Line 25: | Line 25: | ||
<br/><br/> | <br/><br/> | ||
− | In the rule-based-model, we only defined the molecules as described above, with the pockets and where they can bind to. In the simulation, we simplified the visualization of our constructs to the ones shown below. Here, each pocket of the Scaffold construct is already filled with an inducer and the pockets are visualized separately, while in the simulation, three pockets are connected to each other with a certain distance. The same goes for the Center Point and its four Binding Partners, they are again (invisibly) connected with each other at a certain distance. In the simulation in 2D, only the binding of a Binding Partner to a pocket of the Protein Scaffold is simulated, making the model less complete and the rule-based-model better. | + | In the rule-based-model, we only defined the molecules as described above, with the pockets and where they can bind to. In the simulation, we simplified the visualization of our constructs to the ones shown below. Here, each pocket of the Scaffold construct is already filled with an inducer and the pockets are visualized separately, while in the simulation, three pockets are connected to each other with a certain distance. The same goes for the Center Point and its four Binding Partners, they are again (invisibly) connected with each other at a certain distance. In the simulation in 2D, only the binding of a Binding Partner to a pocket of the Protein Scaffold is simulated, making the model less complete and the rule-based-model better. <br/> <br/> |
</h6> | </h6> |
Revision as of 09:06, 30 October 2017