Difference between revisions of "Team:IIT Delhi/Description"

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       <a href="/Team:IIT_Delhi/Description">Description</a>
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       <a href="/Team:IIT_Delhi/Description">Overview</a>
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       <a href="/Team:IIT_Delhi/Results">Results</a>
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       <a href="/Team:IIT_Delhi/Design">Squarewave Generator</a>
  
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       <a href="/Team:IIT_Delhi/Interlab">Interlab</a>
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      <a href="/Team:IIT_Delhi/Photobleaching">Photobleaching</a>
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       <a href="/Team:IIT_Delhi/Improved_Part">Improved Parts</a>
 
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       <a href="/Team:IIT_Delhi/Model">Overview</a>
 
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       <a href="/Team:IIT_Delhi/Write_Model">Writing a Model</a>
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       <a href="/Team:IIT_Delhi/Engagement">Public Engagement</a>
 
       <a href="/Team:IIT_Delhi/Engagement">Public Engagement</a>
 
       <a href="/Team:IIT_Delhi/Collaborations">Collaborations</a>
 
       <a href="/Team:IIT_Delhi/Collaborations">Collaborations</a>
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                                                        <a href="/Team:IIT_Delhi/Safety">Safety</a>
 
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      <a href="/Team:IIT_Delhi/GMM_legislation">GMM Legislation</a>
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      <a href="/Team:IIT_Delhi/berlin">iGEM Berlin</a>
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      <a href="/Team:IIT_Delhi/mohali">Mentoring IISER Mohali</a>
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      <a href="/Team:IIT_Delhi/glasgow">iGEM Glasgow</a>
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<h2 id="pfont">Digital Logic in Synthetic Biology
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<br>
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A large chunk of effort in synthetic biology has been aimed at attempting to view genes as parts of a circuit. Thus, a lot of focus has been directed toward creating biological analogues of digital logic gates, such as an AND or a NOT gate, which give a digital 1 or 0 response, depending on the truth table of the gate.
 +
<br>
 +
However, there is a serious issue in the scale up of these circuits. While that can be attributed to several reasons, one of the major reasons is this simplification under which the systems work. We can see that the output response from the gate is not close to the actual digital “1 or 0” kind that one would ideally want from a logic gate, and in the range that is neither in the ON nor the OFF regime, the response is really graded. 
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<br><br>
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<img src = "https://static.igem.org/mediawiki/2017/4/45/T--IIT_Delhi--picture3.png"><br>
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<br>
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NThus, when a combination of gates is used in conjunction, one could not expect them to remain digital. Just imagine using a 10 input AND gate as shown below, that could possibly be used as an environmental biosensor. If the concentration of a few inputs is in the ON range, while the others are in the middle range, should the device show an ON or an OFF state? It may show neither, as we have seen above, leaving the researcher confused as to how the results must be perceived. <br>
  
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<h2 id="pfont1"><span class="image left"><img src="https://static.igem.org/mediawiki/2017/b/b4/T--IIT_Delhi--Dr.Zia_Shaikh.jpg" alt="" /></span><b id="pfont2">Dr. Zia Shaikh</b><br> Dr. Zia Shaikh is an assistant professor at DBEB, IIT Delhi and is the Professor-in-charge at iGEM IIT Delhi. He has been associated with the team since the past 3 years and has played a vital role in ensuring smooth functioning of the team. He provided us with a well-furnished lab for our project and was instrumental in getting funds for our team. Also, he helped us in the various aspects of our project, despite it not being his core area of research.
 
 
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<h2 id="pfont1"><span class="image left"><img src="https://static.igem.org/mediawiki/2017/b/b4/T--IIT_Delhi--Dr.Zia_Shaikh.jpg" alt="" /></span><b id="pfont2">Dr. Zia Shaikh</b><br> Dr. Zia Shaikh is an assistant professor at DBEB, IIT Delhi and is the Professor-in-charge at iGEM IIT Delhi. He has been associated with the team since the past 3 years and has played a vital role in ensuring smooth functioning of the team. He provided us with a well-furnished lab for our project and was instrumental in getting funds for our team. Also, he helped us in the various aspects of our project, despite it not being his core area of research.
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<h2 id="pfont1"><span class="image right"><img src="https://static.igem.org/mediawiki/2017/b/b6/T--IIT_Delhi--Dr._Stefan_Oehler.jpg" alt="" style="height:200% ; width:150%"/></span><b id="pfont2">Dr. Stefan</b><br> Dr. Stefan is a visiting faculty, from Germany, at DBEB, IIT Delhi. He has been a guiding light for iGEM IIT Delhi since 2015. Even though he is a specialist in Molecular Biology, he was instrumental in our project’s computational analysis as well as team organization and management. He spent countless nights helping us troubleshoot our project and enabled us to present our project in a more detailed manner.
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<h2 id="pfont1"><span class="image left"><img src="https://static.igem.org/mediawiki/2017/b/b4/T--IIT_Delhi--Dr.Zia_Shaikh.jpg" alt="" /></span><b id="pfont2">Dr. Zia Shaikh</b><br> Dr. Zia Shaikh is an assistant professor at DBEB, IIT Delhi and is the Professor-in-charge at iGEM IIT Delhi. He has been associated with the team since the past 3 years and has played a vital role in ensuring smooth functioning of the team. He provided us with a well-furnished lab for our project and was instrumental in getting funds for our team. Also, he helped us in the various aspects of our project, despite it not being his core area of research.
 
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<h2 id="pfont1"><span class="image right"><img src="https://static.igem.org/mediawiki/2017/b/b6/T--IIT_Delhi--Dr._Stefan_Oehler.jpg" alt="" style="height:200% ; width:150%"/></span><b id="pfont2">Dr. Stefan</b><br> Dr. Stefan is a visiting faculty, from Germany, at DBEB, IIT Delhi. He has been a guiding light for iGEM IIT Delhi since 2015. Even though he is a specialist in Molecular Biology, he was instrumental in our project’s computational analysis as well as team organization and management. He spent countless nights helping us troubleshoot our project and enabled us to present our project in a more detailed manner.
 
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Revision as of 14:36, 1 November 2017

iGEM IIT Delhi

Overview Squarewave Generator Interlab
Circuit design and construction Microfluidics and Fluroscence Photobleaching Promoter strength Oscillations
Basic Parts Composite Parts Improved Parts Part Collection
Overview Writing a Model Deterministic Model Stochastic Model Bifurcation and Squareness Resource sharing
Human Practices Integrated Practices Public Engagement Collaborations Safety
Overview GMM Legislation iGEM Berlin Mentoring IISER Mohali iGEM Glasgow
Lab Records Protocols Recipes Medal Criteria
The Team Attributions

ABCDEFG

                                                                                                                                                                                                                 

Digital Logic in Synthetic Biology
A large chunk of effort in synthetic biology has been aimed at attempting to view genes as parts of a circuit. Thus, a lot of focus has been directed toward creating biological analogues of digital logic gates, such as an AND or a NOT gate, which give a digital 1 or 0 response, depending on the truth table of the gate.
However, there is a serious issue in the scale up of these circuits. While that can be attributed to several reasons, one of the major reasons is this simplification under which the systems work. We can see that the output response from the gate is not close to the actual digital “1 or 0” kind that one would ideally want from a logic gate, and in the range that is neither in the ON nor the OFF regime, the response is really graded.



NThus, when a combination of gates is used in conjunction, one could not expect them to remain digital. Just imagine using a 10 input AND gate as shown below, that could possibly be used as an environmental biosensor. If the concentration of a few inputs is in the ON range, while the others are in the middle range, should the device show an ON or an OFF state? It may show neither, as we have seen above, leaving the researcher confused as to how the results must be perceived.




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Undergraduate Laboratory
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