Difference between revisions of "Team:NJU-China"

 
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{{NJU-China}}
 
 
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                <!-- .main-nav start -->
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                    <!-- .row start -->
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                                <div class="col-md-12">
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                                    <!-- .navbar start -->
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                                    <nav class="navbar navbar-default nav-left">                                   
  
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<div class="column full_size" >
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                                        <!-- .navbar-header start -->
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<h1> Welcome to iGEM 2017! </h1>
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                                        <div class="navbar-header">
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<p>Your team has been approved and you are ready to start the iGEM season! </p>
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                                            <!-- .logo start -->
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</div>  
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                                            <div class="logo">
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                                                <a href="https://2017.igem.org/Team:NJU-China">
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                                                    <img src="https://static.igem.org/mediawiki/2017/d/d3/NJU_China_iGEM_2017_Home_logo.png" alt="NJU-CHINA">
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                                                </a>
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                                            </div><!-- logo end -->
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                                        </div><!-- .navbar-header end -->
  
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<div class="clear"></div>
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                                        <!-- Collect the nav links, forms, and other content for toggling -->
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                                        <div class="collapse navbar-collapse">
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                                            <ul class="nav navbar-nav pi-nav">
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                                                <li class="current-menu-item dropdown">
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                                                    <a href="https://2017.igem.org/Team:NJU-China">Home</a>
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                                                </li>
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                                                <li class="dropdown">
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                                                    <a href="https://2017.igem.org/Team:NJU-China/Project">Project</a>
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                                                    <ul class="dropdown-menu">
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                                                        <li><a href="https://2017.igem.org/Team:NJU-China/Project">Description</a></li>
 +
                                                        <li><a href="https://2017.igem.org/Team:NJU-China/InterLab">InterLab</a></li>
 +
                                                    </ul>
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                                                    <!-- .dropdown-menu end -->
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                                                </li>
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                                                <li class="dropdown">
 +
                                                    <a href="https://2017.igem.org/Team:NJU-China/Results/Conclusions">Results</a>
 +
                                                    <ul class="dropdown-menu">
 +
                                                        <li><a href="https://2017.igem.org/Team:NJU-China/Results/Conclusions">Conclusions</a></li>
 +
                                                        <li><a href="https://2017.igem.org/Team:NJU-China/Safety">Safety</a></li>
  
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<div class="column half_size" >
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<h5>Before you start: </h5>
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                                                    </ul><!-- .dropdown-menu end -->
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<p> Please read the following pages:</p>
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                                                </li>
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<ul>
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                                                <li>
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<li> <a href="https://2017.igem.org/Competition">Competition Hub</a> </li>
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                                                    <a href="https://2017.igem.org/Team:NJU-China/Basic_Part">Parts</a>
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<li> <a href="https://2017.igem.org/Competition/Deliverables/Wiki">Wiki Requirements page</a></li>
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                                                </li>
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<li> <a href="https://2017.igem.org/Resources/Template_Documentation">Template documentation</a></li>
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                                                <li>
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</ul>
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                                                    <a href="https://2017.igem.org/Team:NJU-China/Model">Model</a>
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</div>
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                                                </li>                                               
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                                                <li class="dropdown">
 +
                                                    <a href="https://2017.igem.org/Team:NJU-China/Notebook">Notebook</a>
 +
                                                    <ul class="dropdown-menu">
 +
                           
 +
                                                        <li><a href="https://2017.igem.org/Team:NJU-China/Experiments/Protocol">Protocol</a></li>
 +
                                                        <li><a href="https://2017.igem.org/Team:NJU-China/Notebook">Calendar</a></li>
 +
                                                    </ul><!-- .dropdown-menu end -->
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                                                </li>
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                                                <li class="dropdown">
 +
                                                    <a href="https://2017.igem.org/Team:NJU-China/HP">Human Practice</a>
 +
                                                    <ul class="dropdown-menu">
 +
                                                        <li><a href="https://2017.igem.org/Team:NJU-China/HP/Silver">Silver HP</a></li>
 +
                                                        <li><a href="https://2017.igem.org/Team:NJU-China/HP/Gold_Integrated">Intergrated and Gold</a></li>
 +
                                                       
 +
                                                    </ul><!-- .dropdown-menu end -->
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                                                </li>
 +
                                                <li class="dropdown">
 +
                                                    <a href="https://2017.igem.org/Team:NJU-China/Team">Team</a>      <ul class="dropdown-menu">
 +
                                                        <li><a href="https://2017.igem.org/Team:NJU-China/Team">Team</a></li>
 +
                                                        <li><a href="https://2017.igem.org/Team:NJU-China/Attributions">Attributions</a></li>
 +
                                                        <li><a href="https://2017.igem.org/Team:NJU-China/Collaborations">Collaborations</a></li>
 +
                                                    </ul><!-- .dropdown-menu end -->
 +
                                                </li>
 +
                                            </ul><!-- .nav.navbar-nav.pi-nav end -->
  
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<div class="column half_size" >
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                                            <!-- Responsive menu start -->
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<div class="highlight">
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                                            <div id="dl-menu" class="dl-menuwrapper">
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<h5> Project Descriptions</h5>
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                                                <button class="dl-trigger">Open Menu</button>
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<p>Obesity is an increasingly prevalent human condition in the world. Despite major progress in the understanding of the molecular mechanisms leading to obesity, no safe and effective treatment has yet been found. Herein we aim to utilize the RNA interference(RNAi) technology to silence the anti-apoptotic gene BCL2 specifically in white adipose tissue, leading to the ablation of white fat. We use an endogenous nanoparticle exosome on account of its low toxicity and immune response to deliver the nucleotide drug. The exosomal surface will be modified with an adipose tissue-specific circular peptide tPep(CKGGRAKDC) by a glycine-linker to the lysosomal-associated membrane protein 2b(Lamp2b) which is a protein found abundant on the surface of exosomes. The selective delivery of tPep-exosome-siRNA to white adipose will theoretically promote the adipose cell death, ultimately representing a potential approach for the treatment of obesity.</p>
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</div>
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</div>
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<div class="column full_size" >
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                                                <ul class="dl-menu">
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<h5> Wiki template information </h5>
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                                                    <li>
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<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2017.igem.org/Judging/Pages_for_Awards">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
+
                                                        <a href="https://2017.igem.org/Team:NJU-China">Home</a>
 +
                                                    </li>
  
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</div>  
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                                                    <li>
 +
                                                        <a href="https://2017.igem.org/Team:NJU-China/Project">Project</a>
 +
                                                        <ul class="dl-submenu">
 +
                                                            <li><a href="https://2017.igem.org/Team:NJU-China/Project">Description</a></li>
 +
                                                            <li><a href="https://2017.igem.org/Team:NJU-China/InterLab">InterLab</a></li>
 +
                                                        </ul>
 +
                                                    </li>
  
 +
                                                    <li>
 +
                                                        <a href="https://2017.igem.org/Team:NJU-China/Results/Conclusions">Results</a>
 +
                                                        <ul class="dl-submenu">
 +
                                                            li><a href="https://2017.igem.org/Team:NJU-China/Results/Conclusions">Conclusions</a></li>
  
 +
                                                        <li><a href="https://2017.igem.org/Team:NJU-China/Safety">Safety</a></li>
  
 +
                                                        </ul>
 +
                                                    </li>
  
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<div class="column half_size" >
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                                                    <li>
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<h5> Editing your wiki </h5>
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                                                        <a href="https://2017.igem.org/Team:NJU-China/Basic_Part">Parts</a>
−
<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>  
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                                                    </li>
−
<p> <a href="https://2017.igem.org/wiki/index.php?title=Team:Example&action=edit"> </a>Use WikiTools - Edit in the black menu bar to edit this page</p>
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                                                    <li>
 +
                                                        <a href="https://2017.igem.org/Team:NJU-China/Model">Model</a>
 +
                                                    </li>
 +
                                                    <li>
 +
                                                        <a href="https://2017.igem.org/Team:NJU-China/Notebook">Notebook</a>
 +
                                                        <ul class="dl-submenu">
  
−
</div>
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                                                            <li><a href="https://2017.igem.org/Team:NJU-China/Experiments/Protocol">Protocol</a></li>
 +
                                                            <li><a href="https://2017.igem.org/Team:NJU-China/Notebook">Calendar</a></li>
 +
                                                        </ul>
 +
                                                    </li>
 +
                                                    <li>
 +
                                                        <a href="https://2017.igem.org/Team:NJU-China/HP">Human Practice</a>
 +
                                                        <ul class="dl-submenu">
 +
                                                            <li><a href="https://2017.igem.org/Team:NJU-China/HP/Silver">Silver HP</a></li>
 +
                                                            <li><a href="https://2017.igem.org/Team:NJU-China/HP/Gold_Integrated">Intergrated and Gold</a></li>
 +
 
 +
                                                        </ul>
 +
                                                    </li>
  
 +
                                                    <li>
 +
                                                        <a href="https://2017.igem.org/Team:NJU-China/Team">Team</a>
 +
                                                        <ul class="dl-submenu">
 +
                                                            <li><a href="https://2017.igem.org/Team:NJU-China/Team">Team</a></li>
 +
                                                            <li><a href="https://2017.igem.org/Team:NJU-China/Attributions">Attributions</a></li>
 +
                                                            <li><a href="https://2017.igem.org/Team:NJU-China/Collaborations">Collaborations</a></li>
 +
                                                        </ul>                                                       
 +
                                                    </li><!-- Contact li end -->
  
−
<div class="column half_size" >
+
                                                </ul><!-- .dl-menu end -->
−
<h5>Tips</h5>
+
                                            </div><!-- (Responsive menu) #dl-menu end -->
−
<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
+
                                        </div><!-- .navbar.navbar-collapse end -->  
−
<ul>
+
                                    </nav><!-- .navbar end -->
−
<li>State your accomplishments! Tell people what you have achieved from the start. </li>
+
                                </div><!-- .col-md-12 end -->
−
<li>Be clear about what you are doing and how you plan to do this.</li>
+
                            </div><!-- .row end -->          
−
<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
+
                        </div><!-- .main-nav end -->
−
<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
+
                    </div><!-- .container end -->
−
<li>Avoid using very small fonts and low contrast colors; information should be easy to read. </li>
+
                </div><!-- .header-inner end -->
−
<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2017.igem.org/Calendar">iGEM 2017 calendar</a> </li>
+
            </header><!-- #header end -->
−
<li>Have lots of fun! </li>
+
−
</ul>  
+
 
</div>
 
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 +
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 +
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                    >
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 +
                </h2>
  
−
<div class="column half_size" >
+
                <!-- slide divider layer -->
−
<h5>Inspiration</h5>
+
                <div class="ms-layer divider"
−
<p> You can also view other team wikis for inspiration! Here are some examples:</p>
+
                    style="top: 505px; left: 737px;"
−
<ul>
+
                    data-type="text"
−
<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
+
                    data-effect="top(40)"
−
<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
+
                    data-duration="2000"
−
<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
+
                    data-ease="easeOutExpo"
−
<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
+
                    data-delay="1000">
−
<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
+
                    <span class="hr-double left"></span>
−
<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
+
                    <span class="divider-svg">
−
</ul>
+
                        <img src="https://static.igem.org/mediawiki/2017/7/73/NJU_China_iGEM_2017_Home_heading-icon.svg" alt="NJU-CHINA">
−
</div>
+
                    </span>
 +
                    <span class="hr-double right"></span>
 +
                </div>
  
−
<div class="column half_size" >
+
                <!-- slide text layer -->
−
<h5> Uploading pictures and files </h5>
+
                <p class="ms-layer pi-text01"
−
<p> You can upload your pictures and files to the iGEM 2017 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
+
                  style="top: 590px; left: 870px;font-size:30px;"
−
When you upload, set the "Destination Filename" to <br><code>T--YourOfficialTeamName--NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)<br><br>
+
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 +
                  >
 +
                    <img src="https://static.igem.org/mediawiki/2017/8/85/NJU_China_iGEM_2017_Home_nju.png" style="width:200px;">
 +
                </p>
 +
             
 +
            </div><!-- slide end -->
 +
        </div><!-- .master-slider end -->
  
−
<a href="https://2017.igem.org/Special:Upload">
+
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−
UPLOAD FILES
+
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−
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+
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−
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+
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−
</div>
+
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 +
                    <p style="color: white;font-size: 15px;font-family:'Microsoft Yahei';text-indent:20px;letter-spacing:1.5px;">Obesity problem has become increasingly prevalant these years and arouses widespread concern. Traditional methodsare either easy to rebound or associated with side effects, while other effective treatment of obesity has not appeared yet so far. The goal of our project is to develop a new strategy to treat obesity, with building a transplantable system targeting white fat tissues. We packed siRNA into exosomes (nano-sized vesicles secreted by human cells). Then we modified our exosome with a certain peptide targeting white-fat-tissue. The siRNA will cause the apoptosis of fat tissue. Our validation experiments will be carried out at the level of cells and animals (mice). Eventually, we expect to see a specific accumulation of the siRNA in the mice’s white fat tissue and the decrease of mice’s fat and their weights. This project may provide new insights into future treatment of obesity.</p>
 +
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 +
            </div>
 +
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 +
                        </div>
 +
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 +
                            <a href="https://2017.igem.org/Team:NJU-China/Results/Conclusions"><img src="https://static.igem.org/mediawiki/2017/d/d2/NJU_China_iGEM_2017_Home_results.png" style="width: 100px;"></a>
 +
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 +
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 +
                            <a href="https://2017.igem.org/Team:NJU-China/Basic_Part"><img src="https://static.igem.org/mediawiki/2017/f/fb/NJU_China_iGEM_2017_Home_parts.png" style="width: 100px;"></a>
 +
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 +
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 +
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 +
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 +
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 +
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 +
                            <a href="https://2017.igem.org/Team:NJU-China/HP"><img src="https://static.igem.org/mediawiki/2017/d/df/NJU_China_iGEM_2017_Home_HP.png" style="width: 100px;"></a>
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                            <a href="https://2017.igem.org/Team:NJU-China/Team"><img src="https://static.igem.org/mediawiki/2017/e/eb/NJU_China_iGEM_2017_Home_team.png" style="width: 100px;"></a>
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Latest revision as of 01:40, 2 November 2017

NJU-CHINA

NJU-CHINA

NJU-CHINA

Obesity problem has become increasingly prevalant these years and arouses widespread concern. Traditional methodsare either easy to rebound or associated with side effects, while other effective treatment of obesity has not appeared yet so far. The goal of our project is to develop a new strategy to treat obesity, with building a transplantable system targeting white fat tissues. We packed siRNA into exosomes (nano-sized vesicles secreted by human cells). Then we modified our exosome with a certain peptide targeting white-fat-tissue. The siRNA will cause the apoptosis of fat tissue. Our validation experiments will be carried out at the level of cells and animals (mice). Eventually, we expect to see a specific accumulation of the siRNA in the mice’s white fat tissue and the decrease of mice’s fat and their weights. This project may provide new insights into future treatment of obesity.