Difference between revisions of "Team:TU-Eindhoven/Attributions"

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<h3>★  ALERT! </h3>
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<p>This page is used by the judges to evaluate your team for the <a href="https://2017.igem.org/Judging/Medals">medal criterion</a> or <a href="https://2017.igem.org/Judging/Awards"> award listed above</a>. </p>
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<p> Delete this box in order to be evaluated for this medal criterion and/or award. See more information at <a href="https://2017.igem.org/Judging/Pages_for_Awards"> Instructions for Pages for awards</a>.</p>
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<li><a href="#"><img src="https://static.igem.org/mediawiki/2017/9/9c/T--TU-Eindhoven--Team.png" width="128" height="60" alt="Team_Icon" /></a></li>
<div class="column full_size">
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    <li><a href="#">Attributions</a></li>
<h1>Attributions</h1>
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<p> Each team must clearly attribute work done by the student team members on this page. The team must distinguish work done by the students from work done by others, including the host labs, advisors, instructors, and individuals not on the team roster.
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This is a bronze medal requirement. Please see the <a href="https://2017.igem.org/Judging/Medals">Medals requirements page</a> for more details.</p>
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<h5> Why is this page needed? </h5>
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<p>The Attribution requirement helps the judges know what you did yourselves and what you had help with. We don't mind if you get help with difficult or complex techniques, but you must report what work your team did and what work was done by others.</p>
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<p>
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For example, you might choose to work with an animal model during your project. Working with animals requires getting a license and applying far in advance to conduct certain experiments in many countries. This is difficult to achieve during the course of a summer, but much easier if you can work with a postdoc or PI who has the right licenses.</p>
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<h5> What should this page have?</h5>
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<ul>
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<li>General Support</li>
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<li>Project support and advice</li>
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<li>Fundraising help and advice</li>
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<li>Lab support</li>
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<li>Difficult technique support</li>
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<li>Project advisor support</li>
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<li>Wiki support</li>
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<li>Presentation coaching</li>
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<li>Human Practices support</li>
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<li> Thanks and acknowledgements for all other people involved in helping make a successful iGEM team</li>
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</ul>
 
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<br/><br/><br/><br/><br/><br/><br/><br/>
  
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<h1>Project Advisors</h1>
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<h6>Prof.dr.ir. Luc Brunsveld, prof.dr. Maarten Merkx and dr.ir. Tom de Greef helped us with brainstorming, by asking the right questions at the right moment and by advising us on problem solving.</h6><br/>
  
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<h1>Lab Support</h1>
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<h6>Lenne Lemmens MSc is a PhD student at our university in the Chemical Biology group of Luc Brunsveld. Her research involves heterodimerization the 14-3-3 scaffold protein following two directions: orthogonal and human heterodimerization. For the application in synthetic signalling systems and a better understanding of the human heterodimerization respectfully.
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During the whole project she has been a big help in the lab. She has also had an advisory role in both planning and troubleshooting throughout the project. <br/><br/>
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Simone Wouters MSc is a PhD candidate in the Protein Engineering research group of prof. dr. Maarten Merkx. Her research focuses on the controlled activation of antibodies for therapeutic antibodies such as Cetuximab. She has been helpful in the lab, open for questions and in Lenne Lemmens' absence she was available to provide advice where needed.<br/><br/>
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Ir. Rens de Vries is a PhD candidate under the supervision of prof. dr. ir. Luc Brunsveld. In his research, he studies heterodimerization of nuclear receptors and explores their potential as a drug target for Parkinson’s disease. Especially in the final stages of our project he has been helpful with troubleshooting and further steps for the protein purification.<br/><br/>
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In the perspective of this project and any project going on in our biolab the experience from these people mentioned and other people working in the lab can not be missed.
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</h6><br/>
  
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<h1>Safety</h1>
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<h6>Dr. Moniek de Liefde-van Beest is the biosafety officer at our university, informed us about GMO regulations and checked our Safety Forms before submitting them.<br/><br/>
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Ing. Peggy de Graaf-Heuvelmans gave us a lab tour and granted us lab access.</h6><br/>
  
<div class="highlight">
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<h1>Financial Support</h1>
<h5> Can we base our project on a previous one? </h5>
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<h6>Leon Luwijs and Boukje van’t Hoff managed our bank account and made sure we received all the money from our sponsors.</h6><br/>
<p>Yes! You can have a project based on a previous team, or based on someone else's idea, <b>as long as you state this fact very clearly and give credit for the original project.</b> </p>
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<h1>Human practices</h1>
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<h6>Cécile van der Vlugt (RIVM) helped us with our assignment ‘Think Before Doing’ by having discussion sessions with us about how to fill in this assignment.<br/><br/>
  
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Zoë Robaey helped us with our application scenario, by having brainstorm sessions via Skype and via the meeting at SYNENERGENE.<br/><br/>
  
<h5>Inspiration</h5>
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Pim de Vink is a PhD student at our university in the group of dr. Lech Milroy and prof. Luc Brunsveld working on the interface between supramolecular chemistry and chemical biology. He helped us with our application scenario by brainstorming about MMPs.<br/><br/>
<p>Take a look at what other teams have done:</p>
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<ul>
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<li><a href="https://2011.igem.org/Team:Imperial_College_London/Team">2011 Imperial College London</a> (scroll to the bottom)</li>
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<li><a href="https://2014.igem.org/Team:Exeter/Attributions">2014 Exeter </a></li>
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<li><a href="https://2014.igem.org/Team:Melbourne/Attributions">2014 Melbourne </a></li>
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<li><a href="https://2014.igem.org/Team:Valencia_Biocampus/Attributions">2014 Valencia Biocampus</a></li>
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</ul>
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We also talked to stakeholders for our Human Practices, more information about these talks can be found <a href="https://2017.igem.org/Team:TU-Eindhoven/Human_Practices/Stakeholders" target="_blank">here.</a></h6><br/>
  
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<h1>Modeling</h1>
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<h6>The first contact for modeling was with René Verhoef BSc, who was the modeling captain of TU Eindhoven 2016 and they got nominated for the best model. He gave us some code that wasn’t useful for them, and later on, it appeared that it also wasn’t useful for us.<br/><br/>
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Dr.ir. Tom de Greef is one of our advisors and sent us many papers that described the modeling of similar systems. He was the one that advised us to use NFsim and gave us the contact information of Tim Paffen MsC, a PhD student who has used NFsim himself and will receive his degree while we are in Boston. <br/><br/>
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Furthermore, we were very glad with the feedback we received from Dr. ir. Bart Markvoort about our 2D simulation and how he helped us to run NFsim on windows. Bart Markvoort also suggested to investigate more about the Gillespie algorithm (this was before we knew about NFsim) and therefore we contacted Dr. ir. Huub ten Eikelder, and he told us that Gillespie wasn’t the way to go.
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</h6><br/>
  
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<h1>Collaborations</h1>
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<h6>With iGEM team Potsdam we had a nice collaboration including a model, the WIKI and Human Practices. We thank them for their teamwork with us!<br/><br/>
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We thank iGEM Cologne-Duesseldorf to set up the postcard exchange. It was really nice to see what every team was working on in their project depicted on a postcard.<br/><br/>
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The iGEM Waterloo team had a questionnaire about lab costs and lab materials. They had a plan for 3D printing lab materials which also could be customized for the different iGEM teams.<br/><br/>
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The iGEM UNebraska-Lincoln had a questionnaire about methane production in cattle.</h6><br/>
  
<h5>Team training and Project start</h5>
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<h1>WIKI and animations</h1>
<p>Tell us if your institution teaches an iGEM or synthetic biology class and when you started your project:</p>
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<h6>We built the WIKI and animated the movies on the WIKI ourselves.
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</h6><br/>
<li>Does your institution teach an iGEM or synthetic biology course?</li>
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<li>When did you start this course?</li>
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<li>Are the syllabus and course materials freely available online?</li>
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<li>When did you start your brainstorming?</li>
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<li>When did you start in the lab?</li>
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<li>When did you start working on  your project?</li>
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Latest revision as of 17:16, 1 November 2017

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Project Advisors

Prof.dr.ir. Luc Brunsveld, prof.dr. Maarten Merkx and dr.ir. Tom de Greef helped us with brainstorming, by asking the right questions at the right moment and by advising us on problem solving.

Lab Support

Lenne Lemmens MSc is a PhD student at our university in the Chemical Biology group of Luc Brunsveld. Her research involves heterodimerization the 14-3-3 scaffold protein following two directions: orthogonal and human heterodimerization. For the application in synthetic signalling systems and a better understanding of the human heterodimerization respectfully. During the whole project she has been a big help in the lab. She has also had an advisory role in both planning and troubleshooting throughout the project.

Simone Wouters MSc is a PhD candidate in the Protein Engineering research group of prof. dr. Maarten Merkx. Her research focuses on the controlled activation of antibodies for therapeutic antibodies such as Cetuximab. She has been helpful in the lab, open for questions and in Lenne Lemmens' absence she was available to provide advice where needed.

Ir. Rens de Vries is a PhD candidate under the supervision of prof. dr. ir. Luc Brunsveld. In his research, he studies heterodimerization of nuclear receptors and explores their potential as a drug target for Parkinson’s disease. Especially in the final stages of our project he has been helpful with troubleshooting and further steps for the protein purification.

In the perspective of this project and any project going on in our biolab the experience from these people mentioned and other people working in the lab can not be missed.

Safety

Dr. Moniek de Liefde-van Beest is the biosafety officer at our university, informed us about GMO regulations and checked our Safety Forms before submitting them.

Ing. Peggy de Graaf-Heuvelmans gave us a lab tour and granted us lab access.

Financial Support

Leon Luwijs and Boukje van’t Hoff managed our bank account and made sure we received all the money from our sponsors.

Human practices

Cécile van der Vlugt (RIVM) helped us with our assignment ‘Think Before Doing’ by having discussion sessions with us about how to fill in this assignment.

Zoë Robaey helped us with our application scenario, by having brainstorm sessions via Skype and via the meeting at SYNENERGENE.

Pim de Vink is a PhD student at our university in the group of dr. Lech Milroy and prof. Luc Brunsveld working on the interface between supramolecular chemistry and chemical biology. He helped us with our application scenario by brainstorming about MMPs.

We also talked to stakeholders for our Human Practices, more information about these talks can be found here.

Modeling

The first contact for modeling was with René Verhoef BSc, who was the modeling captain of TU Eindhoven 2016 and they got nominated for the best model. He gave us some code that wasn’t useful for them, and later on, it appeared that it also wasn’t useful for us.

Dr.ir. Tom de Greef is one of our advisors and sent us many papers that described the modeling of similar systems. He was the one that advised us to use NFsim and gave us the contact information of Tim Paffen MsC, a PhD student who has used NFsim himself and will receive his degree while we are in Boston.

Furthermore, we were very glad with the feedback we received from Dr. ir. Bart Markvoort about our 2D simulation and how he helped us to run NFsim on windows. Bart Markvoort also suggested to investigate more about the Gillespie algorithm (this was before we knew about NFsim) and therefore we contacted Dr. ir. Huub ten Eikelder, and he told us that Gillespie wasn’t the way to go.

Collaborations

With iGEM team Potsdam we had a nice collaboration including a model, the WIKI and Human Practices. We thank them for their teamwork with us!

We thank iGEM Cologne-Duesseldorf to set up the postcard exchange. It was really nice to see what every team was working on in their project depicted on a postcard.

The iGEM Waterloo team had a questionnaire about lab costs and lab materials. They had a plan for 3D printing lab materials which also could be customized for the different iGEM teams.

The iGEM UNebraska-Lincoln had a questionnaire about methane production in cattle.

WIKI and animations

We built the WIKI and animated the movies on the WIKI ourselves.

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