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Revision as of 12:02, 1 November 2017

MSBT 2017

Project Description

The Construct

Temperature Control

This year, Team Michigan is exploring the applications of temperature-based cellular modulation. We are engineering a temperature-controlled bacterial killswitch, designed to prevent survival of cells outside of a desired range, specifically one that is associated with typical laboratory working conditions.

The Future of Lab Safety

The goal is to develop a genetic switch that leverages a temperature-dependent promoter to trigger self-lysis in cells, relying on Holin and Endolysin to carry out the apoptosis. When our plasmid is implemented, bacteria will lyse itself when outside of predetermined temperature conditions. We see our construct being used as a safety measure; when working with pathogenic bacteria in a lab, it is vital to ensure the death of any bacteria that escape their controlled environment.