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| <div class="headline"> | | <div class="headline"> |
| <div class="container"> | | <div class="container"> |
− | <span class="highlight"> | + | |
− | <h1>SilenshR</h1>
| + | <h1> |
− | <h3>a Bacteria-Mediated Oncogene Silencing as Living Cancer Therapeutic</h3>
| + | <u> SilenshR</u><br> |
− | </span>
| + | |
| + | |
| + | </h1> |
| + | <h3> <u> Bacteria-Mediated Oncogene Silencing as a Living Cancer Therapeutic </u> </h3> |
| </div> | | </div> |
| </div> | | </div> |
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| <div class="container"> | | <div class="container"> |
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− | <body>
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− | <div class="slideshow-container">
| + | |
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− | </div>
| + | |
− | <br>
| + | |
− | | + | |
− | <div style="text-align:center">
| + | |
− | <span class="dot"></span>
| + | |
− | <span class="dot"></span>
| + | |
− | <span class="dot"></span>
| + | |
− | </div>
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− | | + | |
− | </body>
| + | |
− | | + | |
− | | + | |
− | | + | |
− | <!-- First Featurette -->
| + | |
− | <div class="featurette" id="about">
| + | |
− | <img class="featurette-image img-circle img-responsive pull-right" src="http://placehold.it/500x500">
| + | |
− | <h2 class="featurette-heading">The Advantages to a
| + | |
− | <span class="text-muted">Synthetic Biology Approach</span>
| + | |
− | </h2>
| + | |
− | <p class="lead">A cornerstone in synthetic biology is the connection of distinct biological functions to create useful system
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− | level behavior. We can take advantage of how bacteria naturally localize in tumors while failing to survive
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− | in healthy tissue in the body to use bacteria as a cancer-specific delivery mechanism. Also, bacteria can
| + | |
− | mass produce products, invade cells, and release the products directly into the cells. This allows easily-degraded
| + | |
− | compounds to be effective delivered into cancer cells. It also prevents these compounds from affecting healthy
| + | |
− | cells. The combination of these mechanisms creates a powerful, cancer-specific circuit for gene therapy.</p>
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− | </div>
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− | | + | |
− | <hr class="featurette-divider">
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− | | + | |
− | <!-- Second Featurette -->
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− | <div class="featurette" id="services">
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− | <img class="featurette-image img-circle img-responsive pull-left" src="http://placehold.it/500x500">
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− | <h2 class="featurette-heading">Expanding the Possibilities of
| + | |
− | <span class="text-muted">Gene Therapy</span>
| + | |
− | </h2>
| + | |
− | <p class="lead">Anticipating the applications of synthetic biology to healthcare, Columbia iGEM 2017 is devising a therapeutic
| + | |
− | approach to modulate mammalian gene expression at the post-transcriptional level. Recombinant E. coli with
| + | |
− | the capacity to invade mammalian cells will deliver an shRNA payload against an aberrantly expressed gene,
| + | |
− | for example an oncogene in cancer or proinflammatory cytokine in inflammation, to the host cytoplasm. This
| + | |
− | shRNA payload will then inhibit protein function, which can combat mutations that confer resistance to traditional
| + | |
− | therapies, as with the tyrosine kinase inhibitors gefitinib and imatinib. </p>
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− | </div>
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− | | + | |
− | <hr class="featurette-divider">
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− | <!-- Third Featurette -->
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− | <div class="featurette" id="contact">
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− | <img class="featurette-image img-circle img-responsive pull-right" src="http://placehold.it/500x500">
| + | |
− | <h2 class="featurette-heading">The Future
| + | |
− | <span class="text-muted">Outlook</span>
| + | |
− | </h2>
| + | |
− | <p class="lead">Our mechanism to modulate mammalian gene expression can have a variety of applications, extending throughout
| + | |
− | as well beyond healthcare. The engineered bacteria would have a significant application to human health particularly
| + | |
− | in conditions characterized by aberrant gene expression, such as with oncogenes in cancer, cytokines in inflammation,
| + | |
− | and many others. For cancer applications, the engineered bacteria can be taken as an oral probiotic, which
| + | |
− | will then selectively localize in tumor cells to prove gene therapy.</p>
| + | |
− | </div>
| + | |
− | | + | |
− | <hr class="featurette-divider">
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| | | |
| </div> | | </div> |