows&&i.slideCount>i.options.slidesToShow&&(i.$prevArrow.show(),i.$nextArrow.show()),!0===i.options.dots&&i.slideCount>i.options.slidesToShow&&i.$dots.show()},e.prototype.keyHandler=function(i){var e=this;i.target.tagName.match("TEXTAREA|INPUT|SELECT")||(37===i.keyCode&&!0===e.options.accessibility?e.changeSlide({data:{message:!0===e.options.rtl?"next":"previous"}}):39===i.keyCode&&!0===e.options.accessibility&&e.changeSlide({data:{message:!0===e.options.rtl?"previous":"next"}}))},e.prototype.lazyLoad=function(){function e(e){i("img[data-lazy]",e).each(function(){var e=i(this),t=i(this).attr("data-lazy"),o=i(this).attr("data-srcset"),s=i(this).attr("data-sizes")||n.$slider.attr("data-sizes"),r=document.createElement("img");r.onload=function(){e.animate({opacity:0},100,function(){o&&(e.attr("srcset",o),s&&e.attr("sizes",s)),e.attr("src",t).animate({opacity:1},200,function(){e.removeAttr("data-lazy data-srcset data-sizes").removeClass("slick-loading")}),n.$slider.trigger("lazyLoaded",[n,e,t])})},r.onerror=function(){e.removeAttr("data-lazy").removeClass("slick-loading").addClass("slick-lazyload-error"),n.$slider.trigger("lazyLoadError",[n,e,t])},r.src=t})}var t,o,s,n=this;if(!0===n.options.centerMode?!0===n.options.infinite?s=(o=n.currentSlide+(n.options.slidesToShow/2+1))+n.options.slidesToShow+2:(o=Math.max(0,n.currentSlide-(n.options.slidesToShow/2+1)),s=n.options.slidesToShow/2+1+2+n.currentSlide):(o=n.options.infinite?n.options.slidesToShow+n.currentSlide:n.currentSlide,s=Math.ceil(o+n.options.slidesToShow),!0===n.options.fade&&(o>0&&o--,s<=n.slideCount&&s++)),t=n.$slider.find(".slick-slide").slice(o,s),"anticipated"===n.options.lazyLoad)for(var r=o-1,l=s,d=n.$slider.find(".slick-slide"),a=0;a<n.options.slidesToScroll;a++)r<0&&(r=n.slideCount-1),t=(t=t.add(d.eq(r))).add(d.eq(l)),r--,l++;e(t),n.slideCount<=n.options.slidesToShow?e(n.$slider.find(".slick-slide")):n.currentSlide>=n.slideCount-n.options.slidesToShow?e(n.$slider.find(".slick-cloned").slice(0,n.options.slidesToShow)):0===n.currentSlide&&e(n.$slider.find(".slick-cloned").slice(-1*n.options.slidesToShow))},e.prototype.loadSlider=function(){var i=this;i.setPosition(),i.$slideTrack.css({opacity:1}),i.$slider.removeClass("slick-loading"),i.initUI(),"progressive"===i.options.lazyLoad&&i.progressiveLazyLoad()},e.prototype.next=e.prototype.slickNext=function(){this.changeSlide({data:{message:"next"}})},e.prototype.orientationChange=function(){var i=this;i.checkResponsive(),i.setPosition()},e.prototype.pause=e.prototype.slickPause=function(){var i=this;i.autoPlayClear(),i.paused=!0},e.prototype.play=e.prototype.slickPlay=function(){var i=this;i.autoPlay(),i.options.autoplay=!0,i.paused=!1,i.focussed=!1,i.interrupted=!1},e.prototype.postSlide=function(e){var t=this;t.unslicked||(t.$slider.trigger("afterChange",[t,e]),t.animating=!1,t.slideCount>t.options.slidesToShow&&t.setPosition(),t.swipeLeft=null,t.options.autoplay&&t.autoPlay(),!0===t.options.accessibility&&(t.initADA(),t.options.focusOnChange&&i(t.$slides.get(t.currentSlide)).attr("tabindex",0).focus()))},e.prototype.prev=e.prototype.slickPrev=function(){this.changeSlide({data:{message:"previous"}})},e.prototype.preventDefault=function(i){i.preventDefault()},e.prototype.progressiveLazyLoad=function(e){e=e||1;var t,o,s,n,r,l=this,d=i("img[data-lazy]",l.$slider);d.length?(t=d.first(),o=t.attr("data-lazy"),s=t.attr("data-srcset"),n=t.attr("data-sizes")||l.$slider.attr("data-sizes"),(r=document.createElement("img")).onload=function(){s&&(t.attr("srcset",s),n&&t.attr("sizes",n)),t.attr("src",o).removeAttr("data-lazy data-srcset data-sizes").removeClass("slick-loading"),!0===l.options.adaptiveHeight&&l.setPosition(),l.$slider.trigger("lazyLoaded",[l,t,o]),l.progressiveLazyLoad()},r.onerror=function(){e<3?setTimeout(function(){l.progressiveLazyLoad(e+1)},500):(t.removeAttr("data-lazy").removeClass("slick-loading").addClass("slick-lazyload-error"),l.$slider.trigger("lazyLoadError",[l,t,o]),l.progressiveLazyLoad())},r.src=o):l.$slider.trigger("allImagesLoaded",[l])},e.prototype.refresh=function(e){var t,o,s=this;o=s.slideCount-s.options.slidesToShow,!s.options.infinite&&s.currentSlide>o&&(s.currentSlide=o),s.slideCount<=s.options.slidesToShow&&(s.currentSlide=0),t=s.currentSlide,s.destroy(!0),i.extend(s,s.initials,{currentSlide:t}),s.init(),e||s.changeSlide({data:{message:"index",index:t}},!1)},e.prototype.registerBreakpoints=function(){var e,t,o,s=this,n=s.options.responsive||null;if("array"===i.type(n)&&n.length){s.respondTo=s.options.respondTo||"window";for(e in n)if(o=s.breakpoints.length-1,n.hasOwnProperty(e)){for(t=n[e].breakpoint;o>=0;)s.breakpoints[o]&&s.breakpoints[o]===t&&s.breakpoints.splice(o,1),o--;s.breakpoints.push(t),s.breakpointSettings[t]=n[e].settings}s.breakpoints.sort(function(i,e){return s.options.mobileFirst?i-e:e-i})}},e.prototype.reinit=function(){var e=this;e.$slides=e.$slideTrack.children(e.options.slide).addClass("slick-slide"),e.slideCount=e.$slides.length,e.currentSlide>=e.slideCount&&0!==e.currentSlide&&(e.currentSlide=e.currentSlide-e.options.slidesToScroll),e.slideCount<=e.options.slidesToShow&&(e.currentSlide=0),e.registerBreakpoints(),e.setProps(),e.setupInfinite(),e.buildArrows(),e.updateArrows(),e.initArrowEvents(),e.buildDots(),e.updateDots(),e.initDotEvents(),e.cleanUpSlideEvents(),e.initSlideEvents(),e.checkResponsive(!1,!0),!0===e.options.focusOnSelect&&i(e.$slideTrack).children().on("click.slick",e.selectHandler),e.setSlideClasses("number"==typeof e.currentSlide?e.currentSlide:0),e.setPosition(),e.focusHandler(),e.paused=!e.options.autoplay,e.autoPlay(),e.$slider.trigger("reInit",[e])},e.prototype.resize=function(){var e=this;i(window).width()!==e.windowWidth&&(clearTimeout(e.windowDelay),e.windowDelay=window.setTimeout(function(){e.windowWidth=i(window).width(),e.checkResponsive(),e.unslicked||e.setPosition()},50))},e.prototype.removeSlide=e.prototype.slickRemove=function(i,e,t){var o=this;if(i="boolean"==typeof i?!0===(e=i)?0:o.slideCount-1:!0===e?--i:i,o.slideCount<1||i<0||i>o.slideCount-1)return!1;o.unload(),!0===t?o.$slideTrack.children().remove():o.$slideTrack.children(this.options.slide).eq(i).remove(),o.$slides=o.$slideTrack.children(this.options.slide),o.$slideTrack.children(this.options.slide).detach(),o.$slideTrack.append(o.$slides),o.$slidesCache=o.$slides,o.reinit()},e.prototype.setCSS=function(i){var 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Revision as of 12:34, 23 October 2017

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  • Home
  • Experimental
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Cas9 & Cpf1 secretion
and activity
Comparison of endonuclease activity for Cas9 and Cpf1 that has been produced in, and excreted by, HEK293 cells.
MESA two-component system replication
Details on the MESA two-component system, explanation of its relation to our design and the results of its reproduction.
OUTCASST system production
Detailed explanation of the OUTCASST mechanism, experimental progress and technical prospects.
Modeling and
mathematics
Ordinary differential equations, cellular automaton and an object based model for optimal linker-length estimation.
InterLab study participation
Results and details of our measurements for the iGEM 2017 InterLab Study.
Stakeholders & opinions
Interviews and dialogues with stakeholders, potential users, third parties and experts relating to pathogen detection or DNA-based diagnostics.
Risks & safety-issues
Implications and design considerations relating to safety in the usage and implementation of OUTCASST as a diagnostics tool.
Design & integration
OUTCASST toolkit and product design with factors such as bio-safety and user-friendliness taken into account.
Meet our team
About us, our interests and roles in the team and our supervisors.
Sponsors
A listing of our sponsors, how they assisted us and our gratitude for their assistance.
Achievements
A short description of all that we have achieved during our participation in the iGEM.
Intro
The problem
The system
The OUTCASST two-component system
This year, Utrecht University participates in the iGEM for the first time. We aim to create a cheap DNA detection kit for disease diagnosis that is easy to use and does not rely on complicated sequencing technologies.

The problem

Disease diagnosis is of great importance for healthcare. In developing countries, diagnoses often have to be made based on limited information, even though accurate disease determination based on pathogen specific DNA sequences is possible through sequencing technologies. These technologies, however, require specialised equipment and expertise that simply is not available everywhere. The OUTCASST two-component system and detection kit hopes to alleviate this problem.
Start
2
3
4

The system

The OUTCASST two-component system consists of two proteins, expressed to the membrane of a dryable cell. One of the proteins is a Cas9-fusion and the other contains Cpf1. Both proteins can be given a guide RNA that makes it bind to a specific, user-chosen, complementary sequence. When both proteins bind a DNA fragment from a sample, they co-localize, so that a transcription factor is released intracellularly which then induces an intracellular reporter mechanism such as a dye or fluorescent signal.
Binding of components with search-specific gRNA sequences.

Next
DNA sample fragment binds to one of the components.

Next
Fragment binding with both components induces co-localization.

Next
Protease cleaves, transcription factor is released from complex.