Difference between revisions of "Team:DTU-Denmark/Description"

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m (navbar upgrade)
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     <!-- importing style sheet -->
 
     <!-- importing style sheet -->
  
−
     <link rel="stylesheet" type="text/css" href="https://2017.igem.org/Team:DTU-Denmark/stylesheetsub?action=raw&ctype=text/css">
+
     <!-- <link rel="stylesheet" type="text/css" href="https://2017.igem.org/Team:DTU-Denmark/stylesheetsub?action=raw&ctype=text/css"> -->
  
 
     <!-- This tells the browser that your page is responsive -->
 
     <!-- This tells the browser that your page is responsive -->
 +
   
 
     <meta name="viewport" content="width=device-width, initial-scale=1">  
 
     <meta name="viewport" content="width=device-width, initial-scale=1">  
 +
   
 +
    <style>
  
−
</head>
+
    /****************************************************************************************************************/
 +
/************************************** OVERWRITES DEFAULT WIKI SETTINGS ****************************************/
 +
/************************************************* (iGEM CODE) **************************************************/
 +
/****************************************************************************************************************/
 +
 
  
 +
    /* Clear the default wiki settings */
 +
 
 +
    #home_logo, #sideMenu {
 +
      display:none;
 +
    }
 +
   
 +
    #sideMenu, #top_title, .patrollink  {
 +
      display:none;
 +
    }
 +
   
 +
    #content {
 +
      width: 100%;
 +
      padding: 0px;
 +
      margin-top: -7px;
 +
      margin-left: 0px;
 +
    }
  
 +
    body {
 +
      background-color: white;
 +
    }
  
−
<body>
+
    #bodyContent h1, #bodyContent h2, #bodyContent h3, #bodyContent h4, #bodyContent h5 {
−
     <div id="windowcontent" class="rmvpadmarg">
+
      margin-bottom: 0px;
 +
     }
  
−
    <!-- header contains the top navbar creates a 1 column (12) row containing the header and defines the dropdown list -->
 
  
−
    <div class="col-12 rmvpadmarg tofront fixed">
+
/****************************************************************************************************************/
−
        <nav class="navbar">
+
/*********************************************** SETS MAIN STYLES ***********************************************/
−
            <div class="navbarcenter">
+
/****************************************************************************************************************/
−
                <ul class="rmvpadmarg">
+
−
                    <li class="dropdown">
+
−
                        <a href="#" class="dropbtn">Team</a>
+
−
                        <div class="dropdown-content">
+
−
                            <a href="#">Members</a>
+
−
                            <a href="#">Funds</a>
+
−
                            <a href="#">Sponsors</a>
+
−
                        </div>
+
−
                    </li>
+
−
                    <li class="dropdown">
+
−
                        <a href="#" class="dropbtn">Human practices</a>
+
−
                        <div class="dropdown-content">
+
−
                            <a href="#">Integrated practices</a>
+
−
                            <a href="#">Public engagement</a>
+
−
                            <a href="#">Collaborations</a>
+
−
                        </div>
+
−
                    </li>
+
−
                    <li class="dropdown">
+
−
                        <a href="#" class="dropbtn">Notes</a>
+
−
                        <div class="dropdown-content">
+
−
                            <a href="#">Lab diary</a>
+
−
                            <a href="#">Protocols</a>
+
−
                            <a href="#">Criteria</a>
+
−
                            <a href="#">Brainstorm</a>
+
−
                        </div>
+
−
                    </li>   
+
−
                    <li class="dropdown">
+
−
                        <a href="#" class="dropbtn">Modelling</a>
+
−
                        <div class="dropdown-content">
+
−
                            <a href="#">Overview</a>
+
−
                            <a href="#">In depth</a>
+
−
                        </div>
+
−
                    </li> 
+
−
                    <li class="dropdown">
+
−
                        <a href="#" class="dropbtn">Project</a>
+
−
                        <div class="dropdown-content">
+
−
                            <a href="https://2017.igem.org/Team:DTU-Denmark/Description">Description</a>
+
−
                            <a href="#">Results</a>
+
−
                            <a href="#">Prototype</a>
+
−
                        </div>
+
−
                    </li> 
+
−
                </ul>
+
−
            </div>
+
−
        </nav>
+
−
    </div>
+
  
−
     <!-- creates a 3 column (2-8-2) row with the main container and air on each side -->
+
/***** TO OVERWRITE iGEM STYLING WHITHOUT MESSING WITH iGEM HEADER USE #windowcontent PREFIX IN CSS SYLING *****/
−
     <!-- navbarfade starts here -->
+
 
 +
     #windowcontent * {
 +
      box-sizing: border-box;
 +
      font-family: sans-serif, "Times New Roman", Times, serif;
 +
      margin: 0px;
 +
      padding: 0px;
 +
    }
 +
 
 +
    #windowcontent ul, ol {
 +
      list-style: none;
 +
    }
 +
 
 +
    /*makes the website span from edge to edge of the viewport*/
 +
 
 +
    #windowcontent body {
 +
      position: relative;
 +
      width: 100%;
 +
      margin: 0px;
 +
      padding: 0px;
 +
    }
 +
 
 +
    /***** centers all headlines as standard *****/
 +
 
 +
    h1, h2, h3, h4, h5, h6 {
 +
      text-align: center;
 +
    }
 +
 
 +
    /***** defines percentage columns used for layout so everything but the main content spans from edge to edge of the viewport *****/
 +
 
 +
    .col-1 {
 +
      width: 08.33%;
 +
    }
 +
    .col-2 {
 +
      width: 16.66%;
 +
    }
 +
    .col-3 {
 +
      width: 25.00%;
 +
    }
 +
    .col-4 {
 +
      width: 33.33%;
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    }
 +
    .col-5 {
 +
      width: 41.66%;
 +
    }
 +
    .col-6 {
 +
      width: 50.00%;
 +
    }
 +
    .col-7 {
 +
      width: 58.33%;
 +
    }
 +
    .col-8 {
 +
      width: 66.66%;
 +
    }
 +
    .col-9 {
 +
      width: 75.00%;
 +
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 +
    .col-10 {
 +
      width: 83.33%;
 +
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 +
    .col-11 {
 +
      width: 91.66%;
 +
    }
 +
    .col-12 {
 +
      width: 100.0%;
 +
    }
 +
 
 +
    /***** defines columns in pixels used for main content area, so user zoom will not affect the layout *****/
 +
 
 +
    .colp-1 {
 +
      width: calc(1000px/12);
 +
    }
 +
    .colp-2 {
 +
      width: calc(1000px/12*2);
 +
    }
 +
    .colp-3 {
 +
      width: calc(1000px/12*3);
 +
    }
 +
    .colp-4 {
 +
      width: calc(1000px/12*4);
 +
    }
 +
    .colp-5 {
 +
      width: calc(1000px/12*5);
 +
    }
 +
    .colp-6 {
 +
      width: calc(1000px/12*6);
 +
    }
 +
    .colp-7 {
 +
      width: calc(1000px/12*7);
 +
    }
 +
    .colp-8 {
 +
      width: calc(1000px/12*8);
 +
    }
 +
    .colp-9 {
 +
      width: calc(1000px/12*9);
 +
    }
 +
    .colp-10 {
 +
      width: calc(1000px/12*10);
 +
    }
 +
    .colp-11 {
 +
      width: calc(1000px/12*11);
 +
    }
 +
    .colp-12 {
 +
      width: 1000px;
 +
    }
 +
 
 +
    /***** makes all the columns go to the left of the page and "stack" to the right if room *****/
 +
 
 +
    [class*="col-"] {
 +
      float: left;
 +
      padding: 15px;
 +
    }
 +
 
 +
    [class*="colp-"] {
 +
      float: left;
 +
      padding: 15px;
 +
    }
 +
 
 +
    /***** EACH ROW MUST BE 12 COLUMNS (OF THE SAME TYPE) IN TOTAL *****/
 +
    /************ (for example col-4, col-6, col-2 is a row) ***********/
 +
 
 +
 
 +
    /***** clears the row of other content *****/
 +
 
 +
    .row::after {
 +
      content: "";
 +
      clear: both;
 +
      display: table;
 +
    }
 +
 
 +
 
 +
 
 +
/****************************************************************************************************************/
 +
/*************************** HELPING CLASSES - OVERWRITES OTHER PREDEFINED PROPERTIES ***************************/
 +
/****************************************************************************************************************/
 +
 
 +
 
 +
 
 +
    /***** removes margin and padding *****/
 +
 
 +
    #windowcontent .rmvpadmarg {
 +
      margin: 0px;
 +
      padding: 0px;
 +
    }
 +
 
 +
    /***** removes vertical lines on links *****/
 +
 
 +
    #windowcontent .rmvlinkstyle a {
 +
      text-decoration: none;
 +
    }
 +
 
 +
    /***** brings element to front of page, used to bring nav bar in front of everything else *****/
 +
 
 +
    #windowcontent .tofront {
 +
      position: relative;
 +
      z-index: 9999;
 +
    }
 +
 
 +
    /***** sets the position of the element to be given a bottom border *****/
 +
 
 +
    #windowcontent .bottomborder {
 +
      position: relative;
 +
      padding: 25px 0px;
 +
    }
 +
 
 +
    /***** styles borders for h1 elements *****/
 +
 
 +
    #windowcontent h1.bottomborder:after {
 +
      content:"";
 +
      background: black;
 +
      position: absolute;
 +
      left: 150px;
 +
      bottom: 16px;
 +
      height: 1px;
 +
      width: 700px;
 +
    }
 +
 
 +
 
 +
    /***** styles borders for h2 elements *****/
 +
 
 +
    #windowcontent h2.bottomborder:after {
 +
      content:"";
 +
      background: black;
 +
      position: absolute;
 +
      left: 300px;
 +
      bottom: 18px;
 +
      height: 1px;
 +
      width: 400px;
 +
    }
 +
 
 +
    #windowcontent .fixed {
 +
      position: fixed;
 +
    }
 +
 
 +
 
 +
/****************************************************************************************************************/
 +
/**************************************************** NAVBAR ****************************************************/
 +
/****************************************************************************************************************/
 +
 
 +
 
 +
    /***** defines key properties of the nav bar *****/
 +
 
 +
    #windowcontent nav {
 +
      margin: 0px;
 +
      padding: 0px;
 +
      top: 0px;
 +
      width: 100%;
 +
      height: 40px;
 +
    }
 +
 
 +
    /***** helps center navar. The sum of the nav bar choice widths is 1000px (5*200px) *****/
 +
 
 +
    #windowcontent .navbarcenter {
 +
      width: 1000px;
 +
      margin: auto;
 +
    }
 +
 
 +
    /***** sets color of nav bar when the page is scrolled to the top *****/
 +
 
 +
    #windowcontent .navbar {
 +
      background-color: rgba(20,20,20,1);
 +
      box-shadow: 0px 0px 12px 0px rgba(0,0,0,0.7);
 +
    }
 +
 
 +
    /***** sets background of navbar choice buttons when hovered *****/
 +
 
 +
    #windowcontent .dropdown:hover .dropbtn {
 +
      background: -webkit-linear-gradient(180deg, rgba(0,0,0,0.2), rgba(0,0,0,0.1));
 +
      background: -o-linear-gradient(180deg, rgba(0,0,0,0.2), rgba(0,0,0,0.1));
 +
      background: -moz-linear-gradient(180deg, rgba(0,0,0,0.2), rgba(0,0,0,0.1));
 +
      background: linear-gradient(180deg, rgba(0,0,0,0.2), rgba(0,0,0,0.1));
 +
    }
 +
 
 +
    /***** makes nav bar choices float next to each other *****/
 +
 
 +
    #windowcontent .dropdown {
 +
      float: right;
 +
      height: 40px;
 +
    }
 +
 
 +
    /***** layout of nav bar choice buttons *****/
 +
 
 +
    #windowcontent .dropdown .dropbtn {
 +
      height: 40px;
 +
      display: inline-block;
 +
      color: white;
 +
      text-align: center;
 +
      padding: 10px 16px;
 +
      width: 200px;
 +
      text-decoration: none;
 +
      font-size: 1em;
 +
      font-family: sans-serif, "Times New Roman", Times, serif;
 +
    }
 +
 
 +
    /***** hides dropdown choices, sets background and shadows. makes sure that the width is not less than the width of the nav bar choice buttons *****/
 +
 
 +
     #windowcontent .dropdown-content {
 +
      display: none;
 +
      position: absolute;
 +
      background-color: transparent;
 +
      min-width: 200px;
 +
      box-shadow: 0px 8px 16px 0px rgba(0,0,0,0.2);
 +
      z-index: 1;
 +
    }
 +
 
 +
    /***** displays dropdown content when nav bar choice is hovered *****/
 +
 
 +
    #windowcontent .dropdown:hover .dropdown-content, #windowcontent .dropdown:focus .dropdown-content {
 +
      display: block;
 +
    }
 +
 
 +
    /***** defines nav bar dropdown link layout *****/
 +
 
 +
    #windowcontent .dropdown-content a {
 +
      color: black;
 +
      background-color: white;
 +
      padding: 12px 16px;
 +
      text-decoration: none;
 +
      display: block;
 +
      text-align: left;
 +
    }
 +
 
 +
    /***** changes navbar dropdown menu color when choice is hovered *****/
 +
 
 +
    #windowcontent .dropdown-content a:hover, #windowcontent .dropdown-content a:focus {
 +
      background-color: rgb(235,235,235);
 +
    }
 +
 
 +
 
 +
 
 +
/****************************************************************************************************************/
 +
/************************************************* MAIN CONTENT *************************************************/
 +
/****************************************************************************************************************/
 +
 
 +
 
 +
    /***** styles main text area on main page *****/
 +
 
 +
    #windowcontent .maincontainer {
 +
      margin: 0px auto 100px auto;
 +
      width: 1000px;
 +
      text-align: justify;
 +
      clear: both;
 +
      display: table;
 +
    }
 +
 
 +
/****************************************************************************************************************/
 +
/**************************************************** FOOTER ****************************************************/
 +
/****************************************************************************************************************/
 +
 
 +
 
 +
    /***** styles main footer area *****/
 
      
 
      
−
     <div class="maincontainer"
+
     #windowcontent footer {
−
        <!-- creates the main container (text area) -->
+
      background: #848282;
−
        <div class="colp-12 rmvpadmarg" id="startchange">
+
      color: white;
−
            <h1 class="bottomborder">The most neglected tropical disease</h1>
+
      width: 100%;
−
            <div class="row imgmenu">
+
      min-width: 1000px;
−
                <div class="col-5 rmvpadmarg">
+
      position: absolute;
−
                    <div class="imgmenuitem">
+
      text-align: center;
−
                        <a href="#">
+
      color: white;
−
                            <div class="imgmenucontent img1"></div>
+
      font-size: x-small;
−
                            <div class="imgmenuoverlay">
+
      font-family: "Lucida Sans Unicode", "Lucida Grande", sans-serif;
−
                                <h3 class="rmvpadmarg">What is the problem</h3>
+
    }
−
                                <p>Some very informative text that will make the user click the link and learn more about our project</p>
+
−
                            </div>
+
−
                        </a>
+
−
                    </div>
+
−
                </div>
+
−
                <div class="col-2 rmvpadmarg" style="white-space: pre;"><p> </p></div>
+
−
                <div class="col-5 rmvpadmarg">
+
−
                    <div class="imgmenuitem right">
+
−
                        <a href="#">
+
−
                            <div class="imgmenucontent img2"></div>
+
−
                            <div class="imgmenuoverlay">
+
−
                                <h3 class="rmvpadmarg">Where is the problem</h3>
+
−
                                <p>Some more very informative text that will make the user click the link and learn more about our project</p>
+
−
                            </div>
+
−
                        </a>
+
−
                    </div>
+
−
                </div>
+
−
            </div>
+
−
       
+
−
        <h2 class="bottomborder">Project description</h2>
+
  
−
        <p>Envenomation by snakebite is one of the most neglected diseases with an estimated 5 million bites each year. These result in about 100,000 deaths and 400,000 disabilities annually. The only effective treatment is animal derived antivenoms, which frequently causes adverse reactions. As a result they are often only administered as a last resort.
+
    /***** defines a container of same width as main content that contains footer content *****/
−
        </p>
+
  
−
        <p>We aim to develop a detection-assay that enables us to determine what type of snake a snake bite patient is envenomed by. The strategy is to target distinguishable enzymatic features in the different snake venoms by developing suitable substrate-based diagnostic. We hope our diagnostic tool can be useful in identifying the relative composition of specific venom components in a blood sample and thereby allow for the safest course of treatment. See our <a href=https://2017.igem.org/Team:DTU-Denmark/Description>Project Description</a>
+
    #windowcontent .footercontainer {
−
        </p>
+
      width: 1000px;
 +
      margin: 20px auto 25px auto;
 +
    }
  
 +
    /***** centers footer content in the individual columns *****/
 +
   
 +
    #windowcontent .footercolstyle * {
 +
      align-content: center;
 +
      text-align: center;
 +
    }
  
 +
    #windowcontent .footercolstyle a {
 +
      padding: 0px;
 +
    }
  
 +
    /***** styles left footer column *****/
 +
   
 +
    #windowcontent .leftfootercol {
 +
      float: left;
 +
    }
  
 +
    /***** styles right footer column *****/
  
 +
    #windowcontent .rightfootercol {
 +
      float: right;
 +
    }
  
−
<!-- LOREM IPSUM TO TEST SCOLLING -->
+
    /***** gives space between the "find us at" icons *****/
 +
   
 +
    #windowcontent footer img {
 +
      margin: 10px;
 +
    }
  
  
−
<p>
+
    </style>
−
Lorem ipsum dolor sit amet, consectetur adipiscing elit. In a felis sed enim feugiat hendrerit. Curabitur id vulputate risus. Donec porta volutpat posuere. Morbi metus lectus, laoreet quis elit in, bibendum vehicula massa. Vestibulum sit amet tempor libero. Nam urna tellus, suscipit id est sit amet, volutpat ullamcorper ante. Sed venenatis interdum nisl. Nam consectetur libero quis ipsum porttitor, sed placerat diam hendrerit. Cras sit amet massa sit amet nunc tristique tincidunt. Nunc pellentesque, erat et ullamcorper cursus, lacus ligula ultricies tortor, vel suscipit est diam quis nisi. Ut erat sem, aliquam at tortor rutrum, varius lobortis dui. Maecenas ac augue ac arcu blandit commodo eget sit amet sem.
+
−
</p>
+
−
<p>
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<!-- <p>Envenomation by snakebite is one of the most neglected diseases with an estimated 5 million bites. These result in about 100,000 deaths and 400,000 disabilities annually [1]. The only effective treatment is animal derived antivenoms, which frequently causes adverse reactions [2]. As a result they are often only administered as a last resort.</p>
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<p>Envenomation by snakebite is one of the most neglected diseases with an estimated 5 million bites. These result in about 100,000 deaths and 400,000 disabilities annually [1]. The only effective treatment is animal derived antivenoms, which frequently causes adverse reactions [2]. As a result they are often only administered as a last resort.</p>
 
<p>One of the major problems related to treatment of snake bites concerns the lack of identification of the snake. When bitten, it is difficult for most people to remember details about the snake, which makes it almost impossible to confidently administer the correct specific antivenom. Currently, if the snake cannot be identified, multispecies antivenom is used in a consequently higher dose leading to more severe side effects. By solving the venom identification problem it could potentially increase the survival rate of snake bite victims. This is due to decreased diagnosis time and less amount of antivenom necessary for treatment, thereby causing fewer adverse reactions in the patient [3].</p>
 
<p>One of the major problems related to treatment of snake bites concerns the lack of identification of the snake. When bitten, it is difficult for most people to remember details about the snake, which makes it almost impossible to confidently administer the correct specific antivenom. Currently, if the snake cannot be identified, multispecies antivenom is used in a consequently higher dose leading to more severe side effects. By solving the venom identification problem it could potentially increase the survival rate of snake bite victims. This is due to decreased diagnosis time and less amount of antivenom necessary for treatment, thereby causing fewer adverse reactions in the patient [3].</p>
 
<p>We aim to create a novel diagnostic platform by using synthetic biology derived protease activity assay to identify specific venom enzymes that, by developing suitable substrates, can investigate the relative composition of specific venom components in a blood sample. Our goal is to create a diagnostic tool that would make it possible for a clinician to quickly determine which antivenom is necessary, or if it is necessary at all.</p><br /><br />
 
<p>We aim to create a novel diagnostic platform by using synthetic biology derived protease activity assay to identify specific venom enzymes that, by developing suitable substrates, can investigate the relative composition of specific venom components in a blood sample. Our goal is to create a diagnostic tool that would make it possible for a clinician to quickly determine which antivenom is necessary, or if it is necessary at all.</p><br /><br />
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[1] Chippaux JP (1998). <em>Snake-bites: appraisal of the global situation.</em> Bulletin of the World Health Organization, 76(5),515-24.<br />
 
[1] Chippaux JP (1998). <em>Snake-bites: appraisal of the global situation.</em> Bulletin of the World Health Organization, 76(5),515-24.<br />
 
[2] Gutiérrez JM, León G, Lomonte B, Angulo Y (2011). <em>Antivenoms for Snakebite Envenomings. Inflammation and Allergy.</em> Drug Targets 10(5), 369–80.<br />
 
[2] Gutiérrez JM, León G, Lomonte B, Angulo Y (2011). <em>Antivenoms for Snakebite Envenomings. Inflammation and Allergy.</em> Drug Targets 10(5), 369–80.<br />
−
[3] Warrell D, Gutierrez JM, Padilla A (2007). <em>Rabies and Envenomings: a Neglected Public Health Issue: Report of a Consultative Meeting.</em> World Health Organization, Geneva.</p>-->
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[3] Warrell D, Gutierrez JM, Padilla A (2007). <em>Rabies and Envenomings: a Neglected Public Health Issue: Report of a Consultative Meeting.</em> World Health Organization, Geneva.</p>
  
  

Revision as of 17:47, 17 July 2017

Project description

Envenomation by snakebite is one of the most neglected diseases with an estimated 5 million bites. These result in about 100,000 deaths and 400,000 disabilities annually [1]. The only effective treatment is animal derived antivenoms, which frequently causes adverse reactions [2]. As a result they are often only administered as a last resort.

One of the major problems related to treatment of snake bites concerns the lack of identification of the snake. When bitten, it is difficult for most people to remember details about the snake, which makes it almost impossible to confidently administer the correct specific antivenom. Currently, if the snake cannot be identified, multispecies antivenom is used in a consequently higher dose leading to more severe side effects. By solving the venom identification problem it could potentially increase the survival rate of snake bite victims. This is due to decreased diagnosis time and less amount of antivenom necessary for treatment, thereby causing fewer adverse reactions in the patient [3].

We aim to create a novel diagnostic platform by using synthetic biology derived protease activity assay to identify specific venom enzymes that, by developing suitable substrates, can investigate the relative composition of specific venom components in a blood sample. Our goal is to create a diagnostic tool that would make it possible for a clinician to quickly determine which antivenom is necessary, or if it is necessary at all.



References:

[1] Chippaux JP (1998). Snake-bites: appraisal of the global situation. Bulletin of the World Health Organization, 76(5),515-24.
[2] Gutiérrez JM, León G, Lomonte B, Angulo Y (2011). Antivenoms for Snakebite Envenomings. Inflammation and Allergy. Drug Targets 10(5), 369–80.
[3] Warrell D, Gutierrez JM, Padilla A (2007). Rabies and Envenomings: a Neglected Public Health Issue: Report of a Consultative Meeting. World Health Organization, Geneva.

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