Difference between revisions of "Team:XJTLU-CHINA"

 
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{{XJTLU-CHINA}}
 
{{XJTLU-CHINA}}
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<html lang="en-US">
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    <head>
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        <meta charset="utf-8">
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        <meta http-equiv="X-UA-Compatible" content="IE=edge">
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        <meta name="viewport" content="width=device-width, initial-scale=1">
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        <link href="https://fonts.googleapis.com/css?family=PT+Sans|PT+Serif" rel="stylesheet">
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        <title>XJTLU-CHINA 2017</title>
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        <style>
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        .comic{
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        padding-left:10%;
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        p {
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        font-size: 20px !important;
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        @media(min-width: 992px) {
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<html>
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  <head>
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        </style>
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    <title>Team</title>
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    </head>
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    <style>
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    <body>
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    .title{
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<div id="main-content" class="container-fluid">
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    background-image:linear-gradient(120deg, #e0c3fc 0%, #8ec5fc 100%);
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        <img id="homebanner" src="https://static.igem.org/mediawiki/2017/4/4a/Home_project.PNG" class="img-responsive center-block" alt="Responsive image">
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    height: 300px;
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          <div>
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    margin-bottom:20px;
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            <a href="#overview">
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    }
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            <p style="text-align:center;">
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            <img src="https://static.igem.org/mediawiki/2017/0/0d/Home_arrow_down.png" class="img-responsive center-block" alt="Responsive image" style="height: 80px; width: auto;">
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            </p>
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    </style>
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            </a>
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  </head>
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          </div>
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<body>
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<div class="title text-center">
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<h1 id="overview" style="font-weight:900;text-align:center;margin-bottom:5%;">Overview</h1>
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  <h1 style="color:white; font-size:80px; padding-top:100px;">Our Team</h1>
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</div>
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<div class="container">
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<!--Team member introduction--!>
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<!--Wangtianjun--!>
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<div class="row member">
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  <div class="col-sm-7 text-center">
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      <h1 class="member-heading">Tianjun Wang</h1>
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      <h1 class="text-muted">Year 2 Bioinformatics</h2>
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      <h2 class="lead" style="text-align:center;">Personality: Be hardworking than others, but don't tell them so</br>
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      Hobbies: Animation & Cycling</br>
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      One word to iGEM: Persistence
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      </h2>
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  </div>
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  <div class="col-sm-5">
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      <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/7/7e/Wangtianjun.jpg" height=400 width=400>
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  </div>
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</div>
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<hr class="member-divider">
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  <div class="row comic" style="background:#d2e4ee;">
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<!--Gongyijing--!> 
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      <div class="col-md-6">
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<div class="row member">
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       <h1 style="color:#4e7e94;"><i>S. aureus</i> Intestinal Colonization</h1>
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  <div class="col-sm-7 col-sm-push-5 text-center">
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       <p style="color:#4e7e94;">Human intestine is a highly complex microbial ecosystem. It accommodates commensal microflora species, various types of secretory fluids, fermentation metabolites and host defense molecules that promote colonization resistance to pathogenic bacteria. However, <i>Staphylococcus aureus</i>, one of the most opportunistic and invasive pathogens, is capable of disrupting this colonization resistance and infecting the intestine. Patients with <i>S. aureus</i> intestinal colonization suffer from fecal incontinence, diarrhea, pseudomembranous colitis and so on.</p>
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       <h1 class="member-heading">Yijing Gong</h1>
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       </div>
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       <h1 class="text-muted">Year 2 Biological Sciences</h1>
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      <div class="col-md-6" >
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       <h2 class="lead" style="text-align:center;">Personality: Creative, Crazy & Naive</br>
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      <img class="img-responsive center-block comic2" src="https://static.igem.org/mediawiki/2017/8/8c/Home-1.png">
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       Hobbies: Everything that I prefer to do</br>
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       </div>
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       One word to iGEM: Intelligence
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  </div>
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       </h2>
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  </div>  
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  <div class="row comic">
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  <div class="col-sm-5 col-sm-pull-7">
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       <div class="col-md-6 col-md-push-6">
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       <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/2/23/Gongyijing.jpg" height=400 width=400>
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       <h1>Antibiotic Overuse and Superbacteria</h1>
 +
      <p>Due to antibiotic overuse, <i>Staphylococcus aureus</i> develops resistance to various antibiotics and it becomes increasingly difficult to be eliminated. As a leading cause of hospital-acquired infections, methicillin-resistant <i>S. aureus</i> (MRSA) strains are multi-antibiotic resistant. Even the use of vancomycin — one of the last therapeutic resorts against <i>S. aureus</i>, becomes futile. Worse still, community-acquired MRSA strains are much more virulent and cause more morbidity and mortality than hospital-acquired MRSA.</p>
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      </div>
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      <div class="col-md-6 col-md-pull-6" >
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       <img class="img-responsive center-block comic2" src="https://static.igem.org/mediawiki/2017/3/37/Home-2.png">
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      </div>
 
   </div>
 
   </div>
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</div>
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  <div class="row comic" style="background:#fbe1e0;">
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<hr class="member-divider">
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      <div class="col-md-6">
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<!--Fanghaohui--!>
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      <h1 style="color:#f28884;">Antimicrobial Peptides — A Promising Alternative To Antibiotics</h1>
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<div class="row member">
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      <p style="color:#f28884;">Antimicrobial peptides (AMPs) have a reputation for their efficient antimicrobial activity against bacteria, fungi and protozoa. Despite of some promising results in clinical trials, AMPs have difficulties to be made into drugs due to their poor metabolic stability in human body. Therefore, our project aims to genetically engineer <i>Lactococcus lactis</i> (Grenadier Guards) to closely detect <i>S. aureus</i> and throw AMPs (grenades) to eradicate them within a short time after infection.</p>
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  <div class="col-sm-7 text-center">
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      </div>
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       <h1 class="member-heading">Haohui Fang</h1>
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      <div class="col-md-6" >
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       <h1 class="text-muted">Year 1 Applied Chemistry</h2>
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       <img class="img-responsive center-block comic2" src="https://static.igem.org/mediawiki/2017/b/b5/Home-3.png">
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       <h2 class="lead" style="text-align:center;">Personality: Curious, Friendly, Positive & Active, Highly adaptive but slack off sometimes</br>
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      </div>
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       Hobbies: Table tennis, Music & Watching sports games</br>
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  </div>
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       One word to iGEM: Hobby
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       </h2>
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  <div class="row comic">
 +
       <div class="col-md-6 col-md-push-6">
 +
      <h1>Further Applications</h1>
 +
       <p>Our genetically engineered <i>Lactococcus lactis</i> can be made into medicines, such as enteric coated tablets, together with anti-diarrheal medicines, to cure enteritis. In addition, as an important industrial microorganism, <i>L. lactis</i> can be used as food additives in fermented dairy products such as cheese, and yogurt. When they inhabit in the intestinal tract, not only do they regulate micro-ecological balance, but also prevent or reduce the chance of infection.</p>
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       </div>
 +
       <div class="col-md-6 col-md-pull-6" >
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      <img class="img-responsive center-block" src="https://static.igem.org/mediawiki/2017/5/55/Home-4.png">
 +
       </div>
 
   </div>
 
   </div>
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   <div class="col-sm-5">
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      <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/c/c4/Fanghaohui.jpg" height=400 width=400>
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</div><!-- /.container -->     
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   </div>
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</div>
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<hr class="member-divider">
 
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<!--Lihuiting--!> 
 
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<div class="row member">
 
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  <div class="col-sm-7 col-sm-push-5 text-center">
 
−
      <h1 class="member-heading">Huiting Li</h1>
 
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      <h1 class="text-muted">Year 2 Biological Sciences</h1>
 
−
      <h2 class="lead" style="text-align:center;">Personality: Liberalist</br>
 
−
      Hobbies: Imagining & Dreaming</br>
 
−
      One word to iGEM: Cooperation
 
−
      </h2>
 
−
  </div> 
 
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  <div class="col-sm-5 col-sm-pull-7">
 
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      <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/0/03/Lihuiting.jpg" height=400 width=400>
 
−
  </div>
 
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</div> 
 
  
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<hr class="member-divider"> 
 
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<!--Jinziyin--!>
 
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<div class="row member">
 
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  <div class="col-sm-7 text-center">
 
−
      <h1 class="member-heading">Zinyin Jin</h1>
 
−
      <h1 class="text-muted">Year 3 Biological Sciences</h2>
 
−
      <h2 class="lead" style="text-align:center;">Personality: Optimistic</br>
 
−
      Hobbies: Urheen & Calligraphy</br>
 
−
      One word to iGEM: Innovation
 
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      </h2>
 
−
  </div>
 
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  <div class="col-sm-5">
 
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      <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/0/06/Jinziyin.jpg" height=400 width=400>
 
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  </div>
 
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</div>
 
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<hr class="member-divider">
 
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<!--Songyiyou--!> 
 
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<div class="row member">
 
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  <div class="col-sm-7 col-sm-push-5 text-center">
 
−
      <h1 class="member-heading">Yiyou Song</h1>
 
−
      <h1 class="text-muted">Year 2 Bioinformatics</h1>
 
−
      <h2 class="lead" style="text-align:center;">Personality: Complex</br>
 
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      Hobbies: Game</br>
 
−
      One word to iGEM: Creativity
 
−
      </h2>
 
−
  </div> 
 
−
  <div class="col-sm-5 col-sm-pull-7">
 
−
      <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/a/ac/Songyiyou.jpg" height=400 width=400>
 
−
  </div>
 
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</div> 
 
−
 
−
<hr class="member-divider"> 
 
−
<!--Rongzixin--!>
 
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<div class="row member">
 
−
  <div class="col-sm-7 text-center">
 
−
      <h1 class="member-heading">Zixin Rong</h1>
 
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      <h1 class="text-muted">Year 2 Biological Sciences</h2>
 
−
      <h2 class="lead" style="text-align:center;">Personality: Introverted</br>
 
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      Hobbies: Daydreaming & Instrument</br>
 
−
      One word to iGEM: Imagination
 
−
      </h2>
 
−
  </div>
 
−
  <div class="col-sm-5">
 
−
      <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/d/dd/Rongzixin.jpg" height=400 width=400>
 
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  </div>
 
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</div>
 
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<hr class="member-divider">
 
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<!--Panwenlan--!> 
 
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<div class="row member">
 
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  <div class="col-sm-7 col-sm-push-5 text-center">
 
−
      <h1 class="member-heading">Wenlan Pan</h1>
 
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      <h1 class="text-muted">Year 2 Bioinformatics</h1>
 
−
      <h2 class="lead" style="text-align:center;">Personality: Emotional & Perfectionist</br>
 
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      Hobbies: Reading, Sleeping & Eating</br>
 
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      One word to iGEM: Motivated
 
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      </h2>
 
−
  </div> 
 
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  <div class="col-sm-5 col-sm-pull-7">
 
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      <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/b/ba/Panwenlan.jpg" height=400 width=400>
 
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  </div>
 
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</div> 
 
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<hr class="member-divider"> 
 
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<!--Zhangxidan--!>
 
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<div class="row member">
 
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  <div class="col-sm-7 text-center">
 
−
      <h1 class="member-heading">Xidan Zhang</h1>
 
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      <h1 class="text-muted">Year 2 Biological Sciences</h2>
 
−
      <h2 class="lead" style="text-align:center;">Personality: Curious & Persistent</br>
 
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      Hobbies: Puzzle games & Reading novels</br>
 
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      One word to iGEM: Challenge
 
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      </h2>
 
−
  </div>
 
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  <div class="col-sm-5">
 
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      <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/f/f7/Zhangxidan.jpg" height=400 width=400>
 
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  </div>
 
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</div>
 
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<hr class="member-divider">
 
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<!--Hangyuqi--!> 
 
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<div class="row member">
 
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  <div class="col-sm-7 col-sm-push-5 text-center">
 
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      <h1 class="member-heading">Yuqi Hang</h1>
 
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      <h1 class="text-muted">Year 1 Biological Sciences</h1>
 
−
      <h2 class="lead" style="text-align:center;">Personality: Curious & Passionate</br>
 
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      Hobbies: Neuroscience & Philosophy</br>
 
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      One word to iGEM: Opportunity
 
−
      </h2>
 
−
  </div> 
 
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  <div class="col-sm-5 col-sm-pull-7">
 
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      <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/1/17/Hangyuqi.jpg" height=400 width=400>
 
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  </div>
 
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</div> 
 
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<hr class="member-divider"> 
 
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<!--Gongzhiyun--!>
 
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<div class="row member">
 
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  <div class="col-sm-7 text-center">
 
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      <h1 class="member-heading">Zhiyun Gong</h1>
 
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      <h1 class="text-muted">Year 2 Bioinformatics</h2>
 
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      <h2 class="lead" style="text-align:center;">Personality: Always digging deeper in my own personality and depicting the true self </br>
 
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      Hobbies: Switching between deliberating and wandering without destination</br>
 
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      One word to iGEM: Youth
 
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      </h2>
 
−
  </div>
 
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  <div class="col-sm-5">
 
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      <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/5/59/Gongzhiyun.jpg" height=400 width=400>
 
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  </div>
 
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</div>
 
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<hr class="member-divider">
 
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<!--Fengsijie--!> 
 
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<div class="row member">
 
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  <div class="col-sm-7 col-sm-push-5 text-center">
 
−
      <h1 class="member-heading">Sijie Feng</h1>
 
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      <h1 class="text-muted">Year 2 Biological Sciences</h1>
 
−
      <h2 class="lead" style="text-align:center;">Personality: Practical & Open-minded</br>
 
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      Hobbies: Anime tennis</br>
 
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      One word to iGEM: Test
 
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      </h2>
 
−
  </div> 
 
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  <div class="col-sm-5 col-sm-pull-7">
 
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      <img class="member-image img-responsive center-block img-circle" src="https://static.igem.org/mediawiki/2017/6/6e/Fengsijie.jpg" height=400 width=400>
 
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  </div>
 
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</div> 
 
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<hr class="member-divider"> 
 
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<!--supervisors and advisers--!>
 
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<div class="text-center" style="margin-bottom:30px;">
 
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  <h1 style="text-align: center;">The Back-up Team</h1>
 
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  <h2 class="text-muted" style="text-align:center;">In addition, we want to express our sincere thanks to supervisors and advisers for all the help.</h2>
 
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</div>
 
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<div class="row text-center">
 
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  <div class="col-sm-6 col-md-3">
 
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      <img class="img-circle center-block" src="https://static.igem.org/mediawiki/2017/e/ed/Hanguoxia.jpg" width="200" height="200">
 
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      <h2>Dr. Guoxia Han</h2>
 
−
  </div><!--/.col-sm-6 col-md-3-->
 
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  <div class="col-sm-6 col-md-3">
 
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      <img class="img-circle center-block" src="https://static.igem.org/mediawiki/2017/7/7b/Chiu.jpg" width="200" height="200">
 
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      <h2>Dr. David Chiu</h2>
 
−
  </div><!--/.col-sm-6 col-md-3-->
 
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  <div class="col-sm-6 col-md-3">
 
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      <img class="img-circle center-block" src="https://static.igem.org/mediawiki/2017/6/6e/Dechang_Xu.jpg" width="200" height="200">
 
−
      <h2>Dr. Dechang Xu</h2>
 
−
  </div><!--/.col-sm-6 col-md-3-->
 
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  <div class="col-sm-6 col-md-3">
 
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      <img class="img-circle center-block" src="https://static.igem.org/mediawiki/2017/9/9c/Yunpeng_Zhong.jpg" width="200" height="200">
 
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      <h2>Mr. Yunpeng Zhong (MSc)</h2>
 
−
  </div><!--/.col-sm-6 col-md-3-->
 
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</div> <!--/.row-->
 
−
</div><!--container--!>
 
  
 
<!-- banner -->
 
<!-- banner -->
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<div class="text-center" style="background:#ddede3;">
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<div class="text-center" style="background:#cfe5d9;">
 
<h1 style="font-weight:bolder;color:#006934; ">Collaborators and Supporters</h1>
 
<h1 style="font-weight:bolder;color:#006934; ">Collaborators and Supporters</h1>
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<div class="container supporters-logos">
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<div class="container-fluid supporters-logos">
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<div class="row" style="padding-bottom:20px;">
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<div class="row">
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     <div class="col-sm-4">  
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     <div class="col-md-4 col-sm-6">
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         <a href="https://www.synbio-tech.com.cn"><img class="img-responsive center-block" src="https://static.igem.org/mediawiki/2017/3/38/Synbio_tech_logo.png"></a>
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         <a href="http://www.synbio-tech.com.cn"><img class="" src="https://static.igem.org/mediawiki/2017/3/38/Synbio_tech_logo.png"></a>
+
 
     </div>
 
     </div>
 +
 +
    <div class="col-sm-4"> 
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        <a href="https://www.wx2h.com/web/index.php"><img class="img-responsive center-block" src="https://static.igem.org/mediawiki/2017/a/ab/Wuxi_No.2_people%27s_hospital.png"></a>
 +
    </div>   
 
      
 
      
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     <div class="col-md-4 col-sm-6">
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     <div class="col-sm-4">  
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         <a href="http://www.wx2h.com/web/index.php"><img src="https://static.igem.org/mediawiki/2017/f/f7/Wuxi_no2_hospital_logo.png"></a>
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         <a href="https://www.chinapeptides.qianyan.biz"><img class="img-responsive center-block" src="https://static.igem.org/mediawiki/2017/e/e8/Qiang_yao_sheng_wu.png"></a>
 
     </div>
 
     </div>
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    <div class="col-md-4 col-sm-6">
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</div>
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         <a href="http://www.chinapeptides.qianyan.biz"><img src="https://static.igem.org/mediawiki/2017/7/7d/Qiangyao_logo.png"></a>
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<div class="row">
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 +
    <div class="col-sm-4">  
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         <a href="https://www.neb.com"><img class="img-responsive center-block" src="https://static.igem.org/mediawiki/2017/0/06/NEB_logo.png"></a>
 
     </div>
 
     </div>
 
      
 
      
−
    <div class="col-md-4 col-sm-6">  
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    <div class="col-sm-4">
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         <a href="https://www.neb.com"><img class="" src="https://static.igem.org/mediawiki/2017/0/06/NEB_logo.png"></a>
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         <a href="https://www.snapgene.com"><img class="img-responsive center-block" src="https://static.igem.org/mediawiki/2017/c/cb/Snapgene_logo.png"></a>
 
     </div>
 
     </div>
 
      
 
      
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     <div class="col-md-4 col-sm-6">
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     <div class="col-sm-4">
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         <a href="https://www.snapgene.com"><img src="https://static.igem.org/mediawiki/2017/c/cb/Snapgene_logo.png"></a>
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         <a href="https://www.genscript.com"><img class="img-responsive center-block" src="https://static.igem.org/mediawiki/2017/9/9b/Genscript.png"></a>
−
    </div>
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     </div>    
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</div>    
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    <div class="col-md-4 col-sm-6">
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        <a href="http://www.genscript.com"><img src="https://static.igem.org/mediawiki/2017/9/9b/Genscript.png"></a>
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</div><!-- /.container --!>
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</div><!-- /.text-center --!>
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Latest revision as of 07:48, 31 October 2017

XJTLU-CHINA 2017
Responsive image

Overview

S. aureus Intestinal Colonization

Human intestine is a highly complex microbial ecosystem. It accommodates commensal microflora species, various types of secretory fluids, fermentation metabolites and host defense molecules that promote colonization resistance to pathogenic bacteria. However, Staphylococcus aureus, one of the most opportunistic and invasive pathogens, is capable of disrupting this colonization resistance and infecting the intestine. Patients with S. aureus intestinal colonization suffer from fecal incontinence, diarrhea, pseudomembranous colitis and so on.

Antibiotic Overuse and Superbacteria

Due to antibiotic overuse, Staphylococcus aureus develops resistance to various antibiotics and it becomes increasingly difficult to be eliminated. As a leading cause of hospital-acquired infections, methicillin-resistant S. aureus (MRSA) strains are multi-antibiotic resistant. Even the use of vancomycin — one of the last therapeutic resorts against S. aureus, becomes futile. Worse still, community-acquired MRSA strains are much more virulent and cause more morbidity and mortality than hospital-acquired MRSA.

Antimicrobial Peptides — A Promising Alternative To Antibiotics

Antimicrobial peptides (AMPs) have a reputation for their efficient antimicrobial activity against bacteria, fungi and protozoa. Despite of some promising results in clinical trials, AMPs have difficulties to be made into drugs due to their poor metabolic stability in human body. Therefore, our project aims to genetically engineer Lactococcus lactis (Grenadier Guards) to closely detect S. aureus and throw AMPs (grenades) to eradicate them within a short time after infection.

Further Applications

Our genetically engineered Lactococcus lactis can be made into medicines, such as enteric coated tablets, together with anti-diarrheal medicines, to cure enteritis. In addition, as an important industrial microorganism, L. lactis can be used as food additives in fermented dairy products such as cheese, and yogurt. When they inhabit in the intestinal tract, not only do they regulate micro-ecological balance, but also prevent or reduce the chance of infection.

Collaborators and Supporters

Location

Rm 363, Science Building
Xi'an Jiaotong-Liverpool University
111 Ren'ai Road, Suzhou, China
215123

Get in touch

emali

igem@xjtlu.edu.cn

XJTLU-CHINA iGEM 2017