Difference between revisions of "Team:BIT/Prize"

 
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<h1 class="title-h1"><center>Prize<center></h1>
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                                    <div class="texttitle">Abstract</div>
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                                    <p class="lead add-bottom" style="color:#5E5656">The problem of uranium contamination is a source of great concern. Uranium could have severe detrimental health effects (it is particularly harmful to the liver, kidney and bone) and lead to environment issues (chemical and radioactive hazards). <a href="https://2016.igem.org/Team:Peking/HP/311">Current treatment options</a> available for uranium leaks in nuclear power plants or uranium pollution around ore-fields, such as ion exchange, flocculation-setting and phytoremediation, all have limitations including their high cost, low efficiency and the sheer complexity of the involved procedures.</p>
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                                    <p class="lead add-bottom" style="color:#5E5656">To address these problems, Peking iGEM team aims to construct <a href="https://2016.igem.org/Team:Peking/Description">a novel functional biomaterial</a> consisting of multiple functional protein modules. This material is designed to be produced and secreted by bacteria, and self-assembled to form a polymer network. In combination with a specific <a href="https://2016.igem.org/Team:Peking/Uranyl-adsorption">Super Uranyl-binding Protein</a>, it obtains the ability to adsorb uranyl ions. After very short contacting with polluted water, the uranyl-laden biomaterial, which also contains a <a href="https://2016.igem.org/Team:Peking/Clearance">monomeric streptavidin module</a>, could be easily cleared using biotinylated magnetic beads.
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                                    <p class="lead add-bottom" style="color:#5E5656">This uranyl-binding biomaterial shows a series of advantages, such as high specificity, high efficiency, self-assembly and renewability. Furthermore, the uranyl-binding module could be replaced or combined with modules that are capable of binding other heavy metal ions, as well as fluorescent proteins, obtaining <a href="https://2016.igem.org/Team:Peking/Proof">multi-functionality</a>. By taking advantage of modularization in the design, additional applications beyond uranium adsorption could be developed based on this material in the future.</p>
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<h3 class="title-h3"><center>This year Team BIT makes great efforts and have a try to make the project be realized on demonstrate. In the meanwhile we have achieved the criterion of five iGEM Prizes : Integrated Human Practices, Education and Public Engagement, Entrepreneurship, Hardware and Best New Composite Part. Now here are the details for these Prizes.<center></h3>
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                                <p style="text-align:center;"><a href="https://2016.igem.org/Team:Peking/Crosslinking"><img style="width:  %;" src="https://static.igem.org/mediawiki/2016/b/b3/T--Peking--image_H1.png " alt="" /></p></a>
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                                <p style="font-family:raleway-bold, sans-serif !important;font-size:24px !important; text-align:center; margin-top:20px;">Crosslinking</p>
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                                <p style="font-family:raleway-regular, sans-serif !important; font-weight:100;font-size:18px !important; text-align:justify;">By taking advantage of the covalent crosslinking of SpyTag and SpyCatcher, a polymer network was designed to possess special properties, such as strong mechanical strength, large contact area and stable structure. </p>
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                                <p><a href="https://2016.igem.org/Team:Peking/Crosslinking">Learn more...</a></p>
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                                <p style="text-align:center;"><a href="https://2016.igem.org/Team:Peking/Secretion"><img style="width:  %;" src="https://static.igem.org/mediawiki/2016/1/1f/T--Peking--image_H2.png" /></p></a>
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                                <p style="font-family:raleway-bold, sans-serif !important;font-size:24px !important; text-align:center; margin-top:20px;">Secretion</p>
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                                <p style="font-family:raleway-regular, sans-serif !important; font-weight:100;font-size:18px !important; text-align:justify;">To make the polymer network reproductive and economical, a signal peptide library was constructed. We carried out a series of experiments to find an optimal secretion strategy.</p>
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                                <p><a href="https://2016.igem.org/Team:Peking/Secretion">Learn more...</a></p>
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                                <p style="text-align:center;"><a href="https://2016.igem.org/Team:Peking/Clearance"><img style="width:  %;" src="https://static.igem.org/mediawiki/2016/9/95/T--Peking--image_H3.png" alt=""/></p></a>
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                                <p style="font-family:raleway-bold, sans-serif !important;font-size:24px !important; text-align:center; margin-top:20px;">Clearance</p>
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                                <p style="font-family:raleway-regular, sans-serif !important; font-weight:100;font-size:18px !important; text-align:justify;">The monomeric streptavidin constructed in the polymer network could realize the clearance of Spy Crosslinking Network in the environment by interacting with biotinylated magnetic beads. </p>
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                                <p><a href="https://2016.igem.org/Team:Peking/Clearance">Learn more...</a></p>
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                                <p style="text-align:center;"><a href="https://2016.igem.org/Team:Peking/Model"><img style="width:  %;" src="https://static.igem.org/mediawiki/2016/a/aa/T--Peking--image_H4.png
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                                <p style="font-family:raleway-regular, sans-serif !important; font-weight:100;font-size:18px !important; text-align:justify;">To accurately describe the Gel Point (GP) and the Mass Distribution (MD) for our polymer network, we built up two amendatory models that can adequately describe the characters and deepen our knowledge of our novel biomaterial.</p>
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                                <p style="text-align:center;"><a href="https://2016.igem.org/Team:Peking/Software"><img style="width:  %;" src="https://static.igem.org/mediawiki/2016/b/b3/T--Peking--image_H5.png
 
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Based on JACOB, iGEM_BIT opened a platform at China Science and Technology Museum for ordinary communities to understand synthetic biology and microfluidic chip. And a survey had been made to over 300 foreigners. We also discussed with middle students deeply and visited three industries and two healthcare centers for our project.For details please refer to Wiki Page.<a href="https://2017.igem.org/Team:BIT/Engagement" >Click Here</a> to see the Engagement.
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JACOB is offering a new interaction between healthcare and patients, which allows treatments to be concentrated on early detection and precaution. It will improve the cure rate and be a financial relief, so that less conflicts will arise between patients and hospitals. These advantages make JACOB an awesome tool.<a href="https://2017.igem.org/Team:BIT/HP/Gold_Integrated" >Click Here</a> to see the HP/Gold_Integrated.
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JACOB’s portability, efficiency and accessibility are built upon effectual inter-disciplinary applications of synthetic biology and hardware engineering. It can simplify the sample inputs, recognize GFP and RFP simultaneously and sustain a consistent environment for host bacteria E.coli. Overall, JACOB’s core is a creative and evolvable artboard for future practices.<a href=" https://2017.igem.org/Team:BIT/Hardware " target="_blank">Click Here</a>.
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We recharacterized JACOB commercially based on investigations of the market and process of industrialization, in perspectives of consumers, commercial companies, and hospitals. There is a big market of household-level warning-diagnostic tools for serious diseases, just like JACOB. We are currently planning to resolve mass productions jointly cooperating with other institutes or capitals.<a href="https://2017.igem.org/Team:BIT/Entrepreneurship" >Click Here</a> to see the Entrepreneurship. </p>
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We modified and refined the previous part: <a href="http://parts.igem.org/Part:BBa_J37032" >J37032</a>, and created our new part: <a href="http://parts.igem.org/Part:BBa_K2305004" >K2305004</a>,its' fluorescent expression was eighty times higher than the previous part.Here is the link to the<a href=" https://2017.igem.org/Team:BIT/Composite_Part " target="_blank"> Composite_Part</a>.
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To facilitate early diagnosis, we contrived a biosensor of onset-pathological biomarkers with high sensitivity, affordability, and analyte modifiability. Here are three highlights: first, biosensor (aptamer) is able to be artificially designed aimed at target biomarker; second, bioamplifier (gene knock-out, strong promoter, cycle amplifier and dual-fluorescence) realizes improvement of signal to noise ratio; third, micro-fluidic chip and fluorescence detector make it possible that the assay can work in practical.<a href=" https://2017.igem.org/Team:BIT " target="_blank">READ MORE.</a>
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Latest revision as of 02:58, 2 November 2017

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Prize

This year Team BIT makes great efforts and have a try to make the project be realized on demonstrate. In the meanwhile we have achieved the criterion of five iGEM Prizes : Integrated Human Practices, Education and Public Engagement, Entrepreneurship, Hardware and Best New Composite Part. Now here are the details for these Prizes.

Bronze
Bronze

Based on JACOB, iGEM_BIT opened a platform at China Science and Technology Museum for ordinary communities to understand synthetic biology and microfluidic chip. And a survey had been made to over 300 foreigners. We also discussed with middle students deeply and visited three industries and two healthcare centers for our project.For details please refer to Wiki Page.Click Here to see the Engagement.

Bronze
Bronze

JACOB is offering a new interaction between healthcare and patients, which allows treatments to be concentrated on early detection and precaution. It will improve the cure rate and be a financial relief, so that less conflicts will arise between patients and hospitals. These advantages make JACOB an awesome tool.Click Here to see the HP/Gold_Integrated.

Bronze
Bronze

JACOB’s portability, efficiency and accessibility are built upon effectual inter-disciplinary applications of synthetic biology and hardware engineering. It can simplify the sample inputs, recognize GFP and RFP simultaneously and sustain a consistent environment for host bacteria E.coli. Overall, JACOB’s core is a creative and evolvable artboard for future practices.Click Here.




Bronze
Bronze

We recharacterized JACOB commercially based on investigations of the market and process of industrialization, in perspectives of consumers, commercial companies, and hospitals. There is a big market of household-level warning-diagnostic tools for serious diseases, just like JACOB. We are currently planning to resolve mass productions jointly cooperating with other institutes or capitals.Click Here to see the Entrepreneurship.

Bronze
Bronze

We modified and refined the previous part: J37032, and created our new part: K2305004,its' fluorescent expression was eighty times higher than the previous part.Here is the link to the Composite_Part.

Bronze
Bronze

To facilitate early diagnosis, we contrived a biosensor of onset-pathological biomarkers with high sensitivity, affordability, and analyte modifiability. Here are three highlights: first, biosensor (aptamer) is able to be artificially designed aimed at target biomarker; second, bioamplifier (gene knock-out, strong promoter, cycle amplifier and dual-fluorescence) realizes improvement of signal to noise ratio; third, micro-fluidic chip and fluorescence detector make it possible that the assay can work in practical.READ MORE.



Contact Us!

Please keep reading if you want to contact us.