Difference between revisions of "Team:XJTLU-CHINA"

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        <title>XJTLU-CHINA 2017</title>
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<div id="main-content" class="container-fluid">
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          <div>
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            <a href="#overview">
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            <p style="text-align:center;">
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            <img src="https://static.igem.org/mediawiki/2017/0/0d/Home_arrow_down.png" class="img-responsive center-block" alt="Responsive image" style="height: 80px; width: auto;">
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<h1 id="overview" style="font-weight:900;text-align:center;margin-bottom:5%;">Overview</h1>
  
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      <h1 style="color:#4e7e94;"><i>S. aureus</i> Intestinal Colonization</h1>
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      <p style="color:#4e7e94;">Human intestine is a highly complex microbial ecosystem. It accommodates commensal microflora species, various types of secretory fluids, fermentation metabolites and host defense molecules that promote colonization resistance to pathogenic bacteria. However, <i>Staphylococcus aureus</i>, one of the most opportunistic and invasive pathogens, is capable of disrupting this colonization resistance and infecting the intestine. Patients with <i>S. aureus</i> intestinal colonization suffer from fecal incontinence, diarrhea, pseudomembranous colitis and so on.</p>
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      <img class="img-responsive center-block comic2" src="https://static.igem.org/mediawiki/2017/8/8c/Home-1.png">
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      <div class="col-md-6 col-md-push-6">
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      <h1>Antibiotic Overuse and Superbacteria</h1>
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      <p>Due to antibiotic overuse, <i>Staphylococcus aureus</i> develops resistance to various antibiotics and it becomes increasingly difficult to be eliminated. As a leading cause of hospital-acquired infections, methicillin-resistant <i>S. aureus</i> (MRSA) strains are multi-antibiotic resistant. Even the use of vancomycin — one of the last therapeutic resorts against <i>S. aureus</i>, becomes futile. Worse still, community-acquired MRSA strains are much more virulent and cause more morbidity and mortality than hospital-acquired MRSA.</p>
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      </div>
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      <div class="col-md-6 col-md-pull-6" >
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      <img class="img-responsive center-block comic2" src="https://static.igem.org/mediawiki/2017/3/37/Home-2.png">
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  <div class="row comic" style="background:#fbe1e0;">
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      <h1 style="color:#f28884;">Antimicrobial Peptides — A Promising Alternative To Antibiotics</h1>
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      <p style="color:#f28884;">Antimicrobial peptides (AMPs) have a reputation for their efficient antimicrobial activity against bacteria, fungi and protozoa. Despite of some promising results in clinical trials, AMPs have difficulties to be made into drugs due to their poor metabolic stability in human body. Therefore, our project aims to genetically engineer <i>Lactococcus lactis</i> (Grenadier Guards) to closely detect <i>S. aureus</i> and throw AMPs (grenades) to eradicate them within a short time after infection.</p>
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      </div>
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      <div class="col-md-6" >
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      <img class="img-responsive center-block comic2" src="https://static.igem.org/mediawiki/2017/b/b5/Home-3.png">
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  </div>
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  <div class="row comic">
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      <div class="col-md-6 col-md-push-6">
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      <h1>Further Applications</h1>
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      <p>Our genetically engineered <i>Lactococcus lactis</i> can be made into medicines, such as enteric coated tablets, together with anti-diarrheal medicines, to cure enteritis. In addition, as an important industrial microorganism, <i>L. lactis</i> can be used as food additives in fermented dairy products such as cheese, and yogurt. When they inhabit in the intestinal tract, not only do they regulate micro-ecological balance, but also prevent or reduce the chance of infection.</p>
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      </div>
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      <div class="col-md-6 col-md-pull-6" >
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      <img class="img-responsive center-block" src="https://static.igem.org/mediawiki/2017/5/55/Home-4.png">
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<h1> Welcome to iGEM 2017! </h1>
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<div class="text-center" style="background:#cfe5d9;">
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<p>Your team has been approved and you are ready to start the iGEM season! </p>
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<h1 style="font-weight:bolder;color:#006934; ">Collaborators and Supporters</h1>
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</div>  
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<div class="container-fluid supporters-logos">
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<div class="row">
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    <div class="col-sm-4"> 
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        <a href="https://www.synbio-tech.com.cn"><img class="img-responsive center-block" src="https://static.igem.org/mediawiki/2017/3/38/Synbio_tech_logo.png"></a>
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    </div>
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    <div class="col-sm-4"> 
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        <a href="https://www.wx2h.com/web/index.php"><img class="img-responsive center-block" src="https://static.igem.org/mediawiki/2017/a/ab/Wuxi_No.2_people%27s_hospital.png"></a>
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    </div>   
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    <div class="col-sm-4"> 
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        <a href="https://www.chinapeptides.qianyan.biz"><img class="img-responsive center-block" src="https://static.igem.org/mediawiki/2017/e/e8/Qiang_yao_sheng_wu.png"></a>
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<h5>Before you start: </h5>
 
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<p> Please read the following pages:</p>
 
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<ul>
 
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<li>  <a href="https://2017.igem.org/Competition">Competition Hub</a> </li>
 
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<li> <a href="https://2017.igem.org/Competition/Deliverables/Wiki">Wiki Requirements page</a></li>
 
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<li> <a href="https://2017.igem.org/Resources/Template_Documentation">Template documentation</a></li>
 
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</ul>
 
 
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<div class="row">
  
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<div class="highlight">
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        <a href="https://www.neb.com"><img class="img-responsive center-block" src="https://static.igem.org/mediawiki/2017/0/06/NEB_logo.png"></a>
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<h5> Styling your wiki </h5>
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<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>  
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    <div class="col-sm-4">
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        <a href="https://www.snapgene.com"><img class="img-responsive center-block" src="https://static.igem.org/mediawiki/2017/c/cb/Snapgene_logo.png"></a>
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</div>
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    </div>
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    <div class="col-sm-4">
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        <a href="https://www.genscript.com"><img class="img-responsive center-block" src="https://static.igem.org/mediawiki/2017/9/9b/Genscript.png"></a>
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</div>    
  
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<h5> Wiki template information </h5>
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<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2017.igem.org/Judging/Pages_for_Awards">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
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<h5> Editing your wiki </h5>
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<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
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<p> <a href="https://2017.igem.org/wiki/index.php?title=Team:Example&action=edit"> </a>Use WikiTools - Edit in the black menu bar to edit this page</p>
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<!-- footer -->
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<footer>
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    <div class="container-fluid">
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          <div class="col-md-4 loaction">
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              <h4>Location</h4>
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              <p  style="text-align:center;">Rm 363, Science Building<br>
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              Xi'an Jiaotong-Liverpool University<br>
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              111 Ren'ai Road, Suzhou, China<br>
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              215123
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              </p>
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          </div>
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          <div class="col-md-4 social">
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              <h4>Social</h4>
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              <a href=""><img src="https://static.igem.org/mediawiki/2017/9/9f/XJTLU_facebook.png" alt="facebook" width=30 height=30></a>
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              <a href=""><img src="https://static.igem.org/mediawiki/2017/7/72/XJTLU_blog.png" alt="blog" width=30 height=30></a>
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          </div>
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          <div class="col-md-4 contact">
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              <h4>Get in touch</h4>
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              <img src="https://static.igem.org/mediawiki/2017/1/19/XJTLU_email.png" alt="emali" width=30 height=30>
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              <p style="text-align:center;">igem@xjtlu.edu.cn</p>
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          </div>
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        </div>
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    </div>
 
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</div>
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        <p style="text-align:center; color:white;">XJTLU-CHINA iGEM 2017</p>
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<h5>Tips</h5>
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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<ul>
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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<li>Be clear about what you are doing and how you plan to do this.</li>
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2017.igem.org/Calendar">iGEM 2017 calendar</a> </li>
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<li>Have lots of fun! </li>
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<h5>Inspiration</h5>
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<p> You can also view other team wikis for inspiration! Here are some examples:</p>
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<ul>
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<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
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<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
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<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
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<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
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<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
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<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
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<h5> Uploading pictures and files </h5>
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<p> You can upload your pictures and files to the iGEM 2017 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
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When you upload, set the "Destination Filename" to <br><code>T--YourOfficialTeamName--NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)<br><br>
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<a href="https://2017.igem.org/Special:Upload">
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UPLOAD FILES
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Latest revision as of 07:48, 31 October 2017

XJTLU-CHINA 2017
Responsive image

Overview

S. aureus Intestinal Colonization

Human intestine is a highly complex microbial ecosystem. It accommodates commensal microflora species, various types of secretory fluids, fermentation metabolites and host defense molecules that promote colonization resistance to pathogenic bacteria. However, Staphylococcus aureus, one of the most opportunistic and invasive pathogens, is capable of disrupting this colonization resistance and infecting the intestine. Patients with S. aureus intestinal colonization suffer from fecal incontinence, diarrhea, pseudomembranous colitis and so on.

Antibiotic Overuse and Superbacteria

Due to antibiotic overuse, Staphylococcus aureus develops resistance to various antibiotics and it becomes increasingly difficult to be eliminated. As a leading cause of hospital-acquired infections, methicillin-resistant S. aureus (MRSA) strains are multi-antibiotic resistant. Even the use of vancomycin — one of the last therapeutic resorts against S. aureus, becomes futile. Worse still, community-acquired MRSA strains are much more virulent and cause more morbidity and mortality than hospital-acquired MRSA.

Antimicrobial Peptides — A Promising Alternative To Antibiotics

Antimicrobial peptides (AMPs) have a reputation for their efficient antimicrobial activity against bacteria, fungi and protozoa. Despite of some promising results in clinical trials, AMPs have difficulties to be made into drugs due to their poor metabolic stability in human body. Therefore, our project aims to genetically engineer Lactococcus lactis (Grenadier Guards) to closely detect S. aureus and throw AMPs (grenades) to eradicate them within a short time after infection.

Further Applications

Our genetically engineered Lactococcus lactis can be made into medicines, such as enteric coated tablets, together with anti-diarrheal medicines, to cure enteritis. In addition, as an important industrial microorganism, L. lactis can be used as food additives in fermented dairy products such as cheese, and yogurt. When they inhabit in the intestinal tract, not only do they regulate micro-ecological balance, but also prevent or reduce the chance of infection.

Collaborators and Supporters

Location

Rm 363, Science Building
Xi'an Jiaotong-Liverpool University
111 Ren'ai Road, Suzhou, China
215123

Get in touch

emali

igem@xjtlu.edu.cn

XJTLU-CHINA iGEM 2017